{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:11:14Z","timestamp":1760836274478,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21AI109437"],"award-info":[{"award-number":["R21AI109437"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PHPID"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.bmc.2018.01.024","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T14:56:06Z","timestamp":1517583366000},"page":"2251-2261","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans"],"prefix":"10.1016","volume":"26","author":[{"given":"Keisuke","family":"Ishita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stavros","family":"Stefanopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Tjarks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7880-5958","authenticated-orcid":false,"given":"Chad A.","family":"Rappleye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.01.024_b0005","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1369-5274(03)00080-8","volume":"6","author":"Woods","year":"2003","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bmc.2018.01.024_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/00362177485380061","volume":"12","author":"Hammerman","year":"1974","journal-title":"Sabouraudia"},{"key":"10.1016\/j.bmc.2018.01.024_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408410903241444","volume":"36","author":"Pfaller","year":"2010","journal-title":"Crit Rev Microbiol"},{"key":"10.1016\/j.bmc.2018.01.024_b0020","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/500405","volume":"42","author":"Chu","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2018.01.024_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2015.10.004","volume":"30","author":"Vallabhaneni","year":"2016","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.bmc.2018.01.024_b0030","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2217\/fmb.12.102","volume":"7","author":"Sabiiti","year":"2012","journal-title":"Future Microbiol"},{"key":"10.1016\/j.bmc.2018.01.024_b0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","volume":"23","author":"Park","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.bmc.2018.01.024_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.3004404","volume":"4","author":"Brown","year":"2012","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bmc.2018.01.024_b0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.tim.2010.02.004","volume":"18","author":"Denning","year":"2010","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.bmc.2018.01.024_b0050","first-page":"6185","volume":"9","author":"Jinna","year":"2015","journal-title":"Drug Des Develop Ther"},{"key":"10.1016\/j.bmc.2018.01.024_b0055","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1086\/504492","volume":"43","author":"Dodds Ashley","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2018.01.024_b0060","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1128\/AAC.01681-10","volume":"55","author":"Hage","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.01.024_b0065","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1128\/AAC.49.7.2851-2856.2005","volume":"49","author":"Maligie","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.01.024_b0070","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1128\/JCM.00328-10","volume":"48","author":"Messer","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2018.01.024_b0075","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2165\/00128071-200304010-00005","volume":"4","author":"Darkes","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.bmc.2018.01.024_b0080","doi-asserted-by":"crossref","first-page":"805","DOI":"10.4065\/mcp.2011.0247","volume":"86","author":"Lewis","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.bmc.2018.01.024_b0085","first-page":"64","volume":"1","author":"Ramana","year":"2013","journal-title":"Am J Infect Dis Microbiol"},{"key":"10.1016\/j.bmc.2018.01.024_b0090","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/0976-500X.171870","volume":"6","author":"Sharma","year":"2015","journal-title":"J Pharmacol Pharmacother"},{"key":"10.1016\/j.bmc.2018.01.024_b0095","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019703","volume":"4","author":"Roemer","year":"2014","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"10.1016\/j.bmc.2018.01.024_b0100","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1093\/jac\/dkt221","volume":"68","author":"Loyse","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2018.01.024_b0105","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1128\/AAC.00459-13","volume":"57","author":"Edwards","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.01.024_b0110","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bmc.2014.12.006","volume":"23","author":"Khalil","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.01.024_b0115","doi-asserted-by":"crossref","first-page":"136","DOI":"10.25004\/IJPSDR.2009.010302","volume":"1","author":"Siddiqui","year":"2009","journal-title":"Int J Pharm Sci Drug Res"},{"key":"10.1016\/j.bmc.2018.01.024_b0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1159\/000142334","volume":"54","author":"Borelli","year":"2008","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bmc.2018.01.024_b0125","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nrd3074","volume":"9","author":"Ostrosky-Zeichner","year":"2010","journal-title":"Nat Rev Drug Disc"},{"key":"10.1016\/j.bmc.2018.01.024_b0130","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.ejmech.2015.04.015","volume":"97","author":"Ayati","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.01.024_b0135","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.abb.2008.11.003","volume":"481","author":"Nes","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.bmc.2018.01.024_b0140","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1021\/jm1013693","volume":"54","author":"Meanwell","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.01.024_b0145","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/0929867053363540","volume":"12","author":"Lima","year":"2005","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2018.01.024_b0150","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/cr950066q","volume":"96","author":"Patani","year":"1996","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2018.01.024_b0155","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1039\/C5CC04573H","volume":"51","author":"Daniel","year":"2015","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmc.2018.01.024_b0160","first-page":"5033","volume":"6","author":"Joshi","year":"2016","journal-title":"Indo Am J Pharm Res"},{"key":"10.1016\/j.bmc.2018.01.024_b0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1146\/annurev.biochem.75.101304.124125","volume":"77","author":"Cravatt","year":"2008","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.bmc.2018.01.024_b0170","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1021\/ed053p280","volume":"53","author":"Matuszak","year":"1976","journal-title":"J Chem Educ"},{"key":"10.1016\/j.bmc.2018.01.024_b0175","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1248\/cpb.36.2968","volume":"36","author":"Kanao","year":"1988","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmc.2018.01.024_b0180","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.1016\/S0040-4020(02)00383-6","volume":"58","author":"Schiavi","year":"2002","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.01.024_b0185","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1002\/anie.200801030","volume":"47","author":"Shi","year":"2008","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.bmc.2018.01.024_b0190","first-page":"1","volume":"71","author":"Larson","year":"2008","journal-title":"Org React"},{"key":"10.1016\/j.bmc.2018.01.024_b0195","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/0040-4020(78)80205-1","volume":"34","author":"Parnes","year":"1978","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.01.024_b0200","unstructured":"Nitz TJ, Salzwedel K, Finnegan C, Brunton S, Flanagan S, Montalbetti C, Coulter TS. PCT Int Appl WO 2009085256 A1; 2009."},{"key":"10.1016\/j.bmc.2018.01.024_b0205","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1021\/jm049932u","volume":"47","author":"Kitbunnadaj","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.01.024_b0210","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1016\/j.bmcl.2009.05.123","volume":"19","author":"Uto","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.01.024_b0215","unstructured":"Baumann K, Goetschi E, Jolidon S, Limberg A, Luebbers TF. PCT Int Appl WO 2010052199 A1; 2010."},{"key":"10.1016\/j.bmc.2018.01.024_b0220","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1128\/AAC.05502-11","volume":"56","author":"Sionov","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.01.024_b0225","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1086\/593194","volume":"47","author":"Longley","year":"2008","journal-title":"Clin Infect Dis"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617324732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089617324732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:56:01Z","timestamp":1760835361000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089617324732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0968089617324732"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.01.024","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of aminothiazoles against Histoplasma capsulatum and Cryptococcus neoformans","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}