{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:28:52Z","timestamp":1787239732718,"version":"build-2736575974"},"reference-count":53,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"am","delay-in-days":399,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.bmc.2018.07.025","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T14:35:21Z","timestamp":1531838121000},"page":"4452-4460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Cytotoxic and NF-\u03baB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3667-1466","authenticated-orcid":false,"given":"Yulin","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo D.","family":"Anaya-Eugenio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin A.","family":"Czarnecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Ngoc","family":"Ninh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee-Byung","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djaja D.","family":"Soejarto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna E.","family":"Burdette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza J. Carcache","family":"de Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Douglas","family":"Kinghorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.07.025_b0005","article-title":"Syzygium (Myrtaceae): monographing a taxonomic giant via 22 coordinated regional revisions","author":"Ahmad","year":"2016","journal-title":"Peer J Preprints"},{"key":"10.1016\/j.bmc.2018.07.025_b0010","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S2221-1691(14)60215-X","article-title":"Clove (Syzygium aromaticum): a precious spice","volume":"4","author":"Cort\u00e9s-Rojas","year":"2014","journal-title":"Asian Pac J Trop Biomed"},{"key":"10.1016\/j.bmc.2018.07.025_b0015","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1002\/jsfa.6111","article-title":"Pharmacological potentials of Syzygium cumini: a review","volume":"93","author":"Srivastava","year":"2013","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.bmc.2018.07.025_b0020","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/13880200701585956","article-title":"Cytotoxic C-methylated chalcones from Syzygium samarangense","volume":"45","author":"Amor","year":"2007","journal-title":"Pharm Biol"},{"key":"10.1016\/j.bmc.2018.07.025_b0025","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.foodchem.2007.08.086","article-title":"Cytotoxic chalcones and antioxidants from the fruits of Syzygium samarangense (Wax Jambu)","volume":"107","author":"Simirgiotis","year":"2008","journal-title":"Food Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0030","doi-asserted-by":"crossref","first-page":"10257","DOI":"10.1021\/acs.jafc.5b04293","article-title":"New phloroglucinol derivatives from the fruit tree Syzygium jambos and their cytotoxic and antioxidant activities","volume":"63","author":"Li","year":"2015","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0035","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1055\/s-0029-1186102","article-title":"Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy","volume":"75","author":"Laszczyk","year":"2009","journal-title":"Planta Med"},{"key":"10.1016\/j.bmc.2018.07.025_b0040","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.canlet.2012.02.037","article-title":"Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: potential role in prevention and therapy of cancer","volume":"320","author":"Shanmugam","year":"2012","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bmc.2018.07.025_b0045","doi-asserted-by":"crossref","first-page":"33370","DOI":"10.1039\/C4RA02784A","article-title":"Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review","volume":"4","author":"Kamble","year":"2014","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2018.07.025_b0050","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.canlet.2010.06.010","article-title":"Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor","volume":"298","author":"Yang","year":"2010","journal-title":"Cancer Lett"},{"key":"10.1016\/j.bmc.2018.07.025_b0055","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00109-011-0746-2","article-title":"Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice","volume":"89","author":"Shanmugam","year":"2011","journal-title":"J Mol Med"},{"key":"10.1016\/j.bmc.2018.07.025_b0060","first-page":"4375","article-title":"Ursolic acid inhibits nuclear factor-\u03baB activation induced by carcinogenic agents through suppression of I\u03baB\u03b1 kinase and p65 phosphorylation: Correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1","volume":"63","author":"Shishodia","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0065","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.bcp.2013.03.006","article-title":"Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies","volume":"85","author":"Shanmugam","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bmc.2018.07.025_b0070","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/nm1095-1046","article-title":"Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis","volume":"1","author":"Pisha","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.bmc.2018.07.025_b0075","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.2147\/DDDT.S84448","article-title":"Oleanolic acid induces mitochondrial-dependent apoptosis and G0\/G1 phase arrest in gallbladder cancer cells","volume":"9","author":"Li","year":"2015","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.bmc.2018.07.025_b0080","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.drudis.2009.05.015","article-title":"Targeting mitochondrial apoptosis by betulinic acid in human cancers","volume":"14","author":"Fulda","year":"2009","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2018.07.025_b0085","doi-asserted-by":"crossref","first-page":"5623","DOI":"10.21873\/anticanres.11146","article-title":"Discovery of anticancer agents of diverse natural origin","volume":"36","author":"Kinghorn","year":"2016","journal-title":"Anticancer Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0090","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1023\/A:1015941128608","article-title":"Current aspects of practical two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy: applications to structure elucidation","volume":"6","author":"Kriwacki","year":"1989","journal-title":"Pharm Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0095","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/np0502793","article-title":"Dammarane triterpenes from the hypocotyls and fruits of Ceriops tagal","volume":"68","author":"Pakhathirathien","year":"2005","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2018.07.025_b0100","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1021\/acs.jnatprod.7b00138","article-title":"Identification of BMI1 promoter inhibitors from Beaumontia murtonii and Eugenia operculata","volume":"80","author":"Kaneta","year":"2017","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2018.07.025_b0105","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/S0040-4020(01)98316-4","article-title":"Triterpene compounds\u2013VII. The constitution of melaleucic acid","volume":"21","author":"Chopra","year":"1965","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.07.025_b0110","doi-asserted-by":"crossref","first-page":"5673","DOI":"10.1016\/j.bmc.2006.04.021","article-title":"Topical anti-inflammatory activity of 2\u03b1-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae","volume":"14","author":"Aguirre","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0115","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1016\/0031-9422(90)80194-L","article-title":"Cylicodiscic acid, a dihydroxy pentacyclic triterpene carboxylic acid from Cylicodiscus gabunensis","volume":"29","author":"Tchivounda","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.07.025_b0120","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1039\/C6FO00613B","article-title":"Chemical characterization of the main bioactive constituents from fruits of Ziziphus jujuba","volume":"7","author":"Bai","year":"2016","journal-title":"Food Funct"},{"key":"10.1016\/j.bmc.2018.07.025_b0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-2001-14306","article-title":"New antioxidant and antimicrobial ellagic acid derivatives from Pteleopsis hylodendron","volume":"67","author":"Atta-ur-Rahman","year":"2001","journal-title":"Plant Med"},{"key":"10.1016\/j.bmc.2018.07.025_b0130","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.plaphy.2006.04.001","article-title":"Triterpenoids and ellagic acid derivatives from in vitro cultures of Camptotheca acuminata Decaisne","volume":"44","author":"Pasqua","year":"2006","journal-title":"Plant Physiol Biochem"},{"key":"10.1016\/j.bmc.2018.07.025_b0135","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0031-9422(90)89044-A","article-title":"Ellagic compounds from Diplopanax stachyanthus","volume":"29","author":"Khac","year":"1990","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.07.025_b0140","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.sajb.2015.06.009","article-title":"Antimicrobial, antioxidant and butyrylcholinesterase inhibition activities of extracts and isolated compounds from Scadoxus pseudocaulus and semi-synthetic farrerol derivatives","volume":"102","author":"Pagning","year":"2016","journal-title":"S Afr J Bot"},{"key":"10.1016\/j.bmc.2018.07.025_b0145","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0031-9422(00)00348-4","article-title":"C-Methyl-flavonoids from the leaf waxes of some Myrtaceae","volume":"55","author":"Wollenweber","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.07.025_b0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/mrc.4030","article-title":"Muurolane-type sesquiterpenes from marine sponge Dysidea cinerea","volume":"52","author":"Kiem","year":"2014","journal-title":"Magn Reson Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0155","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/mrc.4132","article-title":"Structure elucidation of four new megastigmanes from Sonneratia ovata Backer","volume":"52","author":"Nguyen","year":"2014","journal-title":"Magn Reson Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0160","doi-asserted-by":"crossref","first-page":"11811","DOI":"10.1021\/jf303699t","article-title":"Floral markers of cornflower (Centaurea cyanus) honey and its peroxide antibacterial activity for an alternative treatment of digital dermatitis","volume":"60","author":"Oelschlaegel","year":"2012","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0165","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.phytochem.2003.11.018","article-title":"Structure elucidation and phytotoxicity of C13 nor-isoprenoids from Cestrum parqui","volume":"65","author":"D'Abrosca","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.07.025_b0170","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1021\/jo00357a024","article-title":"Drummondones A and B: unique abscisic acid catabolites incorporating a bicyclo[2.2.2]octane ring system","volume":"51","author":"Powell","year":"1986","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0175","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s12272-013-0135-1","article-title":"Five new sesquiterpene lactones from Inula hupehensis","volume":"36","author":"Ren","year":"2013","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0180","doi-asserted-by":"crossref","first-page":"11673","DOI":"10.1021\/jf1033398","article-title":"Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds","volume":"58","author":"Li","year":"2010","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0185","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0040-4039(01)82292-9","article-title":"Fouquierol and isofouquierol: two new triterpenes of the dammarane series","volume":"1974","author":"Butruille","year":"1974","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2018.07.025_b0190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.phytochem.2017.06.001","article-title":"Chemical constituents from the fruits of Ligustrum japonicum and their inhibitory effects on T cell activation","volume":"141","author":"Ngo","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.07.025_b0195","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1021\/acs.jnatprod.5b00532","article-title":"Cytotoxic barrigenol-like triterpenoids from an extract of Cyrilla racemiflora housed in a repository","volume":"78","author":"Ren","year":"2015","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2018.07.025_b0200","doi-asserted-by":"crossref","first-page":"7512","DOI":"10.1021\/jo971176v","article-title":"NMR chemical shifts of common laboratory solvents as trace impurities","volume":"62","author":"Gottlieb","year":"1997","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2018.07.025_b0205","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1016\/S0040-4020(01)87309-9","article-title":"Total assignment of 13C and 1H spectra of three isomeric triterpenol derivatives by 2D NMR: an investigation of the potential utility of 1H chemical shifts in structural investigations of complex natural products","volume":"42","author":"Reynolds","year":"1986","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.07.025_b0210","first-page":"64","article-title":"High-resolution NMR analysis of the structure of C-24 functionalized steroids","author":"Khripach","year":"2008","journal-title":"Sery Khim Navuk"},{"key":"10.1016\/j.bmc.2018.07.025_b0215","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1021\/np200051j","article-title":"Cytotoxic and NF-\u03baB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues","volume":"74","author":"Ren","year":"2011","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2018.07.025_b0220","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1021\/acs.jnatprod.6b00924","article-title":"Cardiac glycoside constituents of Streblus asper with potential antineoplastic activity","volume":"80","author":"Ren","year":"2017","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2018.07.025_b0225","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/ptr.5091","article-title":"Apoptosis induction by 13-acetoxyrolandrolide through the mitochondrial intrinsic pathway","volume":"28","author":"Mu\u00f1oz Acu\u00f1a","year":"2014","journal-title":"Phytother Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0230","first-page":"1986","article-title":"Triterpenoids from Gentiana veitchiorum","volume":"6","author":"Yang","year":"2014","journal-title":"J Chem Pharm Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0235","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.tet.2003.12.023","article-title":"Partial synthesis of C-ring derivatives from oleanolic and maslinic acids. Formation of several triene systems by chemical and photochemical isomerization processes","volume":"60","author":"Garc\u00eda-Granados","year":"2004","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2018.07.025_b0240","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4314\/tjpr.v11i2.12","article-title":"Isolation and characterization of lup-20(29)-ene-3,28-diol (betulin) from the stem-bark of Adenium obesum (Apocynaceae)","volume":"11","author":"Tijjani","year":"2012","journal-title":"Trop J Pharm Res"},{"key":"10.1016\/j.bmc.2018.07.025_b0245","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrc1588","article-title":"Nuclear factor-\u03baB inhibitors as sensitizers to anticancer drugs","volume":"5","author":"Nakanishi","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2018.07.025_b0250","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/1042819021000038001","article-title":"Mitochondria as a target for inducing death of malignant hematopoietic cells","volume":"44","author":"Solary","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.bmc.2018.07.025_b0255","first-page":"2075","article-title":"Bardoxolone methyl (CDDO-Me) as a therapeutic agent: An update on its pharmacokinetic and pharmacodynamic properties","volume":"8","author":"Wang","year":"2014","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.bmc.2018.07.025_b0260","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/np0104673","article-title":"Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line","volume":"65","author":"Hata","year":"2002","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2018.07.025_b0265","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/sj.leu.2402482","article-title":"Nuclear transcription factor-\u03baB as a target for cancer drug development","volume":"16","author":"Garg","year":"2002","journal-title":"Leukemia"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618310381?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618310381?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:56:55Z","timestamp":1760835415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089618310381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":53,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0968089618310381"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.07.025","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytotoxic and NF-\u03baB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.07.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}