{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T12:24:13Z","timestamp":1786883053958,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.bmc.2021.116074","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T10:41:59Z","timestamp":1613558519000},"page":"116074","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Novel 3-benzylidene\/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4426-5217","authenticated-orcid":false,"given":"Zhongcheng","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Cong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghuai","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116074_b0005","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41582-018-0070-3","volume":"14","author":"Kivipelto","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bmc.2021.116074_b0010","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/med.21434","volume":"37","author":"Bachurin","year":"2017","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2021.116074_b0015","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0140-6736(06)69113-7","volume":"368","author":"Blennow","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2021.116074_b0020","author":"Marucci","year":"2020","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.bmc.2021.116074_b0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cobeha.2020.01.013","volume":"32","author":"Decker","year":"2020","journal-title":"Curr. Opin. Behav. Sci."},{"key":"10.1016\/j.bmc.2021.116074_b0030","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejmech.2018.09.031","volume":"158","author":"Li","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0035","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/1570159X113116660047","volume":"12","author":"Agis-Torres","year":"2014","journal-title":"Curr Neuropharmacol."},{"key":"10.1016\/j.bmc.2021.116074_b0040","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bmc.2021.116074_b0045","doi-asserted-by":"crossref","first-page":"116974","DOI":"10.1016\/j.jns.2020.116974","volume":"416","author":"Uddin","year":"2020","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bmc.2021.116074_b0050","doi-asserted-by":"crossref","first-page":"fs9","DOI":"10.1126\/scisignal.aaf8702","volume":"9","author":"McFadyen","year":"2016","journal-title":"Sci. Signaling."},{"key":"10.1016\/j.bmc.2021.116074_b0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1474-4422(04)00707-0","volume":"3","author":"Zhu","year":"2004","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bmc.2021.116074_b0060","doi-asserted-by":"crossref","first-page":"101191","DOI":"10.1016\/j.arr.2020.101191","volume":"64","author":"Pradeepkiran","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bmc.2021.116074_b0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","volume":"9","author":"Wang","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bmc.2021.116074_b0070","doi-asserted-by":"crossref","first-page":"101256","DOI":"10.1016\/j.arr.2021.101256","volume":"66","author":"Santin","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bmc.2021.116074_b0075","doi-asserted-by":"crossref","first-page":"112787","DOI":"10.1016\/j.ejmech.2020.112787","volume":"206","author":"Manzoor","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0080","doi-asserted-by":"crossref","first-page":"6717","DOI":"10.1021\/jm501690r","volume":"58","author":"Carradori","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0085","doi-asserted-by":"crossref","first-page":"8881","DOI":"10.1021\/acs.jmedchem.9b00017","volume":"62","author":"Zhou","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0090","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1021\/acschemneuro.8b00391","volume":"10","author":"Wang","year":"2018","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bmc.2021.116074_b0095","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2009.07.020","volume":"1290","author":"Li","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bmc.2021.116074_b0100","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbrc.2018.02.024","volume":"497","author":"Wang","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bmc.2021.116074_b0105","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/00005344-200406000-00018","volume":"43","author":"Peng","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bmc.2021.116074_b0110","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neulet.2010.10.025","volume":"487","author":"Peng","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bmc.2021.116074_b0115","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neulet.2008.01.080","volume":"434","author":"Peng","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bmc.2021.116074_b0120","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ejphar.2009.08.036","volume":"621","author":"Peng","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bmc.2021.116074_b0125","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0960-894X(00)80547-8","volume":"2","author":"Sugimoto","year":"1992","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2021.116074_b0130","doi-asserted-by":"crossref","first-page":"115400","DOI":"10.1016\/j.bmc.2020.115400","volume":"28","author":"Luo","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0135","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/slct.201904615","volume":"5","author":"Kamali","year":"2020","journal-title":"ChemistrySelect."},{"key":"10.1016\/j.bmc.2021.116074_b0140","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bmc.2019.01.040","volume":"27","author":"Liu","year":"2019","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0145","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.micromeso.2018.12.018","volume":"279","author":"Abdelhameed","year":"2019","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.bmc.2021.116074_b0150","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bioorg.2017.02.016","volume":"71","author":"Yang","year":"2017","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0155","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ejmech.2016.12.009","volume":"126","author":"Li","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0160","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bmc.2016.11.048","volume":"25","author":"Li","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0165","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1021\/jm401814y","volume":"57","author":"Beck","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0170","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.molcata.2007.02.002","volume":"270","author":"Safari","year":"2007","journal-title":"J. Mol. Catal. A: Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0175","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1016\/S0040-4020(03)00757-9","volume":"59","author":"Kapoor","year":"2003","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2021.116074_b0180","doi-asserted-by":"crossref","first-page":"112180","DOI":"10.1016\/j.ejmech.2020.112180","volume":"192","author":"Sang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0185","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bioorg.2019.03.043","volume":"87","author":"Zhang","year":"2019","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0190","doi-asserted-by":"crossref","first-page":"111958","DOI":"10.1016\/j.ejmech.2019.111958","volume":"187","author":"Sang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0195","doi-asserted-by":"crossref","first-page":"103707","DOI":"10.1016\/j.bioorg.2020.103707","volume":"97","author":"Li","year":"2020","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0200","doi-asserted-by":"crossref","first-page":"115374","DOI":"10.1016\/j.bmc.2020.115374","volume":"28","author":"Yang","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0205","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejmech.2019.01.039","volume":"166","author":"Cong","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0210","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.ejmech.2018.04.058","volume":"152","author":"Jalili-Baleh","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0215","doi-asserted-by":"crossref","first-page":"3947","DOI":"10.1016\/j.bmc.2018.06.017","volume":"26","author":"Li","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0220","first-page":"143","volume":"2018","author":"Binsaleh","year":"1997","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0225","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1016\/j.bmc.2018.11.015","volume":"26","author":"Song","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0230","doi-asserted-by":"crossref","first-page":"115470","DOI":"10.1016\/j.bmc.2020.115470","volume":"28","author":"Santos","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0235","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0223-5234(03)00012-6","volume":"38","author":"Di","year":"2003","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0240","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejmech.2018.05.031","volume":"155","author":"Ghobadian","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0245","doi-asserted-by":"crossref","first-page":"9116","DOI":"10.1021\/acs.jmedchem.9b01012","volume":"62","author":"Hoffmann","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0250","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ejoc.200300782","volume":"2004","author":"Harig","year":"2004","journal-title":"Eur. J. Org. Chem."},{"key":"10.1016\/j.bmc.2021.116074_b0255","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1021\/jo00162a011","volume":"48","author":"Sinhababu","year":"1983","journal-title":"J. Org. Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621000821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621000821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:11:50Z","timestamp":1760836310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621000821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":51,"alternative-id":["S0968089621000821"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116074","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel 3-benzylidene\/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116074"}}