{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:08:47Z","timestamp":1787170127782,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"19","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bmc.2020.115678","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T13:34:11Z","timestamp":1596288851000},"page":"115678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites"],"prefix":"10.1016","volume":"28","author":[{"given":"Kwaku","family":"Kyei-Baffour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexter C.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarko","family":"Boskovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingji","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2020.115678_b0005","unstructured":"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria."},{"key":"10.1016\/j.bmc.2020.115678_h0010","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature03342","article-title":"The global distribution of clinical episodes of Plasmodium falciparum malaria","volume":"434","author":"Snow","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2020.115678_h0015","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pt.2006.05.011","article-title":"Medicines for Malaria Venture: Sustaining antimalarial drug development","volume":"22","author":"Bathurst","year":"2006","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.bmc.2020.115678_h0020","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.3390\/ph3103212","article-title":"Malaria prophylaxis: A comprehensive review","volume":"3","author":"Castelli","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2020.115678_b0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.chom.2018.06.008","article-title":"Malaria vaccines: Recent advances and new horizons","volume":"24","author":"Draper","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bmc.2020.115678_h0030","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/nature19804","article-title":"Diversity-oriented synthesis yields novel multistage antimalarial inhibitors","volume":"538","author":"Kato","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2020.115678_h0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nature14451","article-title":"A novel multiple-stage antimalarial agent that inhibits protein synthesis","volume":"522","author":"Baraga\u00f1a","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2020.115678_h0040","doi-asserted-by":"crossref","first-page":"6032","DOI":"10.1002\/anie.201000775","article-title":"On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory","volume":"49","author":"Wilson","year":"2010","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2020.115678_h0045","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1021\/np200906s","article-title":"Natural products as sources of new drugs over the 30 years from 1981 to 2010","volume":"75","author":"Newman","year":"2012","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2020.115678_h0050","doi-asserted-by":"crossref","first-page":"10210","DOI":"10.1002\/anie.201601967","article-title":"Artemisinin \u2212 A gift from traditional chinese medicine to the world (Nobel Lecture)","volume":"55","author":"Tu","year":"2016","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2020.115678_h0055","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1126\/science.3887571","article-title":"Qinghaosu (artemisinin): an antimalarial drug from China","volume":"228","author":"Klayman","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.bmc.2020.115678_b0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1475-2875-10-144","article-title":"Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria","volume":"10","author":"Achan","year":"2011","journal-title":"Malar J"},{"key":"10.1016\/j.bmc.2020.115678_h0065","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/md14010016","article-title":"Marine isonitriles and their related compounds","volume":"14","author":"Emsermann","year":"2016","journal-title":"Mar Drugs"},{"key":"10.1016\/j.bmc.2020.115678_h0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1039\/b302359c","article-title":"Marine isocyanides and related natural products \u2013structure, biosynthesis and ecology","volume":"21","author":"Garson","year":"2004","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2020.115678_h0075","first-page":"130","article-title":"Marine antimalarials","volume":"7","author":"Fattorusso","year":"2009","journal-title":"Mar Grugs"},{"key":"10.1016\/j.bmc.2020.115678_h0080","doi-asserted-by":"crossref","DOI":"10.1021\/np50090a014","article-title":"Antimalarial activity of sesquiterpenes from the marine sponge Acanthella klethra","volume":"55","author":"Angerhofer","year":"1992","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2020.115678_h0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0040-4020(76)80065-8","article-title":"Axisonitrile-3, axisothiocyanate-3 and axamide-3. Sesquiterpenes with a novel spiro[4,5]decane skeleton from the sponge Axinella cannabina","volume":"32","author":"Di Blasio","year":"1976","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2020.115678_h0090","doi-asserted-by":"crossref","first-page":"13467","DOI":"10.1016\/S0040-4020(98)00818-7","article-title":"Antimalarial activity of kalihinol A and new relative diterpenoids from the Okinawan sponge","volume":"54","author":"Miyaoka","year":"1998","journal-title":"Acanthella sp Tetrahedron"},{"key":"10.1016\/j.bmc.2020.115678_h0095","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1021\/ja00328a073","article-title":"Kalihinol-A, a highly functionalized diisocyano diterpenoid antibiotic from a sponge","volume":"106","author":"Chang","year":"1984","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2020.115678_b0055","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1021\/jacs.6b03899","article-title":"Synthesis of (+)-7,20-diisocyanoadociane and liver-stage antiplasmodial activity of the isocyanoterpene class","volume":"138","author":"Lu","year":"2016","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2020.115678_b0060","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1039\/C4NP00109E","article-title":"Syntheses and biological studies of marine terpenoids derived from inorganic cyanide","volume":"32","author":"Schnermann","year":"2015","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2020.115678_b0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1021\/acsmedchemlett.7b00013","article-title":"Antimalarial properties of simplified kalihinol analogues","volume":"8","author":"Daub","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115678_b0070","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ejmech.2015.06.031","article-title":"Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus","volume":"101","author":"Davis","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115678_b0075","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1016\/j.bmc.2017.03.035","article-title":"Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity","volume":"25","author":"Mohammad","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115678_h0125","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.bmc.2019.03.034","article-title":"Second-generation aryl isonitrile compounds targeting multidrug-resistant staphylococcus aureus","volume":"27","author":"Kyei-Baffour","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115678_h0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgar.2019.04.016","article-title":"An Aryl Isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multi-drug resistant Staphylococcus aureus infections","volume":"19","author":"Mohammad","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.bmc.2020.115678_b0085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/978-1-4939-7847-2_3","article-title":"Phenotypic screening of small molecules with antimalarial activity for three different parasitic life stages","volume":"1787","author":"Kato","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.bmc.2020.115678_b0090","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1021\/jm0010724","article-title":"Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges","volume":"44","author":"Wright","year":"2001","journal-title":"J Med Chem"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620305083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620305083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:08:17Z","timestamp":1760836097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089620305083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":28,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0968089620305083"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115678","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural product-inspired aryl isonitriles as a new class of antimalarial compounds against drug-resistant parasites","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115678"}}