{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:56:00Z","timestamp":1790009760631,"version":"4.0.1"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.bmc.2021.116162","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T21:20:45Z","timestamp":1618867245000},"page":"116162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Synthetic approaches to the 2015\u20132018 new agrochemicals"],"prefix":"10.1016","volume":"39","author":[{"given":"Stephane","family":"Jeanmart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.F.","family":"Edmunds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4219-2739","authenticated-orcid":false,"given":"Clemens","family":"Lamberth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Pouliot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116162_b0005","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bmc.2015.12.014","article-title":"Synthetic approaches to the 2010\u20132014 new agrochemicals","volume":"24","author":"Jeanmart","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0010","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1016\/j.tet.2019.06.043","article-title":"Small ring chemistry in crop protection","volume":"75","author":"Lamberth","year":"2019","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2021.116162_b0015","series-title":"Bioactive carboxylic compound classes: pharmaceuticals and agrochemicals","first-page":"453","article-title":"Pyrethroid esters for the control of insect pests","author":"Mondiere","year":"2016"},{"key":"10.1016\/j.bmc.2021.116162_b0020","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1584\/jpestics.D19-101","article-title":"Global trends in the crop protection industry","volume":"44","author":"Nishimoto","year":"2019","journal-title":"J Pestic Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0025","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1002\/ps.5728","article-title":"Agrochemical industry development, trends in R&D and the impact of regulation","volume":"76","author":"Phillips","year":"2020","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0030","unstructured":"Compendium of Pesticide Common Names; Index of new ISO Common Names. http:\/\/alanwood.net\/pesticides\/index_new_frame.html."},{"key":"10.1016\/j.bmc.2021.116162_b0035","series-title":"Bioactive carboxylic compound classes: pharmaceuticals and agrochemicals","first-page":"405","article-title":"Fungicidal succinate-dehydrogenase-inhibiting Carboxamides","author":"Walter","year":"2016"},{"key":"10.1016\/j.bmc.2021.116162_b0040","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1021\/jf0001334","article-title":"Metabolism of furametpyr: identification of metabolites and in vitro biotransformation in rats and humans","volume":"48","author":"Nagahori","year":"2000","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0045","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1094\/PDIS-07-18-1225-RE","article-title":"Characterization of the VisdhC and VisdhD genes in Venturia inaequalis and sensitivity to fluxapyroxad, pydiflumetofen, inpyrfluxam and benzovindiflupyr","volume":"103","author":"Ayer","year":"2019","journal-title":"Plant Dis"},{"key":"10.1016\/j.bmc.2021.116162_b0050","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1021\/jo00111a021","article-title":"Hydrogen bond donor properties of the difluoromethyl group","volume":"60","author":"Erickson","year":"1995","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0055","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.1016\/S0040-4039(02)00614-7","article-title":"Novel facile synthesis of 2,2,4-substituted 1,2-dihydroquinolines via a modified Skraup reaction","volume":"43","author":"Theoclitou","year":"2002","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2021.116162_b0060","first-page":"155947","article-title":"WO 2014\/103811 (Sumitomo Chemical Company Ltd.)","volume":"161","author":"Matsunaga","year":"2014","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0065","first-page":"2529","article-title":"Facile synthesis of fungicidal N-indanylbenzamide derivatives: rearrangement of tetrahydroquinolines to aminoindanes","volume":"53","author":"Tsushima","year":"1989","journal-title":"Agric Biol Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0070","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1021\/op500128p","article-title":"An atom-efficient route to ethyl 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate (DFMMP) \u2013 a key building block for a novel fungicide family","volume":"18","author":"Jaunzems","year":"2014","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmc.2021.116162_b0075","unstructured":"Matsunaga T, Hiraguri N, Takahashi T, Inui T, Tanimoto M. WO 2015\/118793 (Sumitomo Chemical Company Ltd.). Chem Abstr. 2015;163:331126."},{"key":"10.1016\/j.bmc.2021.116162_b0080","article-title":"WO 2017\/178868 (Stichting I-F Product Collaboration)","volume":"167","author":"Bellandi","year":"2017","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0085","series-title":"Modern crop protection compounds","first-page":"694","article-title":"Succinate dehydrogenase inhibitors: pyridinyl-ethyl benzamide","author":"Coqueron","year":"2019"},{"key":"10.1016\/j.bmc.2021.116162_b0090","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1094\/PDIS-06-19-1140-RE","article-title":"Baseline sensitivity of Botrytis cinerea isolates from strawberry to isofetamid compared to other SDHIs","volume":"104","author":"Zuniga","year":"2020","journal-title":"Plant Dis"},{"key":"10.1016\/j.bmc.2021.116162_b0095","series-title":"Recent highlights in the discovery and optimization of crop protection products","article-title":"Adepidyn \u2013 the first N-methoxy-substituted carboxamide amongst the succinate dehydrogenase inhibitors","author":"Stierli","year":"2021"},{"key":"10.1016\/j.bmc.2021.116162_b0100","first-page":"77","article-title":"Adepidyn fungicide: a novel broad spectrum foliar fungicide for multiple crops","volume":"Vol. VIII","author":"Sierotzki","year":"2017"},{"key":"10.1016\/j.bmc.2021.116162_b0105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1094\/PDIS-05-18-0763-RE","article-title":"Pharmacological characteristics and control efficacy of a novel SDHI fungicide pydiflumetofen against Sclerotinia sclerotiorum","volume":"103","author":"Duan","year":"2019","journal-title":"Plant Dis"},{"key":"10.1016\/j.bmc.2021.116162_b0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pestbp.2019.06.017","article-title":"Bioactivity, physiological characteristics and efficacy of the SDHI fungicide pydiflumetofen against Sclerotinia sclerotiorum","volume":"160","author":"Huang","year":"2019","journal-title":"Pestic Biochem Physiol"},{"key":"10.1016\/j.bmc.2021.116162_b0115","first-page":"37162","article-title":"WO 2010\/063700 (Syngenta Crop Protection AG)","volume":"153","author":"Rajan","year":"2010","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0120","article-title":"WO 2013\/127764 (Syngenta Crop Protection AG)","volume":"159","author":"Stierli","year":"2013","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0125","unstructured":"Kuwabara H, Hasunuma N, Fukami Y. WO 2015\/119246 (Nissan Chemical Industries Ltd.). Chem Abstr. 2015;163:327147."},{"key":"10.1016\/j.bmc.2021.116162_b0130","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1002\/ps.5951","article-title":"Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: its chemical discovery and unusual binding mode","volume":"76","author":"Desbordes","year":"2020","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0135","article-title":"WO 2013\/160387 (Bayer CropScience AG)","volume":"159","author":"Himmler","year":"2013","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0140","article-title":"WO 2011\/061205 (Bayer CropScience AG)","volume":"154","author":"Pazenok","year":"2011","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0145","article-title":"WO 2014\/076007 (Bayer CropScience AG)","volume":"160","author":"Lindner","year":"2014","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0150","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ps.4743","article-title":"Characterization of the mechanism of action of the fungicide fenpicoxamid and its metabolite UK-2A","volume":"74","author":"Young","year":"2018","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0155","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/ps.4588","article-title":"Biological characterization of fenpicoxamid, a new fungicide with utility in cereals and other crops","volume":"73","author":"Owen","year":"2017","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0160","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/ps.4170","article-title":"Propesticides and their use as agrochemicals","volume":"72","author":"Jeschke","year":"2016","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0165","doi-asserted-by":"crossref","first-page":"639","DOI":"10.7164\/antibiotics.49.639","article-title":"C and D, novel antifungal antibiotics from Streptomyces sp. 517\u201302","volume":"49","author":"Ueki","year":"1996","journal-title":"J Antibiot"},{"key":"10.1016\/j.bmc.2021.116162_b0170","article-title":"US 2017\/096414 (Dow AgroSciences LLC)","volume":"166","author":"Jansma","year":"2017","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0175","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/ps.5329","article-title":"Synthesis and biological activity of analogs of the antifungal antibiotic UK-2A. II. Impact of modifications to the macrocycle benzyl position","volume":"75","author":"Owen","year":"2019","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0180","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/ps.5511","article-title":"Synthesis and biological activity of analogs of the antifungal antibiotic UK-2A. III. Impact of modifications to the macrocycle isobutyryl ester position","volume":"76","author":"Owen","year":"2020","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0185","series-title":"Recent highlights in the discovery and optimization of crop protection products","article-title":"The discovery of florylpicoxamid, a new picolinamid for disease control","author":"Meyer","year":"2021"},{"key":"10.1016\/j.bmc.2021.116162_b0190","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1039\/D0GC02063J","article-title":"Design and synthesis of florylpicoxamid, a fungicide derived from renewable raw materials","volume":"22","author":"Babij","year":"2020","journal-title":"Green Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0195","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/(SICI)1521-3773(19990517)38:10<1328::AID-ANIE1328>3.0.CO;2-1","article-title":"Strobilurins: evolution of a new class of active substances","volume":"38","author":"Sauter","year":"1999","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116162_b0200","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.bmc.2018.01.004","article-title":"Design, synthesis and fungicidal evaluation of novel pyraclostrobin analogues","volume":"26","author":"Wang","year":"2018","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115211","article-title":"Discovery of metyltetraprole: identification of the tetrazolinone pharmacophore to overcome QoI resistance","volume":"28","author":"Matsuzaki","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0210","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/ps.5697","article-title":"Antifungal activity of metyltetraprole against the existing QoI-resistant isolates of various plant pathogenic fungi","volume":"76","author":"Matsuzaki","year":"2020","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0215","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/ps.5288","article-title":"Metyltetraprole, a novel putative complex III inhibitor, targets known QoI-resistant strains of Zymoseptoria tritici and Pyrenophora teres","volume":"75","author":"Suemoto","year":"2019","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0220","doi-asserted-by":"crossref","first-page":"11893","DOI":"10.1021\/acs.jafc.9b05185","article-title":"Design, synthesis and structure-activity relationship of new arylpyrazole pyrimidine ether derivatives as fungicides","volume":"67","author":"Zhang","year":"2019","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0225","unstructured":"Toriumi T, Ito T, Nagashima Y. JP 2016\/113426 (Sumitomo Chemical Company Ltd.). Chem Abstr. 2016;165:101059."},{"key":"10.1016\/j.bmc.2021.116162_b0230","series-title":"Bioactive Heterocyclic Compound Classes: Agrochemicals","first-page":"129","article-title":"Sterol biosynthesis inhibiting triazole fungicides","author":"Worthington","year":"2012"},{"key":"10.1016\/j.bmc.2021.116162_b0235","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.yrtph.2019.04.009","article-title":"Innovative selection approach for a new antifungal agent mefentrifluconazole (Revysol) and the impact upon its toxicity profile","volume":"106","author":"Tesh","year":"2019","journal-title":"Regul Toxicol Pharmacol"},{"key":"10.1016\/j.bmc.2021.116162_b0240","article-title":"WO 2015\/091045 (BASF SE)","volume":"163","author":"Vogelbacher","year":"2015","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0245","article-title":"WO 2016\/005211 (BASF SE)","volume":"164","author":"Gebhardt","year":"2016","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pestbp.2019.02.013","article-title":"A novel fungicide aminopyrifen inhibits GWT-1 protein in glycosylphosphatidylinositol-anchor biosynthesis in Neurospora crassa","volume":"156","author":"Hatamoto","year":"2019","journal-title":"Pestic Biochem Physiol"},{"key":"10.1016\/j.bmc.2021.116162_b0255","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1134\/S1068162016040087","article-title":"Novel 3-pyridinecarbonitriles incorporating sulfonamide moieties as anti-breast cancer agents","volume":"42","author":"Ghorab","year":"2016","journal-title":"Russ J Bioorg Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0260","unstructured":"Aizawa R, Araki K. WO 2015\/198486 (Agro-Kanesho Co. Ltd.). Chem Abstr. 2015;164:126972."},{"key":"10.1016\/j.bmc.2021.116162_b0265","unstructured":"Aizawa R, Okada I. WO 2015\/097850 (Agro-Kanesho Co. Ltd.). Chem Abstr. 2015;163:161283."},{"key":"10.1016\/j.bmc.2021.116162_b0270","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1002\/ps.5652","article-title":"Pyridachlometyl has a novel anti-tubulin mode of action which could be useful in anti-resistance management","volume":"76","author":"Matsuzaki","year":"2020","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0275","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1016\/j.bmc.2012.03.035","article-title":"Synthesis and fungicidal activity of tubulin polymerization promoters. Part 2: pyridazines","volume":"20","author":"Lamberth","year":"2012","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0280","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/cmdc.201800404","article-title":"Brain-penetrant triazolopyrimidine and phenylpyrimidine microtubule stabilizers as potential leads to treat human African trypanosomiasis","volume":"13","author":"Monti","year":"2018","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2021.116162_b0285","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1021\/jm5005623","article-title":"Brain-penetrant orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer\u2019s disease and related tauopathies","volume":"57","author":"Lou","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0290","unstructured":"Toriumi T. JP 2015\/214503 (Sumitomo Chemical Co. Ltd.). Chem Abstr. 2015;164:59954."},{"key":"10.1016\/j.bmc.2021.116162_b0295","unstructured":"Nakae Y, Manabe A, Miyamoto T. WO 2014\/129612 (Sumitomo Chemical Co. Ltd.). Chem Abstr. 2014;161:390003."},{"key":"10.1016\/j.bmc.2021.116162_b0300","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1016\/j.tetlet.2012.05.125","article-title":"A new Knoevenagel-type synthesis of fully substituted \u03b3-hydroxybutenolides","volume":"53","author":"Lamberth","year":"2012","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2021.116162_b0305","series-title":"Modern Crop Protection Compounds","first-page":"871","article-title":"Fluopicolide: a new anti-oomycete fungicide","author":"Toquin","year":"2019"},{"key":"10.1016\/j.bmc.2021.116162_b0310","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12272-013-0253-9","article-title":"Synthesis and biological evaluation of glucagon-like peptide-1 receptor agonists","volume":"37","author":"Zhang","year":"2014","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2021.116162_b0315","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1584\/jpestics.D13-017","article-title":"Uptake and transportation behavior of a new fungicidal agent LH-2010A in cucumber plants","volume":"39","author":"Zhang","year":"2014","journal-title":"J Pestic Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0320","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1094\/PDIS-01-19-0143-RE","article-title":"Synergistic effect of combined application of a new fungicide fluopimomide with a biocontrol agent Bacillus methylotrophicus TA-1 for management of gray mold in tomato","volume":"103","author":"Ji","year":"2019","journal-title":"Plant Dis"},{"key":"10.1016\/j.bmc.2021.116162_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.cropro.2019.105040","article-title":"Evaluating a new non-fumigant nematicide fluopimomide for management of Southern root-knot nematodes in tomato","volume":"129","author":"Li","year":"2020","journal-title":"Crop Protect"},{"key":"10.1016\/j.bmc.2021.116162_b0330","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jfluchem.2016.05.005","article-title":"Substituted 4-(1H\u20131,2,3-triazol-1-yl)-tetrafluorobenzoates: selective synthesis and structure","volume":"187","author":"Solodukhin","year":"2016","journal-title":"J Fluorine Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0335","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1021\/acs.inorgchem.5b02634","article-title":"Constructing a catalytic cycle for C-F to C-X (X = O, S, N) bond transformation based on gold-mediated ligand nucleophilic attack","volume":"55","author":"Hu","year":"2016","journal-title":"Inorg Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0340","unstructured":"Tang J, Liu J, Niu F, Han J. CN 103444733 (Shandong United Pesticide Industry Co. Ltd.). Chem Abstr. 2013;160:126871."},{"key":"10.1016\/j.bmc.2021.116162_b0345","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bmc.2015.07.064","article-title":"Discovery of oxathiapiprolin, a new oomycete fungicide that targets an oxysterol binding protein","volume":"24","author":"Pasteris","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0350","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1584\/jpestics.D20-201","article-title":"Development of novel pesticides in the 21st century","volume":"45","author":"Umetsu","year":"2020","journal-title":"J Pestic Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0355","first-page":"80542","article-title":"EP 511036 (Rhone-Poulenc Chimie SA)","volume":"118","author":"Duhamel","year":"1993","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0360","first-page":"79159","article-title":"WO 2015\/189114 (Bayer CropScience AG)","volume":"164","author":"Erver","year":"2015","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0365","doi-asserted-by":"crossref","first-page":"11239","DOI":"10.1002\/chem.201601621","article-title":"A major advance in the synthesis of fluoroalkyl pyrazoles: tuneable regioselectivity and broad substitution patterns","volume":"22","author":"Schmitt","year":"2016","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmc.2021.116162_b0370","first-page":"36949","article-title":"WO 2015\/181097 (Bayer CropScience AG)","volume":"164","author":"Hoemberger","year":"2015","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0375","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.tetlet.2007.02.018","article-title":"Open air palladium catalyzed cyanation \u2013 the use of PMHS to protect from oxygen","volume":"48","author":"Martin","year":"2007","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2021.116162_b0380","unstructured":"Ito H, Fujiwara K, Morimoto M, Tanaka H, Tamagawa Y, Komai H. WO 2005\/070917 (Sankyo Agro Co. Ltd.). Chem Abstr. 2005;143:193918."},{"key":"10.1016\/j.bmc.2021.116162_b0385","unstructured":"Umetani H, Kondo N, Kajino F. WO 2013\/047749 (Mitsui Chemicals Agro Inc.). Chem Abstr. 2013;158:503959."},{"key":"10.1016\/j.bmc.2021.116162_b0390","first-page":"68","volume":"67","author":"Kordes","year":"2019","journal-title":"Agrochemie Nachr Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0395","unstructured":"Shibayama K, Inagaki J, Saiki Y, Mitani A, Kuwahara R, Sato M, Nishimura S, Kuboki M. WO 2011\/081174 (Nippon Soda Co. Ltd.). Chem Abstr. 2011;155:181869."},{"key":"10.1016\/j.bmc.2021.116162_b0400","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s41061-017-0169-9","article-title":"Sulfur-containing agrochemicals","volume":"375","author":"Devendar","year":"2017","journal-title":"Top Curr Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0405","unstructured":"Nakamura T, Kumagai H, Ogawa M. WO 2010\/126170 (Ihara Chemical Industry Co. Ltd.). Chem Abstr. 2010;153:600769."},{"key":"10.1016\/j.bmc.2021.116162_b0410","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.aihch.2016.04.010","article-title":"Thiazole and isothiazole ring-containing compounds in crop protection","volume":"121","author":"Maienfisch","year":"2017","journal-title":"Adv Heterocycl Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0415","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/hlca.19890720609","article-title":"Preparation and synthetic application of a saccharin-derived N-fluorosultam","volume":"72","author":"Differding","year":"1989","journal-title":"Helv Chim Acta"},{"key":"#cr-split#-10.1016\/j.bmc.2021.116162_b0420.1","unstructured":"Nagata T, Kogure A, Kaneko I, Yonekura N, Hanai R. WO 2007\/129454 (Kumiai Chemical Industry Co. Ltd"},{"key":"#cr-split#-10.1016\/j.bmc.2021.116162_b0420.2","unstructured":"Ihara Chemical Industry Co. Ltd.). Chem Abstr. 2007;147:541861."},{"key":"10.1016\/j.bmc.2021.116162_b0425","doi-asserted-by":"crossref","first-page":"6806","DOI":"10.1021\/es301876d","article-title":"The chiral herbicide beflubutamide: isolation of pure enantiomers by HPLC, herbicidal activity of enantiomers and analysis by enantioselective GC-MS","volume":"47","author":"Buerge","year":"2013","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.bmc.2021.116162_b0430","first-page":"49","article-title":"Beflubtuamide, a grain herbicide","volume":"624","author":"Zugaj","year":"2009","journal-title":"Phytoma"},{"key":"10.1016\/j.bmc.2021.116162_b0435","article-title":"WO 2018\/119338 (FMC Corporation)","volume":"169","author":"Shinn","year":"2018","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0440","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1021\/ol0488035","article-title":"Enantioselective hydrogenation of \u03b1-aryloxy \u03b1, \u03b2 -unsaturated acids: asymmetric synthesis of \u03b1 -aryloxycarboxylic acids","volume":"6","author":"Maligres","year":"2004","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2021.116162_b0445","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1007\/s11368-019-02471-8","article-title":"Adsorption-desorption characteristics of pyraclonil in eight agricultural soils","volume":"20","author":"Zhang","year":"2020","journal-title":"J Soils Sediments"},{"key":"10.1016\/j.bmc.2021.116162_b0450","unstructured":"Matsubara K, Niino M. WO 2015\/020156 (Kyoyu Agri Co. Ltd.). Chem Abstr. 2015;162:300206."},{"key":"10.1016\/j.bmc.2021.116162_b0455","series-title":"Modern crop protection compounds","first-page":"252","article-title":"Triketones","author":"Edmunds","year":"2019"},{"key":"10.1016\/j.bmc.2021.116162_b0460","unstructured":"Jonishi H, Okamoto T, Adachi N, Isogai A, Jukurogi T, Konishi H, Fukui F. WO 2013\/168642 (Ishihara Sangyo Kaisha Ltd.). Chem Abstr. 2013;159:742602."},{"key":"10.1016\/j.bmc.2021.116162_b0465","unstructured":"Chang JH. US 4405337 (FMC Corporation). Chem Abstr. 1982;96:199668."},{"key":"10.1016\/j.bmc.2021.116162_b0470","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1515\/znc-1990-0534","article-title":"Interactions of the bleaching herbicide clomazone with reduced glutathione and other thiols","volume":"45c","author":"Vencill","year":"1990","journal-title":"Z Naturforsch"},{"key":"10.1016\/j.bmc.2021.116162_b0475","unstructured":"Bristow JT. WO 2015\/000353 (Rotam Agrochem International Co. Ltd.). Chem Abstr. 2015;162:137856."},{"key":"10.1016\/j.bmc.2021.116162_b0480","article-title":"WO 2019\/209847 (FMC Corportation)","volume":"171","author":"Huang","year":"2019","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0485","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ps.4657","article-title":"Fifty years of herbicide research: comparing the discovery of trifluralin and halauxifen-methyl","volume":"74","author":"Epp","year":"2018","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0490","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bmc.2015.08.011","article-title":"The discovery of ARYLEX active and RINSKOR active: two novel auxin herbicides","volume":"24","author":"Epp","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0495","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1021\/acs.oprd.9b00302","article-title":"Development of a novel route for incorporation of carbon-14 into the pyridine ring of Rinskor active","volume":"23","author":"Johnson","year":"2019","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmc.2021.116162_b0500","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ibmb.2013.11.009","article-title":"The novel isooxazoline ectoparasiticide fluralaner: selective inhibition of arthropod \u03b3 -aminobutyric acid and L-glutamate-gated chloride channels and insecticidal\/acaricidal activity","volume":"45","author":"Gassel","year":"2014","journal-title":"Insect Biochem Mol Biol"},{"key":"10.1016\/j.bmc.2021.116162_b0505","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.vetpar.2014.02.020","article-title":"Discovery and mode of action of afoxolaner, a new isooxazoline parasiticide for dogs","volume":"201","author":"Shoop","year":"2014","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.bmc.2021.116162_b0510","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pestbp.2018.02.002","article-title":"Fluxametamide: a novel isooxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels","volume":"151","author":"Asahi","year":"2018","journal-title":"Pest Biochem Physiol"},{"key":"10.1016\/j.bmc.2021.116162_b0515","doi-asserted-by":"crossref","first-page":"13657","DOI":"10.1021\/acs.est.9b03697","article-title":"Development of S-fluxametamide for bioactivity improvement and risk reduction: systemic evaluation of the novel insecticide fluxametamide at the enantiomeric level","volume":"53","author":"Li","year":"2019","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.bmc.2021.116162_b0520","unstructured":"Kagami T. WO 2016\/002790 (Nissan Chemical Industries Ltd.). Chem Abstr. 2016;164:160135."},{"key":"10.1016\/j.bmc.2021.116162_b0525","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1564\/v30_aug_04","article-title":"Pesticides modes of action and resistance: a perspective from the 2019 IUPAC congress","volume":"30","author":"Dayan","year":"2019","journal-title":"Outlook Pest Manag"},{"key":"10.1016\/j.bmc.2021.116162_b0530","series-title":"Recent Highlights in the Discovery and Optimization of Crop Protection Products","article-title":"The discovery of isocycloseram: a novel isoxazoline insecticide","author":"Cassayre","year":"2021"},{"key":"10.1016\/j.bmc.2021.116162_b0535","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/ps.4308","article-title":"A retrospective look at anthranilic diamide insecticides: discovery and lead optimization to chlorantraniliprole and cyantraniliprole","volume":"73","author":"Selby","year":"2017","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0540","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ps.3406","article-title":"The story of a new insecticidal chemistry class: the diamides","volume":"69","author":"Jeanguenat","year":"2013","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111033","article-title":"Mechanism of the different metabolome responses between Plutella xylostella and Pieris rapae treated with the diamide insecticides","volume":"203","author":"Wang","year":"2020","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.bmc.2021.116162_b0550","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0242052","article-title":"Evaluation of the sublethal effect of tetrachlorantraniliprole on Spodoptera exigua and its potential toxicity to two non-target organisms","volume":"15","author":"Teng","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2021.116162_b0555","article-title":"CN 102020633 (Sinochem Corporation)","volume":"154","author":"Yang","year":"2011","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0560","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1584\/jpestics.30.354","article-title":"Flubendiamide, a novel insecticide highly active against lepidopterous insect pests","volume":"30","author":"Tohnishi","year":"2005","journal-title":"J Pestic Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0565","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/j.cjche.2018.07.003","article-title":"Distribution and degradation kinetics of cyhalodiamide in Chinese rice field environment","volume":"26","author":"Liu","year":"2018","journal-title":"Chin J Chem Eng"},{"key":"10.1016\/j.bmc.2021.116162_b0570","first-page":"1421","article-title":"Toxicity of cyhalodiamide against Bursaphelenchus xylophilus and its preventive effect in the forest","volume":"19","author":"Zhang","year":"2017","journal-title":"Int J Agric Biol"},{"key":"10.1016\/j.bmc.2021.116162_b0575","unstructured":"Zhu B, Xing J, Xu T, Zheng Z, Chen J, Peng W, Xu Y, Kong X, Wei Y, Dong D, Yuang J, Wei W. WO 2012\/034472 (Sinochem Lantian Co. Ltd.). Chem Abstr. 2012;156:363037."},{"key":"10.1016\/j.bmc.2021.116162_b0580","doi-asserted-by":"crossref","first-page":"9464","DOI":"10.1002\/anie.201302550","article-title":"Nicotinic acetylcholine receptor agonists: a milestone for modern crop protection","volume":"52","author":"Jeschke","year":"2013","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116162_b0585","doi-asserted-by":"crossref","first-page":"7865","DOI":"10.1021\/acs.jafc.7b02924","article-title":"Flupyrimin: a novel insecticide acting at the nicotinic acetylcholine receptor","volume":"65","author":"Onozaki","year":"2017","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0590","article-title":"WO 2016\/005276 (Bayer CropScience AG)","volume":"164","author":"Kennedy","year":"2016","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0595","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cropro.2009.06.015","article-title":"Movento, an innovative ambimobile insecticide for sucking pest control in agriculture: biological profile and field performance","volume":"28","author":"Br\u00fcck","year":"2009","journal-title":"Crop Protect"},{"key":"10.1016\/j.bmc.2021.116162_b0600","series-title":"Recent Highlights in the Discovery and Optimization of Crop Protection Products","article-title":"Spiropidion discovery: broad spectrum control of sucking insects and mites for multicrop utility","author":"Muehlebach","year":"2021"},{"key":"10.1016\/j.bmc.2021.116162_b0605","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1002\/ps.5743","article-title":"Spiro N-methoxy piperidine ring containing aryldiones for the control of sucking insects and mites: discovery of spiropidion","volume":"76","author":"Muehlebach","year":"2020","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0610","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1021\/jo01065a044","article-title":"1-Alkoxy-4-phenyl-4-propionoxypiperidines and their 3-methyl homologs as analgesics","volume":"26","author":"Major","year":"1961","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2021.116162_b0615","first-page":"725","article-title":"Benzpyrimoxan: an insecticide for the control of rice plant hoppers","volume":"11","author":"Satoh","year":"2017","journal-title":"Intl Schol Sci Res Innov"},{"key":"10.1016\/j.bmc.2021.116162_b0620","unstructured":"Satoh E, Murata T, Harayama H, Nakano M, Fukatsu K, Inukai K, Kasahara R, Abe Y, Hayashi N, Fujita N. WO 2013\/115391 (Nihon Nohyaku Co. Ltd.). Chem Abstr. 2013;159:319213."},{"key":"10.1016\/j.bmc.2021.116162_b0625","article-title":"WO 2017\/133942 (BASF SE)","volume":"167","author":"Klauber","year":"2017","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0630","article-title":"WO 2018\/082964 (BASF SE)","volume":"168","author":"Gockel","year":"2018","journal-title":"Chem Abstr"},{"key":"10.1016\/j.bmc.2021.116162_b0635","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1021\/acs.oprd.9b00127","article-title":"Development of a scalable process for the insecticidal candidate tyclopyrazoflor. Part 1. Evaluation of [3+2] cyclization strategies to 3-(3-chloro-1H-pyrazol-1-yl)pyridine","volume":"23","author":"Yang","year":"2019","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmc.2021.116162_b0640","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1021\/acs.oprd.9b00129","article-title":"Development of a scalable process for the insecticidal candidate tyclopyrazoflor. Part 3. A scalable synthesis of methyl 3-((3,3,3-trifluoropropyl)thio)propanoate via thiol-ene chemistry","volume":"23","author":"Gray","year":"2019","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmc.2021.116162_b0645","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1021\/acs.oprd.9b00128","article-title":"Development of a scalable process for the insecticidal candidate tyclopyrazoflor. Part 2. Fit-for-purpose optimization of the route to tyclopyrazoflor featuring [3+2] cyclization of 3-hydrazinopyridine.2HCl and methyl acrylate","volume":"23","author":"Yang","year":"2019","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmc.2021.116162_b0650","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/ps.6084","article-title":"Status and outlook for acaricide and insecticide discovery","volume":"77","author":"Jeschke","year":"2021","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0655","unstructured":"Takahashi M, Tanabe T, Ito M, Iwata A, Nokura Y. WO 2014\/104407 (Sumitomo Chemical Co. Ltd.). Chem Abstr. 2014;161:186556."},{"key":"10.1016\/j.bmc.2021.116162_b0660","unstructured":"Shimizu C, Kamezaki M, Nokura Y. WO 2014\/119674 (Sumitomo Chemical Co. Ltd.). Chem Abstr. 2014;161:336371."},{"key":"10.1016\/j.bmc.2021.116162_b0665","unstructured":"Hamamoto I, Koizumi K, Kawaguchi M, Tanigawa H, Nakamura T, Kobayashi T. WO 2011\/105506 (Nippon Soda Co. Ltd.). Chem Abstr. 2011;155:407145."},{"key":"10.1016\/j.bmc.2021.116162_b0670","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.bmcl.2017.02.029","article-title":"The discovery of fluazaindolizine: a new product for the control of plant parasitic nematodes","volume":"27","author":"Lahm","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116162_b0675","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1002\/ps.5481","article-title":"Evaluation of new chemical and biological nematicides for managing Meloidogyne javanica in tomato production and associated double-crops in Florida","volume":"75","author":"Desaeger","year":"2019","journal-title":"Pest Manag Sci"},{"key":"10.1016\/j.bmc.2021.116162_b0680","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2533\/chimia.2020.822","article-title":"Where do agrochemicals come from","volume":"74","author":"Berthon","year":"2020","journal-title":"Chimia"},{"key":"10.1016\/j.bmc.2021.116162_b0685","unstructured":"Lahm GP, Lett RM, Smith BT, Smith BK, Tyler CA. WO 2010\/129500 (E. I. du Pont de Nemours and Co.). Chem Abstr. 2010;153:600785."},{"key":"10.1016\/j.bmc.2021.116162_b0690","unstructured":"El-Awa A. WO 2014\/109933 (E. I. du Pont de Nemours and Co.). Chem Abstr. 2014;161:232263."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962100170X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962100170X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:13:31Z","timestamp":1760836411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962100170X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":139,"alternative-id":["S096808962100170X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116162","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthetic approaches to the 2015\u20132018 new agrochemicals","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116162","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116162"}}