{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:58:18Z","timestamp":1777445898418,"version":"3.51.4"},"reference-count":37,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Science Center Poland","award":["DEC-2011\/02\/A\/NZ4\/00031"],"award-info":[{"award-number":["DEC-2011\/02\/A\/NZ4\/00031"]}]},{"name":"COST","award":["CA15135"],"award-info":[{"award-number":["CA15135"]}]},{"DOI":"10.13039\/501100006723","name":"INST","doi-asserted-by":"publisher","award":["208\/664-1 FUGG"],"award-info":[{"award-number":["208\/664-1 FUGG"]}],"id":[{"id":"10.13039\/501100006723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006723","name":"INST","doi-asserted-by":"publisher","award":["105\/2016"],"award-info":[{"award-number":["105\/2016"]}],"id":[{"id":"10.13039\/501100006723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bmc.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T12:03:26Z","timestamp":1549973006000},"page":"1254-1262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands"],"prefix":"10.1016","volume":"27","author":[{"given":"Dorota","family":"\u0141a\u017cewska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szczepan","family":"Mogilski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Hagenow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Kuder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"G\u0142uch-Lutwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Siwek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Wi\u0119cek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Kaleta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Seibel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Buschauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Filipek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kie\u0107-Kononowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2019.02.020_b0005","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/pr.114.010249","article-title":"International union of basic and clinical pharmacology. XCVIII. Histamine receptors","volume":"67","author":"Panula","year":"2015","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmc.2019.02.020_b0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fphar.2015.00065","article-title":"The histamine H4 receptor: from orphan to the clinic","volume":"6","author":"Thurmond","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0015","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1021\/jm0341047","article-title":"The first potent and selective non-imidazole human histamine H4 receptor antagonists","volume":"46","author":"Jablonowski","year":"2003","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0020","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00210-011-0612-3","article-title":"Expression and functional properties of canine, rat, and murine histamine H4 receptors in Sf9 insect cells","volume":"383","author":"Schnell","year":"2011","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0025","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1124\/mol.111.071266","article-title":"Paradoxical stimulatory effects of the \u201cstandard\u201d histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity","volume":"79","author":"Seifert","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0030","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1124\/mol.110.068395","article-title":"Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits \u03b2-arrestin without activating G proteins","volume":"79","author":"Rosethorne","year":"2011","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0035","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1517\/13543776.2014.959494","article-title":"Novel histamine H4 receptor ligands and their potential therapeutic applications: an update","volume":"24","author":"Kiss","year":"2014","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2019.02.020_b0040","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.2174\/0929867323666160411143151","article-title":"Monocyclic and fused azines and azoles as histamine H4 receptor ligands","volume":"23","author":"\u0141a\u017cewska","year":"2016","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0045","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/164_2016_130","article-title":"Clinical development of histamine H4 receptor antagonists","volume":"241","author":"Thurmond","year":"2017","journal-title":"Handb Exp Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0050","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ejmech.2016.09.074","article-title":"Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening","volume":"125","author":"Levoin","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0055","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1021\/acs.jmedchem.7b01855","article-title":"Discovery of a novel highly selective histamine H4 receptor antagonist for the treatment of atopic dermatitis","volume":"61","author":"Ko","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0060","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.ejmech.2014.06.032","article-title":"Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands","volume":"83","author":"\u0141a\u017cewska","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0065","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ejmech.2015.08.014","article-title":"(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands","volume":"103","author":"Kami\u0144ska","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00011-016-0997-z","article-title":"Aryl-1,3,5-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide","volume":"66","author":"Mogilski","year":"2017","journal-title":"Inflamm Res"},{"key":"10.1016\/j.bmc.2019.02.020_b0075","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/cbdd.12752","article-title":"The synthesis of 1,3,5-triazine derivatives and JNJ7777120 analogues with histamine H4 receptor affinity and their interaction with PTEN promoter","volume":"88","author":"Latacz","year":"2016","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2019.02.020_b0080","doi-asserted-by":"crossref","first-page":"22429","DOI":"10.1021\/jm401727m","article-title":"Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H\u2084 receptor antagonists","volume":"57","author":"Savall","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0085","series-title":"Histamine H4 receptor, a novel drug target for immunoregulation and inflammation","first-page":"21","author":"Schreeb","year":"2013"},{"issue":"20","key":"10.1016\/j.bmc.2019.02.020_b0090","doi-asserted-by":"crossref","first-page":"6571","DOI":"10.1021\/jm8005959","article-title":"Structure-activity studies on a series of 2-aminopyrimidine-containing histamine H4 receptor ligands","volume":"51","author":"Altenbach","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2019.02.020_b0095","first-page":"401","article-title":"Synthesis and hypoglycemic activity of various N-(2-pyrazoline-1-carbaimidoyl)-guanidine derivatives","volume":"36","author":"Brzozowski","year":"1979","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/j.bmc.2019.02.020_b0100","first-page":"7186","article-title":"Diaminopyrimidines as histamine H4 receptor ligands \u2013 Scaffold optimization and pharmacological characterization Bioorg","volume":"17","author":"Sander","year":"2009","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmc.2019.02.020_b0105","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.270.17.9896","article-title":"Transfected aequorin in the measurement of cytosolic Ca2a+ concentration. A critical evaluation","volume":"270","author":"Brini","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2019.02.020_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117185","article-title":"The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity","volume":"10","author":"Wifling","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2019.02.020_b0115","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.phrs.2016.10.010","article-title":"Label-free versus conventional cellular assays: Functional investigations on the human histamine H1 receptor","volume":"114","author":"Lieb","year":"2016","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.bmc.2019.02.020_b0120","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nature10753","article-title":"Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist","volume":"482","author":"Haga","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2019.02.020_b0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nature10236","article-title":"Structure of the human histamine H1 receptor complex with doxepin","volume":"475","author":"Shimamura","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2019.02.020_b0130","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1021\/ci700474a","article-title":"Delineation of agonist binding to the human histamine H4 receptor using mutational analysis, homology modeling, and ab initio calculations","volume":"48","author":"Jongejan","year":"2008","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2019.02.020_b0135","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1043-9471(05)80049-7","article-title":"Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors","volume":"25","author":"Ballesteros","year":"1995","journal-title":"Methods Neurosci"},{"key":"10.1016\/j.bmc.2019.02.020_b0140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/1574889811308020003","article-title":"New pharmacological approaches to the cholinergic system: an overview on muscarinic receptor ligands and cholinesterase inhibitors","volume":"8","author":"Greig","year":"2013","journal-title":"Recent Pat CNS Drug Discov"},{"key":"10.1016\/j.bmc.2019.02.020_b0145","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pbb.2015.03.019","article-title":"Antinociceptive, anti-inflammatory and smooth muscle relaxant of the pyrrolo[3,4-d]pyridazinone derivatives: possible mechanisms of action","volume":"133","author":"Mogilski","year":"2015","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bmc.2019.02.020_b0150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuropharm.2013.03.026","article-title":"Pleiotropic effect of histamine H4 receptor modulation in the central nervous system","volume":"71","author":"Galeotti","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2019.02.020_b0155","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuropharm.2015.05.004","article-title":"The histamine H4-receptor and the central and peripheral nervous system: a critical analysis of the literature","volume":"106","author":"Schneider","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2019.02.020_b0160","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1097\/j.pain.0000000000000319","article-title":"Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation","volume":"156","author":"Sanna","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.bmc.2019.02.020_b0165","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pbb.2009.12.004","article-title":"H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats","volume":"95","author":"Hsieh","year":"2010","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.bmc.2019.02.020_b0170","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1111\/bph.14185","article-title":"Antinociceptive effects of novel histamine H3 and H4 receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse","volume":"175","author":"Popio\u0142ek-Barczyk","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0175","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.jpain.2010.01.268","article-title":"Peripheral formalin injury induces 2 stages of microglial activation in the spinal cord","volume":"11","author":"Li","year":"2010","journal-title":"J Pain"},{"key":"10.1016\/j.bmc.2019.02.020_b0180","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejphar.2007.02.026","article-title":"Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation","volume":"563","author":"Coruzzi","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bmc.2019.02.020_b0185","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ejmech.2017.04.033","article-title":"The computer-aided discovery of novel family of the 5-HT6 serotonin receptor ligands among derivatives of 4-benzyl-1,3,5-triazine","volume":"135","author":"\u0141a\u017cewska","year":"2017","journal-title":"Eur J Med Chem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961831770X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961831770X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:00:58Z","timestamp":1760835658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961831770X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S096808961831770X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2019.02.020","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alkyl derivatives of 1,3,5-triazine as histamine H4 receptor ligands","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}