{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:52:45Z","timestamp":1780361565192,"version":"3.54.1"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010688","name":"Instituto Nacional de Ci\u00eancia e Tecnologia da Criosfera","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["121994\/2019-8"],"award-info":[{"award-number":["121994\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304922\/2018-8"],"award-info":[{"award-number":["304922\/2018-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016179","name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Biodiversidade e Produtos Naturais","doi-asserted-by":"publisher","award":["465637\/2014-0"],"award-info":[{"award-number":["465637\/2014-0"]}],"id":[{"id":"10.13039\/501100016179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["PPM-00255-18"],"award-info":[{"award-number":["PPM-00255-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.bmc.2021.116366","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T18:38:19Z","timestamp":1628879899000},"page":"116366","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic"],"prefix":"10.1016","volume":"46","author":[{"given":"Jacqueline Aparecida","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca Vianna Rodrigues","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Thomaz Nogueira Silva","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Gomes","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5664-7650","authenticated-orcid":false,"given":"Christiane","family":"Contigli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00facia Pinheiro Santos","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116366_b0005","unstructured":"WHO - World Health Organization. Prioritizing diseases for research and development in emergency contexts; 2020. https:\/\/www.who.int\/activities\/prioritizing-diseases-for-research-and-development-in-emergency-contexts. Accessed 3 November 2020."},{"key":"10.1016\/j.bmc.2021.116366_b0010","unstructured":"WHO - World Health Organization. WHO Coronavirus (COVID-19) Dashboard; 2021. https:\/\/covid19.who.int. Accessed 6 July 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0015","unstructured":"WHO - World Health Organization. COVID-19 vaccine tracker and landscape; 2021. https:\/\/www.who.int\/publications\/m\/item\/draft-landscape-of-covid-19-candidate-vaccines. Accessed 6 July 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0020","unstructured":"Craven J. Covid-19 Vaccine Tracker. Regulatory Affairs Professionals Society; 2021. https:\/\/www.raps.org\/news-and-articles\/news-articles\/2020\/3\/covid-19-vaccine-tracker. Accessed 6 July 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0025","unstructured":"WHO - World Health Organization. Status of COVID-19 Vaccines within WHO EUL\/PQ evaluation process; 2021. https:\/\/extranet.who.int\/pqweb\/sites\/default\/files\/documents\/Status_COVID_VAX _20Jan2021_v2.pdf. Accessed 6 July 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0030","unstructured":"WHO - World Health Organization. Q&A Detail\/Coronavirus disease (COVID-19): Vaccines. Is there a vaccine for COVID-19?; 2021. https:\/\/www.who.int\/news-room\/q-a-detail\/coronavirus-disease-(covid-19)-vaccines. Accessed 6 July 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0035","first-page":"1","article-title":"Notable and emerging variants of SARS-CoV-2 virus: a quick glance","author":"Dholariya","year":"2021","journal-title":"Indian J Clin Biochem"},{"key":"10.1016\/j.bmc.2021.116366_b0040","first-page":"4405","article-title":"Evolving biothreat of variant SARS-CoV-2 - molecular properties, virulence and epidemiology","volume":"25","author":"Kannan","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.bmc.2021.116366_b0045","unstructured":"WHO - World Health Organization. Hepatitis; 2019. https:\/\/www.who.int\/health-topics\/hepatitis#tab=tab_1. Accessed 6 July 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0050","first-page":"1","article-title":"Modeling the HIV epidemic: why the 95\u201395-95 target and ART effectiveness parameters matter","volume":"5","author":"Granich","year":"2018","journal-title":"Int J Virol AIDS"},{"key":"10.1016\/j.bmc.2021.116366_b0055","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1007\/s00018-016-2299-6","article-title":"Mechanisms of viral mutation","volume":"73","author":"Sanju\u00e1n","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.bmc.2021.116366_b0060","doi-asserted-by":"crossref","first-page":"S209","DOI":"10.1590\/S0102-311X2001000700031","article-title":"Viroses emergentes e reemergentes","volume":"17","author":"Schatzmayr","year":"2001","journal-title":"Cad Saude Publica"},{"key":"10.1016\/j.bmc.2021.116366_b0065","doi-asserted-by":"crossref","first-page":"584","DOI":"10.4269\/ajtmh.2012.11-0770","article-title":"The history of dengue outbreaks in the Americas","volume":"87","author":"Dick","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.bmc.2021.116366_b0070","doi-asserted-by":"crossref","first-page":"999","DOI":"10.4269\/ajtmh.14-0628","article-title":"Dengue serotype-specific differences in clinical manifestation, laboratory parameters and risk of severe disease in adults, Singapore","volume":"92","author":"Yung","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.bmc.2021.116366_b0075","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.1863-2378.2009.01245.x","article-title":"Re-emergence of West Nile virus in Italy","volume":"57","author":"Monaco","year":"2010","journal-title":"Zoonoses Public Hlth"},{"key":"10.1016\/j.bmc.2021.116366_b0080","unstructured":"WHO - World Health Organization. West Nile virus infections spike in southern and central Europe; 2018. https:\/\/www.euro.who.int\/en\/countries\/italy\/news\/news\/2018\/8\/west-nile-virus-infections-spike-in-southern-and-central-europe. Accessed 11 May 2021."},{"key":"10.1016\/j.bmc.2021.116366_b0085","unstructured":"WHO - World Health Organization. Influenza (Seasonal); 2018. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/influenza-(seasonal). Accessed 3 November 2020."},{"key":"10.1016\/j.bmc.2021.116366_b0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.virusres.2019.02.011","article-title":"Drug repurposing for new, efficient, broad spectrum antivirals","volume":"264","author":"Garc\u00eda-Serradilla","year":"2019","journal-title":"Virus Res"},{"key":"10.1016\/j.bmc.2021.116366_b0095","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1002\/ejoc.201900245","article-title":"Mycophenolic acid: Biogenesis, compound isolation, biological activity, and historical advances in total synthesis","volume":"2019","author":"Halle","year":"2019","journal-title":"European J Org Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0100","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1126\/science.158.3800.537-b","article-title":"Prolongation of life in mice with established Friend Virus Leukemia by inoculation with Sendai virus, interferon, or statolon","volume":"158","author":"Wheelock","year":"1967","journal-title":"Science"},{"key":"10.1016\/j.bmc.2021.116366_b0105","unstructured":"Baranowicz S Prevention and treatment of viral infections. Inventor: Steven Baranowicz. 20 August. Appl: 27 November 2018. United States Patent 10,383,852B2; 2019."},{"key":"10.1016\/j.bmc.2021.116366_b0110","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12015-019-09874-7","article-title":"Targeting of lung cancer stem cell self-renewal pathway by a small molecule verrucarin","volume":"15","author":"Udoh","year":"2019","journal-title":"J Stem Cell Rev Rep"},{"key":"10.1016\/j.bmc.2021.116366_b0115","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.csbj.2020.03.025","article-title":"Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model","volume":"18","author":"Beck","year":"2020","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.bmc.2021.116366_b0120","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.3390\/ijms22041604","article-title":"The ribosome-binding mode of trichothecene mycotoxins rationalizes their structure-activity relationships","volume":"22","author":"Wang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2021.116366_b0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1248\/cpb.c15-00525","article-title":"Cristazine, a new cytotoxic dioxopiperazine alkaloid from the mudflat-sediment-derived fungus Chaetomium cristatum","volume":"64","author":"Yun","year":"2016","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.bmc.2021.116366_b0130","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.bmcl.2012.11.087","article-title":"Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification","volume":"23","author":"Fujishiro","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2021.116366_b0135","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1021\/acs.joc.9b03371","article-title":"Synthesis of potent cytotoxic epidithiodiketopiperazines designed for derivatization","volume":"85","author":"Olsson","year":"2020","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0140","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/S0140-6736(20)30920-X","article-title":"SARS-CoV-2 and viral sepsis: observations and hypotheses","volume":"395","author":"Li","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2021.116366_b0145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/d41586-020-01444-z","article-title":"The sprint to solve coronavirus protein structures - and disarm them with drugs","volume":"581","author":"Scudellari","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2021.116366_b0150","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jmii.2020.03.022","article-title":"Genotype and phenotype of Covid-19: their roles in pathogenesis","volume":"54","author":"Mousavizadeh","year":"2021","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.bmc.2021.116366_b0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2021.116366_b0160","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biochi.2020.04.008","article-title":"Renin-angiotensin system at the heart of Covid-19 pandemic","volume":"174","author":"Alifano","year":"2020","journal-title":"Biochimie"},{"key":"10.1016\/j.bmc.2021.116366_b0165","article-title":"Genomic characterization of a novel SARS-CoV-2","volume":"19","author":"Khailany","year":"2020","journal-title":"Gene Rep"},{"key":"10.1016\/j.bmc.2021.116366_b0170","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41586-020-2223-y","article-title":"Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors","volume":"582","author":"Jin","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2021.116366_b0175","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41579-020-00468-6","article-title":"Coronavirus biology and replication: implications for SARS-CoV-2","volume":"19","author":"V\u2019kovski","year":"2021","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmc.2021.116366_b0180","doi-asserted-by":"crossref","unstructured":"Bagga S, Bouchard MJ. Cell cycle regulation during viral infection. In: Noguchi E, Gadaleta MC, editors. Cell cycle control: mechanisms and protocols. New York: Springer; 2014:165\u2013227. doi:10.1007\/978-1-4939-0888-2_10.","DOI":"10.1007\/978-1-4939-0888-2_10"},{"key":"10.1016\/j.bmc.2021.116366_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25081800","article-title":"Natural bioactive compounds from fungi as potential candidates for protease inhibitors and immunomodulators to apply for coronaviruses","volume":"25","author":"Suwannarach","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116366_b0190","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","article-title":"Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved \u03b1-ketoamide inhibitors","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bmc.2021.116366_b0195","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/CMR.00102-15","article-title":"Approved antiviral drugs over the past 50 years","volume":"29","author":"De Clercq","year":"2016","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2021.116366_b0200","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/ejoc.201001073","article-title":"Modeling and spectroscopic studies of synthetic diazabicyclo analogs of the HIV-1 inhibitor BMS-378806 and evaluation of their antiviral activity","author":"Legnani","year":"2011","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0205","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2217\/fvl.11.2","article-title":"Maraviroc: the first chemokine coreceptor 5 inhibitor","volume":"6","author":"Norton","year":"2011","journal-title":"Future Virol"},{"key":"10.1016\/j.bmc.2021.116366_b0210","doi-asserted-by":"crossref","first-page":"290ra89","DOI":"10.1126\/scitranslmed.aaa5597","article-title":"A screen of approved drugs and molecular probes identifies therapeutics with anti-Ebola virus activity","volume":"7","author":"Johansen","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bmc.2021.116366_b0215","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.4065\/mcp.2011.0309","article-title":"Antiviral drugs for viruses other than human immunodeficiency virus","volume":"86","author":"Razonable","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.bmc.2021.116366_b0220","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1073\/pnas.89.12.5286","article-title":"Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event","volume":"89","author":"De Clercq","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bmc.2021.116366_b0225","first-page":"12","article-title":"Doravine: Researchers DRIVE for a drug ahead of its class","volume":"4","author":"De Rose","year":"2019","journal-title":"Contagion"},{"key":"10.1016\/j.bmc.2021.116366_b0230","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1039\/D0CS01084G","article-title":"Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses","volume":"50","author":"Ma","year":"2021","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.bmc.2021.116366_b0235","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.coph.2020.09.017","article-title":"Recent discoveries in HIV-1 reverse transcriptase inhibitors","volume":"54","author":"Gu","year":"2020","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.bmc.2021.116366_b0240","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.3390\/molecules25081800","article-title":"Natural bioactive compounds from fungi as potential candidates for protease inhibitors and immunomodulators to apply for coronaviruses","volume":"25","author":"Suwannarach","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116366_b0245","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1016\/j.jksus.2020.07.007","article-title":"Structure-based virtual screening of phytochemicals and repurposing of FDA approved antiviral drugs unravels lead molecules as potential inhibitors of coronavirus 3C-like protease enzyme","volume":"32","author":"Bahadur","year":"2020","journal-title":"J King Saud Univ Sci"},{"key":"10.1016\/j.bmc.2021.116366_b0250","article-title":"Using integrated computational approaches to identify safe and rapid treatment for SARS-CoV-2","author":"Al-Khafaji","year":"2020","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.bmc.2021.116366_b0255","first-page":"1","article-title":"A simplified quantitative real-time PCR assay for monitoring SARS-CoV-2 growth in cell culture","volume":"5","author":"Mugisha","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.bmc.2021.116366_b0260","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aal3653","article-title":"Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses","volume":"9","author":"Sheahan","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.bmc.2021.116366_b0265","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/631642","article-title":"Antiviral perspectives for Chikungunya virus","volume":"2014","author":"Parashar","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.bmc.2021.116366_b0270","series-title":"In silico identification of clinically approved medicines against the main protease of SARS-CoV-2, causative agent of Covid-19","author":"Mamidala","year":"2020"},{"key":"10.1016\/j.bmc.2021.116366_b0275","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0280","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1021\/np900116m","article-title":"Breviane spiroditerpenoids from an extreme-tolerant Penicillium sp. isolated from a deep-sea sediment sample","volume":"72","author":"Li","year":"2009","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0285","doi-asserted-by":"crossref","first-page":"8854","DOI":"10.1021\/ja202874d","article-title":"Enantiocontrolled total syntheses of breviones A, B, and C","volume":"133","author":"Yokoe","year":"2011","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2021.116366_b0290","doi-asserted-by":"crossref","first-page":"10996","DOI":"10.1021\/acs.jmedchem.8b00876","article-title":"From oxiranes to oligomers: Architectures of U.S. FDA approved pharmaceuticals containing oxygen heterocycles","volume":"61","author":"Delost","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0295","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1039\/D0QO01421D","article-title":"Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products","volume":"8","author":"Thorat","year":"2021","journal-title":"Org Chem Front"},{"key":"10.1016\/j.bmc.2021.116366_b0300","doi-asserted-by":"crossref","unstructured":"Wu G, Sun X, Y G., et al. Cladosins A\u2013E, hybrid polyketides from a deep-sea-derived fungus, Cladosporium sphaerospermum. J Nat Prod. 2014;77:270\u201375. doi: 10.1021\/np400833x.","DOI":"10.1021\/np400833x"},{"key":"10.1016\/j.bmc.2021.116366_b0305","doi-asserted-by":"crossref","first-page":"11571","DOI":"10.1021\/acs.joc.0c01605","article-title":"Total synthesis of cladosins B and C","volume":"85","author":"Reber","year":"2020","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0310","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.1021\/acs.orglett.9b01017","article-title":"Antiviral meroterpenoid rhodatin and sesquiterpenoids rhodocoranes A-E from the wrinkled peach mushroom, Rhodotus palmatus","volume":"21","author":"Sandargo","year":"2019","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2021.116366_b0315","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/np200766d","article-title":"Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived Alternaria sp. Fungus","volume":"75","author":"Zheng","year":"2012","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0320","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.fitote.2016.05.013","article-title":"Antiviral anthraquinones and azaphilones produced by an endophytic fungus Nigrospora sp. from Aconitum carmichaeli","volume":"112","author":"Zhang","year":"2016","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmc.2021.116366_b0325","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.phytol.2018.11.005","article-title":"A new antiviral 14-nordrimane sesquiterpenoid from an endophytic fungus Phoma sp","volume":"29","author":"Liu","year":"2019","journal-title":"Phytochem Lett"},{"key":"10.1016\/j.bmc.2021.116366_b0330","doi-asserted-by":"crossref","first-page":"104573","DOI":"10.1016\/j.fitote.2020.104573","article-title":"New azaphilones, phomopsones A-C with biological activities from an endophytic fungus Phomopsis sp. CGMCC No.5416","volume":"145","author":"Yang","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmc.2021.116366_b0335","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1021\/acs.jnatprod.9b01169","article-title":"Carneic acids from an endophytic Phomopsis sp. as Dengue virus polymerase inhibitors","volume":"83","author":"Peyrat","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0340","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1021\/acs.jnatprod.5b00650","article-title":"Antiviral merosesquiterpenoids produced by the antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702","volume":"79","author":"Wang","year":"2016","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0345","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.3390\/molecules24152821","article-title":"Broad-spectrum antiviral natural products from the marine-derived Penicillium sp. IMB17-046","volume":"24","author":"Li","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116366_b0350","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s41182-017-0072-7","article-title":"Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses","volume":"45","author":"Raekiansyah","year":"2017","journal-title":"Trop Med Health"},{"key":"10.1016\/j.bmc.2021.116366_b0355","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/md16070229","article-title":"Polyketides and alkaloids from the marine-derived fungus Dichotomomyces cejpii F31\u20131 and the antiviral activity of scequinadoline A against Dengue virus","volume":"16","author":"Wu","year":"2018","journal-title":"Mar Drugs"},{"key":"10.1016\/j.bmc.2021.116366_b0360","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1021\/acs.orglett.7b02238","article-title":"Amino acid-directed strategy for inducing the marine-derived fungus Scedosporium apiospermum F41\u20131 to Maximize Alkaloid Diversity","volume":"19","author":"Huang","year":"2017","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2021.116366_b0365","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/molecules21010034","article-title":"Asteltoxins with antiviral activities from the marine sponge-derived fungus Aspergillus sp. SCSIO XWS02F40","volume":"21","author":"Tian","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116366_b0370","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.fitote.2019.03.031","article-title":"Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301","volume":"135","author":"Liu","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmc.2021.116366_b0375","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.phytochem.2018.07.017","article-title":"Truncateols O-V, further isoprenylated cyclohexanols from the sponge-associated fungus Truncatella angustata with antiviral activities","volume":"155","author":"Zhao","year":"2018","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2021.116366_b0380","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1021\/acs.jnatprod.0c00717","article-title":"L-tryptophan induces a marine-derived Fusarium sp. to produce indole alkaloids with activity against the Zika virus","volume":"83","author":"Guo","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0385","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.celrep.2017.03.071","article-title":"The natural product cavinafungin selectively interferes with Zika and Dengue virus replication by inhibition of the host signal peptidase","volume":"19","author":"Estoppey","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.bmc.2021.116366_b0390","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/np500854j","article-title":"Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola","volume":"78","author":"Ort\u00edz-L\u00f3pez","year":"2015","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0395","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.fitote.2019.02.015","article-title":"Cytotoxic, antimicrobial and antiviral secondary metabolites produced by the plant pathogenic fungus Cytospora sp. CCTU A309","volume":"134","author":"Narmani","year":"2019","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmc.2021.116366_b0400","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1021\/acs.jafc.7b01238","article-title":"Antifungal and antiviral cyclic peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020","volume":"65","author":"Liang","year":"2017","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0405","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1081\/AL-120013045","article-title":"Determination of lead in drinking water by icp-aes with ultrasonic nebulization and flow-injection on-line preconcentration using an amberlite xad-16 resin","volume":"35","author":"Wuilloud","year":"2002","journal-title":"Anal Lett"},{"key":"10.1016\/j.bmc.2021.116366_b0410","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fbioe.2019.00420","article-title":"Recent developments in bioprocessing of recombinant proteins: expression hosts and process development","volume":"7","author":"Tripathi","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.bmc.2021.116366_b0415","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/jof6030140","article-title":"Exploring the antibacterial activity of Pestalotiopsis spp. under different culture conditions and their chemical diversity using LC-ESI-Q-TOF-MS","volume":"6","author":"Aguilar-P\u00e9rez","year":"2020","journal-title":"J Fungi"},{"key":"10.1016\/j.bmc.2021.116366_b0420","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3390\/jof3030034","article-title":"Production and new extraction method of polyketide red pigments produced by ascomycetous fungi from terrestrial and marine habitats","volume":"3","author":"Lebeau","year":"2017","journal-title":"J Fungi"},{"key":"10.1016\/j.bmc.2021.116366_b0425","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1021\/acs.jnatprod.7b00737","article-title":"Bioactivity-based molecular networking for the discovery of drug leads in natural product bioassay-guided fractionation","volume":"81","author":"Nothias","year":"2018","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2021.116366_b0430","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/17460441.2019.1560261","article-title":"Novel antiviral drug discovery strategies to tackle drug-resistant mutants of influenza virus strains","volume":"14","author":"Shin","year":"2019","journal-title":"Expert Opin Drug Discov"},{"key":"10.1016\/j.bmc.2021.116366_b0435","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.drudis.2019.03.011","article-title":"Organ-on-a-chip technology: turning its potential for clinical benefit into reality","volume":"24","author":"Haddrick","year":"2019","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2021.116366_b0440","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1089\/ten.tea.2019.0251","article-title":"Global trends of organoid and organ-on-a-chip in the past decade: a bibliometric and comparative study","volume":"26","author":"Wang","year":"2020","journal-title":"Tissue Eng Part A"},{"key":"10.1016\/j.bmc.2021.116366_b0445","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1006\/abio.2000.4903","article-title":"Fluorescence-based DNA polymerase assay","volume":"289","author":"Tveit","year":"2001","journal-title":"Anal Biochem"},{"key":"10.1016\/j.bmc.2021.116366_b0450","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/CS20050086","article-title":"Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis","volume":"109","author":"Bustin","year":"2005","journal-title":"Clin Sci"},{"key":"10.1016\/j.bmc.2021.116366_b0455","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.bpj.2018.02.038","article-title":"Ensemble docking in drug discovery","volume":"114","author":"Amaro","year":"2018","journal-title":"Biophys J"},{"key":"10.1016\/j.bmc.2021.116366_b0460","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1002\/ejoc.201403678","article-title":"Armochaetoglobins K-R, anti-HIV pyrrole-based cytochalasans from Chaetomium globosum TW1-1","volume":"14","author":"Chen","year":"2015","journal-title":"Eur J Org Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0465","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejmech.2015.02.006","article-title":"Neoechinulin B and its analogues as potential entry inhibitors of influenza viruses, targeting viral hemagglutinin","volume":"93","author":"Chen","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.tetlet.2019.151307","article-title":"Concise, stereocontrolled and modular syntheses of the anti-influenza rubrolides R and S","volume":"60","author":"Moreira","year":"2019","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.bmc.2021.116366_b0475","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3390\/molecules24030481","article-title":"A spotlight on viruses-application of click chemistry to visualize virus-cell interactions","volume":"24","author":"M\u00fcller","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116366_b0480","doi-asserted-by":"crossref","first-page":"40264","DOI":"10.1039\/D0RA06038K","article-title":"Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro","volume":"10","author":"Balaramnavar","year":"2020","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2021.116366_b0485","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1039\/D0MD00288G","article-title":"Indole \u2013 a promising pharmacophore in recent antiviral drug discovery","volume":"11","author":"Dorababu","year":"2020","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0490","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/363418a0","article-title":"Rational design of potent sialidase-based inhibitors of influenza virus replication","volume":"363","author":"von Itzstein","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2021.116366_b0495","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1021\/jm9704098","article-title":"Viracept (Nelfinavir Mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease","volume":"40","author":"Kaldor","year":"1997","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0500","doi-asserted-by":"crossref","DOI":"10.3390\/md18120633","article-title":"A computer-aided drug design approach to predict marine drug-like leads for SARS-CoV-2 main protease inhibition","volume":"18","author":"Gaud\u00eancio","year":"2020","journal-title":"Mar Drugs"},{"key":"10.1016\/j.bmc.2021.116366_b0505","first-page":"1","article-title":"Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3CLpro of novel coronavirus SARS-CoV-2 identified using docking and molecular dynamics","author":"Rao","year":"2020","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.bmc.2021.116366_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2020.106425","article-title":"Reckoning a fungal metabolite, pyranonigrin A as a potential main protease (Mpro) inhibitor of novel SARS-CoV-2 virus identified using docking and molecular dynamics simulation","volume":"264","author":"Rao","year":"2020","journal-title":"Biophys Chem"},{"key":"10.1016\/j.bmc.2021.116366_b0515","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1021\/acs.jcim.0c01010","article-title":"Supercomputer-based ensemble docking drug discovery pipeline with application to Covid-19","volume":"60","author":"Acharya","year":"2020","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2021.116366_b0520","doi-asserted-by":"crossref","first-page":"359","DOI":"10.6026\/97320630012368","article-title":"Docking-based virtual screening of known drugs against murE of Mycobacterium tuberculosis towards repurposing for TB","volume":"12","author":"Brindha","year":"2016","journal-title":"Bioinformation"},{"key":"10.1016\/j.bmc.2021.116366_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173430","article-title":"In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2","volume":"886","author":"Deshpande","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bmc.2021.116366_b0530","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e04642","article-title":"Virtual screening, molecular docking studies and DFT calculations of FDA approved compounds similar to the non-nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz","volume":"6","author":"Jordaan","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.bmc.2021.116366_b0535","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/cbdd.13812","article-title":"Repurposing potential of FDA-approved and investigational drugs for COVID-19 targeting SARS-CoV-2 spike and main protease and validation by machine learning algorithm","volume":"97","author":"Verma","year":"2021","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2021.116366_b0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173648","article-title":"ADMET profile and virtual screening of plant and microbial natural metabolites as SARS-CoV-2 S1 glycoprotein receptor binding domain and main protease inhibitors","volume":"890","author":"Padhi","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bmc.2021.116366_b0545","article-title":"a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against Covid-19","volume":"1\u20138","author":"Cordycepin","year":"2020","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.bmc.2021.116366_b0550","first-page":"1","article-title":"Virtual screening-driven drug discovery of SARS-CoV2 enzyme inhibitors targeting viral attachment, replication, post-translational modification and host immunity evasion infection mechanisms","author":"Quimque","year":"2020","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.bmc.2021.116366_b0555","article-title":"Flavonoids and nucleotide analogs show high affinity for viral proteins of SARS-CoV-2 by in silico analysis: New candidates for the treatment of Covid-19","author":"De Jes\u00fas-Gonz\u00e1lez","year":"2021","journal-title":"Res Sq"},{"key":"10.1016\/j.bmc.2021.116366_b0560","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jtcme.2020.12.002","article-title":"Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: an in silico approach","volume":"11","author":"Rangsinth","year":"2021","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.bmc.2021.116366_b0565","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/sj.bjp.0706972","article-title":"Ergosterol peroxide from an edible mushroom suppresses inflammatory responses in RAW264.7 macrophages and growth of HT29 colon adenocarcinoma cells","volume":"150","author":"Kobori","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2021.116366_b0570","unstructured":"Porter J, Eyberger A. Endophytes for production of podophyllotoxin. Unites States Patent US20040248265A1, 09 Dec 2004; 2004."},{"key":"10.1016\/j.bmc.2021.116366_b0575","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4172\/2324-8955.1000138","article-title":"Cordycepin, an adenosine analogue executes anti rotaviral effect by stimulating induction of type I interferon","volume":"4","author":"Chanda","year":"2015","journal-title":"J Virol Antivir Res"},{"key":"10.1016\/j.bmc.2021.116366_b0580","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.ijbiomac.2020.07.235","article-title":"Structural stability of SARS-CoV-2 3CLpro and identification of quercetin as an inhibitor by experimental screening","volume":"164","author":"Abian","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.bmc.2021.116366_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2021.104909","article-title":"Discovery of naturally occurring inhibitors against SARS-CoV-2 3CLpro from Ginkgo biloba leaves via large-scale screening","volume":"152","author":"Xiong","year":"2021","journal-title":"Fitoterapia"},{"key":"10.1016\/j.bmc.2021.116366_b0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110252","article-title":"Ergosterol ameliorates renal inflammatory responses in mice model of diabetic nephropathy","volume":"128","author":"Liu","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmc.2021.116366_b0595","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12950-021-00268-6","article-title":"Anti-inflammatory potential of Quercetin in Covid-19 treatment","volume":"18","author":"Saeedi-Boroujeni","year":"2021","journal-title":"J Inflamm"},{"key":"10.1016\/j.bmc.2021.116366_b0600","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/FJC.0000000000001000","article-title":"Quercetin efficiently alleviates TNF-\u03b1-stimulated injury by signal transducer and activator of transcription 1 and mitogen-activated protein kinase pathway in H9c2 Cells: a protective role of quercetin in myocarditis","volume":"77","author":"Yang","year":"2021","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621003746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621003746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:50:09Z","timestamp":1778791809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621003746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":120,"alternative-id":["S0968089621003746"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116366","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116366","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116366"}}