{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:24:37Z","timestamp":1771233877244,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.bmc.2023.117410","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T21:17:34Z","timestamp":1688764654000},"page":"117410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for detection of amyloid \u03b2 peptide in Alzheimer mouse models"],"prefix":"10.1016","volume":"92","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengting","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luyang","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xirong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2023.117410_b0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neucom.2019.04.066","article-title":"Multi-modal AD classification via self-paced latent correlation analysis","volume":"355","author":"Zhu","year":"2019","journal-title":"Neurocomputing"},{"key":"10.1016\/j.bmc.2023.117410_b0010","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1111\/bpa.12882","article-title":"Genomic mechanisms in Alzheimer's disease","volume":"30","author":"Bertram","year":"2020","journal-title":"Brain Pathol"},{"key":"10.1016\/j.bmc.2023.117410_b0015","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer\u2019s disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural Regener Res"},{"key":"10.1016\/j.bmc.2023.117410_b0020","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-020-00391-7","article-title":"Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease","volume":"15","author":"Guo","year":"2020","journal-title":"Mol Neurodegen"},{"key":"10.1016\/j.bmc.2023.117410_b0025","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.jalz.2019.09.075","article-title":"The path forward in Alzheimer's disease therapeutics: reevaluating the amyloid cascade hypothesis","volume":"16","author":"Tolar","year":"2020","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.bmc.2023.117410_b0030","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1038\/nn.4017","article-title":"The case for rejecting the amyloid cascade hypothesis","volume":"18","author":"Herrup","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bmc.2023.117410_b0035","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.3233\/JAD-191321","article-title":"Amyloid-\u03b2 in Alzheimer's disease: a study of citation practices of the amyloid cascade hypothesis between 1992 and 2019","volume":"74","author":"Daly","year":"2020","journal-title":"J Alzheimer\u2019s Dis"},{"key":"10.1016\/j.bmc.2023.117410_b0040","first-page":"257","article-title":"A\u03b2 and tau structure-based biomarkers for blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease","volume":"11","author":"Nabers","year":"2019","journal-title":"Alzheimer\u2019s Dementia: Diagn Assess Dis Monit"},{"key":"10.1016\/j.bmc.2023.117410_b0045","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/bpa.12734","article-title":"A\u03b2 oligomers trigger and accelerate A\u03b2 seeding","volume":"30","author":"Katzmarski","year":"2020","journal-title":"Brain Pathol"},{"key":"10.1016\/j.bmc.2023.117410_b0050","first-page":"184","volume":"256","author":"Hardy","year":"1992","journal-title":"Alzheimer's Disease: The Amyloid Cascade Hypothesis"},{"key":"10.1016\/j.bmc.2023.117410_b0055","doi-asserted-by":"crossref","first-page":"S313","DOI":"10.3233\/JAD-2012-129016","article-title":"Recent advances in imaging Alzheimer's disease","volume":"33","author":"Braskie","year":"2013","journal-title":"J Alzheimer\u2019s Dis Jad"},{"key":"10.1016\/j.bmc.2023.117410_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2019.120644","article-title":"Applications of biosensors in Alzheimer's diagnosis","volume":"210","author":"Brazaca","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.bmc.2023.117410_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2021.110017","article-title":"Integrated positron emission tomography\/magnetic resonance imaging in clinical diagnosis of Alzheimer's disease","volume":"145","author":"Gao","year":"2021","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.bmc.2023.117410_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111982","article-title":"Biological applications of near-infrared fluorescence dye probes in monitoring Alzheimer's disease","volume":"187","author":"Gyasi","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2020.115559","article-title":"Versatile near-infrared fluorescent probe for in vivo detection of A\u03b2 oligomers","volume":"28","author":"Zeng","year":"2020","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0080","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/alzrt276","article-title":"Imaging as a biomarker in drug discovery for Alzheimer's disease: is MRI a suitable technology?","volume":"6","author":"Pich","year":"2014","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.bmc.2023.117410_b0085","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00259-011-1960-4","article-title":"Amyloid-\u03b2 imaging with PET in Alzheimer's disease: is it feasible with current radiotracers and technologies?","volume":"39","author":"Moghbel","year":"2012","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1016\/j.bmc.2023.117410_b0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.apsb.2014.12.006","article-title":"Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer\u05f3s disease","volume":"5","author":"Tong","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmc.2023.117410_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2021.109466","article-title":"Research progress of multi-functional fluorescent probes for Alzheimer's disease monitoring","volume":"193","author":"Yang","year":"2021","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.bmc.2023.117410_b0100","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1002\/anie.200500845","article-title":"In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers","volume":"44","author":"Nesterov","year":"2005","journal-title":"Angewandte Chemie"},{"key":"10.1016\/j.bmc.2023.117410_b0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nbt1085","article-title":"In vivo detection of amyloid-\u03b2 deposits by near-infrared imaging using an oxazine-derivative probe","volume":"23","author":"Hintersteiner","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.bmc.2023.117410_b0110","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.chembiol.2010.05.013","article-title":"Probing the probes: fitness factors for small molecule tools","volume":"17","author":"Workman","year":"2010","journal-title":"Chem Biol"},{"key":"10.1016\/j.bmc.2023.117410_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111888","article-title":"Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential","volume":"141","author":"Fu","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmc.2023.117410_b0120","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","article-title":"Curcumin and health","volume":"21","author":"Pulido-Moran","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2023.117410_b0125","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1007\/s13738-022-02522-x","article-title":"A structural and optical study of curcumin and curcumin analogs","volume":"19","author":"Tahay","year":"2022","journal-title":"J Iran Chem Soc"},{"key":"10.1016\/j.bmc.2023.117410_b0130","doi-asserted-by":"crossref","first-page":"6111","DOI":"10.1021\/jm0607193","article-title":"Curcumin, and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for \u03b2-amyloid plaque imaging\\dag","volume":"49","author":"Ryu","year":"2006","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.hermed.2015.03.001","article-title":"Curcumin, a golden spice with low bioavailability","volume":"5","author":"Siviero","year":"2015","journal-title":"J Herbal Med"},{"key":"10.1016\/j.bmc.2023.117410_b0140","first-page":"5259","article-title":"An electron-accepting aza-BODIPY-based donor\u2013acceptor\u2013donor architecture for bright NIR emission","volume":"27","author":"Kage","year":"2021","journal-title":"Chem \u2013 A: Eur J"},{"key":"10.1016\/j.bmc.2023.117410_b0145","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1021\/ja9047043","article-title":"Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-\u03b2 deposits","volume":"131","author":"Ran","year":"2009","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2023.117410_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105167","article-title":"Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for the in vivo optical imaging of amyloid-\u03b2 plaques","volume":"115","author":"Park","year":"2021","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0155","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1021\/acs.analchem.5b04441","article-title":"Amyloid-\u03b2 deposits target efficient near-infrared fluorescent probes: synthesis, vitro evaluation, and in vivo imaging","volume":"88","author":"Fu","year":"2016","journal-title":"Anal Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0160","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.dyepig.2018.12.003","article-title":"A curcumin-based NIR fluorescence probe for detection of amyloid-beta (A\u03b2) plaques in Alzheimer's disease","volume":"163","author":"Si","year":"2019","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.bmc.2023.117410_b0165","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s10965-020-02363-3","article-title":"Antibacterial gauze based on the synergistic antibacterial mechanism of antimicrobial peptides and silver nanoparticles","volume":"28","author":"Chen","year":"2021","journal-title":"J Polym Res"},{"key":"10.1016\/j.bmc.2023.117410_b0170","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1021\/jo400389h","article-title":"Synthesis and photophysical properties of difluoroboron complexes of curcuminoid derivatives bearing different terminal aromatic units and a meso-aryl ring","volume":"78","author":"Felouat","year":"2013","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0175","doi-asserted-by":"crossref","first-page":"16397","DOI":"10.1021\/ja405239v","article-title":"Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer\u2019s disease","volume":"135","author":"Zhang","year":"2013","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2023.117410_b0180","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1021\/acssensors.0c01914","article-title":"In vivo brain imaging of amyloid-\u03b2 aggregates in Alzheimer\u2019s disease with a near-infrared fluorescent probe","volume":"6","author":"Wu","year":"2021","journal-title":"ACS Sensors"},{"key":"10.1016\/j.bmc.2023.117410_b0185","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1021\/acschemneuro.1c00419","article-title":"Curcumin complex analogues as near-infrared fluorescent probes for monitoring all A\u03b2 species in the early Alzheimer\u2019s disease model","volume":"12","author":"Ge","year":"2021","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.bmc.2023.117410_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120686","article-title":"Keto form of curcumin derivatives strongly binds to A\u03b2 oligomers but not fibrils","volume":"270","author":"Yanagisawa","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bmc.2023.117410_b0195","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.7150\/thno.68679","article-title":"Engineering of donor-acceptor-donor curcumin analogs as near-infrared fluorescent probes for <i>in vivo<\/I> imaging of amyloid-\u03b2 species","volume":"12","author":"Fang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bmc.2023.117410_b0200","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1007\/s10895-020-02574-3","article-title":"Spectrofluorometric method development and validation for the determination of curcumin in nanoliposomes and plasma","volume":"30","author":"Karimi","year":"2020","journal-title":"J Fluoresc"},{"key":"10.1016\/j.bmc.2023.117410_b0205","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijleo.2017.09.029","article-title":"Fluorometric based procedure for measuring curcumin concentration in commercial herbal medicines","volume":"149","author":"Nugraha","year":"2017","journal-title":"Optik"},{"key":"10.1016\/j.bmc.2023.117410_b0210","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.saa.2019.01.028","article-title":"Determination of curcuminoid content in turmeric using fluorescence spectroscopy","volume":"213","author":"Ali","year":"2019","journal-title":"Spectrochim Acta. Part A, Mol Biomol Spectrosc"},{"key":"10.1016\/j.bmc.2023.117410_b0215","doi-asserted-by":"crossref","first-page":"11550","DOI":"10.1039\/C4CC03731F","article-title":"A bifunctional curcumin analog for two-photon imaging and inhibiting cross-linking of amyloid beta in Alzheimer's disease","volume":"50","author":"Zhang","year":"2014","journal-title":"Chem Commun"},{"key":"10.1016\/j.bmc.2023.117410_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e06646","article-title":"Exploring the molecular structure, vibrational spectroscopic, quantum chemical calculation and molecular docking studies of curcumin: a potential PI3K\/AKT uptake inhibitor","volume":"7","author":"Govindammal","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.bmc.2023.117410_b0225","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jphotochem.2018.05.028","article-title":"Highly Stoke shifted near-infrared (NIR) emitting donor-pi-acceptor chromophore: Synthesis and combined experimental and computational studies of photophysical properties","volume":"363","author":"Jadhav","year":"2018","journal-title":"J Photochem Photobiol A: Chem"},{"key":"10.1016\/j.bmc.2023.117410_b0230","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1039\/D0QM00617C","article-title":"Nanoprobes with aggregation-induced emission for theranostics","volume":"5","author":"Wu","year":"2021","journal-title":"Mater Chem Front"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623002584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623002584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:22:29Z","timestamp":1760836949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089623002584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":46,"alternative-id":["S0968089623002584"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117410","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and evaluation of curcumin-based near-infrared fluorescent probes for detection of amyloid \u03b2 peptide in Alzheimer mouse models","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117410"}}