{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:07:14Z","timestamp":1790716034200,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007543","name":"Grantov\u00e1 Agentura, Univerzita Karlova","doi-asserted-by":"publisher","award":["678216"],"award-info":[{"award-number":["678216"]}],"id":[{"id":"10.13039\/100007543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004813","name":"Helmholtz-Zentrum f\u00fcr Umweltforschung","doi-asserted-by":"publisher","award":["LO1302"],"award-info":[{"award-number":["LO1302"]}],"id":[{"id":"10.13039\/501100004813","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.bmc.2019.05.024","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T03:42:47Z","timestamp":1558064567000},"page":"2935-2947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1"],"prefix":"10.1016","volume":"27","author":[{"given":"V\u00e1clav","family":"Zima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Berenguer","family":"Albi\u00f1ana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Roj\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Pokorn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr","family":"Pachl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavl\u00edna","family":"\u0158ez\u00e1\u010dov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hudlicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e1clav","family":"Navr\u00e1til","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Majer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Konvalinka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Ko\u017e\u00ed\u0161ek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Machara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2019.05.024_b0005","doi-asserted-by":"crossref","first-page":"8963","DOI":"10.1021\/jm301145k","volume":"55","author":"Bhatt","year":"2012","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0010","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0140-6736(17)33293-2","volume":"391","author":"Iuliano","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2019.05.024_b0015","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1073\/pnas.0308391100","volume":"101","author":"Tumpey","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2019.05.024_b0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1126\/science.1119392","volume":"310","author":"Tumpey","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bmc.2019.05.024_b0025","first-page":"101","author":"Taubenberger","year":"2005","journal-title":"Arch Virol"},{"key":"10.1016\/j.bmc.2019.05.024_b0030","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/viro.2000.0495","volume":"274","author":"Taubenberger","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.bmc.2019.05.024_b0035","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.2174\/092986707782360024","volume":"14","author":"Liu","year":"2007","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0040","volume":"5","author":"Zhang","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2019.05.024_b0045","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1503\/cmaj.090866","volume":"181","author":"Tanaka","year":"2009","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.bmc.2019.05.024_b0050","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S1473-3099(12)70121-4","volume":"12","author":"Dawood","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2019.05.024_b0055","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jcv.2010.02.008","volume":"48","author":"Zepeda","year":"2010","journal-title":"J Clin Virol"},{"key":"10.1016\/j.bmc.2019.05.024_b0060","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jcv.2009.06.004","volume":"45","author":"Gatherer","year":"2009","journal-title":"J Clin Virol"},{"key":"10.1016\/j.bmc.2019.05.024_b0065","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S1473-3099(12)70152-4","volume":"12","author":"Viboud","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2019.05.024_b0070","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1016\/j.vaccine.2010.05.031","volume":"28","author":"Girard","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.bmc.2019.05.024_b0075","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1056\/NEJMoa0903810","volume":"360","author":"Dawood","year":"2009","journal-title":"New Engl J Med"},{"key":"10.1016\/j.bmc.2019.05.024_b0080","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.cell.2009.05.032","volume":"137","author":"Wang","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2019.05.024_b0085","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/363418a0","volume":"363","author":"Vonitzstein","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2019.05.024_b0090","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2165\/00003495-199958040-00016","volume":"58","author":"Dunn","year":"1999","journal-title":"Drugs"},{"key":"10.1016\/j.bmc.2019.05.024_b0095","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/ja963036t","volume":"119","author":"Kim","year":"1997","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2019.05.024_b0100","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00003495-200161020-00011","volume":"61","author":"McClellan","year":"2001","journal-title":"Drugs"},{"key":"10.1016\/j.bmc.2019.05.024_b0105","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/cid\/cir010","volume":"52","author":"Jain","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2019.05.024_b0110","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1021\/jm0002679","volume":"43","author":"Babu","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0115","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1128\/AAC.01311-09","volume":"54","author":"Kubo","year":"2010","journal-title":"Antimicrob Agents Ch"},{"key":"10.1016\/j.bmc.2019.05.024_b0120","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/4371108a","volume":"437","author":"Le","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2019.05.024_b0125","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3390\/v10070339","volume":"10","author":"Pokorna","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.bmc.2019.05.024_b0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature05114","volume":"443","author":"Russell","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2019.05.024_b0135","doi-asserted-by":"crossref","first-page":"10493","DOI":"10.1128\/JVI.00959-08","volume":"82","author":"Xu","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.bmc.2019.05.024_b0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1750-2659.2011.00304.x","volume":"6","author":"Air","year":"2012","journal-title":"Influenza Other Respir Viruses"},{"key":"10.1016\/j.bmc.2019.05.024_b0145","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nature05003","volume":"443","author":"Luo","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2019.05.024_b0150","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/ncomms1390","volume":"2","author":"Amaro","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2019.05.024_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0059873","volume":"8","author":"Greenway","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2019.05.024_b0160","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1021\/ja8085643","volume":"131","author":"Amaro","year":"2009","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2019.05.024_b0165","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/nsmb.1909","volume":"17","author":"Li","year":"2010","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.bmc.2019.05.024_b0170","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/srep01551","volume":"3","author":"Wu","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2019.05.024_b0175","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bpc.2008.11.004","volume":"140","author":"Mitrasinovic","year":"2009","journal-title":"Biophys Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0180","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1139\/cjc-2017-0343","volume":"96","author":"Mohan","year":"2018","journal-title":"Can J Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0185","doi-asserted-by":"crossref","first-page":"8445","DOI":"10.1021\/jm500892k","volume":"57","author":"Xie","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0190","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1021\/acs.jmedchem.8b00929","volume":"61","author":"Zhang","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0195","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ejmech.2016.07.064","volume":"123","author":"Das","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0200","author":"Rudrawar","year":"20101","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2019.05.024_b0205","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1016\/j.bmc.2013.05.054","volume":"21","author":"Rudrawar","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0210","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1007\/s13238-015-0197-6","volume":"6","author":"Wu","year":"2015","journal-title":"Protein Cell"},{"key":"10.1016\/j.bmc.2019.05.024_b0215","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1021\/jm100822f","volume":"53","author":"Mohan","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0220","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1038\/srep02871","volume":"3","author":"Kerry","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2019.05.024_b0225","doi-asserted-by":"crossref","first-page":"10867","DOI":"10.1021\/jo401854w","volume":"78","author":"Adabala","year":"2013","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0230","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1021\/ol701581g","volume":"9","author":"Goddard-Borger","year":"2007","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2019.05.024_b0235","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0003-2697(79)90362-2","volume":"94","author":"Potier","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bmc.2019.05.024_b0240","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/protein\/12.4.271","volume":"12","author":"Betts","year":"1999","journal-title":"Protein Eng"},{"key":"10.1016\/j.bmc.2019.05.024_b0245","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkw853","volume":"45","author":"Navratil","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2019.05.024_b0250","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1042\/BCJ20180764","volume":"475","author":"Kozisek","year":"2018","journal-title":"Biochem J"},{"key":"10.1016\/j.bmc.2019.05.024_b0255","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.antiviral.2011.03.180","volume":"90","author":"Niikura","year":"2011","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmc.2019.05.024_b0260","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ejmech.2016.05.016","volume":"121","author":"Albinana","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.05.024_b0265","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0076-6879(79)63019-7","volume":"63","author":"Williams","year":"1979","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.bmc.2019.05.024_b0270","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1042\/bj0550170","volume":"55","author":"Dixon","year":"1953","journal-title":"Biochem J"},{"key":"10.1016\/j.bmc.2019.05.024_b0275","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1107\/S0909049512006395","volume":"19","author":"Mueller","year":"2012","journal-title":"J Synchrotron Radiat"},{"key":"10.1016\/j.bmc.2019.05.024_b0280","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1107\/S0021889812011715","volume":"45","author":"Krug","year":"2012","journal-title":"J Appl Crystallogr"},{"key":"10.1016\/j.bmc.2019.05.024_b0285","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1107\/S0907444900013780","volume":"56","author":"Vagin","year":"2000","journal-title":"Acta Crystallogr D"},{"key":"10.1016\/j.bmc.2019.05.024_b0290","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"Murshudov","year":"1997","journal-title":"Acta Crystallogr D-Struct Biol"},{"key":"10.1016\/j.bmc.2019.05.024_b0295","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1107\/S0907444993011898","volume":"50","author":"Bailey","year":"1994","journal-title":"Acta Crystallogr D"},{"key":"10.1016\/j.bmc.2019.05.024_b0300","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr D"},{"key":"10.1016\/j.bmc.2019.05.024_b0305","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.bmc.2019.05.024_b0310","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1107\/S0907444904026460","volume":"60","author":"Krissinel","year":"2004","journal-title":"Acta Crystallogr D-Struct Biol"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089619305358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089619305358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:02:11Z","timestamp":1760835731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089619305358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":62,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0968089619305358"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2019.05.024","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2019.05.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}