{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:30Z","timestamp":1787775690258,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.bmc.2021.116417","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T14:15:03Z","timestamp":1632147303000},"page":"116417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["In vitro, ex vivo and in vivo short-term screening of DHEA nitrate derivatives activity over Trypanosoma cruzi Ninoa and TH strains from Oaxaca State, M\u00e9xico"],"prefix":"10.1016","volume":"48","author":[{"given":"Luis Roberto","family":"Dom\u00ednguez-D\u00edaz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma.","family":"Eugenia Ochoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Soto-Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norberto","family":"Farf\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maricela","family":"Morales-Chamorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian","family":"Y\u00e9pez-Mulia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Santillan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Moreno-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2021.116417_b0005","unstructured":"WHO; 2020. Available from: https:\/\/www.who.int\/health-topics\/chagas-disease#tab=tab_1."},{"key":"10.1016\/j.bmc.2021.116417_b0010","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"The Lancet"},{"key":"10.1016\/j.bmc.2021.116417_b0015","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3389\/fpubh.2019.00166","article-title":"Chagas disease: from discovery to a worldwide health problem","volume":"7","author":"Lidani","year":"2019","journal-title":"Front Public Health"},{"key":"10.1016\/j.bmc.2021.116417_b0020","unstructured":"Manual_de_Procedimientos_para_la_Enfermedad_de_Chagas_en_Mexico; 2019. From: https:\/\/www.gob.mx\/cms\/uploads\/attachment\/file\/447946\/Manual_de_Procedimientos_para_la_Enfermedad_de_Chagas_en_Mexico.pdf."},{"key":"10.1016\/j.bmc.2021.116417_b0025","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1191\/0960327106het653oa","article-title":"Toxic side effects of drugs used to treat Chagas\u2019 disease (American trypanosomiasis)","volume":"25","author":"Castro","year":"2006","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.bmc.2021.116417_b0030","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0035-9203(87)90020-4","article-title":"Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease","volume":"81","author":"Filardi","year":"1987","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.bmc.2021.116417_b0035","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.3390\/molecules24203800","article-title":"A Nature-Inspired Design Yields a New Class of Steroids Against Trypanosomatids","volume":"24","author":"Aguilera","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116417_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105906","article-title":"Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review","volume":"55","author":"Santos","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.bmc.2021.116417_b0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1128\/CDLI.5.2.251-253.1998","article-title":"Dehydroepiandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni","volume":"5","author":"Fallon","year":"1998","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.bmc.2021.116417_b0050","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1034\/j.1600-0463.2003.1110205.x","article-title":"The relationships between dehydroepiandrosterone sulphate (DHEAS), the intensity of Schistosoma mansoni infection and parasite-specific antibody responses. A cross-sectional study in residents of endemic communities in north-east Ethiopia","volume":"111","author":"Abebe","year":"2003","journal-title":"Apmis"},{"key":"10.1016\/j.bmc.2021.116417_b0055","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1086\/317919","article-title":"Altered levels of hypothalamic-pituitary-adrenocortical axis hormones in baboons and mice during the course of infection with Schistosoma mansoni","volume":"183","author":"Morales-Montor","year":"2001","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmc.2021.116417_b0060","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2307\/3283826","article-title":"Effects of dehydroepiandrosterone in immunossupressed adult mice infected with Cryptosporidium parvum","volume":"81","author":"Rasmussen","year":"1995","journal-title":"J Parasitol"},{"key":"10.1016\/j.bmc.2021.116417_b0065","doi-asserted-by":"crossref","first-page":"908","DOI":"10.26719\/2000.6.5-6.908","article-title":"Coccidial infection in immunosuppressed mice: prophylaxis and treatment with dehydroepiandrosterone","volume":"6","author":"Khalifa","year":"2000","journal-title":"East Mediterr Health J"},{"key":"10.1016\/j.bmc.2021.116417_b0070","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1086\/376508","article-title":"Dehydroepiandrosterone sulfate levels associated with decreased malaria parasite density and increased hemoglobin concentration in pubertal girls from western Kenya","volume":"188","author":"Leenstra","year":"2003","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmc.2021.116417_b0075","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actatropica.2005.05.005","article-title":"Trypanosoma cruzi: the effects of dehydroepiandrosterone (DHEA) treatment during experimental infection","volume":"95","author":"Santos","year":"2005","journal-title":"Acta Trop"},{"key":"10.1016\/j.bmc.2021.116417_b0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.actatropica.2007.04.010","article-title":"Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats","volume":"102","author":"Santos","year":"2007","journal-title":"Acta Trop"},{"key":"10.1016\/j.bmc.2021.116417_b0085","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.vetpar.2008.01.039","article-title":"Dehydroepiandrosterone increases resistance to experimental infection by Trypanosoma cruzi","volume":"153","author":"Santos","year":"2008","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.bmc.2021.116417_b0090","series-title":"Chapter 4 DHEA Modulates Immune Function: A Review of Evidence Vitamins and Hormones","author":"Prall","year":"2018"},{"key":"10.1016\/j.bmc.2021.116417_b0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.actatropica.2007.04.010","article-title":"Dehydroepiandrosterone affects Trypanosoma cruzi tissue parasite burdens in rats","volume":"102","author":"Domingues Santos","year":"2007","journal-title":"Acta Trop"},{"issue":"5","key":"10.1016\/j.bmc.2021.116417_b0100","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.imbio.2009.05.005","article-title":"Immunomodulatory effects of zinc and DHEA on the Th-1 immune response in rats infected with Trypanosoma cruzi.","volume":"215","author":"Braz\u00e3o","year":"2010","journal-title":"Immunobiology"},{"key":"10.1016\/j.bmc.2021.116417_b0105","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3390\/molecules21030368","article-title":"Binding mode and selectivity of steroids towards glucose-6-phosphate dehydrogenase from the pathogen Trypanosoma cruzi","volume":"21","author":"Ortiz","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2021.116417_b0110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molbiopara.2010.12.006","article-title":"Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids","volume":"176","author":"Gupta","year":"2011","journal-title":"Mol Biochem Parasitol"},{"key":"10.1016\/j.bmc.2021.116417_b0115","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1177\/1087057114546896","article-title":"Discovery of New Uncompetitive Inhibitors of Glucose-6-Phosphate Dehydrogenase","volume":"19","author":"Mercaldi","year":"2014","journal-title":"J Biomol Screen"},{"key":"10.1016\/j.bmc.2021.116417_b0120","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1016\/j.bmc.2010.05.008","article-title":"16-Bromoepiandrosterone, an activator of the mammalian immune system, inhibits glucose 6-phosphate dehydrogenase from Trypanosoma cruzi and is toxic to these parasites grown in culture","volume":"18","author":"Cordeiro","year":"2010","journal-title":"Bioorgan Med Chem"},{"key":"10.1016\/j.bmc.2021.116417_b0125","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/cr000040l","article-title":"Nitric oxide donors: chemical activities and biological applications","volume":"102","author":"Wang","year":"2002","journal-title":"Chem Rev"},{"key":"10.1016\/j.bmc.2021.116417_b0130","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1021\/jm00130a014","article-title":"11\u03b2-Nitrate Estrane Analogues: Potent Estrogens","volume":"32","author":"Peters","year":"1989","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2021.116417_b0135","doi-asserted-by":"crossref","first-page":"6909","DOI":"10.1021\/acs.orglett.9b02522","article-title":"Preparation of Organic Nitrates from Aryldiazoacetates and Fe (NO3)3 9H2O","volume":"21","author":"Thurow","year":"2019","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2021.116417_b0140","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/j.ejmech.2011.02.029","article-title":"Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria","volume":"46","author":"Bertinaria","year":"2011","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.116417_b0145","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.vetpar.2009.03.053","article-title":"Trypanosoma cruzi: dehydroepiandrosterone (DHEA) and immune response during the chronic phase of the experimental Chagas\u2019 disease","volume":"163","author":"Caetano","year":"2009","journal-title":"Vet Parasitol"},{"key":"10.1016\/j.bmc.2021.116417_b0150","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1021\/jo971731t","article-title":"Highly Enantioselective Ring Opening of Cyclic Meso-Anhydrides to Isopropyl Hemiesters with Ti-TADDOLates: An Alternative to Hydrolytic Enzymes","volume":"63","author":"Jaeschke","year":"1998","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2021.116417_b0155","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/0008-6215(90)84248-S","article-title":"Synthesis of some sugar nitrates","volume":"201","author":"Leicach","year":"1990","journal-title":"Carbohydr Res"},{"key":"10.1016\/j.bmc.2021.116417_b0160","article-title":"Synthesis, characterization and in silico screening of potential biological activity of 17\u03b1-ethynyl-3\u03b2, 17\u03b2, 19-trihydroxyandrost-5-en acetylated derivatives","volume":"1225","author":"Ochoa","year":"2020","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmc.2021.116417_b0165","unstructured":"NOM-062-ZOO-1999. Available from: https:\/\/www.gob.mx\/cms\/uploads\/attachment\/file\/203498\/NOM-062-ZOO-1999_220801.pdf."},{"key":"10.1016\/j.bmc.2021.116417_b0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ejmech.2014.09.027","article-title":"In Vitro Antiparasitic Activity of New Thiosemicarbazones in Strains of Trypanosoma Cruzi","volume":"87","author":"Moreno-Rodr\u00edguez","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2021.116417_b0175","doi-asserted-by":"crossref","first-page":"8809","DOI":"10.3390\/ijms21228809","article-title":"Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning","volume":"21","author":"Adasme","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2021.116417_b0180","first-page":"389","article-title":"Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi","volume":"4","author":"Brener","year":"1962","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"10.1016\/j.bmc.2021.116417_b0185","first-page":"51","article-title":"Mexican Trypanosoma cruzi T. cruzi i strains with different degrees of virulence induce diverse humoral and cellular immune responses in a murine experimental infection model","author":"Espinoza","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.bmc.2021.116417_b0190","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1590\/S0074-02761984000200008","article-title":"A rapid method for testing in vivo the susceptibility of different strains of Trypanosoma cruzi to active chemotherapeutic agents","volume":"79","author":"Filardi","year":"1984","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.bmc.2021.116417_b0195","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.actatropica.2011.12.009","article-title":"In vitro and in vivo trypanocidal activity of some benzimidazole derivatives against two strains of Trypanosoma cruzi","volume":"122","author":"D\u00edaz-Chiguer","year":"2012","journal-title":"Acta trop"},{"key":"10.1016\/j.bmc.2021.116417_b0200","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1139\/v78-510","article-title":"13C nuclear magnetic resonance spectra of some C-19-hydroxy, C-5,6 epoxy, C-24 ethyl, and C-19-norsteroids","volume":"56","author":"Herbert","year":"1978","journal-title":"Can J Chem"},{"key":"10.1016\/j.bmc.2021.116417_b0205","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1016\/S0031-9422(98)00312-4","article-title":"The hydroxylation of \u03945-androstenes by Cephalosporium aphidicola","volume":"49","author":"Bensasson","year":"1998","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2021.116417_b0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijrobp.2018.08.002","article-title":"17\u03b1-Ethinyl-androst-5-ene-3\u03b2, 17\u03b2-diol, a Novel Potent Oral Radioprotective Agent, Confers Radioprotection of Hematopoietic Stem and Progenitor Cells in a Granulocyte Colony-Stimulating Factor-Independent Manner","volume":"103","author":"Bai","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.bmc.2021.116417_b0220","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jsbmb.2008.06.016","article-title":"Steroidogenic capacity of Trypanosoma cruzi trypomastigotes","volume":"111","author":"Vacchina","year":"2008","journal-title":"J Steroid Biochem Mol Biol"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621004259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089621004259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:15:22Z","timestamp":1760836522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089621004259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":43,"alternative-id":["S0968089621004259"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116417","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In vitro, ex vivo and in vivo short-term screening of DHEA nitrate derivatives activity over Trypanosoma cruzi Ninoa and TH strains from Oaxaca State, M\u00e9xico","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2021.116417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116417"}}