{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:34:35Z","timestamp":1791660875099,"version":"4.3.4"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"am","delay-in-days":347,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1664577"],"award-info":[{"award-number":["1664577"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21CA228997"],"award-info":[{"award-number":["R21CA228997"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bmc.2021.116400","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T04:10:18Z","timestamp":1631074218000},"page":"116400","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Chemiluminescent probe for the detection of inverse electron demand Diels-Alder reaction between tetrazine and trans-Cyclooctene"],"prefix":"10.1016","volume":"47","author":[{"given":"Kui","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2930-2171","authenticated-orcid":false,"given":"Maksim","family":"Royzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116400_b0005","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nmat3758","volume":"12","author":"Kearney","year":"2013","journal-title":"Nat Mater"},{"key":"10.1016\/j.bmc.2021.116400_b0010","doi-asserted-by":"crossref","first-page":"9762","DOI":"10.1073\/pnas.1405469111","volume":"111","author":"Huebsch","year":"2014","journal-title":"Proceedings of the Nat Acad Sci"},{"key":"10.1016\/j.bmc.2021.116400_b0015","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1021\/ar200084x","volume":"44","author":"Tassa","year":"2011","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.bmc.2021.116400_b0020","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1021\/jacs.5b09974","volume":"138","author":"Tibbitt","year":"2016","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2021.116400_b0025","volume":"4","author":"Srinivasan","year":"2021","journal-title":"Adv Ther"},{"key":"10.1016\/j.bmc.2021.116400_b0030","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1039\/D0SC06099B","volume":"12","author":"Wu","year":"2021","journal-title":"Chem Sci"},{"key":"10.1016\/j.bmc.2021.116400_b0035","doi-asserted-by":"crossref","first-page":"9033","DOI":"10.1002\/anie.201804816","volume":"57","author":"Gnaim","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116400_b0040","first-page":"949","volume":"5","author":"Hananya","year":"2019","journal-title":"Sci"},{"key":"10.1016\/j.bmc.2021.116400_b0045","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/anie.201813032","volume":"58","author":"Son","year":"2019","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116400_b0050","doi-asserted-by":"crossref","first-page":"7508","DOI":"10.1002\/anie.201802143","volume":"57","author":"Bruemmer","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116400_b0055","doi-asserted-by":"crossref","first-page":"13438","DOI":"10.1021\/jacs.6b09173","volume":"138","author":"Hananya","year":"2016","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2021.116400_b0060","doi-asserted-by":"crossref","first-page":"14112","DOI":"10.1002\/anie.201305969","volume":"52","author":"Versteegen","year":"2013","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116400_b0065","doi-asserted-by":"crossref","first-page":"10494","DOI":"10.1002\/anie.201800402","volume":"57","author":"Versteegen","year":"2018","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2021.116400_b0070","first-page":"349","volume":"3","author":"Green","year":"2017","journal-title":"Sci"},{"key":"10.1016\/j.bmc.2021.116400_b0075","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1021\/jacs.7b11217","volume":"140","author":"Carlson","year":"2018","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2021.116400_b0080","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1002\/chem.201905446","volume":"26","author":"de Geus","year":"2020","journal-title":"Chemistry"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621004089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621004089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:15:57Z","timestamp":1760836557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621004089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":16,"alternative-id":["S0968089621004089"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116400","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemiluminescent probe for the detection of inverse electron demand Diels-Alder reaction between tetrazine and trans-Cyclooctene","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116400","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116400"}}