{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:30:50Z","timestamp":1790296250624,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bmc.2021.116071","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T09:46:16Z","timestamp":1613382376000},"page":"116071","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes"],"prefix":"10.1016","volume":"35","author":[{"given":"Suresh","family":"Pola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailesh R.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikishore","family":"Pingali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandurang","family":"Zaware","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baban","family":"Thube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Makadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoshang","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debdutta","family":"Bandyopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshyaya","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Giri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra H.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K.","family":"Ranvir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Sundar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harilal","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeevan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukul R.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116071_b0005","first-page":"113","volume":"4","author":"Singh","year":"2016","journal-title":"Sci Technol J"},{"key":"10.1016\/j.bmc.2021.116071_b0010","unstructured":"International Diabetes Federation. IDF DIABETES ATLAS, 9th ed; 2019."},{"key":"10.1016\/j.bmc.2021.116071_b0015","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1007\/s00125-014-3171-6","volume":"57","author":"Bugger","year":"2014","journal-title":"Diabetologia"},{"key":"10.1016\/j.bmc.2021.116071_b0020","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s00125-012-2742-7","volume":"56","author":"Kostev","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/j.bmc.2021.116071_b0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nrneph.2010.176","volume":"7","author":"Gray","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.bmc.2021.116071_b0030","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2337\/dc13-2114","volume":"37","author":"Martin","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bmc.2021.116071_b0035","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.2337\/dc12-2712","volume":"36","author":"Wukich","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bmc.2021.116071_b0040","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMoa0707943","volume":"358","author":"Metzger","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmc.2021.116071_b0045","unstructured":"National Diabetes Fact Sheet. Department of Health and Human Services, Centres for disease control and prevention; 2007."},{"key":"10.1016\/j.bmc.2021.116071_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115263","volume":"28","author":"Dowarah","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0055","doi-asserted-by":"crossref","unstructured":"(a) Tahrani AA, Bailey CJ, Prato SD, Barnett AH. Lancet. 2011;378:182. (b) UMHS Management of Type 2 Diabetes Mellitus, May 2014.","DOI":"10.1016\/S0140-6736(11)60207-9"},{"key":"10.1016\/j.bmc.2021.116071_b0060","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bmc.2021.116071_b0065","doi-asserted-by":"crossref","first-page":"7499","DOI":"10.1021\/jm501175v","volume":"57","author":"Wacker","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0070","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1021\/jm5011012","volume":"57","author":"Scott","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0075","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1016\/j.bmcl.2017.06.032","volume":"27","author":"Jang","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116071_b0080","first-page":"S76","volume":"153","author":"Overton","year":"2010","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2021.116071_b0085","first-page":"149","volume":"44","author":"Jones","year":"2009","journal-title":"Annu Rep Med Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0090","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.tips.2012.03.014","volume":"33","author":"Hansen","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bmc.2021.116071_b0095","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.bmcl.2018.02.044","volume":"28","author":"Harada","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116071_b0100","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.bmcl.2017.01.091","volume":"27","author":"Zhu","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116071_b0105","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1358\/dnp.2010.23.7.1468395","volume":"23","author":"Dhayal","year":"2010","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.bmc.2021.116071_b0110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","volume":"3","author":"Overton","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.bmc.2021.116071_b0115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cell.2014.09.035","volume":"159","author":"Yore","year":"2014","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.bmc.2021.116071_b0120","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1021\/acs.jmedchem.5b01198","volume":"59","author":"Ritter","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0125","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.drudis.2013.09.011","volume":"18","author":"Kang","year":"2013","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2021.116071_b0130","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1016\/j.bmcl.2013.04.006","volume":"23","author":"Scott","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116071_b0135","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/cbdd.12890","volume":"89","author":"Fu","year":"2017","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2021.116071_b0140","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.transproceed.2011.10.021","volume":"43","author":"Gao","year":"2011","journal-title":"Transplant Proc"},{"key":"10.1016\/j.bmc.2021.116071_b0145","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1517\/13543770903153878","volume":"19","author":"Jones","year":"2009","journal-title":"Expert Opin Ther Pat"},{"key":"10.1016\/j.bmc.2021.116071_b0150","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bioorg.2018.02.009","volume":"77","author":"Nanjan","year":"2018","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0155","unstructured":"Pingali, Harikishore, Zaware, Pandurang. WO 2012\/046249 A1; 2012."},{"key":"10.1016\/j.bmc.2021.116071_b0160","unstructured":"Schr\u00f6dinger Release 2018-4: Glide. New York, NY: Schr\u00f6dinger, LLC; 2018."},{"key":"10.1016\/j.bmc.2021.116071_b0165","unstructured":"Schr\u00f6dinger Release2018-4: LigPrep. New York, NY: Schr\u00f6dinger, LLC; 2018."},{"key":"10.1016\/j.bmc.2021.116071_b0170","unstructured":"Schr\u00f6dinger Release 2018-4: Induced Fit Docking protocol; Glide. Schr\u00f6dinger, LLC, New York, NY, 2019; Prime, Schr\u00f6dinger, LLC, New York, NY; 2018."},{"key":"10.1016\/j.bmc.2021.116071_b0175","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.3390\/molecules24112060","volume":"24","author":"Marc","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116071_b0180","first-page":"1","volume":"2014","author":"Silva","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.bmc.2021.116071_b0185","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1039\/C0NJ00691B","volume":"35","author":"Pratap","year":"2011","journal-title":"New J Chem"},{"key":"10.1016\/j.bmc.2021.116071_b0190","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ardp.200500180","volume":"339","author":"Tuncbilek","year":"2006","journal-title":"Arch Pharm (Weinheim)"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621000791?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621000791?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:11:21Z","timestamp":1760836281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621000791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":38,"alternative-id":["S0968089621000791"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116071","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of a potent G-protein-coupled receptor 119 agonist for the treatment of type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116071"}}