{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:24:27Z","timestamp":1787063067623,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bmc.2018.06.037","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T15:36:21Z","timestamp":1530200181000},"page":"3837-3844","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Antiplasmodial activity of hydroxyethylamine analogs: Synthesis, biological activity and structure activity relationship of plasmepsin inhibitors"],"prefix":"10.1016","volume":"26","author":[{"given":"Amit","family":"Kumar Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinoth","family":"Rajendran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-7940","authenticated-orcid":false,"given":"Whelton","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-8718","authenticated-orcid":false,"given":"Vladimir","family":"Potemkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Poonam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Grishina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikesh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakasha","family":"Kempaiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Durvasula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brajendra K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben M.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brijesh","family":"Rathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.06.037_b0005","unstructured":"World Health Organization. 2016. World Malaria Report 2016. Geneva, Switzerland."},{"key":"10.1016\/j.bmc.2018.06.037_h0010","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2174\/1568026617666170130123520","volume":"17","author":"Gorobets","year":"2017","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_h0015","author":"Poonam","year":"2018","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2018.06.037_b0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","volume":"361","author":"Dondorp","year":"2009","journal-title":"New Engl J Med"},{"key":"10.1016\/j.bmc.2018.06.037_b0020","first-page":"379","volume":"2012","author":"Phyo","year":"1960","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2018.06.037_b0025","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/QCO.0000000000000199","volume":"28","author":"Fairhurst","year":"2015","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.bmc.2018.06.037_b0030","author":"Jacqueline","year":"2006","journal-title":"Nat News"},{"key":"10.1016\/j.bmc.2018.06.037_b0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.4269\/ajtmh.2012.12-0025","volume":"87","author":"Fairhurst","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.bmc.2018.06.037_b0040","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1126\/science.352.6284.398","volume":"352","author":"Roberts","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bmc.2018.06.037_b0045","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0140-6736(10)61963-0","volume":"376","author":"White","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2018.06.037_b0050","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1021\/jm980641t","volume":"42","author":"Haque","year":"1999","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0307-4412(97)00130-1","volume":"25","author":"Berry","year":"1997","journal-title":"Biochem Educ"},{"key":"10.1016\/j.bmc.2018.06.037_b0060","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1073\/pnas.022630099","volume":"99","author":"Banerjee","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2018.06.037_b0065","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1021\/jm020951i","volume":"46","author":"N\u00f6teberg","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0070","doi-asserted-by":"crossref","first-page":"5371","DOI":"10.1016\/j.bmc.2005.06.048","volume":"13","author":"Muthas","year":"2005","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0075","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/med.20082","volume":"26","author":"Ersmark","year":"2006","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2018.06.037_b0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1021\/jm030933g","volume":"47","author":"Ersmark","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0085","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/156802612799362959","volume":"12","author":"Meyers","year":"2012","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0090","doi-asserted-by":"crossref","first-page":"5151","DOI":"10.1021\/jm5014133","volume":"58","author":"Huizing","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0095","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ejmech.2015.03.049","volume":"95","author":"Dan","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0100","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.ejmech.2014.11.036","volume":"90","author":"Motwani","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0105","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1021\/acs.jmedchem.5b01558","volume":"59","author":"Rasina","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0110","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2958.2007.05768.x","volume":"65","author":"Bonilla","year":"2007","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.bmc.2018.06.037_b0115","doi-asserted-by":"crossref","first-page":"4968","DOI":"10.1128\/AAC.00882-09","volume":"53","author":"Moura","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.06.037_b0120","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bmcl.2012.11.118","volume":"23","author":"Ciana","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.06.037_b0125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1021\/ml4004952","volume":"5","author":"Jaudzems","year":"2014","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.06.037_b0130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/prot.22068","volume":"73","author":"Valiente","year":"2008","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2018.06.037_b0135","doi-asserted-by":"crossref","first-page":"14218","DOI":"10.1074\/jbc.274.20.14218","volume":"274","author":"Le Bonniec","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0140","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0014-5793(02)02241-X","volume":"513","author":"Wyatt","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bmc.2018.06.037_b0145","first-page":"0139347","volume":"10","author":"Singh","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2018.06.037_b0150","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1021\/jm100233b","volume":"53","author":"Gupta","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0155","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0968-0896(02)00643-0","volume":"11","author":"Oscarsson","year":"2003","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0160","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1016\/S0968-0896(03)00339-0","volume":"11","author":"Ersmark","year":"2003","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0165","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/157340612800493638","volume":"8","author":"de Souza","year":"2012","journal-title":"Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0170","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/s41598-017-06788-7","volume":"7","author":"Kumar","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2018.06.037_b0175","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1016\/j.bmc.2013.05.052","volume":"21","author":"Rathi","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0180","first-page":"23","volume":"2015","author":"Singh","year":"1817","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0185","first-page":"8","volume":"1999","author":"Westling","year":"2001","journal-title":"Protein Sci"},{"key":"10.1016\/j.bmc.2018.06.037_b0190","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0006-291X(67)80055-X","volume":"27","author":"Schechter","year":"1967","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2018.06.037_b0195","first-page":"48","volume":"2004","author":"Smilkstein","year":"1803","journal-title":"Antimicrob. Agents Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0200","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/expr.1997.4225","volume":"87","author":"Westling","year":"1997","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.bmc.2018.06.037_b0205","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1110\/ps.8.10.2001","volume":"8","author":"Westling","year":"1999","journal-title":"Protein Sci"},{"key":"10.1016\/j.bmc.2018.06.037_b0210","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/ci200454v","volume":"52","author":"Volkamer","year":"2012","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2018.06.037_b0215","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"O'Boyle","year":"2011","journal-title":"Cheminform"},{"key":"10.1016\/j.bmc.2018.06.037_b0220","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0225","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.drudis.2008.07.006","volume":"13","author":"Potemkin","year":"2008","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmc.2018.06.037_b0230","first-page":"14","volume":"35","author":"Potemkin","year":"2010","journal-title":"Drugs Future"},{"key":"10.1016\/j.bmc.2018.06.037_b0235","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2174\/1570163814666170207144018","volume":"14","author":"Potemkin","year":"2017","journal-title":"Curr Drug Discovery Tech"},{"key":"10.1016\/j.bmc.2018.06.037_b0240","author":"Potemkin","year":"2018","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2018.06.037_b0245","unstructured":"Chemosophia S.R.O., Prague, Czech Republic http:\/\/www.chemosophia.com. Accessed 16.03.18."},{"key":"10.1016\/j.bmc.2018.06.037_b0250","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv Drug Delivery Rev"},{"key":"10.1016\/j.bmc.2018.06.037_b0255","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today: Technol"},{"key":"10.1016\/j.bmc.2018.06.037_b0260","unstructured":"NDA 22\u2013268. Coartem (artemether\/lumefantrine) Tablets for treatment of uncomplicated Plasmodium falciparum malaria. Summary review. 2008. p. 18."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961830498X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961830498X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:55:18Z","timestamp":1760835318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961830498X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":53,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S096808961830498X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.06.037","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiplasmodial activity of hydroxyethylamine analogs: Synthesis, biological activity and structure activity relationship of plasmepsin inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.06.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}