{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:28:12Z","timestamp":1783639692844,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001511","name":"Auckland Medical Research Foundation","doi-asserted-by":"publisher","award":["115004"],"award-info":[{"award-number":["115004"]}],"id":[{"id":"10.13039\/501100001511","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001559","name":"Breast Cancer Foundation New Zealand","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.bmc.2021.116092","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T00:12:05Z","timestamp":1615421525000},"page":"116092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Improving the solubility of anti-proliferative thieno[2,3-b]quinoline-2-carboxamides"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-1882","authenticated-orcid":false,"given":"Natalie A.","family":"Haverkate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"van Rensburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sisira","family":"Kumara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3hannes","family":"Reynisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euphemia","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9292-3261","authenticated-orcid":false,"given":"Lisa I.","family":"Pilkington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3425-6552","authenticated-orcid":false,"given":"David","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116092_h0005","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/nchem.2381","volume":"7","author":"Wang","year":"2015","journal-title":"Nat Chem"},{"key":"10.1016\/j.bmc.2021.116092_h0010","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1016\/j.bmcl.2010.08.088","volume":"20","author":"Zeng","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116092_h0015","first-page":"225","volume":"28","author":"Zhou","year":"2012","journal-title":"Oncol Rep"},{"key":"10.1016\/j.bmc.2021.116092_h0020","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejmech.2012.05.029","volume":"54","author":"Feng","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_h0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1039\/c3md00320e","volume":"5","author":"Arabshahi","year":"2014","journal-title":"Med Chem Comm"},{"key":"10.1016\/j.bmc.2021.116092_h0030","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ejmech.2014.09.001","volume":"86","author":"Hung","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_h0035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bmcl.2016.12.009","volume":"27","author":"van Rensburg","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116092_h0040","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1039\/C3MD00290J","volume":"5","author":"Leung","year":"2014","journal-title":"Med Chem Commun"},{"key":"10.1016\/j.bmc.2021.116092_h0045","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12935-016-0293-6","volume":"16","author":"Reynisson","year":"2016","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.bmc.2021.116092_h0050","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1038\/s41598-020-68516-y","volume":"10","author":"Marijan","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2021.116092_h0055","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2147\/DDDT.S121122","volume":"11","author":"Masteli\u0107","year":"2017","journal-title":"Drug Des Develop Ther"},{"key":"10.1016\/j.bmc.2021.116092_h0060","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.bmc.2009.02.049","volume":"17","author":"Reynisson","year":"2009","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_h0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-physiol-030212-183750","volume":"75","author":"Kadamur","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.bmc.2021.116092_h0070","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1242\/jcs.023333","volume":"121","author":"K\u00f6lsch","year":"2008","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bmc.2021.116092_h0075","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.3390\/molecules22122254","volume":"22","author":"Zafar","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116092_h0080","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1039\/C5MD00245A","volume":"6","author":"Arabshahi","year":"2015","journal-title":"Med Chem Commun"},{"key":"10.1016\/j.bmc.2021.116092_h0085","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.bmc.2016.11.041","volume":"25","author":"Eurtivong","year":"2017","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_h0090","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1021\/jm400043d","volume":"56","author":"Romagnoli","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_h0095","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1021\/jm901647p","volume":"53","author":"Katritch","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_b0025","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.bmc.2016.01.047","volume":"24","author":"Leung","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116092_b0030","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1055\/s-0036-1588619","volume":"27","author":"Pilkington","year":"2016","journal-title":"Synlett"},{"key":"10.1016\/j.bmc.2021.116092_b0035","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/molecules23010145","volume":"23","author":"Zafar","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116092_b0040","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1055\/s-1995-3954","volume":"5","author":"Abu-Shanab","year":"1995","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2021.116092_b0045","doi-asserted-by":"crossref","first-page":"9992","DOI":"10.1039\/C4CE01298D","volume":"16","author":"Batisai","year":"2014","journal-title":"CrystEngComm"},{"key":"10.1016\/j.bmc.2021.116092_h0125","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10822-005-8694-y","volume":"19","author":"Tetko","year":"2005","journal-title":"J. Comput. Aid. Mol. Des."},{"key":"10.1016\/j.bmc.2021.116092_h0130","unstructured":"VCCLAB, Virtual Computational Chemistry Laboratory, http:\/\/www.vcclab.org, 2005."},{"key":"10.1016\/j.bmc.2021.116092_b0055","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/minf.201200103","volume":"31","author":"Zhu","year":"2012","journal-title":"Mol Inform"},{"key":"10.1016\/j.bmc.2021.116092_b0060","doi-asserted-by":"crossref","first-page":"1800068","DOI":"10.1002\/minf.201800068","volume":"38","author":"Eurtivong","year":"2019","journal-title":"Mol Inf"},{"key":"10.1016\/j.bmc.2021.116092_b0065","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1039\/C9MD00305C","volume":"10","author":"Leung","year":"2019","journal-title":"Med Chem Comm"},{"key":"10.1016\/j.bmc.2021.116092_b0070","doi-asserted-by":"crossref","first-page":"8127","DOI":"10.1021\/ja00467a001","volume":"99","author":"Allinger","year":"1977","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2021.116092_b0075","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1039\/P29930000187","volume":"2","author":"Goto","year":"1993","journal-title":"J Chem Soc, Perkin Trans"},{"key":"10.1016\/j.bmc.2021.116092_b0080","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/qsar.200730051","volume":"27","author":"Ioakimidis","year":"2008","journal-title":"QSAR Comb Sci"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621001000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621001000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:11:36Z","timestamp":1760836296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621001000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":32,"alternative-id":["S0968089621001000"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116092","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improving the solubility of anti-proliferative thieno[2,3-b]quinoline-2-carboxamides","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116092"}}