{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:50:27Z","timestamp":1786985427159,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["AAAA-A20-120012090029-0"],"award-info":[{"award-number":["AAAA-A20-120012090029-0"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18-53-52004_MNT_a"],"award-info":[{"award-number":["18-53-52004_MNT_a"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["MOST107-2923-B-039-001-MY3"],"award-info":[{"award-number":["MOST107-2923-B-039-001-MY3"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["CMU108-ASIA-11"],"award-info":[{"award-number":["CMU108-ASIA-11"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["CMU108-MF-42"],"award-info":[{"award-number":["CMU108-MF-42"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["CMU108-S-12"],"award-info":[{"award-number":["CMU108-S-12"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["AAAA-A20-120012090029-0"],"award-info":[{"award-number":["AAAA-A20-120012090029-0"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["18-53-52004_MNT_a"],"award-info":[{"award-number":["18-53-52004_MNT_a"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["MOST107-2923-B-039-001-MY3"],"award-info":[{"award-number":["MOST107-2923-B-039-001-MY3"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["CMU108-ASIA-11"],"award-info":[{"award-number":["CMU108-ASIA-11"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["CMU108-MF-42"],"award-info":[{"award-number":["CMU108-MF-42"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Education and Science of the Russian Federation","doi-asserted-by":"publisher","award":["CMU108-S-12"],"award-info":[{"award-number":["CMU108-S-12"]}],"id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","award":["AAAA-A20-120012090029-0"],"award-info":[{"award-number":["AAAA-A20-120012090029-0"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","award":["18-53-52004_MNT_a"],"award-info":[{"award-number":["18-53-52004_MNT_a"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST107-2923-B-039-001-MY3"],"award-info":[{"award-number":["MOST107-2923-B-039-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CMU108-ASIA-11"],"award-info":[{"award-number":["CMU108-ASIA-11"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CMU108-MF-42"],"award-info":[{"award-number":["CMU108-MF-42"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CMU108-S-12"],"award-info":[{"award-number":["CMU108-S-12"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["AAAA-A20-120012090029-0"],"award-info":[{"award-number":["AAAA-A20-120012090029-0"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["18-53-52004_MNT_a"],"award-info":[{"award-number":["18-53-52004_MNT_a"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["MOST107-2923-B-039-001-MY3"],"award-info":[{"award-number":["MOST107-2923-B-039-001-MY3"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU108-ASIA-11"],"award-info":[{"award-number":["CMU108-ASIA-11"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU108-MF-42"],"award-info":[{"award-number":["CMU108-MF-42"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012544","name":"China Medical University, Taiwan","doi-asserted-by":"publisher","award":["CMU108-S-12"],"award-info":[{"award-number":["CMU108-S-12"]}],"id":[{"id":"10.13039\/501100012544","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.bmc.2021.116204","type":"journal-article","created":{"date-parts":[[2021,5,10]],"date-time":"2021-05-10T12:38:03Z","timestamp":1620650283000},"page":"116204","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro"],"prefix":"10.1016","volume":"41","author":[{"given":"Lidia A.","family":"Baltina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh-Chou","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Chi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Hua","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mann-Jen","family":"Hour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia A.","family":"Baltina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tagir R.","family":"Nugumanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia S.","family":"Borisevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2095-9097","authenticated-orcid":false,"given":"Leonard M.","family":"Khalilov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana F.","family":"Petrova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey L.","family":"Khursan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Wen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116204_b0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.antiviral.2016.03.010","article-title":"Zika virus: History, emergence, biology, and prospects for control","volume":"130","author":"Weaver","year":"2016","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2021.116204_b0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ijid.2016.02.001","article-title":"Rapid Spread of Zika virus in the Americas \u2013 Implications for Public Health Preparedness for Mass Gatherings at the 2016 Brazil Olympic Games","volume":"44","author":"Petersen","year":"2016","journal-title":"Int. J. Infection Dis."},{"key":"10.1016\/j.bmc.2021.116204_b0015","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0140-6736(16)00080-5","article-title":"Anticipating the international spread of Zika virus from Brazil","volume":"387","author":"Bogoch","year":"2016","journal-title":"The Lancet"},{"key":"10.1016\/j.bmc.2021.116204_b0020","unstructured":"Understanding gender's role in Zika prevention, therefore, is key to strengthening current and future programs. \/\/ WHO\/PAHO Epidemiological Update Dengue and other Arboviruses Date: Wed 10 Jun 2020. https:\/\/www.paho.org\/en\/documents\/epidemiological-update-dengue-and-other-arboviruses-10-june-2020; Accessed 10 August 2020."},{"key":"10.1016\/j.bmc.2021.116204_b0025","unstructured":"WHO Region of the Americas\/Pan American Health Organization. PLISA Health Information Platform for the Americas: Cases of Zika virus disease, by country or territory; accessed November 2019, http:\/\/www.paho.org\/data\/index.php\/en\/mnu-topics\/zika\/254-zika-weekly-en.html; Accessed 10 August 2020."},{"key":"10.1016\/j.bmc.2021.116204_b0030","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJMra1808246","article-title":"Baud D Zika virus infection \u2013 after the pandemic","volume":"381","author":"Musso","year":"2019","journal-title":"N. Eng. J. Med."},{"key":"10.1016\/j.bmc.2021.116204_b0035","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.micinf.2016.03.003","article-title":"Zika virus \u2013 an overview","volume":"18","author":"Zanluca","year":"2016","journal-title":"Microbes and Infections."},{"key":"10.1016\/j.bmc.2021.116204_b0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.antiviral.2008.08.004","article-title":"Molecular targets for flavivirus drug discovery","volume":"81","author":"Sampath","year":"2009","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bmc.2021.116204_b0045","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/S0140-6736(16)30058-7","article-title":"Guillain-Barr\u00e9 syndrome associated with Zika virus infection","volume":"387","author":"Brasil","year":"2016","journal-title":"The Lancet."},{"key":"10.1016\/j.bmc.2021.116204_b0050","doi-asserted-by":"crossref","unstructured":"Mlakar J, Korva M, Tul N, Popovi\u0107 M, Polj\u0161ak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodu\u0161ek V, Vizjak A, Pi\u017eem J, Petrovec M, Av\u0161i\u010d \u017dupanc T. Zika Virus Associated with Microcephaly. N. Engl. J. Med. 2016; Feb 10. [Epub ahead of print]. https:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1600651.","DOI":"10.1056\/NEJMoa1600651"},{"key":"10.1016\/j.bmc.2021.116204_b0055","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.coi.2018.04.024","article-title":"Zika virus vaccines: immune response, current status, and future challenges","volume":"53","author":"Richner","year":"2018","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bmc.2021.116204_b0060","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-med-040717-051127","article-title":"Zika virus vaccine development: progress in the face of new challenges","volume":"70","author":"Diamond","year":"2019","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bmc.2021.116204_b0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1039\/C4NP00085D","article-title":"Antiviral drug discovery: broad-spectrum drugs from nature","volume":"32","author":"Martinez","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bmc.2021.116204_b0070","first-page":"195","article-title":"Natural Antiviral Compounds","volume":"42","author":"Bekhit","year":"2014","journal-title":"Studies in Nat. Prod. Chem."},{"key":"10.1016\/j.bmc.2021.116204_b0075","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/med.21484","article-title":"Recent progress in the antiviral activity and mechanism study of pentacyclic triterpenoids and their derivatives","volume":"38","author":"Xiao","year":"2018","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bmc.2021.116204_b0080","doi-asserted-by":"crossref","first-page":"262","DOI":"10.2174\/1570193X1103140915105240","article-title":"Antitumor and antiviral activity of Pentacyclic Triterpenes","volume":"11","author":"Paduch","year":"2014","journal-title":"Mini-Rev. Org. Chem."},{"key":"10.1016\/j.bmc.2021.116204_b0085","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1039\/c0np00059k","article-title":"Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases","volume":"28","author":"Sheng","year":"2011","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bmc.2021.116204_b0090","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.apsb.2015.05.005","article-title":"The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb","volume":"5","author":"Wang","year":"2015","journal-title":"Acta Pharmaceutica Sinica, B."},{"key":"10.1016\/j.bmc.2021.116204_b0095","unstructured":"Tolstikov GA, Baltina LA, Grankina VP, Kondratenko RM, Tolstikova TG. Licorice: biodiversity, chemistry, and application in medicine. Novosibirsk: Academic Publishing House \u201cGeo\u201d, 2007 (in Russian)."},{"key":"10.1016\/j.bmc.2021.116204_b0100","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1021\/jf404939f","article-title":"Bioactivity and potential health benefits of licorice","volume":"62","author":"Kao","year":"2014","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bmc.2021.116204_b0105","article-title":"Exploring the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Glycyrrhizic and Glycyrrhetinic Acids","volume":"6699560","author":"Richard","year":"2021","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.bmc.2021.116204_b0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41401-020-0383-9","article-title":"Research progress on the protective effects of licorice-derived 18\u03b2-glycyrrhetinic acid against liver injury","volume":"42","author":"Wu","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bmc.2021.116204_b0115","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2174\/0929867323666160112122256","article-title":"Glycyrrhetinic acid and its derivatives: anti-cancer and cancer chemopreventive properties, mechanisms of action and structure-cytotoxic activity relationship","volume":"23","author":"Roohbakhsh","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116204_b0120","doi-asserted-by":"crossref","first-page":"996","DOI":"10.2174\/138955709788681636","article-title":"Antiviral properties of Glycyrrhizic acid and its semisynthetic derivatives","volume":"9","author":"Pompei","year":"2009","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116204_b0125","doi-asserted-by":"crossref","unstructured":"Baltina LA, Kondratenko RM, Baltina LA (jr.), Plyasunova OA, Pokrovskyi AG, Tolstikov GA. Prospects for the creation of new antiviral drugs based on Glycyrrhizic acid and its derivatives. Pharm. Chem. J. 2009; 43: 539-548. http:\/\/link.springer.com\/article\/10.1007\/s11094-010-0348-2.","DOI":"10.1007\/s11094-010-0348-2"},{"key":"10.1016\/j.bmc.2021.116204_b0130","doi-asserted-by":"crossref","unstructured":"Baltina LA (jr.), Kondratenko RM, Plyasunova OA, Baltina LA, Pokrovskii AG, Khalilov LM, Galin FZ, Tolstikov GA. Synthesis and anti-HIV activity of triterpene conjugates of \u03b1-D-glucosamine. Pharm. Chem. J. 2008; 42: 64-67. http:\/\/link.springer.com\/article\/10.1007\/s11094-008-0061-6.","DOI":"10.1007\/s11094-008-0061-6"},{"key":"10.1016\/j.bmc.2021.116204_b0135","doi-asserted-by":"crossref","unstructured":"Wang LJ, Geng CA, Ma YB, Huang XY, luo J, Chen H, Zhang XM, Chen JJ. Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents. Bioorg. Med. Chem. Lett. 2012; 22: 3473-3479. https:\/\/doi.org\/10.1016\/j.bmcl.2012.03.081.","DOI":"10.1016\/j.bmcl.2012.03.081"},{"key":"10.1016\/j.bmc.2021.116204_b0140","doi-asserted-by":"crossref","unstructured":"Markov AM, Senkova AV, Waeszycki D, Salomatina OV, Salakhutdinov NF, Logashenko EB. Soloxolone methyl inhibits influenza virus replication and reduces virus-induced lung inflammation. Sci. Rep. 2017; 7: 13968. https:\/\/www.nature.com\/articles\/s41598-017-14029-0.","DOI":"10.1038\/s41598-017-14029-0"},{"key":"10.1016\/j.bmc.2021.116204_b0145","doi-asserted-by":"crossref","unstructured":"Baltina LA (jr), Khudobko MV, Mikhailova LR, Baltina LA, Fedorova VA, Orshanskaya YA, Zarubaev VV, Kiselev OI. Synthesis and antiviral activity of amino-acid conjugates of Glycyrrhetic acid. Chem. Nat. Compd. 2014; 50: 473-477. http:\/\/link.springer.com\/article\/10.1007\/s10600-014-0990-0.","DOI":"10.1007\/s10600-014-0990-0"},{"key":"10.1016\/j.bmc.2021.116204_b0150","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1590\/S0103-50532010000900002","article-title":"Glycyrrhizin and Glycyrrhetinic acid: scaffolds to promising new pharmacologically active compounds","volume":"21","author":"Graebin","year":"2010","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.bmc.2021.116204_b0155","doi-asserted-by":"crossref","unstructured":"Mikhailova LR, Baltina LA, Kondratenko RM, Kunert O, Spirikhin LV, Galin FZ, Tolstikov GA. Synthesis and high-resolution spectra of A-nor-derivatives of 11-deoxyglycyrrhetic acid. Chem. Nat. Compd. 2006; 42: 553-557. http:\/\/link.springer.com\/article\/10.1007\/s10600-006-0212-5.","DOI":"10.1007\/s10600-006-0212-5"},{"key":"10.1016\/j.bmc.2021.116204_b0160","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.bmc.2009.10.036","article-title":"Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases","volume":"18","author":"Beseda","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2021.116204_b0165","doi-asserted-by":"crossref","unstructured":"Mikhailova LR, Khudobko MV, Baltina LA (jr), Baltina LA. Beckmann rearrangement of 11-deoxo-Glycyrrhetic acid 3-ketoxime. Chem. Nat. Compd. 2009; 45: 519-521. https:\/\/link.springer.com\/article\/10.1007\/s10600-009-9395-x.","DOI":"10.1007\/s10600-009-9395-x"},{"key":"10.1016\/j.bmc.2021.116204_b0170","doi-asserted-by":"crossref","unstructured":"Baltina LA, Shayakhmetova DM, Baltina LA (jr.), Nugumanov TR. Synthesis of a 1,2,3-thiadiazole of butyl glycyrrhetinate. Chem. Nat. Compd. 2019; 55: 692-695. http:\/\/link.springer.com\/article\/10.1007\/s10600-019-02780-x.","DOI":"10.1007\/s10600-019-02780-x"},{"key":"10.1016\/j.bmc.2021.116204_b0175","doi-asserted-by":"crossref","unstructured":"Khudobko MV, Mikhailova LR, Baltina LA (jr.), Spirikhin LV, Baltina LA Synthesis of 2,11-dioxo-norolean A(1)-12,18(19)-dien-30-oic acid. Chem. Nat. Compd. 2011; 47: 76-78. http:\/\/www.springerlink.com\/openurl.asp?genre=article&id=doi:10.1007\/s10600-011-9834-3.","DOI":"10.1007\/s10600-011-9834-3"},{"key":"10.1016\/j.bmc.2021.116204_b0180","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/cbdd.12308","article-title":"Synthesis of novel heterocyclic ring-fused 18\u03b2-glycyrrhetinic acid derivatives with antitumor and antimetastatic activity","volume":"84","author":"Gao","year":"2014","journal-title":"Chem. Biol. Drug. Des."},{"key":"10.1016\/j.bmc.2021.116204_b0185","doi-asserted-by":"crossref","first-page":"16595","DOI":"10.1038\/s41598-018-34932-4","article-title":"Structure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus","volume":"8","author":"Lien","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bmc.2021.116204_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126645","article-title":"Glycyrrhizic acid derivatives as Dengue virus inhibitors","volume":"29","author":"Baltina","year":"2019","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2021.116204_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198290","article-title":"Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus","volume":"294","author":"Baltina","year":"2021","journal-title":"Virus Res."},{"key":"10.1016\/j.bmc.2021.116204_b0200","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1107\/S0108767307043930","article-title":"A short history of SHELX","volume":"64","author":"Sheldrick","year":"2008","journal-title":"Acta Crystallogr. A"},{"key":"10.1016\/j.bmc.2021.116204_b0205","first-page":"3","article-title":"Crystal structure refinement with SHELXL","volume":"C71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst."},{"key":"10.1016\/j.bmc.2021.116204_b0210","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic. Acids Res."},{"key":"10.1016\/j.bmc.2021.116204_b0215","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1021\/ct300203w","article-title":"Improving the prediction of absolute solvation free energies using the Next Generation OPLS force field","volume":"8","author":"Shivakumar","year":"2012","journal-title":"J. Chem. Theory Comput."},{"issue":"1242\u20131250","key":"10.1016\/j.bmc.2021.116204_b0220","article-title":"Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors","volume":"25","author":"Li","year":"2017","journal-title":"Structure."},{"key":"10.1016\/j.bmc.2021.116204_b0225","unstructured":"Schr\u00f6dinger Release 2020-4: New York, NY: Schr\u00f6dinger, LLC, 2020."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621002121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621002121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:13:56Z","timestamp":1760836436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621002121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":45,"alternative-id":["S0968089621002121"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116204","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116204","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116204"}}