{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:55:57Z","timestamp":1783511757534,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["2P41RR001081"],"award-info":[{"award-number":["2P41RR001081"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["9P41GM103311"],"award-info":[{"award-number":["9P41GM103311"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["15063"],"award-info":[{"award-number":["15063"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bmc.2020.115329","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T20:34:04Z","timestamp":1579638844000},"page":"115329","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies"],"prefix":"10.1016","volume":"28","author":[{"given":"Heba T.","family":"Abdel-Mohsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"El Kerdawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Omar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Berrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed S.","family":"Abdelsamie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda I.","family":"El Diwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2020.115329_b0005","series-title":"Carbonic anhydrases as biocatalysts \u2013 from theory to medical and industrial applications","article-title":"Carbonic anhydrases: an overview","author":"Supuran","year":"2015"},{"key":"10.1016\/j.bmc.2020.115329_b0010","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3109\/14756366.2015.1059333","article-title":"A magnificent enzyme superfamily: carbonic anhydrases, their purification and characterization","volume":"31","author":"Guler","year":"2016","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(96)00198-2","article-title":"Structure and mechanism of carbonic anhydrase","volume":"74","author":"Lindskog","year":"1997","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bmc.2020.115329_b0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/14756366.2012.737323","article-title":"Structural annotation of human carbonic anhydrases","volume":"28","author":"Aggarwal","year":"2013","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0025","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1021\/cr050262p","article-title":"Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding","volume":"108","author":"Krishnamurthy","year":"2008","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2020.115329_b0030","doi-asserted-by":"crossref","first-page":"E25","DOI":"10.3390\/metabo8020025","article-title":"Carbonic anhydrase and metabolism","volume":"8","author":"Supuran","year":"2018","journal-title":"Metabolites"},{"key":"10.1016\/j.bmc.2020.115329_b0035","series-title":"Carbon. Anhydrases New Horizons","first-page":"343","article-title":"The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals","author":"Chegwidden","year":"2000"},{"key":"10.1016\/j.bmc.2020.115329_b0040","series-title":"Carbonic anhydrase: Mechanism, regulation, links to disease, and industrial applications","first-page":"271","article-title":"Carbonic Anhydrases and Brain PH in the Control of Neuronal Excitability","author":"Ruusuvuori","year":"2014"},{"key":"10.1016\/j.bmc.2020.115329_b0045","article-title":"Carbonic anhydrases: current state of the art, therapeutic applications and future","author":"Pastorekova","year":"2004","journal-title":"Prospects"},{"key":"10.1016\/j.bmc.2020.115329_b0050","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.bmc.2007.04.020","article-title":"Carbonic anhydrases as targets for medicinal chemistry","volume":"15","author":"Supuran","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0055","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrd2467","article-title":"Carbonic anhydrases: novel therapeutic applications for inhibitors and activators","volume":"7","author":"Supuran","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2020.115329_b0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nm1534","article-title":"Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation","volume":"13","author":"Gao","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.bmc.2020.115329_b0065","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1517\/17460441.2015.1000857","article-title":"Discovery of novel inhibitors for the treatment of glaucoma","volume":"10","author":"Cholkar","year":"2015","journal-title":"Expet Opin Drug Discov"},{"key":"10.1016\/j.bmc.2020.115329_b0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/1874764711205010083","article-title":"Recent patents on emerging therapeutics for the treatment of glaucoma, age related macular degeneration and uveitis","volume":"5","author":"Vadlapudi","year":"2012","journal-title":"Recent Pat Biomed Eng"},{"key":"10.1016\/j.bmc.2020.115329_b0075","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nrd3554","article-title":"Interfering with pH regulation in tumours as a therapeutic strategy","volume":"10","author":"Neri","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2020.115329_b0080","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcancer.2014.08.002","article-title":"Hypoxia-induced carbonic anhydrase IX as a target for cancer therapy: From biology to clinical use","volume":"31","author":"Pastorek","year":"2015","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.bmc.2020.115329_b0085","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1517\/13543776.2013.798648","article-title":"Anticancer carbonic anhydrase inhibitors: a patent a patent review (2008\u20132013)","volume":"23","author":"Monti","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2020.115329_b0090","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.3390\/metabo7030048","article-title":"Carbonic anhydrase inhibition and the management of hypoxic tumors","volume":"7","author":"Supuran","year":"2017","journal-title":"Metabolites"},{"key":"10.1016\/j.bmc.2020.115329_b0095","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.bbapap.2009.07.027","article-title":"Carbonic anhydrase IX: biochemical and crystallographic characterization of a novel antitumor target","volume":"1804","author":"De Simone","year":"2010","journal-title":"Biochim Biophys Acta-Proteins Proteom"},{"key":"10.1016\/j.bmc.2020.115329_b0100","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3109\/14756366.2012.672983","article-title":"Structure-based drug discovery of carbonic anhydrase inhibitors","volume":"27","author":"Supuran","year":"2012","journal-title":"J. Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0105","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/14756366.2015.1122001","article-title":"How many carbonic anhydrase inhibition mechanisms exist?","volume":"31","author":"Supuran","year":"2016","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0110","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1016\/j.bmcl.2010.05.009","article-title":"Carbonic anhydrase inhibitors","volume":"20","author":"Supuran","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115329_b0115","doi-asserted-by":"crossref","first-page":"615","DOI":"10.2174\/138161208783877848","article-title":"Design of zinc binding functions for carbonic anhydrase inhibitors","volume":"14","author":"Winum","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.bmc.2020.115329_b0120","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bmc.2013.11.016","article-title":"Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies","volume":"22","author":"Bozdag","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2020.115329_b0125","series-title":"Targeting carbonic anhydrases","year":"2014"},{"key":"10.1016\/j.bmc.2020.115329_b0130","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.4155\/fmc.14.68","article-title":"Sulfonamides and their isosteres as carbonic anhydrase inhibitors","volume":"6","author":"Carta","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bmc.2020.115329_b0135","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3109\/14756366.2011.597749","article-title":"A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology","volume":"27","author":"Fabrizi","year":"2012","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0140","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1517\/13543776.2013.782394","article-title":"Anticonvulsant\/antiepileptic carbonic anhydrase inhibitors: a patent review","volume":"23","author":"Aggarwal","year":"2013","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2020.115329_b0145","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2174\/156802607780636726","article-title":"Carbonic anhydrase inhibitors a anticonvulsant agents","volume":"7","author":"Thiry","year":"2007","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0150","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1517\/14728214.13.2.383","article-title":"Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity","volume":"13","author":"Supuran","year":"2008","journal-title":"Expert Opin Emerg Drugs"},{"key":"10.1016\/j.bmc.2020.115329_b0155","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2174\/138955706777934946","article-title":"New zinc binding motifs in the design of selective carbonic anhydrase inhibitors","volume":"6","author":"Winum","year":"2006","journal-title":"Mini-Rev Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0160","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/17460441.2017.1253677","article-title":"Advances in structure-based drug discovery of carbonic anhydrase inhibitors","volume":"12","author":"Supuran","year":"2017","journal-title":"Expert Opin Drug Dis"},{"key":"10.1016\/j.bmc.2020.115329_b0165","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.2174\/092986707781058805","article-title":"Molecular hybridization: a useful tool in the design of new drug prototypes","volume":"14","author":"Viegas-Junior","year":"2007","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0170","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1021\/cr900028p","article-title":"Enzymology of purine and pyrimidine antimetabolites used in the treatment of cancer","volume":"109","author":"Parker","year":"2009","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2020.115329_b0175","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.2174\/1568026616666160609100410","article-title":"The chemistry and bio-medicinal significance of pyrimidines and condensed pyrimidines","volume":"16","author":"Jain","year":"2016","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0180","doi-asserted-by":"crossref","first-page":"17427","DOI":"10.1039\/C6RA28102H","article-title":"Laccase-catalyzed green synthesis and cytotoxic activity of novel pyrimidobenzothiazoles and catechol thioethers","volume":"7","author":"Abdel-Mohsen","year":"2017","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2020.115329_b0185","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1016\/j.ejmech.2010.02.011","article-title":"Novel benzimidazole\u2013pyrimidine conjugates as potent antitumor agents","volume":"45","author":"Abdel-Mohsen","year":"2010","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0190","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1080\/14756366.2016.1235043","article-title":"Carbonic anhydrase inhibitory properties of some uracil derivatives","volume":"32","author":"T\u00fcrko\u011flu","year":"2017","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0195","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1021\/acsmedchemlett.7b00399","article-title":"Discovery of new sulfonamide carbonic anhydrase IX inhibitors incorporating nitrogenous bases","volume":"8","author":"Nocentini","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115329_b0200","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bioorg.2019.03.007","article-title":"Synthesis of benzensulfonamides linked to quinazoline scaffolds as novel carbonic anhydrase inhibitors","volume":"87","author":"El-Azab","year":"2019","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0205","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/14756360290018602","article-title":"Carbonic anhydrase inhibitors with strong topical antiglaucoma properties incorporating a 4-(2-aminopyrimidin-4-yl-amino)-benzenesulfonamide scaffold","volume":"17","author":"Casini","year":"2002","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14756366.2016.1198901","article-title":"Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4 tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I\/II inhibitory and antioxidant activities","volume":"31","author":"Garibov","year":"2016","journal-title":"J Enzym Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0215","series-title":"Targeting carbonic anhydrases future science","first-page":"53","article-title":"Next generation secondary\/tertiary sulfonamide carbonic anhydrase inhibitors. Ch. 4","author":"Thibaudeau","year":"2014"},{"key":"10.1016\/j.bmc.2020.115329_b0220","doi-asserted-by":"crossref","first-page":"30766","DOI":"10.1074\/jbc.M805353200","article-title":"Entrapment of carbon dioxide in the active site of carbonic anhydrase II","volume":"283","author":"Domsic","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0225","doi-asserted-by":"crossref","first-page":"11636","DOI":"10.1039\/c1cc14575d","article-title":"Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II","volume":"47","author":"Di Fiore","year":"2011","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmc.2020.115329_b0230","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1073\/pnas.0904184106","article-title":"Structural study of X-ray induced activation of carbonic anhydrase","volume":"106","author":"Sj\u00f6blom","year":"2009","journal-title":"PNAS"},{"key":"10.1016\/j.bmc.2020.115329_b0235","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ejmech.2019.06.063","article-title":"Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors","volume":"179","author":"Abdel-Mohsen","year":"2019","journal-title":"Eur J Med Chem"},{"issue":"11","key":"10.1016\/j.bmc.2020.115329_b0240","doi-asserted-by":"crossref","first-page":"1900089","DOI":"10.1002\/ardp.201900089","article-title":"New 2,4\u2010disubstituted\u20102\u2010thiopyrimidines as VEGFR\u20102 inhibitors: design, synthesis, and biological evaluation","volume":"352","author":"Abdel\u2010Mohsen","year":"2019","journal-title":"Arch Pharm Chem Life Sci"},{"key":"10.1016\/j.bmc.2020.115329_b0245","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1016\/S0021-9258(18)62326-9","article-title":"The carbon dioxide hydration activity of carbonic anhydrase","volume":"246","author":"Khalifah","year":"1971","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2020.115329_b0250","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1107\/S1744309109036665","article-title":"High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design","volume":"65","author":"Sippel","year":"2009","journal-title":"Acta Crystallogr Sect F"},{"key":"10.1016\/j.bmc.2020.115329_b0255","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera-a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961931716X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808961931716X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:27:47Z","timestamp":1778574467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808961931716X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S096808961931716X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115329","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New thiopyrimidine-benzenesulfonamide conjugates as selective carbonic anhydrase II inhibitors: synthesis, in vitro biological evaluation, and molecular docking studies","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115329","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115329"}}