{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:20:09Z","timestamp":1784402409059,"version":"3.55.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bmc.2019.115239","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T05:38:51Z","timestamp":1576647531000},"page":"115239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Expanding therapeutic opportunities for neurodegenerative diseases: A perspective on the important role of phenotypic screening"],"prefix":"10.1016","volume":"28","author":[{"given":"Susanne E.","family":"Swalley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2019.115239_b0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuropharm.2016.03.021","article-title":"The need for new approaches in CNS drug discovery: why drugs have failed, and what can be done to improve outcomes","volume":"120","author":"Gribkoff","year":"2017","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.bmc.2019.115239_b0010","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/d41573-019-00074-z","article-title":"Trends in clinical success rates and therapeutic focus","volume":"18","author":"Dowden","year":"2019","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"10.1016\/j.bmc.2019.115239_b0015","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1377\/hlthaff.2012.0541","article-title":"An improved approach to measuring drug innovation finds steady rates of first-in-class pharmaceuticals, 1987\u20132011","volume":"32","author":"Lanthier","year":"2013","journal-title":"Health Aff (Millwood)"},{"issue":"4","key":"10.1016\/j.bmc.2019.115239_b0020","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/clpt.2012.236","article-title":"Phenotypic vs. target-based drug discovery for first-in-class medicines","volume":"93","author":"Swinney","year":"2013","journal-title":"Clin Pharmacol Ther"},{"issue":"8","key":"10.1016\/j.bmc.2019.115239_b0025","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrd4336","article-title":"The discovery of first-in-class drugs: origins and evolution","volume":"13","author":"Eder","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2019.115239_b0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/1177391X0700100002","article-title":"FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology","volume":"1","author":"Adachi","year":"2007","journal-title":"Perspect Medicin Chem"},{"issue":"8","key":"10.1016\/j.bmc.2019.115239_b0035","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.chembiol.2019.05.007","article-title":"The convergence of stem cell technologies and phenotypic drug discovery","volume":"26","author":"Friese","year":"2019","journal-title":"Cell Chem Bio"},{"issue":"293","key":"10.1016\/j.bmc.2019.115239_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.aab1201","article-title":"Developing predictive assays: the phenotypic screening \u201crule of 3\u201d","volume":"7","author":"Vincent","year":"2015","journal-title":"Science Transl Med"},{"issue":"22","key":"10.1016\/j.bmc.2019.115239_b0045","doi-asserted-by":"crossref","first-page":"10067","DOI":"10.1021\/acs.jmedchem.6b00670","article-title":"Small molecules in development for the treatment of spinal muscular atrophy","volume":"59","author":"Calder","year":"2016","journal-title":"J Med Chem"},{"issue":"9","key":"10.1016\/j.bmc.2019.115239_b0050","doi-asserted-by":"crossref","first-page":"e0185079","DOI":"10.1371\/journal.pone.0185079","article-title":"In vitro and in vivo effects of 2,4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: context-specific modulation of SMN transcript levels","volume":"12","author":"Cherry","year":"2017","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.bmc.2019.115239_b0055","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1124\/jpet.107.123000","article-title":"Identification and characterization of chloest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis","volume":"322","author":"Bordet","year":"2007","journal-title":"J Pharamcol Exp Ther"},{"issue":"6197","key":"10.1016\/j.bmc.2019.115239_b0060","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1126\/science.1250127","article-title":"SMN2 splicing modifiers improve motor function and longevity in mice with spinal muscular atrophy","volume":"345","author":"Naryshkin","year":"2014","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.bmc.2019.115239_b0065","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1021\/acs.jmedchem.8b00741","article-title":"Discovery of risdiplam, a selective survival of motor neuron-2 (SMN2) gene splicing modifier for the treatment of spinal muscular atrophy (SMA)","volume":"61","author":"Ratni","year":"2018","journal-title":"J Med Chem"},{"issue":"7","key":"10.1016\/j.bmc.2019.115239_b0070","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nchembio.1837","article-title":"SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice","volume":"11","author":"Palacino","year":"2015","journal-title":"Nature Chem Biol"},{"issue":"12","key":"10.1016\/j.bmc.2019.115239_b0075","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/s41589-019-0384-5","article-title":"Structural basis of a small molecule targeting RNA for a specific splicing correction","volume":"15","author":"Campagne","year":"2019","journal-title":"Nature Chem Biol"},{"issue":"2","key":"10.1016\/j.bmc.2019.115239_b0080","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1093\/nar\/gkl1050","article-title":"Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes","volume":"35","author":"Singh","year":"2007","journal-title":"Nuc Acids Res"},{"issue":"8","key":"10.1016\/j.bmc.2019.115239_b0085","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nrd.2017.111","article-title":"Opportunities and challenges in phenotypic drug discovery: an industry perspective","volume":"16","author":"Moffat","year":"2017","journal-title":"Nat Rev Drug Discov"},{"issue":"4","key":"10.1016\/j.bmc.2019.115239_b0090","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.stemcr.2017.08.019","article-title":"Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening","volume":"9","author":"Wang","year":"2017","journal-title":"Stem Cell Reports"},{"issue":"10","key":"10.1016\/j.bmc.2019.115239_b0095","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/j.celrep.2018.11.028","article-title":"Inhibiting steroyl-CoA desaturase ameliorates a-synuclein cytotoxicity","volume":"25","author":"Vincent","year":"2018","journal-title":"Cell Reports"},{"issue":"493","key":"10.1016\/j.bmc.2019.115239_b0100","doi-asserted-by":"crossref","first-page":"eaaq1818","DOI":"10.1126\/scitranslmed.aaq1818","article-title":"Mouse models of neurodegeneration: know your question, know your mouse","volume":"11","author":"Fisher","year":"2019","journal-title":"Science Trans Med"},{"issue":"7689","key":"10.1016\/j.bmc.2019.115239_b0105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nature25032","article-title":"The rise of three-dimensional human brain cultures","volume":"553","author":"Pasca","year":"2018","journal-title":"Nature"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089619313276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089619313276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:05:24Z","timestamp":1760835924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089619313276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0968089619313276"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2019.115239","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expanding therapeutic opportunities for neurodegenerative diseases: A perspective on the important role of phenotypic screening","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2019.115239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115239"}}