{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:18:46Z","timestamp":1783739926236,"version":"3.55.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"am","delay-in-days":721,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007709","name":"Michigan State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI146210"],"award-info":[{"award-number":["R01AI146210"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI153829"],"award-info":[{"award-number":["R01AI153829"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R21AI156732"],"award-info":[{"award-number":["R21AI156732"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.bmc.2022.117066","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T07:59:06Z","timestamp":1665993546000},"page":"117066","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Development of carbohydrate based next-generation anti-pertussis vaccines"],"prefix":"10.1016","volume":"74","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnima","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendar","family":"Deora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2022.117066_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00430-017-0524-z","article-title":"Bordetella Pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance","volume":"207","author":"Dorji","year":"2018","journal-title":"Med Microbiol Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0010","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1128\/CMR.00083-15","article-title":"Pertussis: Microbiology, Disease, Treatment, and Prevention","volume":"29","author":"Kilgore","year":"2016","journal-title":"Clin Microbiol Rev."},{"key":"10.1016\/j.bmc.2022.117066_b0015","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.15585\/mmwr.mm6645a3","article-title":"Global Routine Vaccination Coverage, 2016","volume":"66","author":"Feldstein","year":"2017","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"10.1016\/j.bmc.2022.117066_b0020","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1080\/21505594.2021.1980987","article-title":"Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host","volume":"12","author":"Belcher","year":"2021","journal-title":"Virulence."},{"key":"10.1016\/j.bmc.2022.117066_b0025","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.3201\/eid2706.203850","article-title":"Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis","volume":"27","author":"Ma","year":"2021","journal-title":"Emerg Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0030","doi-asserted-by":"crossref","unstructured":"Chasaide CN, Mills KHG. Next-Generation Pertussis Vaccines Based on the Induction of Protective T Cells in the Respiratory Tract. Vaccines. 2020;8:10.3390\/vaccines8040621.","DOI":"10.3390\/vaccines8040621"},{"key":"10.1016\/j.bmc.2022.117066_b0035","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4049\/jimmunol.2000676","article-title":"Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases","volume":"205","author":"Damron","year":"2020","journal-title":"J Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0040","doi-asserted-by":"crossref","first-page":"e1008625","DOI":"10.1371\/journal.ppat.1008625","article-title":"Whoop! There it is: The surprising resurgence of pertussis","volume":"16","author":"Fullen","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmc.2022.117066_b0045","first-page":"329","article-title":"Whooping Cough: A Brief History to the 19th Century","volume":"29","author":"Weston","year":"2012","journal-title":"Can Bull Med Hist."},{"key":"10.1016\/j.bmc.2022.117066_b0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00005792-197511000-00001","article-title":"Pertussis","volume":"54","author":"Olson","year":"1975","journal-title":"Medicine"},{"key":"10.1016\/j.bmc.2022.117066_b0055","doi-asserted-by":"crossref","first-page":"ftv075","DOI":"10.1093\/femspd\/ftv075","article-title":"Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme","volume":"73","author":"Masin","year":"2015","journal-title":"Pathog Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0060","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/infdis\/jit639","article-title":"Pertussis pathogenesis\u2013what we know and what we don't know","volume":"209","author":"Hewlett","year":"2014","journal-title":"J Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0065","doi-asserted-by":"crossref","first-page":"e1010764","DOI":"10.1371\/journal.ppat.1010764","article-title":"Bps polysaccharide of Bordetella pertussis resists antimicrobial peptides by functioning as a dual surface shield and decoy and converts Escherichia coli into a respiratory pathogen","volume":"18","author":"Fullen","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmc.2022.117066_b0070","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s40272-015-0149-x","article-title":"Protecting Newborns Against Pertussis: Treatment and Prevention Strategies","volume":"17","author":"Salim","year":"2015","journal-title":"Paediatr Drugs."},{"key":"10.1016\/j.bmc.2022.117066_b0075","doi-asserted-by":"crossref","first-page":"ftv068","DOI":"10.1093\/femspd\/ftv068","article-title":"Bordetella pertussis transmission","volume":"73","author":"Trainor","year":"2015","journal-title":"Pathog Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/cid\/ciz840","article-title":"Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization","volume":"71","author":"de Graaf","year":"2020","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s100960050435","article-title":"Bordetella pertussis infection: pathogenesis, diagnosis, management, and the role of protective immunity","volume":"19","author":"Kerr","year":"2000","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0090","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1080\/14760584.2019.1588727","article-title":"The burden of pertussis in older adults: what is the role of vaccination? A systematic literature review","volume":"18","author":"Kandeil","year":"2019","journal-title":"Expert Rev Vaccines."},{"key":"10.1016\/j.bmc.2022.117066_b0095","unstructured":"https:\/\/www.cdc.gov\/pertussis\/surv-reporting.html."},{"key":"10.1016\/j.bmc.2022.117066_b0100","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S1473-3099(17)30390-0","article-title":"An update of the global burden of pertussis in children younger than 5 years: a modelling study","volume":"17","author":"Yeung","year":"2017","journal-title":"Lancet Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/jama.1933.02740280007003","article-title":"Vaccination against whooping cough","volume":"101","author":"Madsen","year":"1933","journal-title":"J Am Med Assoc."},{"key":"10.1016\/j.bmc.2022.117066_b0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.coi.2015.05.008","article-title":"Pertussis vaccines and the challenge of inducing durable immunity","volume":"35","author":"Warfel","year":"2015","journal-title":"Curr Opin Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0115","first-page":"11","article-title":"Pertussis surveillance\u2013United States, 1989\u20131991","volume":"8","author":"Davis","year":"1992","journal-title":"MMWR Morb Mortal Wkly Rep."},{"key":"10.1016\/j.bmc.2022.117066_b0120","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0140-6736(75)90907-1","article-title":"Use of pertussis vaccine in an epidemic involving hospital staff","volume":"2","author":"Linnemann","year":"1975","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2022.117066_b0125","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/INF.0b013e31818a8958","article-title":"Pertussis Vaccine: A Critique","volume":"28","author":"Robbins","year":"2009","journal-title":"Pediatr Infect Dis J."},{"key":"10.1016\/j.bmc.2022.117066_b0130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1586\/14760584.4.2.173","article-title":"Acellular pertussis vaccines in Japan: past, present and future","volume":"4","author":"Watanabe","year":"2005","journal-title":"Expert Rev Vaccines."},{"key":"10.1016\/j.bmc.2022.117066_b0135","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/01.inf.0000177282.53500.77","article-title":"Resurgence of pertussis in Europe","volume":"24","author":"Celentano","year":"2005","journal-title":"Pediatr Infect Dis J."},{"key":"10.1016\/j.bmc.2022.117066_b0140","unstructured":"Adams DA, Gallagher KM, Jajosky RA, Sharp P, Anderson WJ, Abellera JP, Aranas AE, Mayes M, Wodajo MS, Onweh DH, Park M. Prevention. Summary of notifiable diseases--United States, 2010. MMWR Morb Mortal Wkly Rep. 2012;59:1-111."},{"key":"10.1016\/j.bmc.2022.117066_b0145","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.4161\/hv.29253","article-title":"Development of improved pertussis vaccine","volume":"10","author":"Rumbo","year":"2014","journal-title":"Hum Vaccin Immunother."},{"key":"10.1016\/j.bmc.2022.117066_b0150","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jinf.2005.10.020","article-title":"The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys","volume":"53","author":"de Melker","year":"2006","journal-title":"J Infect."},{"key":"10.1016\/j.bmc.2022.117066_b0155","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1086\/504803","article-title":"Bordetella Pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT)","volume":"43","author":"Ward","year":"2006","journal-title":"Clin Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0160","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/clinids\/1.3.401","article-title":"Pertussis toxin: the cause of the harmful effects and prolonged immunity of whooping cough. A hypothesis","volume":"1","author":"Pittman","year":"1979","journal-title":"Rev Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0165","doi-asserted-by":"crossref","first-page":"S264","DOI":"10.1093\/infdis\/174.Supplement_3.S264","article-title":"Acellular pertussis vaccines developed in Japan and their application for disease control","volume":"174","author":"Aoyama","year":"1996","journal-title":"J Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0170","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1073\/pnas.1324149111","article-title":"Toward a new vaccine for pertussis","volume":"111","author":"Robbins","year":"2014","journal-title":"Proc Natl Acad Sci, USA"},{"key":"10.1016\/j.bmc.2022.117066_b0175","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00006454-199702000-00003","article-title":"Unchanged efficacy of a pertussis toxoid vaccine throughout the two years after the third vaccination of infants","volume":"16","author":"Taranger","year":"1997","journal-title":"Pediatr Infect Dis J."},{"key":"10.1016\/j.bmc.2022.117066_b0180","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00431-001-0893-5","article-title":"Long-term clinical effectiveness of an acellular pertussis component vaccine and a whole cell pertussis component vaccine","volume":"161","author":"Lugauer","year":"2002","journal-title":"Eur J Pediatr."},{"key":"10.1016\/j.bmc.2022.117066_b0185","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1542\/peds.2014-1729","article-title":"Duration of Pertussis Immunity After DTaP Immunization: A Meta-analysis","volume":"135","author":"McGirr","year":"2015","journal-title":"Pediatrics"},{"key":"10.1016\/j.bmc.2022.117066_b0190","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/mi.2012.54","article-title":"Immunity to the respiratory pathogen Bordetella pertussis","volume":"5","author":"Higgs","year":"2012","journal-title":"Mucosal Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.bmc.2022.117066_b0195","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1093\/infdis\/jit560","article-title":"Immune responses to pertussis vaccines and disease","volume":"209","author":"Edwards","year":"2014","journal-title":"J Infect Dis."},{"key":"10.1016\/j.bmc.2022.117066_b0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2567.1998.00401.x","article-title":"Distinct T-cell subtypes induced with whole cell and acellular pertussis vaccines in children","volume":"93","author":"Ryan","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.bmc.2022.117066_b0205","doi-asserted-by":"crossref","first-page":"e1003264","DOI":"10.1371\/journal.ppat.1003264","article-title":"Relative Contribution of Th1 and Th17 Cells in Adaptive Immunity to Bordetella pertussis: Towards the Rational Design of an Improved Acellular Pertussis Vaccine","volume":"9","author":"Ross","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bmc.2022.117066_b0210","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/INF.0b013e31816591f7","article-title":"Safety of a fifth dose of diphtheria and tetanus toxoid and acellular pertussis vaccine in children experiencing extensive, local reactions to the fourth dose","volume":"27","author":"Rennels","year":"2008","journal-title":"Pediatr Infect Dis J."},{"key":"10.1016\/j.bmc.2022.117066_b0215","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.1365-2249.2000.01306.x","article-title":"Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE responses against pertussis toxin but not against common allergens","volume":"121","author":"Ryan","year":"2000","journal-title":"Clin Exp Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0220","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1038\/s41385-018-0080-x","article-title":"Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T(RM) cells","volume":"11","author":"Allen","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0225","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/mi.2014.93","article-title":"A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine","volume":"8","author":"Dunne","year":"2015","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0230","doi-asserted-by":"crossref","first-page":"e00935","DOI":"10.1128\/IAI.00935-17","article-title":"The Adjuvant Bordetella Colonization Factor A Attenuates Alum-Induced Th2 Responses and Enhances Bordetella pertussis Clearance from Mouse Lungs","volume":"86","author":"Jennings-Gee","year":"2018","journal-title":"Infect Immun."},{"key":"10.1016\/j.bmc.2022.117066_b0235","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1073\/pnas.1314688110","article-title":"Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model","volume":"111","author":"Warfel","year":"2014","journal-title":"Proc Natl Acad Sci, USA"},{"key":"10.1016\/j.bmc.2022.117066_b0240","doi-asserted-by":"crossref","first-page":"7175","DOI":"10.1128\/IAI.68.12.7175-7179.2000","article-title":"Characterization of bactericidal immune responses following vaccination with acellular pertussis vaccines in adults","volume":"68","author":"Weingart","year":"2000","journal-title":"Infect Immun."},{"key":"10.1016\/j.bmc.2022.117066_b0245","doi-asserted-by":"crossref","first-page":"7346","DOI":"10.1128\/IAI.72.12.7346-7351.2004","article-title":"Acellular Pertussis Vaccines and Complement Killing of Bordetella pertussis","volume":"72","author":"Weiss","year":"2004","journal-title":"Infect Immun."},{"key":"10.1016\/j.bmc.2022.117066_b0250","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nchem.399","article-title":"Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research","volume":"1","author":"Boltje","year":"2009","journal-title":"Nat Chem."},{"key":"10.1016\/j.bmc.2022.117066_b0255","first-page":"205","article-title":"Invited review: Diversity of endotoxin and its impact on pathogenesis","volume":"12","author":"Trent","year":"2006","journal-title":"J Endotoxin Res."},{"key":"10.1016\/j.bmc.2022.117066_b0260","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/nrmicro1861","article-title":"Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions","volume":"6","author":"Weidenmaier","year":"2008","journal-title":"Nat Rev Microbiol."},{"key":"10.1016\/j.bmc.2022.117066_b0265","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1574-6968.1992.tb05475.x","article-title":"Characterization of the common antigenic lipopolysaccharide O-chains produced by Bordetella bronchiseptica and Bordetella parapertussis","volume":"76","author":"Di Fabio","year":"1992","journal-title":"FEMS Microbiol Lett."},{"key":"10.1016\/j.bmc.2022.117066_b0270","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1042\/bj0740398","article-title":"Specific lipopolysaccharides of Bordetella","volume":"74","author":"Maclennan","year":"1960","journal-title":"Biochem J."},{"key":"10.1016\/j.bmc.2022.117066_b0275","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1046\/j.1462-5822.1999.00004.x","article-title":"Signalling and cellular specificity of airway nitric oxide production in pertussis","volume":"1","author":"Flak","year":"1999","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.bmc.2022.117066_b0280","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.4049\/jimmunol.173.3.1959","article-title":"Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A","volume":"173","author":"Schaeffer","year":"2004","journal-title":"J Immunol."},{"key":"10.1016\/j.bmc.2022.117066_b0285","doi-asserted-by":"crossref","first-page":"7124","DOI":"10.1128\/IAI.72.12.7124-7130.2004","article-title":"Interactions of pulmonary collectins with Bordetella bronchiseptica and Bordetella pertussis lipopolysaccharide elucidate the structural basis of their antimicrobial activities","volume":"72","author":"Schaeffer","year":"2004","journal-title":"Infect Immun."},{"key":"10.1016\/j.bmc.2022.117066_b0290","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.micinf.2009.12.002","article-title":"Evidence for an intact polysaccharide capsule in Bordetella pertussis","volume":"12","author":"Neo","year":"2010","journal-title":"Microbes Infect."},{"key":"10.1016\/j.bmc.2022.117066_b0295","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1111\/cmi.12264","article-title":"The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement-mediated killing","volume":"16","author":"Ganguly","year":"2014","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.bmc.2022.117066_b0300","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1111\/j.1365-2958.2010.07297.x","article-title":"The Bps polysaccharide of Bordetella pertussis promotes colonization and biofilm formation in the nose by functioning as an adhesin","volume":"77","author":"Conover","year":"2010","journal-title":"Mol Microbiol."},{"key":"10.1016\/j.bmc.2022.117066_b0305","doi-asserted-by":"crossref","first-page":"e115243","DOI":"10.1371\/journal.pone.0115243","article-title":"Evidence for a role of the polysaccharide capsule transport proteins in pertussis pathogenesis","volume":"9","author":"Hoo","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bmc.2022.117066_b0310","doi-asserted-by":"crossref","first-page":"5156","DOI":"10.1128\/jb.176.16.5156-5159.1994","article-title":"Structural characterization of the lipid A of Bordetella pertussis 1414 endotoxin","volume":"176","author":"Caroff","year":"1994","journal-title":"J Bacteriol."},{"key":"10.1016\/j.bmc.2022.117066_b0315","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0008-6215(94)84061-X","article-title":"Structure of a hexasaccharide proximal to the hydrophobic region of lipopolysaccharides present in Bordetella pertussis endotoxin preparations","volume":"259","author":"Lebbar","year":"1994","journal-title":"Carbohydr Res."},{"key":"10.1016\/j.bmc.2022.117066_b0320","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0014-5793(00)01720-8","article-title":"Structure of the Bordetella pertussis 1414 endotoxin","volume":"477","author":"Caroff","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bmc.2022.117066_b0325","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1432-1033.1976.tb10962.x","article-title":"7-O-(2-Amino-2-deoxy-alpha-D-glucopyranosyl)-L-glycero-D-manno-heptose. A constituent of the endotoxin of Bordetella pertussis","volume":"70","author":"Chaby","year":"1976","journal-title":"Eur J Biochem."},{"key":"10.1016\/j.bmc.2022.117066_b0330","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1432-1033.1977.tb11615.x","article-title":"2-O-(beta-D-glucuronyl)-7-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-L-glycero-D-manno-heptose: a constituent of the Bordetella pertussis endotoxin","volume":"76","author":"Chaby","year":"1977","journal-title":"Eur J Biochem."},{"key":"10.1016\/j.bmc.2022.117066_b0335","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1128\/jb.150.1.27-35.1982","article-title":"Isolation of a trisaccharide containing 2-amino-2-deoxy-D-galacturonic acid from the Bordetella pertussis endotoxin","volume":"150","author":"Moreau","year":"1982","journal-title":"J Bacteriol."},{"key":"10.1016\/j.bmc.2022.117066_b0340","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1128\/jb.159.2.611-617.1984","article-title":"Structure of the terminal reducing heptasaccharide of polysaccharide 1 isolated from the Bordetella pertussis endotoxin","volume":"159","author":"Moreau","year":"1984","journal-title":"J Bacteriol."},{"key":"10.1016\/j.bmc.2022.117066_b0345","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.3390\/ijms22031029","article-title":"Conserved Structural Features of Core Oligosaccharides among the Lipopolysaccharides of Respiratory Pathogens from the Genus Bordetella Analyzed Exclusively by NMR Spectroscopy","volume":"22","author":"Ucieklak","year":"2021","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.bmc.2022.117066_b0350","first-page":"499","article-title":"Characterization of the antibodies responsible for thebactericidal activity patterns' of antisera to Bordetella pertussis","volume":"8","author":"Dolby","year":"1965","journal-title":"Immunology"},{"key":"10.1016\/j.bmc.2022.117066_b0355","doi-asserted-by":"crossref","unstructured":"Ackers J, DOLBY JM. The antigen of Bordetella pertussis that induces bactericidal antibody and its relationship to protection of mice. Microbiology. 1972;70:371-382.","DOI":"10.1099\/00221287-70-2-371"},{"key":"10.1016\/j.bmc.2022.117066_b0360","first-page":"905","article-title":"Characterization and comparative bactericidal activity of monoclonal antibodies to Bordetella pertussis lipo-oligosaccharide A","volume":"137","author":"Archambault","year":"1991","journal-title":"Microbiology"},{"key":"10.1016\/j.bmc.2022.117066_b0365","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1128\/iai.60.7.2718-2725.1992","article-title":"Immunological characterization of the lipooligosaccharide B band of Bordetella pertussis","volume":"60","author":"Martin","year":"1992","journal-title":"Infect Immun."},{"key":"10.1016\/j.bmc.2022.117066_b0370","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1099\/00221287-142-4-971","article-title":"Epitopes of Bordetella pertussis lipopolysaccharides as potential markers for typing of isolates with monoclonal antibodies","volume":"142","author":"Le Blay","year":"1996","journal-title":"Microbiology"},{"key":"10.1016\/j.bmc.2022.117066_b0375","doi-asserted-by":"crossref","first-page":"7381","DOI":"10.1128\/IAI.73.11.7381-7389.2005","article-title":"Epitope of the vaccine-type Bordetella pertussis strain 186 lipooligosaccharide and antiendotoxin activity of antibodies directed against the terminal pentasaccharide-tetanus toxoid conjugate","volume":"73","author":"Niedziela","year":"2005","journal-title":"Infect Immun."},{"key":"10.1016\/j.bmc.2022.117066_b0380","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1073\/pnas.1100782108","article-title":"Oligosaccharide conjugates of Bordetella pertussis and bronchiseptica induce bactericidal antibodies, an addition to pertussis vaccine","volume":"108","author":"Kubler-Kielb","year":"2011","journal-title":"Proc Natl Acad Sci, USA"},{"key":"10.1016\/j.bmc.2022.117066_b0385","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4161\/hv.22847","article-title":"An improved whole cell pertussis vaccine with reduced content of endotoxin","volume":"9","author":"Dias","year":"2013","journal-title":"Hum Vaccin Immunother."},{"key":"10.1016\/j.bmc.2022.117066_b0390","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.carres.2013.05.002","article-title":"Comparison of lipopolysaccharide structures of Bordetella pertussis clinical isolates from pre- and post-vaccine era","volume":"378","author":"AlBitar-Nehme","year":"2013","journal-title":"Carbohydr Res."},{"key":"10.1016\/j.bmc.2022.117066_b0395","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1002\/anie.201915913","article-title":"Chemical Synthesis and Immunological Evaluation of a Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine","volume":"59","author":"Wang","year":"2020","journal-title":"Angew Chem Int Ed."},{"key":"10.1016\/j.bmc.2022.117066_b0400","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3390\/vaccines9060645","article-title":"Structure and Immunogenicity of the Bordetella pertussis LOS-Derived Oligosaccharides in the Endosomal-Like Pre-Processing Mice Model","volume":"9","author":"Koj","year":"2021","journal-title":"Vaccines."},{"key":"10.1016\/j.bmc.2022.117066_b0405","doi-asserted-by":"crossref","first-page":"16596","DOI":"10.1021\/jacs.8b08473","article-title":"Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice","volume":"140","author":"Wu","year":"2018","journal-title":"J Am Chem Soc."},{"key":"10.1016\/j.bmc.2022.117066_b0410","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/acschembio.9b00381","article-title":"Synthesis and Immunological Evaluation of Disaccharide Bearing MUC-1 Glycopeptide Conjugates with Virus-like Particles","volume":"14","author":"Wu","year":"2019","journal-title":"ACS Chem Biol."},{"key":"10.1016\/j.bmc.2022.117066_b0415","doi-asserted-by":"crossref","first-page":"4233","DOI":"10.1002\/chem.201603599","article-title":"An Overview of Structural Features of Antibacterial Glycoconjugate Vaccines That Influence Their Immunogenicity","volume":"23","author":"Khatun","year":"2017","journal-title":"Chem Eur J."},{"key":"10.1016\/j.bmc.2022.117066_b0420","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1128\/IAI.67.3.1424-1431.1999","article-title":"Characterization of human bactericidal antibodies to Bordetella pertussis","volume":"67","author":"Weiss","year":"1999","journal-title":"Infect Immun."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962200459X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962200459X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:21:27Z","timestamp":1760836887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962200459X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":84,"alternative-id":["S096808962200459X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2022.117066","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of carbohydrate based next-generation anti-pertussis vaccines","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2022.117066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117066"}}