{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:41:43Z","timestamp":1792212103312,"version":"4.4.0"},"reference-count":160,"publisher":"Elsevier BV","issue":"16","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Chinese Academy of Sciences President\u2019s International Fellowship Initiative","award":["2019PT054"],"award-info":[{"award-number":["2019PT054"]}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["CAM201803"],"award-info":[{"award-number":["CAM201803"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.bmc.2019.07.005","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T19:44:23Z","timestamp":1562269463000},"page":"3511-3531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":820,"title":["1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview"],"prefix":"10.1016","volume":"27","author":[{"given":"Khurshed","family":"Bozorov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haji A.","family":"Aisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2019.07.005_b0005","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ejmech.2018.08.002","article-title":"Pyrrole: an insight into recent pharmacological advances with structure activity relationship","volume":"157","author":"Ahmad","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0010","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/cr900028p","article-title":"Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer","volume":"109","author":"Parker","year":"2009","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2019.07.005_b0015","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejmech.2017.09.039","article-title":"2-Aminothiophene scaffolds: diverse biological and pharmacological attributes in medicinal chemistry","volume":"140","author":"Bozorov","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0020","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ejmech.2015.08.018","article-title":"Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties","volume":"102","author":"Bozorov","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0025","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ejmech.2014.07.065","article-title":"Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Part 1","volume":"84","author":"Bozorov","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0030","doi-asserted-by":"crossref","first-page":"31417","DOI":"10.1039\/C7RA04808D","article-title":"Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2","volume":"7","author":"Bozorov","year":"2017","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2019.07.005_b0035","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ejmech.2014.11.039","article-title":"Bioactive Benzofuran derivatives: a review","volume":"97","author":"Khanam","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0040","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ejmech.2014.11.047","article-title":"Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry","volume":"90","author":"Naik","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0045","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1021\/cr300122t","article-title":"Acid hydrazides, potent reagents for synthesis of oxygen-, nitrogen-, and\/or sulfur-containing heterocyclic rings","volume":"114","author":"Majumdar","year":"2014","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2019.07.005_b0050","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ejmech.2016.01.009","article-title":"The importance of triazole scaffold in the development of anticonvulsant agents","volume":"109","author":"Ayati","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0055","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.ejmech.2014.09.089","article-title":"Benzotriazole: an overview on its versatile biological behavior","volume":"97","author":"Briguglio","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0060","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bioorg.2018.03.032","article-title":"New advances in synthesis and clinical aspects of pyrazolo[3,4-d]pyrimidine scaffolds","volume":"78","author":"Abdellatif","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0065","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/S0968-0896(02)00239-0","article-title":"5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods","volume":"10","author":"Herr","year":"2002","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0070","doi-asserted-by":"crossref","first-page":"6087","DOI":"10.1016\/j.bmc.2015.07.045","article-title":"Imidazopyridines as a source of biological activity and their pharmacological potentials\u2014infrared and Raman spectroscopic evidence of their content in pharmaceuticals and plant materials","volume":"23","author":"Dymi\u0144ska","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0075","unstructured":"Reports regarding the use of triazoles in the Scopus database in: www.scopus.com, 2018."},{"key":"10.1016\/j.bmc.2019.07.005_b0080","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bioorg.2017.01.010","article-title":"Medicinal attributes of 1,2,3-triazoles: current developments","volume":"71","author":"Dheer","year":"2017","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0085","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ejmech.2018.04.008","article-title":"Harnessing pyrrolidine iminosugars into dimeric structures for the rapid discovery of divalent glycosidase inhibitors","volume":"151","author":"Carmona","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0090","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1021\/acs.jmedchem.7b01574","article-title":"Selective inhibitors of human neuraminidase 3","volume":"61","author":"Guo","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0095","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2018.02.017","article-title":"The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: application to 18F-radiolabeling","volume":"148","author":"Gonzalez","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0100","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1055\/s-0036-1591985","article-title":"Copper-mediated late-stage iodination and 123 I-labelling of triazole-benzimidazole bioactives","volume":"29","author":"Fjellaksel","year":"2018","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2019.07.005_b0105","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1021\/acs.jmedchem.8b00240","article-title":"18F-positron emitting\/trimethine cyanine-fluorescent contrast for image-guided prostate cancer management","volume":"61","author":"Kommidi","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0110","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.bmcl.2017.08.066","article-title":"Radiosynthesis and biological evaluation of 18F-labeled 4-anilinoquinazoline derivative (18F-FEA-Erlotinib) as a potential EGFR PET agent","volume":"28","author":"Huang","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0115","doi-asserted-by":"crossref","first-page":"13784","DOI":"10.1039\/C8NJ02388C","article-title":"Oxa\/thiazole-tetrahydropyran triazole-linked hybrids with selective antiproliferative activity against human tumour cells","volume":"42","author":"Valdomir","year":"2018","journal-title":"New J Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0120","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1016\/j.bmc.2018.04.055","article-title":"Boronic acid inhibitors of the class A \u03b2-lactamase KPC-2","volume":"26","author":"Zhou","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0125","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.ejmech.2017.11.052","article-title":"Hetero-Diels-Alder reactions of novel 3-triazolyl-nitrosoalkenes as an approach to functionalized 1,2,3-triazoles with antibacterial profile","volume":"143","author":"Lopes","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0130","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1016\/j.bmcl.2018.09.011","article-title":"Antimicrobial 1,3,4-trisubstituted-1,2,3-triazolium salts","volume":"28","author":"Fletcher","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0135","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02423-17","article-title":"In vitro antifungal activity of novel triazole efinaconazole and five comparators against dermatophyte isolates","volume":"62","author":"Rezaei-Matehkolaei","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2019.07.005_b0140","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1002\/slct.201800319","article-title":"Click chemistry inspired design, synthesis and molecular docking studies of coumarin, quinolinone linked 1,2,3-triazoles as promising anti-microbial agents","volume":"3","author":"Savanur","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0145","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00044-018-2146-4","article-title":"Evaluation of triazole and isoxazole derivatives as potential anti-infective agents","volume":"27","author":"Tarawneh","year":"2018","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2019.07.005_b0150","doi-asserted-by":"crossref","first-page":"9790","DOI":"10.1002\/slct.201801905","article-title":"Synthesis and antimalarial evaluation of [1,2,3]-triazole-tethered sulfonamide-berberine hybrids","volume":"3","author":"Batra","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0155","doi-asserted-by":"crossref","first-page":"3282","DOI":"10.1039\/C7NJ04060A","article-title":"Synthesis, optical properties, and antioxidant and anticancer activity of benzoheterazole dendrimers with triazole bridging unit","volume":"42","author":"Rajavelu","year":"2018","journal-title":"New J Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0160","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/10426507.2017.1417293","article-title":"Synthesis and in-vitro antioxidant activities of some coumarin derivatives containing 1,2,3-triazole ring","volume":"193","author":"Kumar","year":"2018","journal-title":"Phosphorus, Sulfur Silicon Relat Elem"},{"key":"10.1016\/j.bmc.2019.07.005_b0165","doi-asserted-by":"crossref","first-page":"6338","DOI":"10.1002\/slct.201800905","article-title":"Synthesis, characterization, antibacterial and antioxidant studies of some heterocyclic compounds from triazole-linked chalcone derivatives","volume":"3","author":"Santosh","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0170","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1002\/anie.201710527","article-title":"A general approach towards triazole-linked adenosine diphosphate ribosylated peptides and proteins","volume":"57","author":"Liu","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2019.07.005_b0175","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1039\/C8OB00686E","article-title":"How are 1,2,3-triazoles accommodated in helical secondary structures?","volume":"16","author":"Ben Haj Salah","year":"2018","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0180","doi-asserted-by":"crossref","first-page":"5689","DOI":"10.1021\/acs.chemrev.5b00302","article-title":"Alkaloids and isoprenoids modification by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition (click chemistry): toward new functions and molecular architectures","volume":"116","author":"Kacprzak","year":"2016","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2019.07.005_b0185","doi-asserted-by":"crossref","first-page":"14726","DOI":"10.1021\/acs.chemrev.6b00466","article-title":"Ruthenium-catalyzed azide alkyne cycloaddition reaction: scope, mechanism, and applications","volume":"116","author":"Johansson","year":"2016","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2019.07.005_b0190","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s10593-019-02414-8","article-title":"Recent methods for the synthesis of NH-1,2,3-triazoles (microreview)","volume":"55","author":"Efimov","year":"2019","journal-title":"Chem Heterocycl Compd"},{"key":"10.1016\/j.bmc.2019.07.005_b0195","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.tetlet.2015.03.136","article-title":"New click-chemistry methods for 1,2,3-triazoles synthesis: recent advances and applications","volume":"56","author":"Totobenazara","year":"2015","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0200","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jfluchem.2018.02.012","article-title":"Chemistry of fluoroalkyl-substituted 1,2,3-triazoles","volume":"210","author":"Usachev","year":"2018","journal-title":"J Fluorine Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0205","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.drudis.2017.05.014","article-title":"The 1,2,3-triazole ring as a bioisostere in medicinal chemistry","volume":"22","author":"Bonandi","year":"2017","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2019.07.005_b0210","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ejmech.2017.12.039","article-title":"Natural compounds and combination therapy in colorectal cancer treatment","volume":"144","author":"Rejhov\u00e1","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0215","first-page":"99","article-title":"Chapter 5 \u2013 chemosensitization by ursolic acid: a new avenue for cancer therapy","volume":"Vol 2","author":"Prasad","year":"2018"},{"key":"10.1016\/j.bmc.2019.07.005_b0220","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1871520616666160811113531","article-title":"Recent advancements in 1,4-disubstituted 1H-1,2,3-triazoles as potential anticancer agents","volume":"18","author":"Lal","year":"2018","journal-title":"Anti-Cancer Agents Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0225","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ejmech.2018.06.058","article-title":"Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities","volume":"156","author":"Ding","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0230","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ejmech.2018.08.010","article-title":"MMB triazole analogs are potent NF-\u03baB inhibitors and anti-cancer agents against both hematological and solid tumor cells","volume":"157","author":"Janganati","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0235","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ejmech.2018.04.005","article-title":"Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents","volume":"151","author":"Yu","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0240","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.ejmech.2018.08.056","article-title":"Synthesis and biological evaluation of novel Jiyuan Oridonin A-1,2,3-triazole-azole derivatives as antiproliferative agents","volume":"157","author":"Ke","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0245","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1016\/j.bmc.2017.11.005","article-title":"Design, synthesis and biological mechanisms research on 1,2,3-triazole derivatives of Jiyuan Oridonin A","volume":"26","author":"Ke","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0250","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ejmech.2018.08.036","article-title":"Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway","volume":"157","author":"Wei","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0255","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1016\/j.bmc.2018.06.026","article-title":"Synthesis, antitumor activity evaluation and mechanistic study of novel hederacolchiside A1 derivatives bearing an aryl triazole moiety","volume":"26","author":"Li","year":"2018","journal-title":"Biorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0260","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1016\/j.bmcl.2018.05.038","article-title":"Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore","volume":"28","author":"Wu","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0265","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1002\/slct.201801810","article-title":"Triazole biheterocycles from cinchona alkaloids: coordination and antiproliferative properties","volume":"3","author":"Boraty\u0144ski","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0270","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejmech.2018.01.100","article-title":"Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A","volume":"148","author":"Abou Samra","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0275","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1007\/s00044-018-2213-x","article-title":"Novel triazoles of 3-acetylbetulin and betulone as anticancer agents","volume":"27","author":"B\u0119benek","year":"2018","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2019.07.005_b0280","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ejmech.2017.12.050","article-title":"4\u03b2-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-II\u03b1 inhibition and potential anticancer agents for prostate cancer","volume":"144","author":"Reddy","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0285","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.bioorg.2018.08.028","article-title":"Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity","volume":"81","author":"Bian","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0290","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ejmech.2018.01.006","article-title":"Synthesis and biological evaluation of novel bavachinin analogs as anticancer agents","volume":"145","author":"Gupta","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0295","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/cbdd.13203","article-title":"Novel quinazolin-4(3H)-one linked to 1,2,3-triazoles: synthesis and anticancer activity","volume":"92","author":"Safavi","year":"2018","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2019.07.005_b0300","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2174\/1573407213666170329131557","article-title":"2-((1H-1,2,3-Triazol-1-yl)methyl)-3-phenylquinazolin-4(3H)-ones: design, synthesis and evaluation as anti-cancer agents","volume":"14","author":"Vasu","year":"2018","journal-title":"Curr Bioact Compd"},{"key":"10.1016\/j.bmc.2019.07.005_b0305","doi-asserted-by":"crossref","first-page":"3741","DOI":"10.1016\/j.bmcl.2018.10.016","article-title":"Design, synthesis and evaluation of novel hybrids between 4-anilinoquinazolines and substituted triazoles as potent cytotoxic agents","volume":"28","author":"Le-Nhat-Thuy","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0310","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bmcl.2018.02.032","article-title":"Design and synthesis of 1,4-substituted 1H\u20131,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3K\u03b3 isoform selective activity","volume":"28","author":"Srinivas","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0315","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.1021\/acs.jmedchem.8b00938","article-title":"Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors","volume":"61","author":"Kettle","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0320","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/cbdd.12055","article-title":"The future of peptide-based drugs","volume":"81","author":"Craik","year":"2013","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2019.07.005_b0325","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bioorg.2018.08.030","article-title":"Identification of novel and selective non-peptide inhibitors targeting the polo-box domain of polo-like kinase 1","volume":"81","author":"Chen","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0330","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bmc.2017.10.023","article-title":"\u03b1-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors","volume":"26","author":"Matthiesen","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0335","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1016\/j.bmc.2018.04.041","article-title":"Novel leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry","volume":"26","author":"Cao","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2018.08.100","article-title":"A \u03b2-glucuronidase-responsive albumin-binding prodrug for potential selective kinase inhibitor-based cancer chemotherapy","volume":"158","author":"Compain","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0345","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.1016\/j.bmc.2018.06.016","article-title":"Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors","volume":"26","author":"Chen","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0350","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1016\/j.bmc.2018.03.045","article-title":"Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as P-glycoprotein-mediated multidrug resistance inhibitors","volume":"26","author":"Gao","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0355","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejmech.2018.01.031","article-title":"Design, synthesis and in vitro biological evaluation of novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing a thiosemicarbazide moiety","volume":"146","author":"Geng","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0360","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bmcl.2017.11.038","article-title":"Synthesis, antitumor activity, and cytotoxicity of 4-substituted 1-benzyl-5-diphenylstibano-1H-1,2,3-triazoles","volume":"28","author":"Yamada","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0365","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1016\/j.bmcl.2018.05.020","article-title":"Synthesis, characterization and cytotoxicity studies of 1,2,3-triazoles and 1,2,4-triazolo [1,5-a] pyrimidines in human breast cancer cells","volume":"28","author":"Gilandoust","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0370","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejmech.2018.06.055","article-title":"Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents","volume":"156","author":"Allam","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0375","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bmcl.2018.01.011","article-title":"Design and synthesis of novel dasatinib derivatives as inhibitors of leukemia stem cells","volume":"28","author":"Li","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0380","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.bioorg.2018.01.037","article-title":"Discovery of thinopyrimidine-triazole conjugates as c-Met targeting and apoptosis inducing agents","volume":"77","author":"Wang","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0385","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bioorg.2018.07.026","article-title":"Imidazopyridine linked triazoles as tubulin inhibitors, effectively triggering apoptosis in lung cancer cell line","volume":"80","author":"Sayeed","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0390","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.ejmech.2017.10.061","article-title":"Design, synthesis and biological evaluation of novel benzimidazole amidines as potent multi-target inhibitors for the treatment of non-small cell lung cancer","volume":"143","author":"Bistrovi\u0107","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0395","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ejmech.2018.02.077","article-title":"Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity","volume":"150","author":"Borowiecki","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0400","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ejmech.2018.07.018","article-title":"Synthesis and evaluation of the cytotoxic activity of Furanaphthoquinones tethered to 1H-1,2,3-triazoles in Caco-2, Calu-3, MDA-MB231 cells","volume":"156","author":"Costa","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0405","doi-asserted-by":"crossref","first-page":"15546","DOI":"10.1039\/C8NJ01249K","article-title":"Synthesis and biological evaluation of triazole and isoxazole-tagged benzothiazole\/benzoxazole derivatives as potent cytotoxic agents","volume":"42","author":"Dadmal","year":"2018","journal-title":"New J Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0410","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1039\/C7NJ04964A","article-title":"Design, synthesis, anti-proliferative evaluation and docking studies of 1: H-1,2,3-triazole tethered ospemifene-isatin conjugates as selective estrogen receptor modulators","volume":"42","author":"Kumar","year":"2018","journal-title":"New J Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2018.07.029","article-title":"1,2,3-Triazole tethered Indole-3-glyoxamide derivatives as multiple inhibitors of 5-LOX, COX-2 & tubulin: their anti-proliferative & anti-inflammatory activity","volume":"81","author":"Naaz","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0420","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.bmcl.2018.05.017","article-title":"N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity","volume":"28","author":"Schlapbach","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0425","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.ejmech.2017.10.041","article-title":"Exploration of 1,2,3-triazole-pyrimidine hybrids as potent reversal agents against ABCB1-mediated multidrug resistance","volume":"143","author":"Wang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0430","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejmech.2017.11.008","article-title":"Discovery of novel 2,4-diarylaminopyrimidine analogues as ALK and ROS1 dual inhibitors to overcome crizotinib-resistant mutants including G1202R","volume":"143","author":"Wang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0435","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1016\/j.bmcl.2018.09.021","article-title":"1,2,3-Triazole fused with pyridine\/pyrimidine as new template for antimicrobial agents: regioselective synthesis and identification of potent N-heteroarenes","volume":"28","author":"Marepu","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0440","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.ejmech.2018.08.086","article-title":"Boronic ester-linked macrocyclic lipopeptides as serine protease inhibitors targeting Escherichia coli type I signal peptidase","volume":"157","author":"Sza\u0142aj","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0445","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bioorg.2018.01.016","article-title":"Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids","volume":"77","author":"Lal","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0450","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejmech.2018.02.056","article-title":"Molecular interaction of novel benzothiazolyl triazolium analogues with calf thymus DNA and HSA-their biological investigation as potent antimicrobial agents","volume":"150","author":"Maddili","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0455","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.ejmech.2018.06.039","article-title":"Rational modification of a lead molecule: improving the antifungal activity of indole \u2013 triazole \u2013 amino acid conjugates","volume":"155","author":"Mishra","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0460","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.ejmech.2018.03.034","article-title":"Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties","volume":"150","author":"Yu","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0465","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.bmcl.2018.02.001","article-title":"Substitution of terminal amide with 1H-1,2,3-triazole: identification of unexpected class of potent antibacterial agents","volume":"28","author":"Bi","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0470","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bmcl.2017.11.039","article-title":"Towards smart biocide-free anti-biofilm strategies: click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria","volume":"28","author":"Sall","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0475","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.ejmech.2018.08.070","article-title":"Synthesis of 1,2,3-triazole linked 4(3H)-Quinazolinones as potent antibacterial agents against multidrug-resistant Staphylococcus aureus","volume":"157","author":"Gatadi","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0480","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.ejmech.2018.05.055","article-title":"Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates","volume":"155","author":"Yadav","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0485","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1002\/slct.201801622","article-title":"Design, synthesis and biological evaluation of triazole-containing 2-phenylindole and salicylic acid as quorum sensing inhibitors against Pseudomonas aeruginosa","volume":"3","author":"Srinivasarao","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0490","doi-asserted-by":"crossref","first-page":"8111","DOI":"10.1002\/slct.201801364","article-title":"Regioselective synthesis, antibacterial, molecular docking and fingerprint applications of 1-benzhydrylpiperazine derivatized 1,4-disubstituted 1,2,3-triazoles","volume":"3","author":"Govindaiah","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0495","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s00044-017-2072-x","article-title":"Convenient synthesis, antimalarial and antimicrobial potential of thioethereal 1,4-disubstituted 1,2,3-triazoles with ester functionality","volume":"27","author":"Kaushik","year":"2018","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2019.07.005_b0500","doi-asserted-by":"crossref","DOI":"10.1002\/ardp.201800005","article-title":"Synthesis, evaluation, and molecular docking studies of aryl urea-triazole-based derivatives as anti-urease agents","volume":"351","author":"Moghimi","year":"2018","journal-title":"Arch Pharm"},{"key":"10.1016\/j.bmc.2019.07.005_b0505","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/j.ejmech.2017.10.042","article-title":"Synthesis, antibacterial properties and 2D-QSAR studies of quinolone-triazole conjugates","volume":"143","author":"Faidallah","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0510","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejmech.2017.12.017","article-title":"1,3,5-Triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity","volume":"144","author":"Yang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0515","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.1021\/acs.jmedchem.7b01569","article-title":"Antitubercular bis-substituted cyclam derivatives: structure-activity relationships and in vivo studies","volume":"61","author":"Spain","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0520","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ejmech.2018.10.031","article-title":"Design synthesis and antitubercular activity of 4-alkoxy-triazoloquinolones able to inhibit the M. tuberculosis DNA gyrase","volume":"161","author":"Carta","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0525","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.ejmech.2017.11.090","article-title":"Synthesis and in vitro evaluation of novel substituted isatin-propylene-1H-1,2,3-triazole-4-methylene-moxifloxacin hybrids for their anti-mycobacterial activities","volume":"143","author":"Yan","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0530","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ejmech.2018.02.067","article-title":"Synthesis and antimycobacterial activity of 1-(\u03b2-d-Ribofuranosyl)-4-coumarinyloxymethyl- \/ -coumarinyl-1,2,3-triazole","volume":"150","author":"Srivastava","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0535","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1039\/C8MD00055G","article-title":"Triazole-diindolylmethane conjugates as new antitubercular agents: synthesis, bioevaluation, and molecular docking","volume":"9","author":"Danne","year":"2018","journal-title":"MedChemComm"},{"key":"10.1016\/j.bmc.2019.07.005_b0540","doi-asserted-by":"crossref","first-page":"16997","DOI":"10.1039\/C8RA03197E","article-title":"1,2,3-Triazole-fused spirochromenes as potential anti-tubercular agents: synthesis and biological evaluation","volume":"8","author":"Ashok","year":"2018","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2019.07.005_b0545","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1021\/acs.jmedchem.7b01870","article-title":"2H-1,2,3-triazole-based dipeptidyl nitriles: potent, selective, and trypanocidal rhodesain inhibitors by structure-based design","volume":"61","author":"Giroud","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0550","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ejmech.2018.03.033","article-title":"Synthesis, antiamoebic activity and docking studies of metronidazole-triazole-styryl hybrids","volume":"150","author":"Negi","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0555","doi-asserted-by":"crossref","first-page":"4850","DOI":"10.1016\/j.bmc.2018.08.025","article-title":"Synthesis and SAR of new isoxazole-triazole bis-heterocyclic compounds as analogues of natural lignans with antiparasitic activity","volume":"26","author":"Zimmermann","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0560","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.ejmech.2018.08.087","article-title":"Synthesis and evaluation of novel arctigenin derivatives as potential anti-Toxoplasma gondii agents","volume":"158","author":"Zhang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0565","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/1568026618666171215101158","article-title":"Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents","volume":"18","author":"Hu","year":"2018","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0570","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s13738-018-1330-2","article-title":"Design, synthesis, activity evaluation and QSAR studies of novel antimalarial 1,2,3-triazolo-\u03b2-lactam derivatives","volume":"15","author":"Jarrahpour","year":"2018","journal-title":"J Iran Chem Soc"},{"key":"10.1016\/j.bmc.2019.07.005_b0575","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejmech.2017.12.051","article-title":"Antimalarial naphthoquinones. Synthesis via click chemistry, in vitro activity, docking to PfDHODH and SAR of lapachol-based compounds","volume":"145","author":"Brand\u00e3o","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0580","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ejmech.2018.02.021","article-title":"Pyrimidine-chloroquinoline hybrids: synthesis and antiplasmodial activity","volume":"148","author":"Chopra","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0585","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ejmech.2018.01.017","article-title":"In vitro antiplasmodial efficacy of synthetic coumarin-triazole analogs","volume":"145","author":"Yadav","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0590","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ejmech.2018.06.042","article-title":"Synthesis and antiplasmodial activity of glyco-conjugate hybrids of phenylhydrazono-indolinones and glycosylated 1,2,3-triazolyl-methyl-indoline-2,3-diones","volume":"155","author":"Thakur","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0595","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.2174\/1568026618666181002110116","article-title":"Design, synthesis and antileishmanial activity of naphthotriazolyl-4-oxoquinolines","volume":"18","author":"Oliveira","year":"2018","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0600","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ejmech.2018.04.003","article-title":"Anti-leishmanial click modifiable thiosemicarbazones: design, synthesis, biological evaluation and in silico studies","volume":"151","author":"Temraz","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0605","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ejmech.2018.01.046","article-title":"Synthesis and leishmanicidal activity of eugenol derivatives bearing 1,2,3-triazole functionalities","volume":"146","author":"Teixeira","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0610","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejmech.2018.05.014","article-title":"Synthesis and evaluation of novel triazolyl quinoline derivatives as potential antileishmanial agents","volume":"154","author":"Upadhyay","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0615","doi-asserted-by":"crossref","first-page":"10220","DOI":"10.1002\/slct.201802002","article-title":"Potential antileishmanial activity of a triazole-based hybrid peptide against leishmania major","volume":"3","author":"Maji","year":"2018","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2019.07.005_b0620","doi-asserted-by":"crossref","first-page":"242","DOI":"10.2174\/1573406413666170906121318","article-title":"Identification of 1-aryl-1H-1,2,3-triazoles as potential new antiretroviral agents","volume":"14","author":"Gonzaga","year":"2018","journal-title":"Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0625","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejmech.2017.11.028","article-title":"Design, synthesis, and biological evaluation of new 1,2,3-triazolo-2\u2032-deoxy-2\u2032-fluoro- 4\u2032-azido nucleoside derivatives as potent anti-HBV agents","volume":"143","author":"Liu","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0630","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1016\/j.bmcl.2018.09.019","article-title":"Synthesis, biological evaluation and molecular modeling of a novel series of fused 1,2,3-triazoles as potential anti-coronavirus agents","volume":"28","author":"Karypidou","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0635","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bmcl.2017.12.025","article-title":"Synthesis of pentacyclic iminosugars with constrained butterfly-like conformation and their HIV-RT inhibitory activity","volume":"28","author":"Yan","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0640","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1016\/j.bmc.2018.04.029","article-title":"Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B","volume":"26","author":"Liu","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0645","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.ejmech.2018.06.028","article-title":"Dihydropyrimidinone\/1,2,3-triazole hybrid molecules: synthesis and anti-varicella-zoster virus (VZV) evaluation","volume":"155","author":"Kaoukabi","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0650","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ejmech.2018.09.029","article-title":"Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library","volume":"158","author":"Wu","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0655","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ejmech.2018.03.059","article-title":"Targeting the entrance channel of NNIBP: discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus","volume":"151","author":"Tian","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0660","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.bioorg.2018.10.023","article-title":"Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro \u03b1-glucosidase inhibition, kinetic, and docking study","volume":"83","author":"Saeedi","year":"2019","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0665","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bioorg.2018.08.008","article-title":"Synthesis of 1H\u20131,2,3-triazole derivatives as new \u03b1-glucosidase inhibitors and their molecular docking studies","volume":"81","author":"Avula","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0670","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1007\/s11164-017-3210-2","article-title":"Synthesis, docking and ADME prediction of novel 1,2,3-triazole-tethered coumarin derivatives as potential neuroprotective agents","volume":"44","author":"Kumari","year":"2018","journal-title":"Res Chem Intermed"},{"key":"10.1016\/j.bmc.2019.07.005_b0675","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bmcl.2018.01.020","article-title":"Synthesis and biological evaluation of longanlactone analogues as neurotrophic agents","volume":"28","author":"Reddy","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0680","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1021\/acsmedchemlett.8b00103","article-title":"Riluzole-triazole hybrids as novel chemical probes for neuroprotection in amyotrophic lateral sclerosis","volume":"9","author":"Sweeney","year":"2018","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0685","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejmech.2018.08.094","article-title":"4-Hydroxy-1,2,3-triazole moiety as bioisostere of the carboxylic acid function: a novel scaffold to probe the orthosteric \u03b3-aminobutyric acid receptor binding site","volume":"158","author":"Giraudo","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0690","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1021\/acs.jmedchem.7b01279","article-title":"A Dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate","volume":"61","author":"Chrovian","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0695","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.ejmech.2018.03.035","article-title":"Syntheses and in vitro evaluation of new S1PR1 compounds and initial evaluation of a lead F-18 radiotracer in rodents","volume":"150","author":"Luo","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0700","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.bmcl.2018.02.058","article-title":"Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HT2A receptor (5-HT2AR) antagonist M100907","volume":"28","author":"Gilbertson","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0705","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ejmech.2018.04.058","article-title":"Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds","volume":"152","author":"Jalili-Baleh","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0710","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bioorg.2018.04.030","article-title":"Novel 3-phenylcoumarin\u2013lipoic acid conjugates as multi-functional agents for potential treatment of Alzheimer's disease","volume":"79","author":"Jalili-Baleh","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0715","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ejmech.2018.03.082","article-title":"Novel sarsasapogenin-triazolyl hybrids as potential anti-Alzheimer's agents: design, synthesis and biological evaluation","volume":"151","author":"Wang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0720","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1039\/C7MD00457E","article-title":"Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors","volume":"9","author":"Wu","year":"2018","journal-title":"MedChemComm"},{"key":"10.1016\/j.bmc.2019.07.005_b0725","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ejmech.2017.12.065","article-title":"Novel click modifiable thioquinazolinones as anti-inflammatory agents: design, synthesis, biological evaluation and docking study","volume":"144","author":"Moussa","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0730","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bioorg.2018.03.005","article-title":"Synthesis of some novel orcinol based coumarin triazole hybrids with capabilities to inhibit RANKL-induced osteoclastogenesis through NF-\u03baB signaling pathway","volume":"78","author":"Rama Krishna","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0735","doi-asserted-by":"crossref","first-page":"4860","DOI":"10.1021\/acs.jmedchem.8b00168","article-title":"Structure-guided modification of heterocyclic antagonists of the P2Y14 receptor","volume":"61","author":"Yu","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0740","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bmcl.2018.01.060","article-title":"Acetazolamide-based [18F]-PET tracer: in vivo validation of carbonic anhydrase IX as a sole target for imaging of CA-IX expressing hypoxic solid tumors","volume":"28","author":"More","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.005_b0745","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ejmech.2018.06.021","article-title":"Design and synthesis of novel benzenesulfonamide containing 1,2,3-triazoles as potent human carbonic anhydrase isoforms I, II, IV and IX inhibitors","volume":"155","author":"Kumar","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0750","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.ejmech.2018.03.030","article-title":"Synthesis of novel 4-functionalized 1,5-diaryl-1,2,3-triazoles containing benzenesulfonamide moiety as carbonic anhydrase I, II, IV and IX inhibitors","volume":"150","author":"Vats","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0755","doi-asserted-by":"crossref","first-page":"5332","DOI":"10.1021\/acs.jmedchem.8b00549","article-title":"Click chemistry-based discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as orally active hypoxia-inducing factor prolyl hydroxylase inhibitors with favorable safety profiles for the treatment of anemia","volume":"61","author":"Wu","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0760","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.ejmech.2017.10.034","article-title":"Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a\/\u03b2-catenin pathway","volume":"143","author":"Rajan","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0765","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1080\/00397911.2018.1440315","article-title":"One-pot synthesis of novel 1,2,3-triazole-pyrimido[4,5-c]isoquinoline hybrids and evaluation of their antioxidant activity","volume":"48","author":"Narsimha","year":"2018","journal-title":"Synth Commun"},{"key":"10.1016\/j.bmc.2019.07.005_b0770","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bioorg.2018.06.005","article-title":"Design, synthesis and biological evaluation of novel 1,2,3-triazole linked coumarinopyrazole conjugates as potent anticholinesterase, anti-5-lipoxygenase, anti-tyrosinase and anti-cancer agents","volume":"80","author":"Chekir","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0775","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bmc.2017.12.004","article-title":"1,5-Disubstituted 1,2,3-triazole linked disaccharides: metal-free syntheses and screening of a new class of ribonuclease A inhibitors","volume":"26","author":"Kayet","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0780","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bmc.2017.11.032","article-title":"7-Methylguanosine monophosphate analogues with 5\u2032-(1,2,3-triazoyl) moiety: synthesis and evaluation as the inhibitors of cNIIIB nucleotidase","volume":"26","author":"Kozarski","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0785","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1021\/acs.jmedchem.7b01626","article-title":"Systematic tuning of fluoro-galectin-3 interactions provides thiodigalactoside derivatives with single-digit nM affinity and high selectivity","volume":"61","author":"Peterson","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0790","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.bioorg.2017.12.025","article-title":"Design, synthesis, and biological evaluation of novel substituted benzamide derivatives bearing a 1,2,3-triazole moiety as potent human dihydroorotate dehydrogenase inhibitors","volume":"76","author":"Lu","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0795","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1021\/acs.jmedchem.7b00925","article-title":"Design, synthesis, and in vitro and in vivo evaluation of ouabain analogues as potent and selective Na, K-ATPase \u03b14 isoform inhibitors for male contraception","volume":"61","author":"Syeda","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.005_b0800","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.bmcl.2018.05.030","article-title":"Development of autotaxin inhibitors: a series of zinc binding triazoles","volume":"28","author":"Thomson","year":"2018","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089619308260?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089619308260?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:02:43Z","timestamp":1760835763000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089619308260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":160,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0968089619308260"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2019.07.005","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2019.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}