{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T21:05:31Z","timestamp":1785618331741,"version":"3.56.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bmc.2020.115491","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T10:51:11Z","timestamp":1586861471000},"page":"115491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers"],"prefix":"10.1016","volume":"28","author":[{"given":"Yunchan","family":"Nam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Deok","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyoung","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Hyoung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohyeong","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Sook","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Gandini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Tae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald W.","family":"Zamponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yeol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2020.115491_b0005","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmc.2020.115491_b0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"Berridge","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bmc.2020.115491_b0015","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat Rev Mol Cell Bio"},{"key":"10.1016\/j.bmc.2020.115491_b0020","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","volume":"131","author":"Clapham","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2020.115491_b0025","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.lfs.2010.09.013","volume":"87","author":"Parkash","year":"2010","journal-title":"Life Sci"},{"key":"10.1016\/j.bmc.2020.115491_b0030","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00232-005-0778-z","volume":"205","author":"Schreiber","year":"2005","journal-title":"J Membr Biol"},{"key":"10.1016\/j.bmc.2020.115491_b0035","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.biocel.2019.01.008","volume":"108","author":"Weiss","year":"2019","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.bmc.2020.115491_b0040","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrd.2015.5","volume":"15","author":"Zamponi","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2020.115491_b0045","author":"Weiss","year":"2019","journal-title":"J Med Genet"},{"key":"10.1016\/j.bmc.2020.115491_b0050","first-page":"2375","volume":"175","author":"Snutch","year":"2017","journal-title":"Pharmacol"},{"key":"10.1016\/j.bmc.2020.115491_b0055","doi-asserted-by":"crossref","unstructured":"Teleb M, Rizk OH, Zhang F, et al. Bioorg Chem. 2019, 88, 102915.","DOI":"10.1016\/j.bioorg.2019.04.009"},{"key":"10.1016\/j.bmc.2020.115491_b0060","doi-asserted-by":"crossref","unstructured":"Teleb M, Rizk OH, Zhang F, et al. Bioorg Chem. 2019, 83, 354.","DOI":"10.1016\/j.bioorg.2018.10.054"},{"key":"10.1016\/j.bmc.2020.115491_b0065","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1016\/j.bmc.2018.03.031","volume":"26","author":"Sairaman","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115491_b0070","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3390\/md16120475","volume":"16","author":"Wang","year":"2018","journal-title":"Mar drugs"},{"key":"10.1016\/j.bmc.2020.115491_b0075","unstructured":"Gunaratna MJ, Hua DH, Zou B, et al. Alkivoc. 2019, part iii, 22."},{"key":"10.1016\/j.bmc.2020.115491_b0080","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/glia.20063","volume":"48","author":"Latour","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.bmc.2020.115491_b0085","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrc2171","volume":"7","author":"Monteith","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2020.115491_b0090","doi-asserted-by":"crossref","first-page":"31666","DOI":"10.1074\/jbc.R112.343061","volume":"287","author":"Monteith","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2020.115491_b0095","doi-asserted-by":"crossref","unstructured":"Suo A, Childers A, D'Silva A, et al. Oncotarget. 2018, 9, 8573.","DOI":"10.18632\/oncotarget.24194"},{"key":"10.1016\/j.bmc.2020.115491_b0100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrc.2017.18","volume":"17","author":"Monteith","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2020.115491_b0105","doi-asserted-by":"crossref","first-page":"pii: E48","DOI":"10.3390\/cancers9050048","volume":"9","author":"B\u00fcsselberg","year":"2017","journal-title":"Cancers"},{"key":"10.1016\/j.bmc.2020.115491_b0110","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.bbamem.2014.12.016","volume":"1848","author":"Lastraioli","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2020.115491_b0115","first-page":"180","volume":"1835","author":"Akl","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2020.115491_b0120","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1016\/j.bbamem.2014.08.016","volume":"1848","author":"Stewart","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2020.115491_b0125","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1423-0127-20-23","volume":"20","author":"Chen","year":"2013","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.bmc.2020.115491_b0130","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1152\/jn.2002.88.1.196","volume":"88","author":"Hirooka","year":"2002","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bmc.2020.115491_b0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ceca.2007.03.006","volume":"43","author":"Lu","year":"2008","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bmc.2020.115491_b0140","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1158\/1541-7786.MCR-13-0485","volume":"12","author":"Dziegielewska","year":"2014","journal-title":"Mol Cancer Res"},{"key":"10.1016\/j.bmc.2020.115491_b0145","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1111\/pcmr.12155","volume":"26","author":"Das","year":"2013","journal-title":"Pigment Cell Melanoma Res"},{"key":"10.1016\/j.bmc.2020.115491_b0150","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1158\/1078-0432.CCR-15-0490","volume":"21","author":"White","year":"2015","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bmc.2020.115491_b0155","doi-asserted-by":"crossref","unstructured":"Dziegielewska B, Gray LS, Dziegielewski J. Pflugers Arch.-Eur. J. Physiol. 2014, 466, 801.","DOI":"10.1007\/s00424-014-1444-z"},{"key":"10.1016\/j.bmc.2020.115491_b0160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1124\/mol.62.2.210","volume":"62","author":"Bertolesi","year":"2002","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.bmc.2020.115491_b0165","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.3390\/molecules19079864","volume":"19","author":"Rim","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2020.115491_b0170","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bmcl.2015.12.010","volume":"26","author":"Byun","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0175","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/j.bmcl.2014.01.071","volume":"24","author":"Choi","year":"2014","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0180","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1016\/j.bmcl.2013.10.049","volume":"23","author":"Jang","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0185","doi-asserted-by":"crossref","first-page":"7123","DOI":"10.1016\/j.bmcl.2012.09.076","volume":"22","author":"Rim","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0190","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.bmcl.2011.11.083","volume":"22","author":"Kang","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0195","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1016\/j.bmcl.2007.08.070","volume":"17","author":"Seo","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0200","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1248\/cpb.59.1285","volume":"59","author":"Pillaiyar","year":"2011","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.bmc.2020.115491_b0205","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/jhet.24","volume":"46","author":"Regina","year":"2009","journal-title":"J Heterocycl Chem"},{"key":"10.1016\/j.bmc.2020.115491_b0210","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1016\/j.bmc.2006.01.005","volume":"10","author":"Park","year":"2006","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115491_b0215","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1381-1169(99)00286-1","volume":"152","author":"Paetzold","year":"2000","journal-title":"Mol Catal A-Chem"},{"key":"10.1016\/j.bmc.2020.115491_b0220","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.tetlet.2008.03.045","volume":"49","author":"Henrik","year":"2008","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2020.115491_b0225","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13041-019-0524-6","volume":"12","author":"Garcia-Caballero","year":"2019","journal-title":"Mol Brain"},{"key":"10.1016\/j.bmc.2020.115491_b0230","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1158\/0008-5472.CAN-17-3061","volume":"78","author":"Sall\u00e1n","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2020.115491_b0235","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tips.2008.10.004","volume":"1","author":"Iftinca","year":"2009","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bmc.2020.115491_b0240","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.neuron.2014.07.036","volume":"5","author":"Garcia-Caballero","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2020.115491_b0245","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1093\/jnci\/82.13.1113","volume":"82","author":"Rubinstein","year":"1990","journal-title":"J Natl Cancer Inst"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620303126?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620303126?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:08:26Z","timestamp":1760836106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089620303126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":49,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0968089620303126"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115491","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115491"}}