{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:37:58Z","timestamp":1783039078261,"version":"3.54.6"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Research and Development Plan","award":["2017YFD0200506"],"award-info":[{"award-number":["2017YFD0200506"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21472062"],"award-info":[{"award-number":["21472062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31701820"],"award-info":[{"award-number":["31701820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005234","name":"Central China Normal University","doi-asserted-by":"publisher","award":["2016YBZZ030"],"award-info":[{"award-number":["2016YBZZ030"]}],"id":[{"id":"10.13039\/501100005234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.bmc.2017.11.021","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T15:00:17Z","timestamp":1510585217000},"page":"84-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Design and synthesis of highly selective pyruvate dehydrogenase complex E1 inhibitors as bactericides"],"prefix":"10.1016","volume":"26","author":[{"given":"Yuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leifeng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.11.021_b0005","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1021\/bi00270a022","volume":"22","author":"Lowe","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2017.11.021_b0010","doi-asserted-by":"crossref","first-page":"45969","DOI":"10.1074\/jbc.M104116200","volume":"276","author":"Nemeria","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bmc.2013.11.051","volume":"22","author":"He","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0020","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1042\/BST0330772","volume":"33","author":"Leeper","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.bmc.2017.11.021_b0025","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1039\/b403619k","volume":"2","author":"Mann","year":"2004","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1474-9726.2012.00805.x","volume":"11","author":"Stacpoole","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.bmc.2017.11.021_b0035","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.bmc.2012.01.019","volume":"20","author":"He","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0040","doi-asserted-by":"crossref","first-page":"8911","DOI":"10.1039\/C4OB01347F","volume":"12","author":"Feng","year":"2014","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0045","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1016\/j.bmc.2014.04.003","volume":"22","author":"He","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0050","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.bmc.2015.02.047","volume":"23","author":"He","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0055","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.bmc.2016.03.011","volume":"24","author":"He","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0060","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.1128\/JB.187.17.6005-6018.2005","volume":"187","author":"Schreiner","year":"2005","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2017.11.021_b0065","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1046-5928(02)00712-X","volume":"28","author":"Szurmak","year":"2003","journal-title":"Protein Expression Purif"},{"key":"10.1016\/j.bmc.2017.11.021_b0070","doi-asserted-by":"crossref","first-page":"12775","DOI":"10.1021\/bi061582l","volume":"45","author":"Seifert","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2017.11.021_b0075","doi-asserted-by":"crossref","first-page":"20196","DOI":"10.1074\/jbc.273.32.20196","volume":"273","author":"Dobritzsch","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1126\/science.275.5296.67","volume":"275","author":"Kern","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bmc.2017.11.021_b0085","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.1016\/j.bmc.2011.10.035","volume":"19","author":"Ren","year":"2011","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0090","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1016\/j.str.2008.10.010","volume":"16","author":"Kato","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.bmc.2017.11.021_b0095","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1021\/bi030200y","volume":"43","author":"Arjunan","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2017.11.021_b0100","doi-asserted-by":"crossref","first-page":"15296","DOI":"10.1074\/jbc.M600656200","volume":"281","author":"Arjunan","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0105","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1021\/bi0118557","volume":"41","author":"Arjunan","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2017.11.021_b0110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3177\/jnsv.37.257","volume":"37","author":"Urata","year":"1991","journal-title":"J Nutr Sci Vitaminol"},{"key":"10.1016\/j.bmc.2017.11.021_b0115","unstructured":"http:\/\/www.ebi.ac.uk\/Tools\/msa\/clustalo\/."},{"key":"10.1016\/j.bmc.2017.11.021_b0120","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/j.bmc.2010.03.031","volume":"18","author":"Bag","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0125","doi-asserted-by":"crossref","first-page":"5652","DOI":"10.1016\/j.bmc.2017.08.038","volume":"25","author":"He","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0130","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1021\/jm8015602","volume":"52","author":"He","year":"2009","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0135","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1021\/jo980800g","volume":"63","author":"Sawyer","year":"1988","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0140","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.3390\/molecules20045625","volume":"20","author":"Sun","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2017.11.021_b0145","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1039\/C4OB00744A","volume":"12","author":"Du","year":"2014","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0150","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/febs.12657","volume":"281","author":"Feng","year":"2014","journal-title":"FEBS J"},{"key":"10.1016\/j.bmc.2017.11.021_b0155","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2009","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmc.2017.11.021_b0160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/nar\/gkh381","volume":"32","author":"Dolinsky","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2017.11.021_b0165","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/ps.688","volume":"59","author":"Lee","year":"2003","journal-title":"Pest Manage Sci"},{"key":"10.1016\/j.bmc.2017.11.021_b0170","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1021\/jf203772d","volume":"60","author":"Xu","year":"2012","journal-title":"J Agric Food Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961731622X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961731622X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:52:09Z","timestamp":1760835129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961731622X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S096808961731622X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.11.021","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and synthesis of highly selective pyruvate dehydrogenase complex E1 inhibitors as bactericides","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.11.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}