{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:46:48Z","timestamp":1787838408540,"version":"build-2784847793"},"reference-count":61,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bmc.2020.115759","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T23:57:49Z","timestamp":1599868669000},"page":"115759","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study"],"prefix":"10.1016","volume":"28","author":[{"given":"Hanan Gaber","family":"Abdulwahab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa F.","family":"Harras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagwan Galal","family":"El Menofy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany M.","family":"Hegab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma M.","family":"Essa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adli AbdAllah","family":"Selim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer M.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba S.A.","family":"El-Zahabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2020.115759_b0005","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1128\/mr.53.1.85-108.1989","article-title":"Microbial ureases: significance, regulation, and molecular characterization","volume":"53","author":"Mobley","year":"1989","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.bmc.2020.115759_b0010","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/ar960022j","article-title":"70 Years of crystalline urease: what have we learned?","volume":"30","author":"Karplus","year":"1997","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.bmc.2020.115759_b0015","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/jcp.2009.072595","article-title":"Ureases as a target for the treatment of gastric and urinary infections","volume":"63","author":"Follmer","year":"2010","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.bmc.2020.115759_b0020","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1517\/13543776.2011.574615","article-title":"Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review","volume":"21","author":"Kosikowska","year":"2011","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2020.115759_b0025","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.toxicon.2015.11.020","article-title":"Ureases as multifunctional toxic proteins: A review","volume":"110","author":"Carlini","year":"2016","journal-title":"Toxicon"},{"key":"10.1016\/j.bmc.2020.115759_b0030","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1248\/bpb.17.1329","article-title":"Inhibition of helicobacter pylori urease activity by hydroxamic acid derivatives","volume":"17","author":"Odake","year":"1994","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bmc.2020.115759_b0035","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1007\/s00044-012-0318-1","article-title":"Antimicrobial and anti-urease activities of newly synthesized morpholine derivatives containing an azole nucleus","volume":"22","author":"Betkas","year":"2013","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2020.115759_b0040","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1016\/j.bmc.2012.07.002","article-title":"Synthesis, biological evaluation and molecular docking studies of 2,5-substituted-1,4-benzoquinone as novel urease inhibitors","volume":"20","author":"You","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0045","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1016\/j.ejmech.2011.09.009","article-title":"Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors","volume":"46","author":"Aslam","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0050","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bioorg.2018.05.017","article-title":"1-[(4'-Chlorophenyl) carbonyl-4-(aryl) thiosemicarbazide derivatives as potent urease inhibitors: Synthesis, in vitro and in silico studies","volume":"79","author":"Ali","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bioorg.2018.04.004","article-title":"Synthetic nicotinic\/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies","volume":"79","author":"Ali","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0060","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1016\/S0024-3205(03)00708-2","article-title":"Urease inhibitory activity of simple alpha, beta-unsaturated ketones","volume":"73","author":"Tanaka","year":"2003","journal-title":"Life Sci"},{"key":"10.1016\/j.bmc.2020.115759_b0065","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1080\/14756360802188420","article-title":"Synthesis and biological evaluation of some new N(4)-substituted isatin-3-thiosemicarbazones","volume":"24","author":"Pervez","year":"2009","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0070","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.ejmech.2014.01.001","article-title":"Synthesis and in vitro urease inhibitory activity of N, N0-disubstituted thioureas","volume":"74","author":"Khan","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0075","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jccs.201190017","article-title":"Synthesis and urease inhibition studies of barbituric and thiobarbituric acid derived sulphonamides","volume":"58","author":"Rauf","year":"2011","journal-title":"J Chin Chem Soci"},{"key":"10.1016\/j.bmc.2020.115759_b0080","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/j.bmc.2015.05.038","article-title":"Design and synthesis of new barbituric- and thiobarbituric acid derivatives as potent urease inhibitors: structure activity relationship and molecular modeling studies","volume":"23","author":"Rauf","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0085","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00775-013-0983-7","article-title":"The crystal structure of Sporosarcina pasteurii urease in a complex with citrate provides new hints for inhibitor design","volume":"18","author":"Benini","year":"2013","journal-title":"J Biol Inorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0090","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s007750000204","article-title":"Structure-based computational study of the catalytic and inhibition mechanism of urease","volume":"6","author":"Musiani","year":"2001","journal-title":"J Biol Inorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0095","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1128\/mr.59.3.451-480.1995","article-title":"Molecular Biology of Microbial Ureases","volume":"59","author":"Mobley","year":"1995","journal-title":"Microbiol Rev"},{"key":"10.1016\/j.bmc.2020.115759_b0100","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00117401","article-title":"Molecular modeling studies on the urease active site and the enzyme-catalyzed urea hydrolysis","volume":"4","author":"Ramiro","year":"1990","journal-title":"J Comp Aided Mol Design"},{"key":"10.1016\/j.bmc.2020.115759_b0105","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ejps.2019.01.023","article-title":"New thiobarbituric acid scaffold-based small molecules: Synthesis, cytotoxicity, 2D-QSAR, pharmacophore modelling and in-silico ADME Screening","volume":"130","author":"El-Zahabi","year":"2019","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.bmc.2020.115759_b0110","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1016\/j.bmcl.2009.04.132","article-title":"Exploration of novel thiobarbituric acid-, rhodanine-and thiohydantoin-based HIV-1 integrase inhibitors","volume":"19","author":"Rajamaki","year":"2009","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2020.115759_b0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-422X-8-18","article-title":"Characterization of thiobarbituric acid derivatives as inhibitors of hepatitis C virus NS5B polymerase","volume":"8","author":"Lee","year":"2011","journal-title":"Virology J"},{"key":"10.1016\/j.bmc.2020.115759_b0120","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.bmc.2003.08.035","article-title":"Synthesis of some newer derivatives of substitute quinazolinonyl-2-oxo\/thiobarbituric acid as potent anticonvulsant agents","volume":"12","author":"Archana","year":"2004","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0125","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.ejmech.2009.05.023","article-title":"Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities","volume":"44","author":"Yan","year":"2009","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0130","first-page":"481","article-title":"Green chemistry 1: Simple and efficient synthesis -in water- and antibacterial activity of 5-arylidene derivatives of thiobarbituric and barbituric acids","volume":"8","author":"Bamanie","year":"2012","journal-title":"J Amer Sci"},{"key":"10.1016\/j.bmc.2020.115759_b0135","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jfluchem.2012.06.032","article-title":"Synthesis and biological evaluation of new barbituric and thiobarbituric acid fluoro analogs of benzenesulfonamides as antidiabetic and antibacterial agents","volume":"142","author":"Faidallah","year":"2012","journal-title":"J Fluorine Chem"},{"issue":"18","key":"10.1016\/j.bmc.2020.115759_b0140","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/cmdc.201800414","article-title":"Exploiting the thiobarbituric acid scaffold for antibacterial activity","volume":"13","author":"Sharma","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2020.115759_b0145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5155\/eurjchem.6.2.163-168.1224","article-title":"Synthesis of novel cyanoacetamides derivatives and their urease inhibition studies","volume":"6","author":"Rauf","year":"2015","journal-title":"Eur J Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0150","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.1016\/j.bmc.2014.05.057","article-title":"Synthesis and structure-activity relationship of thiobarbituric acid derivatives as potent inhibitors of urease","volume":"22","author":"Khan","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cclet.2015.12.035","article-title":"Development of bis-thiobarbiturates as successful urease inhibitors and their molecular modeling studies","volume":"27","author":"Rahim","year":"2016","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.bmc.2020.115759_b0160","doi-asserted-by":"crossref","first-page":"1800314","DOI":"10.1002\/ardp.201800314","article-title":"Utility of anthranilic acid and diethylacetylenedicarboxylate for the synthesis of nitrogenous organo\/organometallic compounds as urease inhibitors","volume":"352","author":"El-Zahabi","year":"2019","journal-title":"Arch Pharm Chem Life Sci"},{"key":"10.1016\/j.bmc.2020.115759_b0165","doi-asserted-by":"crossref","first-page":"103577","DOI":"10.1016\/j.bioorg.2020.103577","article-title":"New benzenesulfonamide scaffold-based cytotoxic agents: design, synthesis, cell viability, apoptotic activity and radioactive tracing studies","volume":"96","author":"Nissan","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0170","doi-asserted-by":"crossref","first-page":"115444","DOI":"10.1016\/j.bmc.2020.115444","article-title":"New acrylamide-sulisoxazole conjugates as dihydropteroate synthase inhibitors","volume":"28","author":"Nasr","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0175","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejmech.2017.04.069","article-title":"Design, synthesis and biological evaluation of some novel sulfonamide derivatives as apoptotic agents","volume":"135","author":"Mohamed","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0180","unstructured":"Bonnert R, Cage P, Hunt F, Walters I, Willis P. Preparation of pyrimidine compounds as modulators of chemokine receptor activity. US 2005\/0234077 A1; 2005."},{"key":"10.1016\/j.bmc.2020.115759_b0185","doi-asserted-by":"crossref","first-page":"103437","DOI":"10.1016\/j.bioorg.2019.103437","article-title":"Synthesis of novel 2-aminobenzothiazole derivatives as potential antimicrobial agents with dual DNA gyrase\/topoisomerase IV inhibition","volume":"94","author":"Ismail","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0190","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0021-9258(18)84560-4","article-title":"The isolation and crystallization of the enzyme urease: preliminary paper","volume":"69","author":"Sumner","year":"1926","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0195","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0010-8545(99)00093-4","article-title":"Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms","volume":"190\u2013192","author":"Ciurli","year":"1999","journal-title":"Coord Chem Rev"},{"key":"10.1016\/j.bmc.2020.115759_b0200","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.bpc.2004.03.009","article-title":"Jack bean urease (EC 3.5.1.5) aggregation monitored by dynamic and static light scattering","volume":"111","author":"Follmer","year":"2004","journal-title":"Biophys Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0205","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1107\/S0907444901021503","article-title":"Crystallization and preliminary X-ray structure determination of jack bean urease with a bound antibody fragment","volume":"58","author":"Sheridan","year":"2002","journal-title":"Acta Crystallogr Sect D"},{"key":"10.1016\/j.bmc.2020.115759_b0210","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phytochem.2007.06.034","article-title":"Insights into the role and structure of plant ureases","volume":"69","author":"Follmer","year":"2008","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2020.115759_b0215","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1271\/bbb.90895","article-title":"Inhibitory activity against urease of quercetin glycosides isolated from Allium cepa and Psidium guajava","volume":"74","author":"Shabana","year":"2010","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.bmc.2020.115759_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bioorg.2019.02.051","article-title":"Isoindolin-1-one derivatives as urease inhibitors: Design, synthesis, biological evaluation, molecular docking and in-silico ADME evaluation","volume":"87","author":"Peytam","year":"2019","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0225","first-page":"204","article-title":"Proteus bacilli: features and virulence factors","volume":"61","author":"R\u00f3zalski","year":"2007","journal-title":"Postepy Hig Med Dosw"},{"key":"10.1016\/j.bmc.2020.115759_b0230","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1021\/bi3000897","article-title":"Klebsiella aerogenesUreF:identification of the UreG binding site and role in enhancing the fidelity of urease activation","volume":"51","author":"Boer","year":"2012","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2020.115759_b0235","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1286-4579(00)00312-9","article-title":"Bacterial ureases in infectious diseases","volume":"2","author":"Burne","year":"2000","journal-title":"Microbes Infect"},{"key":"10.1016\/j.bmc.2020.115759_b0240","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/CMR.11.4.589","article-title":"Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors","volume":"11","author":"Podschun","year":"1998","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2020.115759_b0245","doi-asserted-by":"crossref","first-page":"103282","DOI":"10.1016\/j.bioorg.2019.103282","article-title":"Rational design of some substituted phenyl azanediyl (bis) methylene phosphonic acid derivatives as potential anticancer agents and imaging probes: computational inputs, chemical synthesis, radiolabeling, biodistribution and gamma scintigraphy","volume":"92","author":"Khedr","year":"2019","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0250","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ejmech.2018.04.014","article-title":"Novel hydrazide-hydrazone and amide substituted coumarin derivatives: synthesis, cytotoxicity screening, microarray, radiolabelling and in vivo pharmacokinetic studies","volume":"151","author":"Nasr","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0255","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1021\/ci500562t","article-title":"Reduction of Urease Activity by Interaction with flap covering the active site","volume":"55","author":"Macomber","year":"2015","journal-title":"J Chem Inf Model"},{"issue":"36","key":"10.1016\/j.bmc.2020.115759_b0260","doi-asserted-by":"crossref","first-page":"24327","DOI":"10.1016\/S0021-9258(18)54232-0","article-title":"Identification of the essential cysteine residue in Klebsiella aerogenes urease","volume":"266","author":"Todd","year":"1991","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0265","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1039\/C6DT00652C","article-title":"Inactivation of urease by 1,4-benzoquinone: chemistry at the protein surface","volume":"45","author":"Mazzei","year":"2016","journal-title":"Dalton Trans"},{"key":"10.1016\/j.bmc.2020.115759_b0270","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1021\/ac60252a045","article-title":"Phenol-hypochlorite reaction for determination of ammonia","volume":"39","author":"Weatherburn","year":"1967","journal-title":"Anal Chem"},{"key":"10.1016\/j.bmc.2020.115759_b0275","unstructured":"Clinical and Laboratory Standards Institute, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, M07Ed11, 11th ed., Wayne, PA, USA: Clinical and Laboratory Standards Institute, 2018."},{"key":"10.1016\/j.bmc.2020.115759_b0280","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13065-016-0220-x","article-title":"Platelet-12 lipoxygenase targeting via newly synthesized curcumin derivative radiolabeled with technetium-99m","volume":"10","author":"Al-Wabli","year":"2016","journal-title":"Chem Cent J"},{"key":"10.1016\/j.bmc.2020.115759_b0285","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejps.2015.05.002","article-title":"99mTc-amitrole as a novel selective imaging probe for solid tumor: in silico and preclinical pharmacological study","volume":"76","author":"Essa","year":"2015","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.bmc.2020.115759_b0290","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1021\/acs.molpharmaceut.9b00517","article-title":"Superiority of DEAE-Dx stabilized cationic bile-based vesicles over conventional vesicles for enhanced hepatic delivery of daclatasvir","volume":"16","author":"Boseila","year":"2019","journal-title":"Mol Pharm"},{"key":"10.1016\/j.bmc.2020.115759_b0295","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1080\/09553002.2019.1524945","article-title":"Radiosynthesis, molecular modeling studies and biological evaluation of 99mTc-ifosfamide complex as a novel probe for solid tumor imaging","volume":"94","author":"Motaleb","year":"2018","journal-title":"Int J Rad Biol"},{"issue":"10","key":"10.1016\/j.bmc.2020.115759_b0300","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.apradiso.2010.04.031","article-title":"Labeling of ceftriaxone for infective inflammation imaging using 99mTc eluted from 99Mo\/99mTc generator based on zirconium molybdate","volume":"68","author":"Mostafa","year":"2010","journal-title":"Appl Radiat Isot"},{"key":"10.1016\/j.bmc.2020.115759_b0305","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ejps.2018.06.029","article-title":"I-131 doping of silver nanoparticles platform for tumor theranosis guided drug delivery","volume":"122","author":"Sakr","year":"2018","journal-title":"Eur J Pharm Sci"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620305897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089620305897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:09:26Z","timestamp":1760836166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089620305897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":61,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0968089620305897"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115759","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2020.115759","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115759"}}