{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:24:35Z","timestamp":1775708675080,"version":"3.50.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012478","name":"Secretaria de Ciencia y Tecnolog\u00eda - Universidad Nacional de C\u00f3rdoba","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.bmc.2020.115355","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T11:33:49Z","timestamp":1580902429000},"page":"115355","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Zn phthalocyanines loaded into liposomes: Characterization and enhanced performance of photodynamic activity on glioblastoma cells"],"prefix":"10.1016","volume":"28","author":[{"given":"Mariana","family":"Miretti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas C.","family":"Tempesti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9sar G.","family":"Prucca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bmc.2020.115355_b0005","first-page":"250","article-title":"Photodynamic therapy of cancer: an update","volume":"61","author":"Agostinis","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bmc.2020.115355_b0010","doi-asserted-by":"crossref","first-page":"276109","DOI":"10.1155\/2008\/276109","article-title":"Photodynamic therapy and the development of metal-based photosensitisers","volume":"2008","author":"Josefsen","year":"2008","journal-title":"Met-Based Drugs"},{"issue":"4","key":"10.1016\/j.bmc.2020.115355_b0015","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1572-1000(05)00007-4","article-title":"Mechanisms in photodynamic therapy: part one\u2014photosensitizers, photochemistry and cellular localization","volume":"1","author":"Castano","year":"2004","journal-title":"Photodiagn Photodyn Ther"},{"issue":"4","key":"10.1016\/j.bmc.2020.115355_b0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/BJ20150942","article-title":"New photosensitizers for photodynamic therapy","volume":"473","author":"Abrahamse","year":"2016","journal-title":"Biochem J"},{"issue":"9","key":"10.1016\/j.bmc.2020.115355_b0025","doi-asserted-by":"crossref","first-page":"20523","DOI":"10.3390\/ijms160920523","article-title":"Photodynamic Efficiency: From Molecular Photochemistry to Cell Death","volume":"16","author":"Bacellar","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.bmc.2020.115355_b0030","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/molecules21030342","article-title":"Nanotechnology-based drug delivery systems for photodynamic therapy of cancer: a review","volume":"21","author":"Calixto","year":"2016","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.bmc.2020.115355_b0035","doi-asserted-by":"crossref","first-page":"10228","DOI":"10.3390\/ijms160510228","article-title":"Cell death pathways and phthalocyanine as an efficient agent for photodynamic cancer therapy","volume":"16","author":"Mfouo-Tynga","year":"2015","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.bmc.2020.115355_b0040","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1088\/0031-9155\/50\/11\/011","article-title":"Characterization of Photofrin photobleaching for singlet oxygen dose estimation during photodynamic therapy of MLL cells in vitro","volume":"50","author":"Dysart","year":"2005","journal-title":"Phys Med Biol"},{"issue":"18","key":"10.1016\/j.bmc.2020.115355_b0045","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1021\/jp051163i","article-title":"Lifetime and diffusion of singlet oxygen in a cell","volume":"109","author":"Skovsen","year":"2005","journal-title":"J Phys Chem B"},{"issue":"1","key":"10.1016\/j.bmc.2020.115355_b0050","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3390\/molecules17010098","article-title":"Like a bolt from the blue: phthalocyanines in biomedical optics","volume":"17","author":"Sekkat","year":"2011","journal-title":"Molecules"},{"issue":"6","key":"10.1016\/j.bmc.2020.115355_b0055","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1021\/cr030707e","article-title":"Bioinorganic photochemistry: frontiers and mechanisms","volume":"105","author":"Szaci\u0142owski","year":"2005","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2020.115355_b0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ccr.2017.08.003","article-title":"Phthalocyanines as medicinal photosensitizers: developments in the last five years","volume":"379","author":"Li","year":"2019","journal-title":"Coord Chem Rev"},{"key":"10.1016\/j.bmc.2020.115355_b0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/978-1-4684-4406-3_8","article-title":"Light dosimetry in tissue: application to photoradiation therapy","volume":"160","author":"Doiron","year":"1983","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"10.1016\/j.bmc.2020.115355_b0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1751-1097.1985.tb01554.x","article-title":"In vivo and post mortem measurements of the attenuation spectra of light in mammalian tissues","volume":"42","author":"Wilson","year":"1985","journal-title":"Photochem Photobiol"},{"issue":"5","key":"10.1016\/j.bmc.2020.115355_b0075","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12551-017-0293-3","article-title":"Nanomedicine associated with photodynamic therapy for glioblastoma treatment","volume":"9","author":"de Paula","year":"2017","journal-title":"Biophys Rev"},{"key":"10.1016\/j.bmc.2020.115355_b0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1476-4598-9-135","article-title":"Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics","volume":"9","author":"Krakstad","year":"2010","journal-title":"Molecular cancer"},{"key":"10.1016\/j.bmc.2020.115355_b0085","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fphar.2017.00166","article-title":"Targeted nanotechnology in glioblastoma multiforme","volume":"8","author":"Glaser","year":"2017","journal-title":"Front Pharmacol"},{"issue":"10","key":"10.1016\/j.bmc.2020.115355_b0090","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"New Engl J Med"},{"issue":"10","key":"10.1016\/j.bmc.2020.115355_b0095","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1517\/17425240903167942","article-title":"New strategies to deliver anticancer drugs to brain tumors","volume":"6","author":"Laquintana","year":"2009","journal-title":"Expert Opin Drug Del"},{"key":"10.1016\/j.bmc.2020.115355_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2015.02.002","article-title":"Overcoming the blood-brain tumor barrier for effective glioblastoma treatment","volume":"19","author":"van Tellingen","year":"2015","journal-title":"Drug Resist Updates: Rev Comment Antimicrob Anticancer Chemot"},{"issue":"170","key":"10.1016\/j.bmc.2020.115355_b0105","first-page":"1","article-title":"Advances in glioblastoma multiforme treatment: new models for nanoparticle therapy","volume":"9","author":"Ozdemir-Kaynak","year":"2018","journal-title":"Front Physiol"},{"issue":"5","key":"10.1016\/j.bmc.2020.115355_b0110","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/bjc.1994.163","article-title":"In vivo fluorescence and photodynamic activity of zinc phthalocyanine administered in liposomes","volume":"69","author":"van Leengoed","year":"1994","journal-title":"Br J Cancer"},{"issue":"15","key":"10.1016\/j.bmc.2020.115355_b0115","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.2217\/nnm.15.67","article-title":"Antimicrobial photodynamic inactivation in nanomedicine: small light strides against bad bugs","volume":"10","author":"Yin","year":"2015","journal-title":"Nanomedicine (London, England)"},{"issue":"2","key":"10.1016\/j.bmc.2020.115355_b0120","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat Rev Drug Disc"},{"key":"10.1016\/j.bmc.2020.115355_b0125","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.jphotobiol.2016.09.002","article-title":"Photodynamic performance of zinc phthalocyanine in HeLa cells: a comparison between DPCC liposomes and BSA as delivery systems","volume":"163","author":"Garc\u00eda","year":"2016","journal-title":"J Photochem Photobiol, B"},{"issue":"4","key":"10.1016\/j.bmc.2020.115355_b0130","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1039\/c0pp00289e","article-title":"Photophysical behaviour and photodynamic activity of zinc phthalocyanines associated to liposomes","volume":"10","author":"Garc\u00eda","year":"2011","journal-title":"Photochem Photobiol Sci: Off J Eur Photochem Assoc Eur Soc Photobiol"},{"key":"10.1016\/j.bmc.2020.115355_b0135","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejmech.2018.03.077","article-title":"A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy","volume":"151","author":"Huang","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115355_b0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jphotochemrev.2015.05.002","article-title":"Enhancing photodynamic therapy of refractory solid cancers: combining second-generation photosensitizers with multi-targeted liposomal delivery","volume":"23","author":"Weijer","year":"2015","journal-title":"J Photochem Photobiol, C"},{"issue":"83","key":"10.1016\/j.bmc.2020.115355_b0145","doi-asserted-by":"crossref","first-page":"79631","DOI":"10.1039\/C6RA16015H","article-title":"Chloro-aluminium phthalocyanine loaded in ultradeformable liposomes for photobiology studies on human glioblastoma","volume":"6","author":"Silva","year":"2016","journal-title":"RSC Adv"},{"issue":"1\u20132","key":"10.1016\/j.bmc.2020.115355_b0150","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ijpharm.2010.05.017","article-title":"Uptake and intracellular release kinetics of liposome formulations in glioma cells","volume":"395","author":"Bellavance","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.bmc.2020.115355_b0155","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1039\/b822111c","article-title":"Rational design of a reactive yet stable organic-based photocatalyst","volume":"7","author":"Gerdes","year":"2009","journal-title":"Dalton Trans"},{"issue":"1","key":"10.1016\/j.bmc.2020.115355_b0160","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1038\/s41598-019-39390-0","article-title":"Effectiveness of ZnPc and of an amine derivative to inactivate Glioblastoma cells by Photodynamic Therapy: an in vitro comparative study","volume":"9","author":"Velazquez","year":"2019","journal-title":"Sci Rep"},{"issue":"17","key":"10.1016\/j.bmc.2020.115355_b0165","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1021\/bi00636a033","article-title":"Vesicles of variable diameter prepared by a modified injection method","volume":"16","author":"Kremer","year":"1977","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/j.bmc.2020.115355_b0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0304-3835(90)90139-O","article-title":"Delivery of the tumour photosensitizer zinc(II)-phthalocyanine to serum proteins by different liposomes: studies in vitro and in vivo","volume":"49","author":"Ginevra","year":"1990","journal-title":"Cancer Lett"},{"issue":"11","key":"10.1016\/j.bmc.2020.115355_b0175","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1073\/pnas.73.11.3862","article-title":"Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry","volume":"73","author":"Mabrey","year":"1976","journal-title":"Proc Natl Acad Sci"},{"issue":"1\u20132","key":"10.1016\/j.bmc.2020.115355_b0180","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ijpharm.2004.07.045","article-title":"The effects of lyophilization on the stability of liposomes containing 5-FU","volume":"291","author":"Glavas-Dodov","year":"2005","journal-title":"Int J Pharm"},{"issue":"1\u20132","key":"10.1016\/j.bmc.2020.115355_b0185","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ijpharm.2011.05.034","article-title":"Liposome preparation using a hollow fiber membrane contactor\u2013application to spironolactone encapsulation","volume":"415","author":"Laouini","year":"2011","journal-title":"Int J Pharm"},{"issue":"5","key":"10.1016\/j.bmc.2020.115355_b0190","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1751-1097.1995.tb09151.x","article-title":"In situ comparison of 665 nm and 633 nm wavelength light penetration in the human prostate gland","volume":"62","author":"Lee","year":"1995","journal-title":"Photochem Photobiol"},{"issue":"1","key":"10.1016\/j.bmc.2020.115355_b0195","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0041-008X(65)90081-5","article-title":"A toxicologic study of dimethyl sulfoxide","volume":"7","author":"Willson","year":"1965","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"10.1016\/j.bmc.2020.115355_b0200","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0031-6989(73)80041-4","article-title":"Some pharmacological properties of pyridine","volume":"5","author":"Leslie","year":"1973","journal-title":"Pharmacol Res Commun"},{"key":"10.1016\/j.bmc.2020.115355_b0205","series-title":"Handbook of pharmaceutical excipients","author":"Rowe","year":"2009"},{"issue":"5","key":"10.1016\/j.bmc.2020.115355_b0210","first-page":"74","article-title":"Dimethyl sulfoxide USP, PhEur in approved pharmaceutical products and medical devices","volume":"32","author":"McKim","year":"2008","journal-title":"Pharm Technol"},{"issue":"2","key":"10.1016\/j.bmc.2020.115355_b0215","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/B:PHAM.0000016235.32639.23","article-title":"Solubilizing excipients in oral and injectable formulations","volume":"21","author":"Strickley","year":"2004","journal-title":"Pharm Res"},{"issue":"1","key":"10.1016\/j.bmc.2020.115355_b0220","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.chemphyslip.2004.09.010","article-title":"Preparation of 100 nm diameter unilamellar vesicles containing zinc phthalocyanine and cholesterol for use in photodynamic therapy","volume":"133","author":"Oliveira","year":"2005","journal-title":"Chem Phys Lipids"},{"issue":"03","key":"10.1016\/j.bmc.2020.115355_b0225","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1142\/S1088424610002008","article-title":"Photophysical properties of microencapsulated phthalocyanines","volume":"14","author":"Diz","year":"2010","journal-title":"J Porphyrins Phthalocyanines"},{"issue":"3","key":"10.1016\/j.bmc.2020.115355_b0230","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/(SICI)1520-6017(200003)89:3<355::AID-JPS7>3.0.CO;2-H","article-title":"Lyophilization of cationic lipid-protamine-DNA (LPD) complexes","volume":"89","author":"Li","year":"2000","journal-title":"J Pharm Sci"},{"issue":"20","key":"10.1016\/j.bmc.2020.115355_b0235","first-page":"7495","article-title":"Photosensitization with zinc (II) phthalocyanine as a switch in the decision between apoptosis and necrosis","volume":"61","author":"Fabris","year":"2001","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.bmc.2020.115355_b0240","doi-asserted-by":"crossref","first-page":"22772","DOI":"10.3390\/ijms151222772","article-title":"Regulated necrosis in HeLa cells induced by ZnPc photodynamic treatment: a new nuclear morphology","volume":"15","author":"Soriano","year":"2014","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.bmc.2020.115355_b0245","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00418-012-1012-6","article-title":"Vehiculization determines the endocytic internalization mechanism of Zn(II)-phthalocyanine","volume":"139","author":"Soriano","year":"2013","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.bmc.2020.115355_b0250","series-title":"Optical spectra of phthalocyanines and related compounds","author":"Isago","year":"2015"},{"issue":"3","key":"10.1016\/j.bmc.2020.115355_b0255","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/1011-1344(92)80020-V","article-title":"Steady state and time-resolved spectroscopic studies on zinc(II) phthalocyanine in liposomes","volume":"16","author":"Valduga","year":"1992","journal-title":"J Photochem Photobiol, B"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620301462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620301462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:07:07Z","timestamp":1760836027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089620301462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0968089620301462"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115355","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zn phthalocyanines loaded into liposomes: Characterization and enhanced performance of photodynamic activity on glioblastoma cells","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115355","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115355"}}