{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:08:36Z","timestamp":1774638516931,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.bmc.2021.115993","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T04:53:06Z","timestamp":1610167986000},"page":"115993","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Cytoprotective activities of kinetin purine isosteres"],"prefix":"10.1016","volume":"33","author":[{"given":"Barbara","family":"Makov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8515-3035","authenticated-orcid":false,"given":"V\u00e1clav","family":"Mik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Li\u0161kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"V\u00edtek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Medved\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6698-0644","authenticated-orcid":false,"given":"Beata","family":"Monfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Ru\u010dilov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Kadlecov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8570-1866","authenticated-orcid":false,"given":"Prashant","family":"Khirsariya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoila","family":"G\u00e1ndara Barreiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libor","family":"Havl\u00ed\u010dek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Zatloukal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Soural","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Paruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-3019","authenticated-orcid":false,"given":"Benoit","family":"D'Autr\u00e9aux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e1n","family":"Hajd\u00fach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miroslav","family":"Strnad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-8941","authenticated-orcid":false,"given":"Ji\u0159\u00ed","family":"Voller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.115993_b0005","series-title":"Hormones in Ageing and Longevity. Healthy Ageing and Longevity","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-63001-4_14","article-title":"Plant hormone cytokinins for modulating human aging and age-related diseases","volume":"6","author":"Voller","year":"2017"},{"key":"10.1016\/j.bmc.2021.115993_b0010","doi-asserted-by":"crossref","first-page":"100958","DOI":"10.1016\/j.arr.2019.100958","article-title":"The plant hormone kinetin in disease therapy and healthy aging","volume":"55","author":"Kadlecov\u00e1","year":"2019","journal-title":"Age Res Rev"},{"key":"10.1016\/j.bmc.2021.115993_b0015","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1006\/bbrc.1994.1752","article-title":"Kinetin delays the onset of ageing characteristics in human fibroblasts","volume":"201","author":"Rattan","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2021.115993_b0020","article-title":"A mechanism for the in vivo formation of N6-furfuryladenine, kinetin, as a secondary oxidative damage product of DNA","author":"Barciszewski","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bmc.2021.115993_b0025","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/hmg\/ddh046","article-title":"Rescue of a human mRNA splicing defect by the plant cytokinin kinetin","volume":"13","author":"Slaugenhaupt","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.bmc.2021.115993_b0030","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/ejhg.2009.212","article-title":"Modulation of aberrant NF1 pre-mRNA splicing by kinetin treatment","volume":"18","author":"Pros","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.bmc.2021.115993_b0035","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1203\/PDR.0b013e31822e1825","article-title":"Kinetin improves IKBKAP mRNA splicing in patients with familial dysautonomia","volume":"70","author":"Axelrod","year":"2011","journal-title":"Pediatr Res"},{"key":"10.1016\/j.bmc.2021.115993_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211602","article-title":"Combinatorial treatment increases IKAP levels in human cells generated from Familial Dysautonomia patients","volume":"14","author":"Yannai","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2021.115993_b0045","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2013.07.030","article-title":"A neo-substrate that amplifies catalytic activity of parkinson\u2019s-disease- related kinase PINK1","volume":"154","author":"Hertz","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2021.115993_b0050","doi-asserted-by":"crossref","first-page":"E7081","DOI":"10.1073\/pnas.1801772115","article-title":"N6-Furfuryladenine is protective in Huntington\u2019s disease models by signaling huntingtin phosphorylation","volume":"115","author":"Bowie","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.bmc.2021.115993_b0055","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.pbi.2009.07.002","article-title":"Cytokinin action in plant development","volume":"12","author":"Werner","year":"2009","journal-title":"Curr Opin Plant Biol"},{"key":"10.1016\/j.bmc.2021.115993_b0060","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1016\/j.bmc.2007.03.038","article-title":"Preparation, biological activity and endogenous occurrence of N6-benzyladenosines","volume":"15","author":"Dole\u017eal","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0065","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1002\/ijc.24168","article-title":"Pharmacogenomics and analogues of the antitumour agent N 6 -isopentenyladenosine","volume":"124","author":"Colombo","year":"2009","journal-title":"Int J Cancer"},{"key":"10.1016\/j.bmc.2021.115993_b0070","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/15257770903155550","article-title":"Novel isopentenyladenosine analogues: synthesis, characterization, and evaluation of antiproliferative activity on bladder carcinoma cells","volume":"28","author":"Ottria","year":"2009","journal-title":"Nucleosides Nucleotides Nucleic Acids"},{"key":"10.1016\/j.bmc.2021.115993_b0075","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.1016\/j.bmc.2010.09.030","article-title":"N6-Alkyladenosines: synthesis and evaluation of in vitro anticancer activity","volume":"18","author":"Ottria","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080755","article-title":"N6-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1. Fraidenraich D, ed.","volume":"8","author":"Amiable","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2021.115993_b0085","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2174\/1871520611313040016","article-title":"N6-Isopentenyladenosine and its analogue n6-benzyladenosine induce cell cycle arrest and apoptosis in bladder carcinoma T24 cells","volume":"13","author":"Castiglioni","year":"2013","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0090","doi-asserted-by":"crossref","DOI":"10.1002\/cpnc.61","article-title":"Synthesis of Cytokinins via Enzymatic Arsenolysis of purine nucleosides","volume":"75","author":"Oslovsky","year":"2018","journal-title":"Curr Protoc Nucleic Acid Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0095","doi-asserted-by":"crossref","first-page":"115230","DOI":"10.1016\/j.bmc.2019.115230","article-title":"New aromatic 6-substituted 2\u2032-deoxy-9-(\u03b2)-d-ribofuranosylpurine derivatives as potential plant growth regulators","volume":"28","author":"Matu\u0161kov\u00e1","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0100","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1073\/pnas.1415525112","article-title":"Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia","volume":"112","author":"Yoshida","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.bmc.2021.115993_b0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/2472555218792264","article-title":"Development of a screening platform to identify small molecules that modify ELP1 Pre-mRNA splicing in familial dysautonomia","volume":"24","author":"Salani","year":"2019","journal-title":"SLAS Disc: Adv Sci Drug Disc"},{"key":"10.1016\/j.bmc.2021.115993_b0110","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.ejmech.2018.03.043","article-title":"New cytokinin derivatives possess UVA and UVB photoprotective effect on human skin cells and prevent oxidative stress","volume":"150","author":"H\u00f6nig","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0115","series-title":"United States Patent: 10676475 \u2013 Compounds for improving mRNA splicing","author":"Slaugenhaupt","year":"2020"},{"key":"10.1016\/j.bmc.2021.115993_b0120","series-title":"United States Patent: 10167286 \u2013 Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease","author":"de Roulet","year":"2019"},{"key":"10.1016\/j.bmc.2021.115993_b0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1039\/jr9600000131","article-title":"26. Pyrrolo[2,3-d]pyrimidines","author":"Davoll","year":"1960","journal-title":"J Chem Soc"},{"key":"10.1016\/j.bmc.2021.115993_b0130","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1021\/jo01075a023","article-title":"Potential purine antagonists. XXIII. Synthesis of some 7-substituted amino-v-triazolo(d)pyrimidines1","author":"Weiss","year":"1960","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0135","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/0031-9422(73)85105-2","article-title":"Influence of alterations in the purine ring on biological activity of cytokinins","volume":"12","author":"Rogozi\u0144ska","year":"1973","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2021.115993_b0140","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.phytochem.2018.02.008","article-title":"Cytokinin activity of N6-benzyladenine derivatives assayed by interaction with the receptors in planta, in vitro, and in silico","volume":"149","author":"Savelieva","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2021.115993_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phytochem.2018.02.015","article-title":"Design, synthesis and perception of fluorescently labeled isoprenoid cytokinins","volume":"150","author":"Kubiasov\u00e1","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2021.115993_b0150","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1021\/ja01592a021","article-title":"Potential purine antagonists. II. Synthesis of some 7- and 5,7-substituted pyrazolo [4,3-d]pyrimidines","volume":"78","author":"Robins","year":"1956","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2021.115993_b0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-11470-9","article-title":"Physiologically relevant reconstitution of iron-sulfur cluster biosynthesis uncovers persulfide-processing functions of ferredoxin-2 and frataxin","volume":"10","author":"Gervason","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2021.115993_b0160","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/cne.10662","article-title":"Expression of Prox1 defines regions of the avian otocyst that give rise to sensory or neural cells","volume":"460","author":"Stone","year":"2003","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.bmc.2021.115993_b0165","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2144\/03345dd02","article-title":"One-step cellular caspase-3\/7 assay","volume":"34","author":"Carrasco","year":"2003","journal-title":"Biotechniques"},{"key":"10.1016\/j.bmc.2021.115993_b0170","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1089\/jmf.2016.3829","article-title":"Neuroprotective effect of halophyte Salicornia herbacea L. is mediated by activation of heme oxygenase-1 in mouse hippocampal HT22 cells","volume":"20","author":"Kim","year":"2017","journal-title":"J Med Food"},{"key":"10.1016\/j.bmc.2021.115993_b0175","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbrc.2003.09.019","article-title":"EGCG corrects aberrant splicing of IKAP mRNA in cells from patients with familial dysautonomia","volume":"310","author":"Anderson","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2021.115993_b0180","doi-asserted-by":"crossref","first-page":"111806","DOI":"10.1016\/j.ejmech.2019.111806","article-title":"Synthesis and biological evaluation of triterpenoid thiazoles derived from betulonic acid, dihydrobetulonic acid, and ursonic acid","volume":"185","author":"Borkov\u00e1","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0185","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/js9803205","article-title":"MDCK (Madin-Darby Canine Kidney) cells: a tool for membrane permeability screening","volume":"88","author":"Irvine","year":"1999","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.bmc.2021.115993_b0190","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0169-409X(00)00128-9","article-title":"Caco-2 monolayers in experimental and theoretical predictions of drug transport","volume":"46","author":"Artursson","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bmc.2021.115993_b0195","first-page":"1","article-title":"PAST: paleontological statistics software package for education and data analysis","volume":"4","author":"Hammer","year":"2001","journal-title":"Palaeontol Electron"},{"key":"10.1016\/j.bmc.2021.115993_b0200","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1080\/10543401003618983","article-title":"Statistical inference for tumor growth inhibition T\/C ratio","volume":"20","author":"Wu","year":"2010","journal-title":"J Biopharm Stat"},{"key":"10.1016\/j.bmc.2021.115993_b0205","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1021\/co500090t","article-title":"Directed solid-phase synthesis of trisubstituted imidazo[4,5- c ]pyridines and imidazo[4,5- b ]pyridines","volume":"16","author":"Lemrov\u00e1","year":"2014","journal-title":"ACS Comb. Sci."},{"key":"10.1016\/j.bmc.2021.115993_b0210","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ejmech.2017.12.053","article-title":"Novel non-sulfonamide 5-HT 6 receptor partial inverse agonist in a group of imidazo[4,5- b ]pyridines with cognition enhancing properties","volume":"144","author":"Vanda","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.115993_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40673-017-0062-x","article-title":"Friedreich Ataxia: current status and future prospects","volume":"4","author":"B\u00fcrk","year":"2017","journal-title":"Cerebellum Ataxias"},{"key":"10.1016\/j.bmc.2021.115993_b0220","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1210\/en.2011-0184","article-title":"Estrogen protection in Friedreich\u2019s Ataxia skin fibroblasts","volume":"152","author":"Richardson","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.bmc.2021.115993_b0225","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2050-6511-13-12","article-title":"R- and S-Equol have equivalent cytoprotective effects in Friedreich\u2019s Ataxia","volume":"13","author":"Richardson","year":"2012","journal-title":"BMC Pharmacol Toxicol."},{"key":"10.1016\/j.bmc.2021.115993_b0230","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004986","article-title":"Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis","volume":"5","author":"Ferriero","year":"2013","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bmc.2021.115993_b0235","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tiv.2014.09.014","article-title":"Cell viability assessment using the Alamar blue assay: a comparison of 2D and 3D cell culture models","volume":"29","author":"Bonnier","year":"2015","journal-title":"Toxicol In Vitro"},{"key":"10.1016\/j.bmc.2021.115993_b0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/jnc.12220","article-title":"Frataxin: a protein in search for a function","volume":"126","author":"Pastore","year":"2013","journal-title":"J Neurochem"},{"key":"10.1016\/j.bmc.2021.115993_b0245","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1020642808437","article-title":"Calcein as a fluorescent iron chemosensor for the determination of low molecular weight iron in biological fluids","volume":"16","author":"Ali","year":"2003","journal-title":"Biometals"},{"key":"10.1016\/j.bmc.2021.115993_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-017-0149-0","article-title":"The SH-SY5Y cell line in Parkinson\u2019s disease research: a systematic review","volume":"12","author":"Xicoy","year":"2017","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.bmc.2021.115993_b0255","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fncel.2015.00091","article-title":"Researching glutamate \u2013 induced cytotoxicity in different cell lines: a comparative\/collective analysis\/study","volume":"9","author":"Kritis","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.bmc.2021.115993_b0260","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddiscovery.2017.13","article-title":"MPP+ induces necrostatin-1-and ferrostatin-1-sensitive necrotic death of neuronal SH-SY5Y cells","volume":"3","author":"Ito","year":"2017","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.bmc.2021.115993_b0265","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10517-007-0390-6","article-title":"Expression of NMDA receptors in multipotent stromal cells of human adipose tissue under conditions of retinoic acid-induced differentiation","volume":"144","author":"Kulikov","year":"2007","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.bmc.2021.115993_b0270","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/1756-0500-1-95","article-title":"Identification and classification of genes regulated by phosphatidylinositol 3-kinase- and TRKB-mediated signalling pathways during neuronal differentiation in two subtypes of the human neuroblastoma cell line SH-SY5Y","volume":"1","author":"Nishida","year":"2008","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.bmc.2021.115993_b0275","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1086\/318810","article-title":"Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia","volume":"68","author":"Slaugenhaupt","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.bmc.2021.115993_b0280","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S1367-5931(03)00055-3","article-title":"Profiling drug-like properties in discovery research","volume":"7","author":"Di","year":"2003","journal-title":"Curr Opin Chem Biol"},{"key":"10.1016\/j.bmc.2021.115993_b0285","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.apsb.2012.10.004","article-title":"Preclinical experimental models of drug metabolism and disposition in drug discovery and development","volume":"2","author":"Zhang","year":"2012","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"10.1016\/j.bmc.2021.115993_b0290","article-title":"A new PAMPA model proposed on the basis of a synthetic phospholipid membrane. Hofmann A, ed.","volume":"10","author":"Yu","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2021.115993_b0295","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4103\/0378-6323.157446","article-title":"Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin","volume":"81","author":"Wanitphakdeedecha","year":"2015","journal-title":"Indian J Dermatol Venereol Leprol"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621000018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621000018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:10:13Z","timestamp":1760836213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621000018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":59,"alternative-id":["S0968089621000018"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.115993","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytoprotective activities of kinetin purine isosteres","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.115993","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"115993"}}