{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:41:05Z","timestamp":1760838065415,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["17K08225","18F18412","20 K05712"],"award-info":[{"award-number":["17K08225","18F18412","20 K05712"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010795","name":"Tokyo Ohka Foundation for The Promotion of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011313","name":"Tokyo Biochemical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.bmc.2022.116764","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T02:04:01Z","timestamp":1652061841000},"page":"116764","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors"],"prefix":"10.1016","volume":"67","author":[{"given":"Hidetoshi","family":"Satoh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Saga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shohei","family":"Ujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyu","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Nishiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kasumi","family":"Tada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Deguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiya","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Hosoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Morita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2022.116764_b0005","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/nrd4003","article-title":"Strategies for optimizing the response of cancer and normal tissues to radiation","volume":"12","author":"Moding","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2022.116764_h0010","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/med.21386","article-title":"Radioprotective agents: strategies and translational advances","volume":"36","author":"Kamran","year":"2016","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2022.116764_h0015","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s12272-018-1083-6","article-title":"Pharmacology of natural radioprotectors","volume":"41","author":"Mum","year":"2018","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2022.116764_b0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/biomedicines8110461","article-title":"Radioprotection and radiomitigation: from the bench to clinical practice","volume":"8","author":"Obrador","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/j.bmc.2022.116764_b0020","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.285.5434.1733","article-title":"A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy","volume":"285","author":"Komarov","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bmc.2022.116764_h0030","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1021\/jm0495935","article-title":"Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles","volume":"48","author":"Arienti","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2022.116764_h0035","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature05077","article-title":"The pathological response to DNA damage does not contribute to p53-mediated tumour suppression","volume":"443","author":"Christophorou","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2022.116764_h0040","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05541","article-title":"Restoration of p53 function leads to tumor regression in vivo","volume":"445","author":"Ventura","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2022.116764_h0045","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cell.2012.04.026","article-title":"Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence","volume":"149","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2022.116764_h0050","doi-asserted-by":"crossref","first-page":"8566","DOI":"10.1038\/srep08566","article-title":"Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation","volume":"5","author":"Wang","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2022.116764_h0055","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41467-021-21145-z","article-title":"p53 dynamics vary tissues and are linked with radiation sensitivity","volume":"12","author":"Stewart-Ornstein","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2022.116764_b0030","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1126\/science.8023157","article-title":"Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations","volume":"265","author":"Cho","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.bmc.2022.116764_h0065","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/sj.cdd.4401768","article-title":"Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53","volume":"13","author":"Morita","year":"2006","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bmc.2022.116764_h0070","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.18632\/oncotarget.1535","article-title":"Evaluation of zinc(II) chelators for inhibiting p53-mediated apoptosis","volume":"4","author":"Morita","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2022.116764_h0075","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2020.601124","article-title":"Protective effects of p53 regulatory agents against high-LET radiation-induced injury in mice","volume":"8","author":"Morita","year":"2020","journal-title":"Front Public Health"},{"key":"10.1016\/j.bmc.2022.116764_h0080","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1080\/09553002.2021.1941377","article-title":"Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice","volume":"97","author":"Nishiyama","year":"2021","journal-title":"Int J Rad Biol"},{"key":"10.1016\/j.bmc.2022.116764_b0040","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1016\/j.bmc.2014.06.017","article-title":"Design and synthesis of 8-hydroxyquinoline-based radioprotective agents","volume":"22","author":"Ariyasu","year":"2014","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2022.116764_b0045","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1158\/1535-7163.MCT-16-0554","article-title":"A chemical modulator of p53 transactivation that acts as a radioprotective agonist","volume":"17","author":"Morita","year":"2018","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.bmc.2022.116764_b0050","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3390\/life11101087","article-title":"A novel RNA synthesis inhibitor, STK160830, has negligible DNA-intercalating activity for triggering a p53 response, and can inhibit p53-dependent apoptosis","volume":"11","author":"Morita","year":"2021","journal-title":"Life"},{"key":"10.1016\/j.bmc.2022.116764_b0055","unstructured":"Jean-Jacques, C.; Jianmin, F.; Rajender, K.; Kashinath, S.; Zaihui, Z. Pyrazole and pyrrole compounds useful in treating iron disorders. US2009058730."},{"key":"10.1016\/j.bmc.2022.116764_b0060","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1016\/j.tet.2006.04.005","article-title":"Synthesis of 5-aryl-2-oxopyrrole derivatives as synthons for highly substituted pyrroles","volume":"62","author":"Matten","year":"2006","journal-title":"Tetrahedron"},{"key":"10.1016\/j.bmc.2022.116764_h0110","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0022-2836(85)90134-2","article-title":"Calculation of protein conformations by proton-proton distance constraints: a new efficient algorithm","volume":"186","author":"Braun","year":"1985","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmc.2022.116764_h0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0076-6879(07)30012-8","article-title":"NMR methods for studying protein-protein interactions involved in translation initiation","volume":"430","author":"Marintchev","year":"2007","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.bmc.2022.116764_b0070","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1021\/cc010043r","article-title":"Rapid parallel synthesis of polymer-bound enones utilizing microwave-assisted solid-phase chemistry","volume":"4","author":"Strohmeier","year":"2002","journal-title":"J Comb Chem"},{"key":"10.1016\/j.bmc.2022.116764_b0075","unstructured":"Aguilar, N.; Fernandez, J.; Terricabras, E.; Carceller, G. E.; Salas, S. J. Substituted tricyclic compounds with activity towards EP1 receptors. WO\/2013\/149997 A1."},{"key":"10.1016\/j.bmc.2022.116764_b0080","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1021\/acs.jmedchem.5b01525","article-title":"Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6\/8 Dual Inhibitors","volume":"59","author":"Rodrigues","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2022.116764_b0085","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1021\/jo970045r","article-title":"Highly enantioselective synthesis of both enantiomers of \u03b3-substituted butenolides by Bakers\u2019 yeast reduction and lipase-catalyzed hydrolysis. Total synthesis of (3AS, 6aS)-Ethisolide, Whisky Lactone, and (-)-Avenaciolide","volume":"63","author":"Tsuboi","year":"1998","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2022.116764_b0090","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/acs.jmedchem.5b01979","article-title":"Development and in vitro evaluation of a microbicide gel formulation for a novel non-nucleoside reverse transcriptase inhibitor belonging to N-dihydro-alkyloxy-benzyl-oxopyrimidines (N-DABOs) family","volume":"59","author":"Tintori","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2022.116764_b0095","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2: a complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J Appl Cryst"},{"key":"10.1016\/j.bmc.2022.116764_b0100","first-page":"3","article-title":"SHELXT-integrated space-group and crystal-structure determination","volume":"A71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst"},{"key":"10.1016\/j.bmc.2022.116764_b0105","first-page":"3","article-title":"Crystal structure refinement with SHELXL","volume":"C71","author":"Sheldrick","year":"2015","journal-title":"Acta Cryst"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089622001560?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089622001560?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:19:12Z","timestamp":1760836752000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089622001560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":31,"alternative-id":["S0968089622001560"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2022.116764","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2022.116764","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"116764"}}