{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:07:12Z","timestamp":1789510032649,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005278","name":"Universidad de Antioquia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bmc.2018.11.030","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T06:15:45Z","timestamp":1542867345000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids"],"prefix":"10.1016","volume":"27","author":[{"given":"Jilmar A.","family":"Murillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulieth A.","family":"Upegui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana M.","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Robledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winston","family":"Qui\u00f1ones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Echeverri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelio","family":"San Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio F.","family":"Olivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2018.11.030_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4614-4726-9_1","article-title":"Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas","volume":"764","author":"Hotez","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.bmc.2018.11.030_b0010","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.pt.2006.09.004","article-title":"Leishmaniasis and poverty","volume":"22","author":"Alvar","year":"2006","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.bmc.2018.11.030_b0015","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S1995-7645(12)60084-4","article-title":"Leishmaniasis: current status of available drugs and new potential drug targets","volume":"5","author":"Singh","year":"2012","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.bmc.2018.11.030_b0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00001432-200310000-00005","article-title":"Current treatment approaches to leishmaniasis","volume":"16","author":"Berman","year":"2003","journal-title":"Curr Opin Infect Diseases"},{"key":"10.1016\/j.bmc.2018.11.030_b0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tmaid.2006.09.004","article-title":"Cutaneous leishmaniasis treatment","volume":"5","author":"Minodier","year":"2007","journal-title":"Travel Med Infect Disease"},{"key":"10.1016\/j.bmc.2018.11.030_b0030","series-title":"World Health Organization Communicable diseases 2002: global defence against the infectious disease threat \/ edited by Mary Kay Kindhauser","author":"Kindhauser","year":"2003"},{"key":"10.1016\/j.bmc.2018.11.030_h0035","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bmc.2013.11.048","article-title":"Natural product based leads to fight against leishmaniasis","volume":"22","author":"Singh","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2018.11.030_h0040","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1039\/b100455g","article-title":"Plant natural products with leishmanicidal activity","volume":"18","author":"Chan-Bacab","year":"2001","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2018.11.030_b0040","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1016\/j.bmcl.2012.09.023","article-title":"Synthesis and antituberculosis activity of novel unfolded and macrocyclic derivatives of ent-kaurane steviol","volume":"22","author":"Khaybullin","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.11.030_b0045","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.fitote.2013.09.007","article-title":"Terpenoids and their anti-HIV-1 activities from Excoecaria acerifolia","volume":"91","author":"Huang","year":"2013","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmc.2018.11.030_b0050","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1248\/cpb.56.1030","article-title":"Beyerene derivatives and a sesquiterpene dimer from Japanese Cypress (Chamaecyparis obtusa)","volume":"56","author":"Gao","year":"2008","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmc.2018.11.030_b0055","doi-asserted-by":"crossref","first-page":"12453","DOI":"10.1021\/ja072447e","article-title":"16-Aza-ent-beyerene and 16-Aza-ent-trachylobane: potent mechanism-based inhibitors of recombinant ent-kaurene synthase from Arabidopsis thaliana","volume":"129","author":"Roy","year":"2007","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2018.11.030_b0060","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1590\/S0100-40422005000100017","article-title":"G\u00eanero Baccharis (Asteraceae): aspectos qu\u00edmicos, econ\u00f4micos e biol\u00f3gicos","volume":"28","author":"Verdi","year":"2005","journal-title":"Quim Nova"},{"key":"10.1016\/j.bmc.2018.11.030_b0065","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.phytochem.2006.02.018","article-title":"Insect-antifeedant and antibacterial activity of diterpenoids from species of Plectranthus","volume":"67","author":"Wellsow","year":"2006","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.11.030_b0070","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.phytochem.2006.11.010","article-title":"ent-Beyerene diterpenoids from the heartwood of Excoecaria parvifolia","volume":"68","author":"Grace","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.11.030_b0075","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.phytochem.2010.08.011","article-title":"TNF-a inhibitory diterpenoids from the Chinese mangrove plant Excoecaria agallocha L","volume":"71","author":"Li","year":"2010","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.11.030_b0080","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.1016\/j.bmcl.2005.07.090","article-title":"New clerodane diterpenoids from Laetia procera (Poepp.) Eichler (Flacourtiaceae), with antiplasmodial and antileishmanial activities","volume":"15","author":"Jullian","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2018.11.030_b0085","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1248\/bpb.29.1775","article-title":"Antileishmanial activity of natural diterpenes from Cistus sp. and semisynthetic derivatives there of","volume":"29","author":"Fokialakis","year":"2006","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bmc.2018.11.030_b0090","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0031-9422(02)00361-8","article-title":"Abietane diterpenoids and triterpenoic acids from Salvia cilicica and their antileishmanial activities","volume":"61","author":"Tan","year":"2002","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.11.030_b0095","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijantimicag.2004.08.010","article-title":"In vitro activity of C20-diterpenoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum","volume":"25","author":"Gonz\u00e1lez","year":"2005","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bmc.2018.11.030_b0100","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0031-9422(00)84036-4","article-title":"Diterpenoids from Baccharis tola","volume":"22","author":"San Martin","year":"1983","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.11.030_b0105","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1021\/jf2044907","article-title":"The leaves of Stevia rebaudiana (Bertoni), their constituents and the analyses thereof: a review","volume":"60","author":"W\u00f6lwer-Rieck","year":"2012","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2018.11.030_b0110","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0031-9422(03)00426-6","article-title":"Molecules of interest stevioside","volume":"64","author":"Geuns","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2018.11.030_b0115","article-title":"(\u2212)-Isosteviol as a versatile ex-chiral-pool building block for organic chemistry","volume":"5539\u20135554","author":"Lohoelter","year":"2013","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2018.11.030_b0120","article-title":"The enantioselective total synthesis of (-)-myltaylenol","volume":"1491\u20131492","author":"Doye","year":"1997","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmc.2018.11.030_b0125","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejmech.2016.03.009","article-title":"Synthesis, cytotoxic activity evaluation and HQSAR study of novel isosteviol derivatives as potential anticancer agents","volume":"115","author":"Liu","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2018.11.030_b0130","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1021\/ol400385w","article-title":"Synthesis of skeletally diverse and stereochemically complex library templates derived from isosteviol and steviol","volume":"15","author":"Hutt","year":"2013","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2018.11.030_b0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mossman","year":"1983","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.bmc.2018.11.030_b0140","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1128\/AAC.49.4.1652-1655.2005","article-title":"In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives","volume":"49","author":"Robledo","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2018.11.030_b0145","series-title":"Statistical method in biological assay","author":"Finney","year":"1978"},{"key":"10.1016\/j.bmc.2018.11.030_b0150","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.exppara.2009.02.012","article-title":"Leishmania (Viannia) panamensis: an in vitro assay using the expression of GFP for screening of antileishmanial drug","volume":"122","author":"Varela","year":"2009","journal-title":"Exp Parasitol"},{"key":"10.1016\/j.bmc.2018.11.030_b0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.actatropica.2011.11.015","article-title":"Improvement of the green fluorescent protein reporter system in Leishmania spp. for the in vitro and in vivo screening of antileishmanial drugs","volume":"122","author":"Pulido","year":"2012","journal-title":"Acta Trop"},{"key":"10.1016\/j.bmc.2018.11.030_b0160","article-title":"Cutaneous leishmaniasis in the dorsal skin of hamsters: a useful model for the screening of antileishmanial drugs","volume":"62","author":"Robledo","year":"2012","journal-title":"J Vis Exp"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618316158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089618316158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:00:01Z","timestamp":1760835601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089618316158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0968089618316158"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2018.11.030","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antileishmanial activity and cytotoxicity of ent-beyerene diterpenoids","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2018.11.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}