{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:23:20Z","timestamp":1785907400731,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T00:00:00Z","timestamp":1651622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bmc.2022.116790","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T11:54:38Z","timestamp":1651665278000},"page":"116790","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds"],"prefix":"10.1016","volume":"65","author":[{"given":"Greeshma","family":"Gopalan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Palo-Nieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia N.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Hallberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Larhed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3 Pt 2","key":"10.1016\/j.bmc.2022.116790_b0005","first-page":"R820","article-title":"Discovery of L-162,313: a nonpeptide that mimics the biological actions of angiotensin II","volume":"268","author":"Kivlighn","year":"1995","journal-title":"Am J Physiol"},{"issue":"4","key":"10.1016\/j.bmc.2022.116790_b0010","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1074\/jbc.270.4.1493","article-title":"Non-peptide angiotensin agonist. Functional and molecular interaction with the AT1 receptor","volume":"270","author":"Perlman","year":"1995","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.bmc.2022.116790_b0015","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1124\/mol.51.2.301","article-title":"Dual Agonistic and Antagonistic Property of Nonpeptide Angiotensin AT1 Ligands: Susceptibility to Receptor Mutations","volume":"51","author":"Perlman","year":"1997","journal-title":"Mol Pharmacol"},{"issue":"3","key":"10.1016\/j.bmc.2022.116790_b0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0960-894X(96)00017-0","article-title":"L-162,389: a potent orally active angiotensin II receptor antagonist with balanced affinity to both AT1 and AT2 receptor subtypes","volume":"6","author":"Rivero","year":"1996","journal-title":"Bioorg Med Chem Lett"},{"issue":"6","key":"10.1016\/j.bmc.2022.116790_b0025","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1021\/jm031031i","article-title":"First Reported Nonpeptide AT1 Receptor Agonist (L-162,313) Acts as an AT2 Receptor Agonist in Vivo","volume":"47","author":"Wan","year":"2004","journal-title":"J Med Chem"},{"issue":"24","key":"10.1016\/j.bmc.2022.116790_b0030","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1021\/jm049715t","article-title":"Design, synthesis, and biological evaluation, of the first selective nonpeptide AT2 receptor agonist","volume":"47","author":"Wan","year":"2004","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2022.116790_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2021.101152","article-title":"Seven days treatment with the angiotensin II type 2 receptor agonist C21 in hospitalized COVID-19 patients; a placebo-controlled randomised multi-centre double-blind phase 2 trial","volume":"41","author":"Tornling","year":"2021","journal-title":"EClinicalMedicine"},{"issue":"2","key":"10.1016\/j.bmc.2022.116790_b0040","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/med.21449","article-title":"Small-molecule AT2 receptor agonists","volume":"38","author":"Hallberg","year":"2018","journal-title":"Med Res Rev"},{"key":"10.1016\/j.bmc.2022.116790_b0045","doi-asserted-by":"crossref","unstructured":"Larhed M, Hallberg M, Hallberg A. Nonpeptide AT2 receptor agonists. Med Chem Rev. 2016;51:69-82. 10.29200\/acsmedchemrev-v51.ch5.","DOI":"10.29200\/acsmedchemrev-v51.ch5"},{"issue":"24","key":"10.1016\/j.bmc.2022.116790_b0050","doi-asserted-by":"crossref","first-page":"7160","DOI":"10.1021\/jm0606185","article-title":"Selective angiotensin II AT2 receptor agonists: Arylbenzylimidazole structure-activity relationships","volume":"49","author":"Wu","year":"2006","journal-title":"J Med Chem"},{"issue":"22","key":"10.1016\/j.bmc.2022.116790_b0055","doi-asserted-by":"crossref","first-page":"7166","DOI":"10.1016\/j.bmc.2007.07.026","article-title":"Selective angiotensin II AT2 receptor agonists devoid of the imidazole ring system","volume":"15","author":"Murugaiah","year":"2007","journal-title":"Bioorg Med Chem"},{"issue":"14","key":"10.1016\/j.bmc.2022.116790_b0060","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.1016\/j.bmc.2008.05.066","article-title":"Selective angiotensin II AT2 receptor agonists: Benzamide structure\u2013activity relationships","volume":"16","author":"Wallinder","year":"2008","journal-title":"Bioorg Med Chem"},{"issue":"12","key":"10.1016\/j.bmc.2022.116790_b0065","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1016\/j.bmc.2010.03.064","article-title":"Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition","volume":"18","author":"Mahalingam","year":"2010","journal-title":"Bioorg Med Chem"},{"issue":"2","key":"10.1016\/j.bmc.2022.116790_b0070","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1021\/ml500427r","article-title":"Interconversion of Functional Activity by Minor Structural Alterations in Nonpeptide AT2 Receptor Ligands","volume":"6","author":"Wallinder","year":"2014","journal-title":"ACS Med Chem Lett"},{"issue":"12","key":"10.1016\/j.bmc.2022.116790_b0075","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1039\/C9MD00402E","article-title":"High affinity rigidified AT2 receptor ligands with indane scaffolds","volume":"10","author":"Wallinder","year":"2019","journal-title":"Medchemcomm"},{"issue":"7","key":"10.1016\/j.bmc.2022.116790_b0080","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1021\/jm0613469","article-title":"Synthesis of a new class of druglike angiotensin II C-terminal mimics with affinity for the AT2 receptor","volume":"50","author":"Georgsson","year":"2007","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.bmc.2022.116790_b0085","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2174\/1389203718666170203150344","article-title":"Angiotensin Peptides as AT2 Receptor Agonists","volume":"18","author":"Hallberg","year":"2017","journal-title":"Curr Protein Pept Sci"},{"issue":"10","key":"10.1016\/j.bmc.2022.116790_b0090","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1021\/ml500278g","article-title":"Saralasin and Sarile Are AT2 Receptor Agonists","volume":"5","author":"Guimond","year":"2014","journal-title":"ACS Med Chem Lett"},{"issue":"5","key":"10.1016\/j.bmc.2022.116790_b0095","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1021\/jm2015099","article-title":"From the First Selective Non-Peptide AT2 Receptor Agonist to Structurally Related Antagonists","volume":"55","author":"Murugaiah","year":"2012","journal-title":"J Med Chem"},{"issue":"1\u20133","key":"10.1016\/j.bmc.2022.116790_b0100","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2012.11.032","article-title":"Comparative functional properties of two structurally similar selective nonpeptide drug-like ligands for the angiotensin II type-2 (AT2) receptor. Effects on neurite outgrowth in NG108-15 cells","volume":"699","author":"Guimond","year":"2013","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.bmc.2022.116790_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115859","article-title":"N-(Methyloxycarbonyl)thiophene sulfonamides as high affinity AT2 receptor ligands","volume":"29","author":"Wannberg","year":"2021","journal-title":"Bioorg Med Chem"},{"issue":"5","key":"10.1016\/j.bmc.2022.116790_b0110","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1021\/jo100148x","article-title":"Catalyst-Controlled Regioselective Suzuki Couplings at Both Positions of Dihaloimidazoles, Dihalooxazoles, and Dihalothiazoles","volume":"75","author":"Strotman","year":"2010","journal-title":"J Org Chem"},{"issue":"26","key":"10.1016\/j.bmc.2022.116790_b0115","doi-asserted-by":"crossref","first-page":"9582","DOI":"10.1021\/jo9612990","article-title":"Microwave-promoted palladium-catalyzed coupling reactions","volume":"61","author":"Larhed","year":"1996","journal-title":"J Org Chem"},{"issue":"5","key":"10.1016\/j.bmc.2022.116790_b0120","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1021\/op300003b","article-title":"Evaluation of a Nonresonant Microwave Applicator for Continuous-Flow Chemistry Applications","volume":"16","author":"\u00d6hrngren","year":"2012","journal-title":"Org Process Res Dev"},{"key":"10.1016\/j.bmc.2022.116790_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.116804","article-title":"2-Alkyl Substituted Benzimidazoles as a New Class of Selective AT2 Receptor Ligands","author":"Roy","year":"2022","journal-title":"Bioorg Med Chem."},{"key":"10.1016\/j.bmc.2022.116790_b0130","doi-asserted-by":"crossref","unstructured":"T. Chhabria M, Patel S, Modi P, S. Brahmkshatriya P. Thiazole: A Review on Chemistry, Synthesis and Therapeutic Importance of its Derivatives. Curr Top Med Chem. 2016;16(26):2841-2862. 10.2174\/1568026616666160506130731.","DOI":"10.2174\/1568026616666160506130731"},{"key":"10.1016\/j.bmc.2022.116790_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.112016","article-title":"Thiazole-containing compounds as therapeutic targets for cancer therapy","volume":"188","author":"Sharma","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2022.116790_b0140","doi-asserted-by":"crossref","unstructured":"Vasile S, Hallberg A, Sallander J, Hallberg M, \u00c5qvist J, Guti\u00e9rrez-de-Ter\u00e1n H. Evolution of Angiotensin Peptides and Peptidomimetics as Angiotensin II Receptor Type 2 (AT2) Receptor Agonists. Biomol 2020, Vol 10, Page 649. 2020;10(4):649. 10.3390\/BIOM10040649.","DOI":"10.3390\/biom10040649"},{"issue":"3","key":"10.1016\/j.bmc.2022.116790_b0145","first-page":"391","article-title":"The Effect of Cytochrome P450 Metabolism on Drug Response, Interactions, and Adverse Effects","volume":"76","author":"Lynch","year":"2007","journal-title":"Am Fam Physician"},{"issue":"1","key":"10.1016\/j.bmc.2022.116790_b0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pharmthera.2012.12.007","article-title":"Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation","volume":"138","author":"Zanger","year":"2013","journal-title":"Pharmacol Ther."},{"issue":"2","key":"10.1016\/j.bmc.2022.116790_b0155","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3987\/COM-95-S91","article-title":"New approach to the imidazolutidine moiety of MK-996","volume":"42","author":"Senanayake","year":"1996","journal-title":"Heterocycles"},{"issue":"9","key":"10.1016\/j.bmc.2022.116790_b0160","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/0006-2952(94)90520-7","article-title":"Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance","volume":"47","author":"Brian","year":"1994","journal-title":"Biochem Pharmacol"},{"issue":"11","key":"10.1016\/j.bmc.2022.116790_b0165","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/S0090-9556(24)14938-0","article-title":"Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes","volume":"27","author":"Obach","year":"1999","journal-title":"Drug Metab Dispos"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089622001821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089622001821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:18:12Z","timestamp":1760836692000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089622001821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":33,"alternative-id":["S0968089622001821"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2022.116790","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Angiotensin II AT2 receptor ligands with phenylthiazole scaffolds","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2022.116790","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"116790"}}