{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:23:07Z","timestamp":1793305387167,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","award":["LR 07\/2017"],"award-info":[{"award-number":["LR 07\/2017"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","award":["RASSR17032"],"award-info":[{"award-number":["RASSR17032"]}],"id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bmc.2023.117376","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T16:50:30Z","timestamp":1686847830000},"page":"117376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds"],"prefix":"10.1016","volume":"90","author":[{"given":"Ibrahim S.","family":"Al Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-8636","authenticated-orcid":false,"given":"Angela","family":"Corona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed S.","family":"Koko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-5929","authenticated-orcid":false,"given":"Tariq A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridha","family":"Ben Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Daoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyfeddine","family":"Rahali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Tramontano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8413-4342","authenticated-orcid":false,"given":"Rainer","family":"Schobert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noureddine","family":"Amdouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7305-346X","authenticated-orcid":false,"given":"Bernhard","family":"Biersack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2023.117376_b0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41579-021-00639-z","article-title":"Infectious disease in an era of global change","volume":"20","author":"Baker","year":"2022","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmc.2023.117376_b0010","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/tropicalmed2030036","article-title":"Neglected tropical diseases: epidemiology ad global burden","volume":"2","author":"Mitra","year":"2017","journal-title":"Trop Med Infect Dis"},{"key":"10.1016\/j.bmc.2023.117376_b0015","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.jhin.2020.09.022","article-title":"Potential sources, modes of transmission and effectiveness of prevention measures against SARS-CoV-2","volume":"106","author":"Kampf","year":"2020","journal-title":"J Hospit Infect"},{"key":"10.1016\/j.bmc.2023.117376_b0020","unstructured":"http:\/\/www.who.int\/mediacentre\/factsheets\/fs375\/en\/; Accessed November 12, 2020."},{"key":"10.1016\/j.bmc.2023.117376_b0025","first-page":"129","article-title":"Novel benzoxaborole, nitroimidazole and aminopyrazoles with activity against experimental cutaneous leishmaniasis","volume":"11","author":"van Bocxlaer","year":"2019","journal-title":"IJP: Drugs Drug Resist"},{"key":"10.1016\/j.bmc.2023.117376_b0030","doi-asserted-by":"crossref","first-page":"e0189906","DOI":"10.1371\/journal.pone.0189906","article-title":"\u0301\u0301The mosquitoes that destroy your fac\u00e9\u0301: social impact of cutaneous leishmaniasis in south-eastern Morocco, a quality study","volume":"12","author":"Bennis","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2023.117376_b0035","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1371\/journal.pntd.0000259","article-title":"Marring leishmaniasis: the stigmatization and the impact of cutaneous leishmaniasis in Pakistan and Afghanistan","volume":"2","author":"Kassi","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.bmc.2023.117376_b0040","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.apjtm.2016.06.012","article-title":"Toxoplasmosis and anti-Toxoplasma effects of medicinal plant extracts \u2013 a mini-review","volume":"9","author":"Al Nasr","year":"2016","journal-title":"Asian Pac J Trop Med"},{"key":"10.1016\/j.bmc.2023.117376_b0045","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1126\/science.367.6478.611","article-title":"Combo of two HIV vaccines fails its big tests","volume":"367","author":"Cohen","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bmc.2023.117376_b0050","first-page":"1","article-title":"Advances toward curing HIV-1 infection in tissue reservoirs","volume":"94","author":"Henderson","year":"2018","journal-title":"J Virol"},{"key":"10.1016\/j.bmc.2023.117376_b0055","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.antiviral.2013.01.007","article-title":"Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments","volume":"98","author":"Men\u00e9ndez-Arias","year":"2013","journal-title":"Antivir Res"},{"key":"10.1016\/j.bmc.2023.117376_b0060","doi-asserted-by":"crossref","first-page":"S847","DOI":"10.1093\/infdis\/jix430","article-title":"The role of HIV-1 drug-resistant minority variants in treatment failure","volume":"216","author":"Stella-Ascariz","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bmc.2023.117376_b0065","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/S1473-3099(17)30702-8","article-title":"HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis","volume":"18","author":"Gupta","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.bmc.2023.117376_b0070","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1128\/CMR.00061-07","article-title":"The relationship between leishmaniasis and AIDS: the second 10 years","volume":"21","author":"Alvar","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.bmc.2023.117376_b0075","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1097\/QAD.0000000000001574","article-title":"HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment","volume":"31","author":"Singh","year":"2017","journal-title":"AIDS"},{"key":"10.1016\/j.bmc.2023.117376_b0080","doi-asserted-by":"crossref","first-page":"40850","DOI":"10.1074\/jbc.R112.389056","article-title":"Human immunodeficiency virus reverse transcriptase: 25 years of research, drug discovery, and promise","volume":"287","author":"Le Grice","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0085","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1038\/sj.emboj.7601076","article-title":"Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release","volume":"25","author":"Nowotny","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.bmc.2023.117376_b0090","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/ja411408x","article-title":"Calcium inhibition of ribonuclease H1 two-metal ion catalysis","volume":"136","author":"Rosta","year":"2014","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2023.117376_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2019.104613","article-title":"an unexploited target for antiviral intervention against HIV and hepatitis B virus","volume":"171","author":"Tramontano","year":"2019","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2023.117376_b0100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/2049-632X.12051","article-title":"components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities","volume":"68","author":"Esposito","year":"2013","journal-title":"Pathog Dis."},{"key":"10.1016\/j.bmc.2023.117376_b0105","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s12275-015-4652-0","article-title":"From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors","volume":"53","author":"Xu","year":"2015","journal-title":"J Microbiol"},{"key":"10.1016\/j.bmc.2023.117376_b0110","doi-asserted-by":"crossref","first-page":"e0195168","DOI":"10.1371\/journal.pone.0195168","article-title":"Prenylated phloroglucinols from Hypericum scruglii, an endemic species of Sardinia (Italy), as new dual HIV-1 inhibitors effective on HIV-1 replication","volume":"13","author":"Sanna","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2023.117376_b0115","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1093\/nar\/gkw060","article-title":"Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors","volume":"44","author":"Schneider","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2023.117376_b0120","doi-asserted-by":"crossref","first-page":"729","DOI":"10.3390\/v12070729","article-title":"Targeting HIV-1 RNase H: N\u2019-(2-hydroxy-benzylidene)-3,4,5-trihydroxybenzoylhydrazone as selective inhibitor active against NNRTIs-resistant variants","volume":"12","author":"Corona","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.bmc.2023.117376_b0125","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.2174\/0929867328666211007121837","article-title":"Multicomponent reactions in the synthesis of antiviral compounds","volume":"29","author":"Botta","year":"2022","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0130","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1021\/jm1009428","article-title":"Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents","volume":"54","author":"Evdokimov","year":"2011","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0135","article-title":"Active compounds for combating greasy skin","author":"Marat","year":"2016","journal-title":"Eur Pat"},{"key":"10.1016\/j.bmc.2023.117376_b0140","article-title":"Synthesis, characterization and in vitro bioactivity studies of isoindolin-1-3-phosphonate compounds","author":"Jelali","year":"2021","journal-title":"J Heterocycl Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0145","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.jep.2007.01.015","article-title":"Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae","volume":"111","author":"Osorio","year":"2007","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmc.2023.117376_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105099","article-title":"p-Trifluoromethyl- and p-pentafluorothio-substituted curcuminoids of the 2,6-di[(E)-benzylidene)]cycloalkanone type: syntheses and activities against Leishmania major and Toxoplasma gondii parasites","volume":"114","author":"Al Nasr","year":"2021","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2008.03.007","article-title":"In vitro immunomodulating properties of selected Sudanese medicinal plants","volume":"118","author":"Koko","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmc.2023.117376_b0160","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1128\/AAC.00056-14","article-title":"Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type I RNase H inhibitors","volume":"58","author":"Corona","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2023.117376_b0165","doi-asserted-by":"crossref","first-page":"e2100123","DOI":"10.1002\/ardp.202100123","article-title":"Garcinol from Garcinia indica inhibits HIV-1 reverse transcriptase-associated ribonuclease H","volume":"354","author":"Corona","year":"2021","journal-title":"Arch Pharm"},{"key":"10.1016\/j.bmc.2023.117376_b0170","unstructured":"Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Scalmani G, Barone V, Petersson GA, Nakatsuji H, Li X, Caricato M, Marenich AV, Bloino J, Janesko BG, Gomperts R, Mennucci B, Hratchian HP, Ortiz JV, Izmaylov AF, Sonnenberg JL, Williams-Young D, Ding F, Lipparini F, Egidi F, Goings J, Peng B, Petrone A, Henderson T, Ranasinghe D, Zakrzewski VG, Gao J, Rega N, Zheng G, Liang W, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Vreven T, Throssell K, Montgomery Jr. JA, Peralta JE, Ogliaro F, Bearpark MJ, Heyd JJ, Brothers EN, Kudin KN, Staroverov VN, Keith TA, Kobayashi R, Normand J, Raghavachari K, Rendell AP, Burant JC, Iyengar SS, Tomasi J, Cossi M, Millam JM, Klene M, Adamo C, Cammi R, Ochterski JW, Martin RL, Morokuma K, Farkas O, Foresman JB, Fox DJ. Gaussian 16, Revision B.01, Gaussian Inc. Wallingford CT, 2016."},{"key":"10.1016\/j.bmc.2023.117376_b0175","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","article-title":"Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density","volume":"37","author":"Lee","year":"1988","journal-title":"Phys Rev B"},{"key":"10.1016\/j.bmc.2023.117376_b0180","doi-asserted-by":"crossref","DOI":"10.1063\/1.3382344","article-title":"A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu","volume":"132","author":"Grimme","year":"2010","journal-title":"J Chem Phys"},{"key":"10.1016\/j.bmc.2023.117376_b0185","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1063\/1.438955","article-title":"Self-consistent molecular orbital methods. XX. a basis set for correlated wave functions","volume":"72","author":"Krishnan","year":"1980","journal-title":"J Chem Phys"},{"key":"10.1016\/j.bmc.2023.117376_b0190","first-page":"1995","article-title":"Quantum calculation of molecular energies and energy gradients in solution by a conductor solvent model","volume":"102","author":"Barone","year":"1998","journal-title":"Chem A Eur J"},{"key":"10.1016\/j.bmc.2023.117376_b0195","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1080\/00268976.2018.1548715","article-title":"Structural, energetic and spectroscopic characterisation of 5-fluorouracil anticarcinogenic drug isomers, tautomers and ions","volume":"117","author":"Othmani","year":"2019","journal-title":"Mol Phys"},{"key":"10.1016\/j.bmc.2023.117376_b0200","doi-asserted-by":"crossref","first-page":"26125","DOI":"10.1021\/acsomega.0c03727","article-title":"A unified approach to CO2\u2013amine reaction mechanisms","volume":"5","author":"Said","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmc.2023.117376_b0205","unstructured":"Molecular operating environment (MOE), 2013.08. Chemical Computing Group Inc., Montreal, 2016."},{"key":"10.1016\/j.bmc.2023.117376_b0210","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.compbiolchem.2018.03.021","article-title":"Combined QSAR, molecular docking and molecular dynamics study on new acetylcholinesterase and butyrylcholinesterase inhibitors","volume":"74","author":"Daoud","year":"2018","journal-title":"Comput Biol Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0215","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1080\/07391102.2021.1882340","article-title":"In silico design of enzyme \u03b1-amylase and \u03b1-glucosidase inhibitors using molecular docking, molecular dynamic, conceptual DFT investigation and pharmacophore modelling","volume":"40","author":"Chenafa","year":"2021","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.bmc.2023.117376_b0220","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.str.2009.09.016","article-title":"Structure of HIV-1 reverse transcriptase with the inhibitor \u03b2-thujaplicinol bound at the RNase H active site","volume":"17","author":"Himmel","year":"2009","journal-title":"Structure"},{"key":"10.1016\/j.bmc.2023.117376_b0225","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1021\/ci800293n","article-title":"Validation of molecular docking programs for virtual screening against dihydropteroate synthase","volume":"49","author":"Hevener","year":"2009","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2023.117376_b0230","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2023.117376_b0235","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A boiled-egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2023.117376_b0240","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117376_b0245","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/ph13010008","article-title":"Colchicine-binding site inhibitors from chemistry to clinic: a review","volume":"13","author":"McLoughlin","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2023.117376_b0250","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1128\/AAC.00548-09","article-title":"In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences","volume":"53","author":"Vermeersch","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2023.117376_b0255","doi-asserted-by":"crossref","first-page":"e01351","DOI":"10.1128\/AAC.01351-17","article-title":"A 2-hydroxyisoquinoline-1,3-dione active-site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase","volume":"61","author":"Kirby","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2023.117376_b0260","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/glycob\/1.6.631","article-title":"Molecular modelling of protein-carbohydrate interactions. docking of monosaccharides in the binding site of concanavalin A","volume":"1","author":"Imberty","year":"1991","journal-title":"Glycobiology"},{"key":"10.1016\/j.bmc.2023.117376_b0265","volume":"Vol. 12","author":"Jeffrey","year":"1997"},{"key":"10.1016\/j.bmc.2023.117376_b0270","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1021\/acsomega.6b00123","article-title":"Free energy-based virtual screening and optimization of RNase H inhibitors of HIV-1 reverse transcriptase","volume":"1","author":"Zhang","year":"2016","journal-title":"ACS Omega"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623002249?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623002249?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:25:30Z","timestamp":1760837130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089623002249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":54,"alternative-id":["S0968089623002249"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117376","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Versatile anti-infective properties of pyrido- and dihydropyrido[2,3-d]pyrimidine-based compounds","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117376"}}