{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:21:16Z","timestamp":1790713276842,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007472","name":"University of Kentucky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007472","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bmc.2017.12.018","type":"journal-article","created":{"date-parts":[[2017,12,17]],"date-time":"2017-12-17T10:06:23Z","timestamp":1513505183000},"page":"573-580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Novel fluconazole derivatives with promising antifungal activity"],"prefix":"10.1016","volume":"26","author":[{"given":"Nishad","family":"Thamban Chandrika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjib K.","family":"Shrestha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy X.","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlind C.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Garneau-Tsodikova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2017.12.018_b0005","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.bmc.2009.11.009","article-title":"New small-size peptides possessing antifungal activity","volume":"18","author":"Garibotto","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.12.018_b0010","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/infdis\/167.5.1247","article-title":"Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980\u20131990. National Nosocomial Infections Surveillance System","volume":"167","author":"Beck-Sague","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmc.2017.12.018_b0015","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/CMR.00029-06","article-title":"Epidemiology of invasive candidiasis: a persistent public health problem","volume":"20","author":"Pfaller","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2017.12.018_b0020","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1002\/1097-0142(19920601)69:11<2653::AID-CNCR2820691106>3.0.CO;2-8","article-title":"Nosocomial pneumonia in patients having bone marrow transplant. Attributable mortality and risk factors","volume":"69","author":"Pannuti","year":"1992","journal-title":"Cancer"},{"key":"10.1016\/j.bmc.2017.12.018_b0025","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and aspergillosis","volume":"12","author":"Latge","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2017.12.018_b0030","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1128\/JCM.38.5.1974-1976.2000","article-title":"Prevalence of Cryptococcus neoformans var. neoformans (Serotype D) and Cryptococcus neoformans var. grubii (Serotype A) isolates in New York City","volume":"38","author":"Steenbergen","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2017.12.018_b0035","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1469-0691.2001.tb00005.x","article-title":"Uncommon opportunistic fungi: new nosocomial threats","volume":"7","author":"Groll","year":"2001","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.bmc.2017.12.018_b0040","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1086\/516480","article-title":"Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation","volume":"175","author":"Wald","year":"1997","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmc.2017.12.018_b0045","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1086\/514731","article-title":"Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC)","volume":"28","author":"Viscoli","year":"1999","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2017.12.018_b0050","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1473-3099(10)70218-8","article-title":"Emerging opportunistic yeast infections","volume":"11","author":"Miceli","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2017.12.018_b0055","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1128\/JCM.02117-09","volume":"48","author":"Pfaller","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2017.12.018_b0060","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1097\/CCM.0000000000000221","volume":"42","author":"Puig-Asensio","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.bmc.2017.12.018_b0065","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1093\/jac\/dkt083","article-title":"Invasive candidiasis in intensive care units in China: a multicentre prospective observational study","volume":"68","author":"Guo","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2017.12.018_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408410903241444","article-title":"Epidemiology of invasive mycoses in North America","volume":"36","author":"Pfaller","year":"2010","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.bmc.2017.12.018_b0075","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3201\/eid1210.060389","article-title":"Active surveillance for candidemia, Australia","volume":"12","author":"Chen","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bmc.2017.12.018_b0080","doi-asserted-by":"crossref","first-page":"3952","DOI":"10.1128\/JCM.01130-12","article-title":"In vitro susceptibilities of yeast species to fluconazole and voriconazole as determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) study","volume":"50","author":"Wang","year":"2012","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2017.12.018_b0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1086\/655683","article-title":"Epidemiology of opportunistic fungal infections in Latin America","volume":"51","author":"Nucci","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2017.12.018_b0090","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/jac\/dku460","article-title":"Antifungal susceptibilities of Candida glabrata species complex, Candida krusei, Candida parapsilosis species complex and Candida tropicalis causing invasive candidiasis in China: 3 year national surveillance","volume":"70","author":"Xiao","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2017.12.018_b0095","doi-asserted-by":"crossref","first-page":"11178","DOI":"10.1016\/j.tet.2006.09.021","article-title":"Design and synthesis of fluconazole\/bile acid conjugate using click reaction","volume":"62","author":"Pore","year":"2006","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2017.12.018_b0100","first-page":"2173","article-title":"Azole antifungal resistance in Candida albicans and emerging non-albicans Candida species","volume":"7","author":"Whaley","year":"2016","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bmc.2017.12.018_b0105","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.1128\/AAC.00229-15","article-title":"Amphiphilic tobramycin analogues as antibacterial and antifungal agents","volume":"59","author":"Shrestha","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2017.12.018_b0110","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1021\/acs.jmedchem.5b01375","article-title":"Synthesis and bioactivities of kanamycin B-derived cationic amphiphiles","volume":"58","author":"Fosso","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2017.12.018_b0115","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1016\/j.bmc.2016.06.010","article-title":"Synthesis and investigation of novel benzimidazole derivatives as antifungal agents","volume":"24","author":"Thamban Chandrika","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2017.12.018_b0120","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1002\/cmdc.201600236","article-title":"Identification of ebsulfur analogues with broad-spectrum antifungal activity","volume":"11","author":"Ngo","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2017.12.018_b0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ejmech.2017.03.075","article-title":"Novel alkylated azoles as potent antifungals","volume":"133","author":"Shrestha","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2017.12.018_b0130","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/ja.2010.110","article-title":"Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides","volume":"63","author":"Chang","year":"2010","journal-title":"J Antibiot"},{"key":"10.1016\/j.bmc.2017.12.018_b0135","doi-asserted-by":"crossref","first-page":"e73843","DOI":"10.1371\/journal.pone.0073843","article-title":"Membrane lipid-modulated mechanism of action and non-cytotoxicity of novel fungicide aminoglycoside FG08","volume":"8","author":"Shrestha","year":"2013","journal-title":"PLoS One"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617319338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617319338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:52:49Z","timestamp":1760835169000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617319338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0968089617319338"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2017.12.018","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel fluconazole derivatives with promising antifungal activity","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2017.12.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}