{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:14:00Z","timestamp":1778577240880,"version":"3.51.4"},"reference-count":59,"publisher":"Elsevier BV","issue":"17","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":696,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["865-15"],"award-info":[{"award-number":["865-15"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bmc.2019.07.006","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T11:28:09Z","timestamp":1562239689000},"page":"3797-3804","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Thiazolidinedione and thiazole derivatives potentiate norfloxacin activity against NorA efflux pump over expression in Staphylococcus aureus 1199B strains"],"prefix":"10.1016","volume":"27","author":[{"given":"Pedro Silvino","family":"Pereira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo Alves de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Paulo Marcelino","family":"Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00edcera Datiane de Morais","family":"Oliveira-Tintino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saulo Relison","family":"Tintino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irwin Rose de Alencar","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamerson Ferreira","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Marchand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Douglas Melo","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Desterro","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresinha Gon\u00e7alves","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2019.07.006_b0005","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1128\/jb.177.10.2827-2833.1995","article-title":"Molecular characterization of the staphylococcal multidrug resistance export protein QacC","volume":"177","author":"Paulsen","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2019.07.006_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! An update from the infectious diseases society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2019.07.006_b0015","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1086\/524891","article-title":"The epidemic of antibiotic-resistant infections: a call to action for the medical community from the infectious diseases society of America","volume":"46","author":"Spellberg","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2019.07.006_b0020","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/cmdc.201700286","article-title":"Searching for novel inhibitors of the S. aureus NorA efflux pump: synthesis and biological evaluation of the 3-phenyl-1,4-benzothiazine analogues","volume":"12","author":"Felicetti","year":"2017","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2019.07.006_b0025","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1056\/NEJMp1408040","article-title":"Antibiotic resistance \u2014 problems, progress, and prospects","volume":"371","author":"Nathan","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmc.2019.07.006_b0030","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1038\/nbt1206-1497","article-title":"Antibacterial discovery and development\u2014the failure of success?","volume":"24","author":"Prabhavathi","year":"2006","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.bmc.2019.07.006_b0035","first-page":"78","article-title":"Prevalence of methicillin-resistant Staphylococcus Aureus (MRSA) in a Tertiary Care Hospital in Northern India","volume":"2","author":"Devi","year":"2010","journal-title":"J Lab Phys"},{"key":"10.1016\/j.bmc.2019.07.006_b0040","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1186\/s12889-017-4910-7","article-title":"Situational analysis of antibiotic use and resistance in Ghana: policy and regulation","volume":"17","author":"Yevutsey","year":"2017","journal-title":"BMC Public Health"},{"key":"10.1016\/j.bmc.2019.07.006_b0045","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrmicro3161","article-title":"Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus","volume":"12","author":"Foster","year":"2014","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmc.2019.07.006_b0050","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jama.298.15.1763","article-title":"Invasive methicillin-resistant <EMPH TYPE=\u201cITAL\u201d>Staphylococcus aureus<\/EMPH> infections in the United States","volume":"298","author":"Klevens","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.bmc.2019.07.006_b0055","doi-asserted-by":"crossref","first-page":"E3801","DOI":"10.1073\/pnas.1523199113","article-title":"Comparative genome-scale modelling of Staphylococcus aureus strains identifies strain-specific metabolic capabilities linked to pathogenicity","volume":"113","author":"Bosi","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2019.07.006_b0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/(SICI)1097-4636(1999)48:5<613::AID-JBM4>3.0.CO;2-#","article-title":"In vitro elution of vancomycin from biodegradable beads","volume":"48","author":"Liu","year":"1999","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.bmc.2019.07.006_b0065","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1039\/b212695h","article-title":"Anti-staphylococcal plant natural products","volume":"21","author":"Gibbons","year":"2004","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2019.07.006_b0070","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1073\/pnas.1419939112","article-title":"AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity","volume":"112","author":"Blair","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2019.07.006_b0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.drup.2016.06.007","article-title":"Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials","volume":"28","author":"Hernando-Amado","year":"2016","journal-title":"Drug Resist Updates"},{"key":"10.1016\/j.bmc.2019.07.006_b0080","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.biochem.78.082907.145923","article-title":"Multidrug resistance in bacteria","volume":"78","author":"Nikaido","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.bmc.2019.07.006_b0085","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/07853890701195262","article-title":"Efflux pumps as antimicrobial resistance mechanisms","volume":"39","author":"Poole","year":"2007","journal-title":"Ann Med"},{"key":"10.1016\/j.bmc.2019.07.006_b0090","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro1464","article-title":"Multidrug-resistance efflux pumps? Not just for resistance","volume":"4","author":"Piddock","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmc.2019.07.006_b0095","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/MMBR.64.4.672-693.2000","article-title":"Molecular properties of bacterial multidrug transporters","volume":"64","author":"Putman","year":"2000","journal-title":"Microbiol Mol Biol Rev: MMBR"},{"key":"10.1016\/j.bmc.2019.07.006_b0100","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1016\/j.addr.2005.04.004","article-title":"Bacterial resistance to antibiotics: active efflux and reduced uptake","volume":"57","author":"Kumar","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bmc.2019.07.006_b0105","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/cmdc.201000006","article-title":"Efflux pump inhibitors: a strategy to combat p-glycoprotein and the NorA multidrug resistance pump","volume":"5","author":"Zhang","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2019.07.006_b0110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/cbdd.12478","article-title":"Antibiotic adjuvants: diverse strategies for controlling drug-resistant pathogens","volume":"85","author":"Gill","year":"2015","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2019.07.006_b0115","doi-asserted-by":"crossref","unstructured":"Hershberger E, Donabedian S, Konstantinou K, Zervos MJ. Quinupristin-dalfopristin resistance in gram-positive bacteria: mechanism of resistance and epidemiology. 2004;38.","DOI":"10.1086\/380125"},{"key":"10.1016\/j.bmc.2019.07.006_b0120","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1016\/j.ejmech.2010.05.006","article-title":"Substituted dihydronaphthalenes as efflux pump inhibitors of Staphylococcus aureus","volume":"45","author":"Thota","year":"2010","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0125","doi-asserted-by":"crossref","DOI":"10.2174\/1871523016666170616120346","article-title":"Synthesis of new thiazolyl coupled pyrazoles bearing 2,4-thiazolidinedionyl pharmacophore and their anti-inflammatory and antibacterial evaluation","volume":"16","author":"Khillare","year":"2017","journal-title":"Anti-Inflammatory Anti-Allergy Agents Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0223-5234(02)01447-2","article-title":"Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents","volume":"38","author":"Holla","year":"2003","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0135","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bmcl.2003.09.077","article-title":"Phenolic thiazoles as novel orally-active neuroprotective agents","volume":"14","author":"Harnett","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2019.07.006_b0140","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ejmech.2012.06.013","article-title":"Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs","volume":"54","author":"El-Messery","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0145","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejmech.2011.10.023","article-title":"Substituted thiazoles V. Synthesis and antitumor activity of novel thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues","volume":"47","author":"Al-Omary","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0150","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0223-5234(01)01266-1","article-title":"Synthesis and antitubercular activity of imidazo[2,1-b]thiazoles","volume":"36","author":"Andreani","year":"2001","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0155","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1016\/j.bmc.2010.03.058","article-title":"Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles","volume":"18","author":"Branowska","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0160","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejmech.2014.08.012","article-title":"2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation","volume":"86","author":"Cardoso","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0165","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1016\/j.bmc.2007.06.049","article-title":"Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives","volume":"15","author":"Bozda\u011f-D\u00fcndar","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/10408444.2017.1351420","article-title":"Thiazolidinedione drugs in the treatment of type 2 diabetes mellitus: past, present and future","volume":"48","author":"Davidson","year":"2018","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.bmc.2019.07.006_b0175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.diabet.2015.02.003","article-title":"Antidiabetic agents: potential anti-inflammatory activity beyond glucose control","volume":"41","author":"Scheen","year":"2015","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.bmc.2019.07.006_b0180","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1210\/jc.2005-0469","article-title":"Direct thiazolidinedione action in the human ovary: insulin-independent and insulin-sensitizing effects on steroidogenesis and insulin-like growth factor binding protein-1 production","volume":"90","author":"Seto-Young","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.bmc.2019.07.006_b0185","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejmech.2017.06.035","article-title":"Conventional and microwave-assisted synthesis of new 1 H-benzimidazole-thiazolidinedione derivatives: a potential anticancer scaffold","volume":"138","author":"Sharma","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0190","doi-asserted-by":"crossref","first-page":"3859","DOI":"10.1016\/j.bmc.2006.01.043","article-title":"Synthesis and antimicrobial activity of novel 2-thiazolylimino-5-arylidene-4-thiazolidinones","volume":"14","author":"Vicini","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0195","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ejmech.2017.09.047","article-title":"Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi","volume":"141","author":"de Oliveira Filho","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0200","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jep.2007.01.032","article-title":"Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant","volume":"110","author":"Houghton","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmc.2019.07.006_b0205","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/157489112799829710","article-title":"Bacterial efflux pumps involved in multidrug resistance and their inhibitors: rejuvinating the antimicrobial chemotherapy","volume":"7","author":"Bhardwaj","year":"2012","journal-title":"Recent Pat Anti-Infect Drug Discovery"},{"key":"10.1016\/j.bmc.2019.07.006_b0210","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1874285801307010059","article-title":"Multidrug efflux pumps in Staphylococcus aureus: an update","volume":"7","author":"Costa","year":"2013","journal-title":"Open Microbiol J"},{"key":"10.1016\/j.bmc.2019.07.006_b0215","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/1471-2180-11-241","article-title":"Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus","volume":"11","author":"Costa","year":"2011","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.bmc.2019.07.006_b0220","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2217\/fmb.13.16","article-title":"Inhibition of drug efflux pumps in Staphylococcus aureus: current status of potentiating existing antibiotics","volume":"8","author":"Schindler","year":"2013","journal-title":"Future Microbiol"},{"key":"10.1016\/j.bmc.2019.07.006_b0225","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccc.2007.12.011","article-title":"Antibiotic adverse reactions and drug interactions","volume":"24","author":"Granowitz","year":"2008","journal-title":"Crit Care Clin"},{"key":"10.1016\/j.bmc.2019.07.006_b0230","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1021\/acs.jmedchem.6b01281","article-title":"Improved potency of indole-based NorA efflux pump inhibitors: from serendipity toward rational design and development","volume":"60","author":"Buonerba","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2016.05.007","article-title":"Optimization of a novel series of pyranopyridine RND efflux pump inhibitors","volume":"33","author":"Aron","year":"2016","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bmc.2019.07.006_b0240","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cimid.2018.03.001","article-title":"In vitro e in silico evaluation of the inhibition of Staphylococcus aureus efflux pumps by caffeic and gallic acid","volume":"57","author":"dos Santos","year":"2018","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"10.1016\/j.bmc.2019.07.006_b0245","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1021\/jm0004190","article-title":"Flavonolignan and flavone inhibitors of a Staphylococcus a ureus multidrug resistance pump: structure\u2212activity relationships","volume":"44","author":"Guz","year":"2001","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0250","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/S1359-6446(04)03115-0","article-title":"Compound lipophilicity for substrate binding to human P450s in drug metabolism","volume":"9","author":"Lewis","year":"2004","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.bmc.2019.07.006_b0255","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1016\/j.bmc.2008.05.030","article-title":"Citral derived amides as potent bacterial NorA efflux pump inhibitors","volume":"16","author":"Thota","year":"2008","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0260","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ejmech.2008.02.015","article-title":"Quantitative structure\u2013activity relationship (QSAR) of aryl alkenyl amides\/imines for bacterial efflux pump inhibitors","volume":"44","author":"Nargotra","year":"2009","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2019.07.006_b0265","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10822-005-8694-y","article-title":"Virtual computational chemistry laboratory \u2013 design and description","volume":"19","author":"Tetko","year":"2005","journal-title":"J Comput Aided Mol Des"},{"key":"10.1016\/j.bmc.2019.07.006_b0270","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejphar.2014.07.020","article-title":"Non-antibiotic agent ginsenoside 20(S)-Rh2 enhanced the antibacterial effects of ciprofloxacin in vitro and in vivo as a potential NorA inhibitor","volume":"740","author":"Zhang","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bmc.2019.07.006_b0275","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1093\/jac\/dks232","article-title":"Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus","volume":"67","author":"Kalia","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2019.07.006_b0280","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/jac\/dkq186","article-title":"Piperine as an inhibitor of Rv1258c, a putative multidrug efflux pump of Mycobacterium tuberculosis","volume":"65","author":"Sharma","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.bmc.2019.07.006_b0285","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cbi.2018.01.016","article-title":"New 1,3-benzodioxole derivatives: synthesis, evaluation of in vitro schistosomicidal activity and ultrastructural analysis","volume":"283","author":"Silva","year":"2018","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.bmc.2019.07.006_b0290","series-title":"15th informational supplement, M100-S15","article-title":"Clinical and, Laboratory Standards Institute Performance standards for antimicrobial susceptibility testing","author":"CLSI","year":"2005"},{"key":"10.1016\/j.bmc.2019.07.006_b0295","unstructured":"NCCLS. Standards, National Committee for Clinical Laboratory. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard. 2003:1\u201347."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961930481X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961930481X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:28:05Z","timestamp":1778574485000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961930481X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":59,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S096808961930481X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2019.07.006","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Thiazolidinedione and thiazole derivatives potentiate norfloxacin activity against NorA efflux pump over expression in Staphylococcus aureus 1199B strains","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2019.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}