{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:26:00Z","timestamp":1790061960599,"version":"4.0.1"},"reference-count":70,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"QUE Oncology Inc"},{"DOI":"10.13039\/501100001537","name":"University of Auckland Biopharma Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council Future Fellowship","doi-asserted-by":"publisher","award":["FT130101215"],"award-info":[{"award-number":["FT130101215"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bmc.2018.05.012","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T12:36:23Z","timestamp":1525869383000},"page":"3406-3413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay"],"prefix":"10.1016","volume":"26","author":[{"given":"Ralph J.","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Azimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack U.","family":"Flanagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Inserra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Monteith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.05.012_b0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2018.05.012_b0010","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1127883","volume":"312","author":"Vig","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bmc.2018.05.012_b0015","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.tibs.2006.09.007","volume":"31","author":"Taylor","year":"2006","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.bmc.2018.05.012_b0020","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1073\/pnas.0603161103","volume":"103","author":"Zhang","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2018.05.012_b0025","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature05108","volume":"443","author":"Yeromin","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2018.05.012_b0030","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nature04147","volume":"437","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2018.05.012_b0035","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1083\/jcb.200604015","volume":"174","author":"Luik","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.bmc.2018.05.012_b0040","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1074\/jbc.M115.685289","volume":"291","author":"Palty","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jmb.2014.09.021","volume":"427","author":"Shim","year":"2015","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmc.2018.05.012_b0050","author":"Vaeth","year":"2017","journal-title":"Nature Commun"},{"key":"10.1016\/j.bmc.2018.05.012_b0055","doi-asserted-by":"crossref","first-page":"5827","DOI":"10.1073\/pnas.1502264112","volume":"112","author":"Davis","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2018.05.012_b0060","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/1535-7163.MCT-10-0923","volume":"10","author":"McAndrew","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2018.05.012_b0065","doi-asserted-by":"crossref","first-page":"C402","DOI":"10.1152\/ajpcell.00355.2015","volume":"310","author":"Spinelli","year":"2016","journal-title":"Am J Physiol-Cell Ph"},{"key":"10.1016\/j.bmc.2018.05.012_b0070","doi-asserted-by":"crossref","first-page":"C414","DOI":"10.1152\/ajpcell.00349.2015","volume":"310","author":"Son","year":"2016","journal-title":"Am J Physiol-Cell Ph"},{"key":"10.1016\/j.bmc.2018.05.012_b0075","doi-asserted-by":"crossref","first-page":"C457","DOI":"10.1152\/ajpcell.00064.2015","volume":"309","author":"Vashisht","year":"2015","journal-title":"Am J Physiol-Cell Ph"},{"key":"10.1016\/j.bmc.2018.05.012_b0080","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.bbamcr.2015.11.030","volume":"1863","author":"Chen","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2018.05.012_b0085","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.bbamcr.2015.10.003","volume":"1863","author":"Jardin","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2018.05.012_b0090","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bbamcr.2015.12.009","volume":"1863","author":"Hoth","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2018.05.012_b0095","first-page":"2067","volume":"138","author":"Xie","year":"2016","journal-title":"In J Cancer"},{"key":"10.1016\/j.bmc.2018.05.012_b0100","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/BD-2010-0307","volume":"32","author":"Chavez","year":"2010","journal-title":"Breast Dis"},{"key":"10.1016\/j.bmc.2018.05.012_b0105","doi-asserted-by":"crossref","first-page":"11983","DOI":"10.1074\/jbc.M114.598425","volume":"290","author":"Didiasova","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0110","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ccr.2008.12.019","volume":"15","author":"Yang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bmc.2018.05.012_b0115","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.immunol.021908.132550","volume":"28","author":"Hogan","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bmc.2018.05.012_b0120","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1124\/mi.10.4.4","volume":"10","author":"Putney","year":"2010","journal-title":"Mol Interv"},{"key":"10.1016\/j.bmc.2018.05.012_b0125","first-page":"707","volume":"4","author":"Sweeney","year":"2009","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2018.05.012_b0130","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/aps.2015.52","volume":"36","author":"Zhang","year":"2015","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.bmc.2018.05.012_b0135","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00374562","volume":"428","author":"Franzius","year":"1994","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.bmc.2018.05.012_b0140","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1085\/jgp.20028601","volume":"120","author":"Kozak","year":"2002","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.bmc.2018.05.012_b0145","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1111\/j.1476-5381.1994.tb17072.x","volume":"113","author":"Chung","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2018.05.012_b0150","doi-asserted-by":"crossref","first-page":"15225","DOI":"10.1073\/pnas.1103315108","volume":"108","author":"Chen","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2018.05.012_b0155","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ceca.2004.04.004","volume":"36","author":"Enfissi","year":"2004","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bmc.2018.05.012_b0160","first-page":"1784","volume":"30","author":"Sakakura","year":"2003","journal-title":"Gan Kagaku Ryoho"},{"key":"10.1016\/j.bmc.2018.05.012_b0165","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1038\/onc.2014.366","volume":"34","author":"Wang","year":"2015","journal-title":"Oncogene"},{"key":"10.1016\/j.bmc.2018.05.012_b0170","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1074\/jbc.M309297200","volume":"279","author":"Zitt","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0175","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.biocel.2011.04.016","volume":"43","author":"Law","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bmc.2018.05.012_b0180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.molimm.2012.12.011","volume":"54","author":"Chen","year":"2013","journal-title":"Mol Immunol"},{"key":"10.1016\/j.bmc.2018.05.012_b0185","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4049\/jimmunol.1302586","volume":"192","author":"Kim","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.bmc.2018.05.012_b0190","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.4049\/jimmunol.0802887","volume":"183","author":"Di Sabatino","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.bmc.2018.05.012_b0195","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrc2171","volume":"7","author":"Monteith","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2018.05.012_b0200","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrc3105","volume":"11","author":"Prevaskaya","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2018.05.012_b0205","doi-asserted-by":"crossref","first-page":"31666","DOI":"10.1074\/jbc.R112.343061","volume":"287","author":"Monteith","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0210","doi-asserted-by":"crossref","first-page":"C509","DOI":"10.1152\/ajpcell.00364.2015","volume":"310","author":"Fiorio Pla","year":"2016","journal-title":"Am J Physiol-Cell Ph"},{"key":"10.1016\/j.bmc.2018.05.012_b0215","first-page":"817","article-title":"Future","volume":"8","author":"Tian","year":"2016","journal-title":"Med Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0220","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1200\/JCO.2003.04.136","volume":"21","author":"Hussain","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bmc.2018.05.012_b0225","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4155\/ppa.14.7","volume":"3","author":"Peverello","year":"2014","journal-title":"Pharm Pat Anal"},{"key":"10.1016\/j.bmc.2018.05.012_b0230","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.3816\/CBC.2009.s.008","volume":"9","author":"Anders","year":"2009","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.bmc.2018.05.012_b0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/annonc\/mds196","volume":"23","author":"Crown","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.bmc.2018.05.012_b0240","first-page":"106","article-title":"Cancer","volume":"12","author":"Wahba","year":"2015","journal-title":"Biol Med"},{"key":"10.1016\/j.bmc.2018.05.012_b0245","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bmc.2016.11.007","volume":"25","author":"Azimi","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0250","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1039\/b500413f","volume":"3","author":"Norris","year":"2005","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0255","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1021\/jo900768c","volume":"74","author":"Zhao","year":"2009","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0260","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.1016\/j.ejmech.2011.05.024","volume":"46","author":"Gao","year":"2011","journal-title":"Euro J Med Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0265","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1016\/j.bmcl.2010.09.095","volume":"20","author":"Lin","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.05.012_b0270","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bmcl.2003.10.004","volume":"14","author":"Lo","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.05.012_b0275","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/jm990383f","volume":"43","author":"Genin","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0280","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0960-894X(01)00059-2","volume":"11","author":"Guzman-Perez","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.05.012_b0285","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1134\/S107036320710012X","volume":"77","author":"Pakal'nis","year":"2007","journal-title":"Russ J Gen Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0290","doi-asserted-by":"crossref","first-page":"3885","DOI":"10.1007\/s00044-011-9929-1","volume":"21","author":"Hanif Khan","year":"2012","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2018.05.012_b0295","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jorganchem.2013.07.068","volume":"745\u2013746","author":"Enthaler","year":"2013","journal-title":"J Organomet Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0300","doi-asserted-by":"crossref","first-page":"11251","DOI":"10.1016\/0040-4020(95)00672-U","volume":"51","author":"Zelenin","year":"1995","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.05.012_b0305","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1021\/jo800251g","volume":"73","author":"Fustero","year":"2008","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0310","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0022-1139(96)03570-1","volume":"83","author":"Singh","year":"1997","journal-title":"J Fluorine Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0315","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jhet.5570420424","volume":"42","author":"Bonacorso","year":"2005","journal-title":"Heterocyclic Chem"},{"key":"10.1016\/j.bmc.2018.05.012_b0320","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1021\/ci3001277","volume":"52","author":"Irwin","year":"2012","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2018.05.012_b0325","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molonc.2015.09.006","volume":"10","author":"Azimi","year":"2016","journal-title":"Mol Oncol"},{"key":"10.1016\/j.bmc.2018.05.012_b0330","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/1535-7163.MCT-10-0923","volume":"10","author":"McAndrew","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2018.05.012_b0335","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.tips.2005.02.002","volume":"26","author":"Monteith","year":"2005","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bmc.2018.05.012_b0340","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejphar.2013.02.022","volume":"704","author":"Rice","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bmc.2018.05.012_b0345","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1038\/emboj.2012.207","volume":"31","author":"Vetter","year":"2012","journal-title":"EMBO J"},{"key":"10.1016\/j.bmc.2018.05.012_b0350","doi-asserted-by":"crossref","first-page":"e59293","DOI":"10.1371\/journal.pone.0059293","volume":"8","author":"Sousa","year":"2003","journal-title":"PLoS One"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618306424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618306424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:55:46Z","timestamp":1760835346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089618306424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":70,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0968089618306424"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.05.012","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}