{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:16:43Z","timestamp":1790957803520,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bmc.2018.04.056","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T13:51:18Z","timestamp":1524837078000},"page":"3287-3295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Efficiency of newly prepared thiazole derivatives against some cutaneous fungi"],"prefix":"10.1016","volume":"26","author":[{"given":"Salama A.","family":"Ouf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobhi M.","family":"Gomha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Eweis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Ouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab A.","family":"Sharawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.04.056_b0005","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1080\/13693780601070107","article-title":"Analysis of the dermatophyte species isolated in the British Isles between 1980 and 2005 and review of worldwide dermatophyte trends over the last three decades","volume":"45","author":"Borman","year":"2007","journal-title":"Med Mycol"},{"key":"10.1016\/j.bmc.2018.04.056_b0010","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2174\/1389557516666160630120725","article-title":"New progress in azole compounds as antimicrobial agents","volume":"17","author":"Zhang","year":"2017","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0015","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1086\/367933","article-title":"Voriconazole: a new triazole antifungal agent","volume":"36","author":"Johnson","year":"2003","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2018.04.056_b0020","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.molstruc.2017.10.045","article-title":"Synthesis, characterization and antibacterial activity of a new calcium complex using sodium 2-mercaptobenzothiazole and 1, 10-phenanthroline as ligands","volume":"1154","author":"Gulab","year":"2018","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmc.2018.04.056_b0025","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/ardp.201200014","article-title":"Synthesis of some azoles incorporating a sulfonamide moiety as anticonvulsant agents","volume":"345","author":"Farag","year":"2012","journal-title":"Arch Pharm (Weinheim)"},{"key":"10.1016\/j.bmc.2018.04.056_b0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/1871520616666161221112042","article-title":"Role of azoles in cancer prevention and treatment: present and future perspectives","volume":"18","author":"Ahmad","year":"2018","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0035","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1021\/jm00004a008","article-title":"Studies on new acidic azoles as glucose-lowering agents in obese, diabetic db\/db mice","volume":"38","author":"Kees","year":"1995","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1574-6968.2006.00350.x","article-title":"Azole antifungals as novel chemotherapeutic agents against murine tuberculosis","volume":"261","author":"Ahmad","year":"2006","journal-title":"FEMS Microbiol Lett"},{"key":"10.1016\/j.bmc.2018.04.056_b0045","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s12272-013-0083-9","article-title":"New anti-inflammatory thiazolyl-carbonyl-thiosemicarbazides and thiazolyl-azoles with antioxidant properties as potential iNOS inhibitors","volume":"36","author":"Tiperciuc","year":"2013","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2018.04.056_b0050","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11046-016-0045-0","article-title":"New antifungal agents and new formulations against dermatophytes","volume":"182","author":"Gupta","year":"2017","journal-title":"Mycopathologia"},{"key":"10.1016\/j.bmc.2018.04.056_b0055","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1046\/j.0933-7407.2003.00932.x","article-title":"Action mechanisms of modern antifungal agents and resulting problems in the management of onychomycosis","volume":"46","author":"Seebacher","year":"2003","journal-title":"Mycoses"},{"key":"10.1016\/j.bmc.2018.04.056_b0060","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000018032","article-title":"Tinea capitis dermatophytes: susceptibility to antifungal drugs tested in vitro and in vivo","volume":"197","author":"Mock","year":"1998","journal-title":"Dermatology"},{"key":"10.1016\/j.bmc.2018.04.056_b0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ejmech.2005.01.013","article-title":"Synthesis, antibacterial andantifungal activity ofsomenew thiazolylhydrazone derivatives containing 3-substituted cyclobutane ring","volume":"41","author":"Cukurovali","year":"2006","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0070","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ejmech.2007.03.014","article-title":"Synthesis of some novel 2,4-disubstituted thiazoles as possible antimicrobial agents","volume":"43","author":"Karegoudar","year":"2008","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0075","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.ejmech.2008.09.029","article-title":"Synthesis and antimicrobial evaluation of 1- (benzofuran-2- yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)- 1,3-thiazol-2-yl]-1Hpyrazoles","volume":"44","author":"Abdel-Wahab","year":"2009","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0080","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1016\/j.bmc.2004.06.033","article-title":"Syntheses and evaluation of antioxidant activity of sydnonyl substituted thiazolidinone and thiazoline derivatives","volume":"12","author":"Shih","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0085","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1016\/j.bmc.2007.04.003","article-title":"Synthesis of new S-derivatives of clubbed triazole as anti-Mycobacterium tuberculosis agents","volume":"15","author":"Shiradkar","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0090","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1016\/j.bmc.2008.04.021","article-title":"Synthesis and preliminary evaluation of some substituted coumarins as anticonvulsant agents","volume":"16","author":"Amin","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13065-017-0335-8","article-title":"A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents","volume":"11","author":"Gomha","year":"2017","journal-title":"Chem Cent J"},{"key":"10.1016\/j.bmc.2018.04.056_b0100","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/molecules23030685","article-title":"Thiazoles and Thiazolidinones as COX\/LOX Inhibitors","volume":"23","author":"Liaras","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2018.04.056_b0105","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00894-006-0131-1","article-title":"Structure-based 3D-QSAR studies on thiazoles as 5-HT3 receptor antagonists","volume":"13","author":"Zhu","year":"2007","journal-title":"J Mol Model"},{"key":"10.1016\/j.bmc.2018.04.056_b0110","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/j.bmcl.2007.01.022","article-title":"Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: modulation of isozyme selectivity by incorporation of phenyl ring substituents","volume":"17","author":"Clark","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.04.056_b0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.mycmed.2013.07.056","article-title":"Efficacy of some synthesized thiazoles against dermatophytes","volume":"23","author":"Ouf","year":"2013","journal-title":"J Mycol Med"},{"key":"10.1016\/j.bmc.2018.04.056_b0120","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/jhet.3040","article-title":"Synthesis, characterization, and antifungal activity evaluation of some novel arylazothiazoles","volume":"55","author":"Ouf","year":"2018","journal-title":"J. Heterocyclic Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0125","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of Pan Assay Interference Compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2307\/1592511","article-title":"Minimum inhibitory concentration determinations for various antimicrobial agents against 1570 bacterial isolates from turkey poults","volume":"44","author":"Salmon","year":"2000","journal-title":"Avian Dis"},{"key":"10.1016\/j.bmc.2018.04.056_b0135","unstructured":"Clinical and Laboratory Standards Institute (CLSI). Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard, 2nd ed. CLSI document M38\u2013A2. Clinical and Laboratory Standards Institute, Wayne, PA, 2008."},{"key":"10.1016\/j.bmc.2018.04.056_b0140","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1128\/JCM.39.3.954-958.2001","article-title":"In vitro fungicidal activities of voriconazole, itraconazole, and amphotericin B against opportunistic moniliaceous and dematiaceous fungi","volume":"39","author":"Espinel-Ingroff","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2018.04.056_b0145","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1128\/AAC.45.6.1828-1835.2001","article-title":"Optimal susceptibility testing conditions for detection of azole resistance in Aspergillus spp.: NCCLS collaborative study","volume":"45","author":"Espinel-Ingroff","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.04.056_b0150","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1023\/A:1010900403141","article-title":"Partial purification and some biochemical characteristics of exocellular keratinase from Trichophyton mentagrophytes var. erinacei","volume":"150","author":"Muhsin","year":"2000","journal-title":"Mycopathologia"},{"key":"10.1016\/j.bmc.2018.04.056_b0155","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1128\/JCM.37.10.3332-3337.1999","article-title":"Quantification of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicans","volume":"37","author":"Arthington-Skaggs","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.bmc.2018.04.056_b0160","unstructured":"Molecular Operating Environment (MOE), version 2011.10. Chemical Computing Group Inc; Montreal, QC, Canada, 2011."},{"key":"10.1016\/j.bmc.2018.04.056_b0165","doi-asserted-by":"crossref","first-page":"e01106","DOI":"10.1128\/AAC.01106-16","article-title":"In Vitro activities of novel azole compounds ATTAF-1 and ATTAF-2 against fluconazole-susceptible and -resistant isolates of Candida species","volume":"61","author":"Fakhim","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.04.056_b0170","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.3390\/molecules15064129","volume":"15","author":"Heeres","year":"2010","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2018.04.056_b0175","first-page":"819","article-title":"Comparison of the in vitro activity of fluconazole against Candida albicans and dermatophytes","volume":"45","author":"Wildfeuer","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bmc.2018.04.056_b0180","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jhazmat.2006.08.073","article-title":"An assessment of structure and toxicity correlation in organochlorine pesticides","volume":"143","author":"Kaushik","year":"2007","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.bmc.2018.04.056_b0185","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.bmcl.2007.10.111","article-title":"2-Hydroxyphenacyl azoles and related azolium derivatives as antifungal agents","volume":"18","author":"Emami","year":"2008","journal-title":"Bioorganic Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.04.056_b0190","first-page":"439","article-title":"Synthesis of 1-[2 (substituted phenyl)-4-oxothiazolidin-3-yl]-3-(6-fluro-7-chloro-1, 3-benzothiazol-2-yl)-ureas as anthelmintic agent","volume":"7","author":"Sarkar","year":"2013","journal-title":"J Pharm Res"},{"key":"10.1016\/j.bmc.2018.04.056_b0195","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.ejmech.2011.06.012","article-title":"New azole antifungal agents with novel modes of action: synthesis and biological studies of new tridentate ligands based on pyrazole and triazole","volume":"46","author":"Bendaha","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0200","first-page":"1056","article-title":"Studies on the antifungal activity of the new imidazole antimycotic lanoconazole in infected sites. Distribution in the skin and in vitro activity in the presence of stratum corneum","volume":"47","author":"Niwano","year":"1997","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.bmc.2018.04.056_b0205","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1128\/AAC.01520-12","article-title":"Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants","volume":"57","author":"Sun","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.04.056_b0210","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2885.2003.00456.x","article-title":"Antifungal agents of use in animal health chemical, biochemical and pharmacological aspects","volume":"26","author":"Bossche","year":"2003","journal-title":"J Vet Pharmacol Ther"},{"key":"10.1016\/j.bmc.2018.04.056_b0215","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/CMR.12.4.501","article-title":"Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance","volume":"12","author":"Ghannoum","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2018.04.056_b0220","first-page":"10","volume":"4","author":"McClanahan","year":"2009","journal-title":"BioFiles"},{"key":"10.1016\/j.bmc.2018.04.056_b0225","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2174\/1389557516666160118112103","article-title":"The mechanistic targets of antifungal agents: An Overview","volume":"16","author":"Mazu","year":"2016","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0230","doi-asserted-by":"crossref","first-page":"247","DOI":"10.21608\/ejbo.2014.490","article-title":"Effect of fluconazole and terbinafine on the activities of lanosterol 14 \u03b1-demethylase and squalene epoxidase in ergosterol biosynthetic pathway","volume":"54","author":"Sayed","year":"2014","journal-title":"Egypt J Bot"},{"key":"10.1016\/j.bmc.2018.04.056_b0235","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1128\/AAC.48.9.3272-3278.2004","article-title":"The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis","volume":"48","author":"Bossche","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.04.056_b0240","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/CMR.00046-13","article-title":"Tissue penetration of antifungal agents","volume":"27","author":"Felton","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2018.04.056_b0245","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1128\/AAC.27.5.832","article-title":"Activity of UK-49,858, a bis-triazole derivative, against experimental infections with Candida albicans and Trichophyton mentagrophytes","volume":"27","author":"Richardson","year":"1985","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.04.056_b0250","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ddr.430080135","article-title":"The in vivo antifungal activity of broad-spectrum azoles","volume":"8","author":"Van Cutsem","year":"1986","journal-title":"Drug Dev Res"},{"key":"10.1016\/j.bmc.2018.04.056_b0255","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1021\/jm0494772","article-title":"Synthesis and in vitro and in vivo structure-activity relationships of novel antifungal triazoles for dermatology","volume":"48","author":"Meerpoel","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0260","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1021\/jm048972v","article-title":"Unveiling the full potential of flexible receptor docking using multiple crystallographic structures","volume":"48","author":"Barril","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.04.056_b0265","series-title":"Computational drug design","author":"Young","year":"2009"},{"key":"10.1016\/j.bmc.2018.04.056_b0270","first-page":"293","article-title":"Molecular docking study of 2-aminoimidazole substituted ligand as inhibitors as cytochrome p 450-dependent lanosterol 14\u03b1- demethylase (p45014dm, cyp51) in the ergosterol-biosynthesis","volume":"3","author":"Nikose","year":"2016","journal-title":"EJPMR"},{"key":"10.1016\/j.bmc.2018.04.056_b0275","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3390\/molecules22071211","article-title":"Synthesis, antitumor evaluation and molecular docking of new morpholine based heterocycles","volume":"22","author":"Muhammad","year":"2017","journal-title":"Molecules"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618304140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618304140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:55:24Z","timestamp":1760835324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089618304140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0968089618304140"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.04.056","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficiency of newly prepared thiazole derivatives against some cutaneous fungi","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.04.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}