{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:56:49Z","timestamp":1791831409195,"version":"4.3.4"},"reference-count":62,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bmc.2018.02.043","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T13:43:30Z","timestamp":1519393410000},"page":"2928-2936","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-\u03b2-lactamases"],"prefix":"10.1016","volume":"26","author":[{"given":"Dong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marios S.","family":"Markoulides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitrijs","family":"Stepanovs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Rydzik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"El-Hussein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corentin","family":"Bon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos J.A.G.","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus-Daniel","family":"Umland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel T.","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"von Delft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Brem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-6942","authenticated-orcid":false,"given":"Michael A.","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.02.043_b0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1473-3099(14)70071-4","volume":"14","author":"Versporten","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2018.02.043_b0010","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0923-2508(91)90084-N","volume":"142","author":"Fr\u00e9re","year":"1991","journal-title":"Res Microbiol"},{"key":"10.1016\/j.bmc.2018.02.043_b0015","first-page":"37","volume":"8","author":"Neu","year":"1987","journal-title":"Curr Clin Top Infect Dis"},{"key":"10.1016\/j.bmc.2018.02.043_b0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/dkg050","volume":"51","author":"Webber","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2018.02.043_b0025","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.mib.2010.09.006","volume":"13","author":"Bush","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bmc.2018.02.043_b0030","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S1473-3099(11)70056-1","volume":"11","author":"Cornaglia","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2018.02.043_b0035","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/j.1875-9114.2012.01157.x","volume":"32","author":"George","year":"2012","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bmc.2018.02.043_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/a705983c","volume":"16","author":"Matagne","year":"1999","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2018.02.043_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1039\/a705983c","volume":"16","author":"Matagne","year":"1999","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2018.02.043_b0050","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1039\/C4MT00066H","volume":"6","author":"Karsisiotis","year":"2014","journal-title":"Metallomics"},{"key":"10.1016\/j.bmc.2018.02.043_b0055","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/AAC.11.5.852","volume":"11","author":"Reading","year":"1977","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.02.043_b0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1054\/drup.2000.0137","volume":"3","author":"Page","year":"2000","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.bmc.2018.02.043_b0065","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.mib.2011.07.026","volume":"14","author":"Coleman","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bmc.2018.02.043_b0070","doi-asserted-by":"crossref","first-page":"27960","DOI":"10.1074\/jbc.M113.485979","volume":"288","author":"Ehmann","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0075","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2165\/11318430-000000000-00000","volume":"70","author":"Bebrone","year":"2010","journal-title":"Drugs"},{"key":"10.1016\/j.bmc.2018.02.043_b0080","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13445","volume":"510","author":"King","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2018.02.043_b0085","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1016\/j.febslet.2015.08.015","volume":"589","author":"Meini","year":"2015","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bmc.2018.02.043_b0090","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1128\/CMR.18.2.306-325.2005","volume":"18","author":"Walsh","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2018.02.043_b0095","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/cr030102i","volume":"105","author":"Fisher","year":"2005","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2018.02.043_b0100","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.1021\/bi100894r","volume":"49","author":"Gonzalez","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2018.02.043_b0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3797\/scipharm.1302-08","volume":"81","author":"Faridoon","year":"2013","journal-title":"N Sci Pharm"},{"key":"10.1016\/j.bmc.2018.02.043_b0110","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1021\/jm400769b","volume":"56","author":"van Berkel","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0115","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/cmdc.201300350","volume":"8","author":"Makena","year":"2013","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2018.02.043_b0120","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/nchem.2110","volume":"6","author":"Brem","year":"2014","journal-title":"Nat Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0125","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/s41467-017-00601-9","volume":"8","author":"Lisa","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2018.02.043_b0130","volume":"61","author":"Cahill","year":"2017","journal-title":"J Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.02.043_b0135","unstructured":"Shaffer JE, Thomson SA, Oxathi(SIV)azol-5-one compounds, Google Patents, 1992."},{"key":"10.1016\/j.bmc.2018.02.043_b0140","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1039\/B403052D","volume":"2","author":"Brana","year":"2004","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0145","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1021\/jm100213c","volume":"53","author":"Lassaux","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0150","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1107\/S0021889809045701","volume":"43","author":"Winter","year":"2010","journal-title":"J Appl Crystallogr"},{"key":"10.1016\/j.bmc.2018.02.043_b0155","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.bmc.2018.02.043_b0160","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.bmc.2018.02.043_b0165","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1107\/S205979831700331X","volume":"73","author":"Collins","year":"2017","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"10.1016\/j.bmc.2018.02.043_b0170","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1107\/S0907444909047337","volume":"66","author":"Kabsch","year":"2010","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.bmc.2018.02.043_b0175","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1107\/S2059798316020234","volume":"73","author":"Krojer","year":"2017","journal-title":"Acta Crystallogr D Struct Biol"},{"key":"10.1016\/j.bmc.2018.02.043_b0180","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15123","volume":"8","author":"Pearce","year":"2017","journal-title":"Nat Comm"},{"key":"10.1016\/j.bmc.2018.02.043_b0185","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1107\/S0907444911056058","volume":"68","author":"Smart","year":"2012","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.bmc.2018.02.043_b0190","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1107\/S0907444911001314","volume":"67","author":"Murshudov","year":"2011","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"10.1016\/j.bmc.2018.02.043_b0195","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1016\/j.bmc.2012.03.052","volume":"20","author":"Harada","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0200","doi-asserted-by":"crossref","first-page":"4706","DOI":"10.1021\/jm9801399","volume":"41","author":"Fresneau","year":"1998","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0205","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0022-2860(99)00354-3","volume":"522","author":"Castineiras","year":"2000","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmc.2018.02.043_b0210","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/j.bmcl.2012.02.100","volume":"22","author":"Zvarec","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.02.043_b0215","first-page":"2831","volume":"346","author":"Khodair","year":"2011","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.bmc.2018.02.043_b0220","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ejmech.2014.06.013","volume":"83","author":"Ramesh","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0225","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.bmcl.2010.11.041","volume":"21","author":"Maccari","year":"2011","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.02.043_b0230","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1016\/j.ejmech.2010.09.031","volume":"45","author":"Chen","year":"2010","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0235","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1016\/j.tetlet.2013.04.012","volume":"54","author":"Subbaiah","year":"2013","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2018.02.043_b0240","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.1021\/jo202608w","volume":"77","author":"Meyer","year":"2012","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0245","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1016\/j.tet.2010.07.017","volume":"66","author":"Matsui","year":"2010","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.02.043_b0250","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1016\/j.bmc.2010.05.030","volume":"18","author":"Talele","year":"2010","journal-title":"Biorg Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0255","doi-asserted-by":"crossref","first-page":"3769","DOI":"10.1016\/j.bmcl.2013.04.092","volume":"23","author":"Min","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.02.043_b0260","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.ejmech.2017.04.035","volume":"135","author":"Skagseth","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0265","unstructured":"Spicer T e.a., ML302, A Novel \u03b2-lactamase (BLA) Inhibitor, Probe Reports from the NIH Molecular Libraries Program, National Center for Biotechnology Information, 2010."},{"key":"10.1016\/j.bmc.2018.02.043_b0270","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1039\/C6SC04524C","volume":"8","author":"Li","year":"2017","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmc.2018.02.043_b0275","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1039\/b802311e","volume":"6","author":"Li\u00e9nard","year":"2008","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0280","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1021\/ja303579d","volume":"134","author":"King","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2018.02.043_b0285","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1021\/jm201243p","volume":"55","author":"Mendgen","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.02.043_b0290","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cbpa.2010.02.018","volume":"14","author":"Welsch","year":"2010","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.bmc.2018.02.043_b0295","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1517\/17460441.2012.688743","volume":"7","author":"Tomasic","year":"2012","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmc.2018.02.043_b0300","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1592\/phco.28.5.646","volume":"28","author":"Ramirez","year":"2008","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bmc.2018.02.043_b0305","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1080\/17460441.2017.1388370","volume":"12","author":"Kaminskyy","year":"2017","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmc.2018.02.043_b0310","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.tibs.2015.12.007","volume":"41","author":"Pettinati","year":"2016","journal-title":"Trends Biochem Sci"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618301858?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618301858?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:53:58Z","timestamp":1760835238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089618301858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0968089618301858"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.02.043","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structure activity relationship studies on rhodanines and derived enethiol inhibitors of metallo-\u03b2-lactamases","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.02.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}