{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:26:51Z","timestamp":1792009611990,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bmc.2018.08.034","type":"journal-article","created":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T16:13:46Z","timestamp":1535559226000},"page":"4942-4951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria"],"prefix":"10.1016","volume":"26","author":[{"given":"Tejosmita","family":"Sen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashmiri","family":"Neog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangita","family":"Sarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Manna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Prasanna","family":"Deka Boruah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0711-0328","authenticated-orcid":false,"given":"Pranjal","family":"Gogoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.08.034_b0005","unstructured":"World Health Organization, Global tuberculosis report 2016. http:\/\/apps.who.int\/medicinedocs\/en\/d\/Js23098en\/; 2016 Accessed 11.05. 18."},{"key":"10.1016\/j.bmc.2018.08.034_b0010","unstructured":"World Health, Roadmap for zoonotic tuberculosis. http:\/\/www.who.int\/tb\/publications\/2017\/zoonotic_TB\/en\/; 2017 Accessed 11.05.18."},{"key":"10.1016\/j.bmc.2018.08.034_b0015","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0140-6736(10)60410-2","article-title":"Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis","volume":"375","author":"Gandhi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2018.08.034_b0020","doi-asserted-by":"crossref","unstructured":"S. Ramaswamy J.M. Musser Molecular genetic basis of antimicrobial agent resistance in Mycobacterium tuberculosis 1998 update Tubercle Lung Dis 79 1998 3 29.","DOI":"10.1054\/tuld.1998.0002"},{"key":"10.1016\/j.bmc.2018.08.034_b0025","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1128\/AAC.01577-08","article-title":"A balancing act: efflux\/influx in mycobacterial drug resistance","volume":"53","author":"Louw","year":"2009","journal-title":"Antimicrob Agen Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0030","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1159\/000109769","article-title":"Importance of the efflux pump systems in the resistance of Mycobacterium tuberculosis to fluoroquinolones and linezolid","volume":"53","author":"Escribano","year":"2007","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bmc.2018.08.034_b0035","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1128\/AAC.01570-07","article-title":"Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism","volume":"52","author":"Spies","year":"2008","journal-title":"Antimicrob Agen Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0040","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.addr.2005.04.004","article-title":"Bacterial resistance to antibiotics: active efflux and reduced uptake","volume":"57","author":"Kumar","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bmc.2018.08.034_b0045","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chembiol.2006.01.005","article-title":"Dual inhibition of mycobacterial fatty acid biosynthesis and degradation by 2-alkynoic acids","volume":"13","author":"Morbidoni","year":"2006","journal-title":"Chem Biol"},{"key":"10.1016\/j.bmc.2018.08.034_b0050","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/1471-2180-11-231","article-title":"Characterization of a Mycobacterium smegmatis uvrA mutant impaired in dormancy induced by hypoxia and low carbon concentration","volume":"11","author":"Cordone","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.bmc.2018.08.034_b0055","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/nar\/gkr830","article-title":"A TetR-like regulator broadly affects the expressions of diverse genes in Mycobacterium smegmatis","volume":"40","author":"Yang","year":"2011","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.bmc.2018.08.034_b0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3389\/fmicb.2015.00613","article-title":"PE11 (Rv1169c) selectively alters fatty acid components of Mycobacterium smegmatis and host cell interleukin-6 level accompanied with cell death","volume":"6","author":"Deng","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bmc.2018.08.034_b0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/mmi.13383","article-title":"NapM, a new nucleoid-associated protein, broadly regulates gene expression and affects mycobacterial resistance to anti-tuberculosis drugs","volume":"101","author":"Liu","year":"2016","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.bmc.2018.08.034_b0070","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.diagmicrobio.2013.02.033","article-title":"Expression analysis of efflux pump genes among drug-susceptible and multidrug-resistant Mycobacterium tuberculosis clinical isolates and reference strains","volume":"76","author":"Calgin","year":"2013","journal-title":"Diagnos Microbiol Infect Dis"},{"key":"10.1016\/j.bmc.2018.08.034_b0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1089\/mdr.2009.0054","article-title":"Microarray analysis of efflux pump genes in multidrug-resistant Mycobacterium tuberculosis during stress induced by common anti-tuberculous drugs","volume":"16","author":"Gupta","year":"2010","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.bmc.2018.08.034_b0080","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/ol103164n","article-title":"New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4","volume":"13","author":"Zhuang","year":"2011","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2018.08.034_b0085","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1021\/jacs.5b00056","article-title":"Discovery of antibiotic (E)-3-(3-carboxyphenyl)-2-(4-cyanostyryl) quinazolin-4 (3 H)-one","volume":"137","author":"Bouley","year":"2015","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2018.08.034_b0090","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejmech.2014.10.084","article-title":"Synthetic approaches, functionalization and therapeutic potential of quinazoline and quinazolinone skeletons: the advances continue","volume":"90","author":"Khan","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.08.034_b0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bmc.2006.09.065","article-title":"Synthesis and pharmacological evaluation of some 3-phenyl-2-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents","volume":"15","author":"Alagarsamy","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.08.034_b0100","first-page":"293","article-title":"Synthesis and antitubercular activity of Mannich bases of 2-methyl-3H-quinazolin-4-ones","volume":"15","author":"Nandy","year":"2006","journal-title":"Indian J Heterocyc Chem"},{"key":"10.1016\/j.bmc.2018.08.034_b0105","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0960-894X(01)00190-1","article-title":"Antitumor agents. Part 204: 1 synthesis and biological evaluation of substituted 2-aryl quinazolinones","volume":"11","author":"Xia","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.08.034_b0110","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1099\/mic.0.045716-0","article-title":"An alkylaminoquinazoline restores antibiotic activity in Gram-negative resistant isolates","volume":"157","author":"Mahamoud","year":"2011","journal-title":"Microbiology"},{"key":"10.1016\/j.bmc.2018.08.034_b0115","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1021\/jm010911z","article-title":"New pyridoquinoline derivatives as potential inhibitors of the fluoroquinolone efflux pump in resistant enterobacter a erogenes strains","volume":"44","author":"Chevalier","year":"2001","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2018.08.034_b0120","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S0924-8579(03)00215-2","article-title":"4-alkoxy and 4-thioalkoxyquinoline derivatives as chemosensitizers for the chloramphenicol-resistant clinical Enterobacter aerogenes 27 strain","volume":"22","author":"Gallo","year":"2003","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bmc.2018.08.034_b0125","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1042\/bj20030963","article-title":"Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates","volume":"376","author":"Mall\u00e9a","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.bmc.2018.08.034_b0130","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ijantimicag.2006.03.010","article-title":"Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates","volume":"27","author":"Ghisalberti","year":"2006","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bmc.2018.08.034_b0135","doi-asserted-by":"crossref","first-page":"7579","DOI":"10.1002\/anie.201402779","article-title":"Base controlled selectivity in the synthesis of linear and angular fused quinazolinones by a palladium-catalyzed carbonylation\/nucleophilic aromatic substitution sequence","volume":"53","author":"Chen","year":"2014","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2018.08.034_h0140","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0960-894X(00)00622-3","article-title":"Atropisomeric quinazolin-4-one derivatives are potent noncompetitive \u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists","volume":"11","author":"Welch","year":"2001","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.08.034_h0145","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1016\/j.tetlet.2011.04.019","article-title":"A novel approach for the one-pot synthesis of linear and angular fused quinazolinones","volume":"52","author":"Maity","year":"2011","journal-title":"Tetrahed Lett"},{"key":"10.1016\/j.bmc.2018.08.034_h0150","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1021\/ja02025a001","article-title":"The synthesis of alkylketodihydroquinazolines from anthranilic nitrile","volume":"24","author":"Bogert","year":"1902","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2018.08.034_h0155","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1021\/ja02011a008","article-title":"3,5-Bibrom-2-aminobenzoic acid: its nitrile and the synthesis of quinazolines from the latter","volume":"25","author":"Bogert","year":"1903","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2018.08.034_b0150","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1021\/ol402350x","article-title":"Iron -catalyzed one-Pot 2,3-diarylquinazolinone formation from 2-nitrobenzamides and alcohols","volume":"15","author":"Wang","year":"2013","journal-title":"Organ Lett"},{"key":"10.1016\/j.bmc.2018.08.034_b0155","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1128\/AAC.48.7.2415-2423.2004","article-title":"Efflux pump-mediated intrinsic drug resistance in Mycobacterium smegmatis","volume":"48","author":"Li","year":"2004","journal-title":"Antimicrob Agent Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2180-11-35","article-title":"Ethidium bromide transport across Mycobacterium smegmatis cell-wall: correlation with antibiotic resistance","volume":"11","author":"Rodrigues","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.bmc.2018.08.034_b0165","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1128\/AAC.42.8.2032","article-title":"Prevalence of a putative efflux mechanism among fluoroquinolone-resistant clinical isolates of Streptococcus pneumoniae","volume":"42","author":"Brenwald","year":"1998","journal-title":"Antimicrob Agent Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0170","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/jac\/dkg121","article-title":"A multidrug efflux phenotype mutant of Streptococcus pyogenes","volume":"51","author":"Jones","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0175","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1093\/jac\/dkn178","article-title":"Plant phenolic compounds as ethidium bromide efflux inhibitors in Mycobacterium smegmatis","volume":"62","author":"Lechner","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0180","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1016\/j.bmc.2012.02.039","article-title":"Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis","volume":"20","author":"Gr\u00f6blacher","year":"2012","journal-title":"Bioorgan Med Chem"},{"key":"10.1016\/j.bmc.2018.08.034_b0185","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1128\/AAC.50.2.810-812.2006","article-title":"Piperine, a phytochemical potentiator of ciprofloxacin against Staphylococcus aureus","volume":"50","author":"Khan","year":"2006","journal-title":"Antimicrob Agent Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0190","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/jac\/dkl510","article-title":"Contribution of the Rv2333c efflux pump (the Stp protein) from Mycobacterium tuberculosis to intrinsic antibiotic resistance in Mycobacterium bovis BCG","volume":"59","author":"Ram\u00f3n-Garc\u00eda","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2018.08.034_b0195","article-title":"Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates","volume":"10","author":"Li","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2018.08.034_b0200","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1021\/acs.orglett.6b00113","article-title":"Synthesis of pyrido-fused quinazolinone derivatives via copper-catalyzed domino reaction","volume":"18","author":"Liu","year":"2016","journal-title":"Organ Lett"},{"key":"10.1016\/j.bmc.2018.08.034_b0205","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/adsc.201701286","article-title":"Copper-mediated tandem C (sp2)-H amination and annulation of arenes with 2-aminopyridines: synthesis of pyrido-fused Quinazolinone derivatives","volume":"360","author":"Liu","year":"2018","journal-title":"Adv Synth Catal"},{"key":"10.1016\/j.bmc.2018.08.034_b0210","doi-asserted-by":"crossref","first-page":"6413","DOI":"10.1016\/j.tetlet.2015.09.142","article-title":"Pd\/C-catalyzed carbonylative C-H activation with DMF as the CO source","volume":"56","author":"Chen","year":"2015","journal-title":"Tetrahed Lett"},{"key":"10.1016\/j.bmc.2018.08.034_b0215","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dkn070","article-title":"Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis","volume":"61","author":"Rodrigues","year":"2008","journal-title":"J Antimicrob Chemother (JAC)"},{"key":"10.1016\/j.bmc.2018.08.034_b0220","series-title":"Antibiotics in laboratory medicine","author":"Lorian","year":"2005"},{"key":"10.1016\/j.bmc.2018.08.034_b0225","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0001-706X(97)00079-X","article-title":"The Alamar Blue\u00ae assay to determine drug sensitivity of African trypanosomes (Tb rhodesiense and Tb gambiense) in vitro","volume":"68","author":"R\u00e4z","year":"1997","journal-title":"Acta Tropica"},{"key":"10.1016\/j.bmc.2018.08.034_b0230","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1128\/AAC.42.4.795","article-title":"Accumulation of norfloxacin by Mycobacterium aurum and Mycobacterium smegmatis","volume":"42","author":"Williams","year":"1998","journal-title":"Antimicrob Agent Chemother"}],"updated-by":[{"DOI":"10.1016\/j.bmc.2021.116152","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000}}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618312781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618312781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:58:06Z","timestamp":1760835486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089618312781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":48,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0968089618312781"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.08.034","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efflux pump inhibition by 11H-pyrido[2,1-b]quinazolin-11-one analogues in mycobacteria","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.08.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}