{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:59:00Z","timestamp":1767664740012,"version":"build-2065373602"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310197\/2021-0","408208\/2018-0"],"award-info":[{"award-number":["310197\/2021-0","408208\/2018-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["0673\/13-CT-Infra","155675\/2016-8"],"award-info":[{"award-number":["0673\/13-CT-Infra","155675\/2016-8"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-00789-22","APQ-01116-21","APQ-01487-22","APQ-04686-22"],"award-info":[{"award-number":["APQ-00789-22","APQ-01116-21","APQ-01487-22","APQ-04686-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003105","name":"Universidade Federal de Uberl\u00e2ndia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.506794\/2020-01"],"award-info":[{"award-number":["88881.506794\/2020-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bmc.2023.117488","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T05:23:35Z","timestamp":1696483415000},"page":"117488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Discovery and structural optimization of a new series of N-acyl-2-aminobenzothiazole as inhibitors of Zika virus"],"prefix":"10.1016","volume":"95","author":[{"given":"Renieidy Fl\u00e1via Clemente","family":"Dias","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz Murta Rezende Moraes","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha Marques","family":"Cassani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danilo Nascimento","family":"Farago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna Andr\u00e9","family":"Antoniucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Eduardo","family":"de Oliveira Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"de Oliveira Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Jorge","family":"Pilau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Gomes","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafaela Salgado","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso","family":"de Oliveira Rezende J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2023.117488_b0005","doi-asserted-by":"crossref","unstructured":"Santos LLM, de Aquino EC, Fernandes SM, Ternes YMF, Feres VC de R. Dengue, chikungunya, and Zika virus infections in Latin America and the Caribbean: a systematic review. Revista Panamericana de Salud P\u00fablica. 2023;47:1. 10.26633\/RPSP.2023.34.","DOI":"10.26633\/RPSP.2023.34"},{"key":"10.1016\/j.bmc.2023.117488_b0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.virol.2020.01.015","article-title":"Zika virus-spread, epidemiology, genome, transmission cycle, clinical manifestation, associated challenges, vaccine and antiviral drug development","volume":"543","author":"Pielnaa","year":"2020","journal-title":"Virology"},{"key":"10.1016\/j.bmc.2023.117488_b0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.antiviral.2016.03.010","article-title":"Zika virus: History, emergence, biology, and prospects for control","volume":"130","author":"Weaver","year":"2016","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2023.117488_b0020","doi-asserted-by":"crossref","DOI":"10.1590\/S1518-8787.2016050006791","article-title":"Emerging arboviruses and public health challenges in Brazil","volume":"50","author":"Lima-Camara","year":"2016","journal-title":"Rev Saude Publica"},{"key":"10.1016\/j.bmc.2023.117488_b0025","doi-asserted-by":"crossref","first-page":"898","DOI":"10.3390\/pathogens9110898","article-title":"Zika Virus","volume":"9","author":"Masmejan","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.bmc.2023.117488_b0030","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable Non\u2013Vector-borne Transmission of Zika Virus, Colorado, USA","volume":"17","author":"Foy","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.bmc.2023.117488_b0035","doi-asserted-by":"crossref","unstructured":"Besnard M, Last\u00e8re S, Teissier A, Cao-Lormeau VM, Musso D. Evidence of perinatal transmission of Zika virus, French Polynesia, December 2013 and February 2014. Eurosurveillance. 2014;19. 10.2807\/1560-7917.ES2014.19.13.20751.","DOI":"10.2807\/1560-7917.ES2014.19.13.20751"},{"key":"10.1016\/j.bmc.2023.117488_b0040","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.htct.2018.01.011","article-title":"Risk of Zika virus transmission by blood donations in Brazil","volume":"40","author":"Magnus","year":"2018","journal-title":"Hematol Transfus Cell Ther"},{"key":"10.1016\/j.bmc.2023.117488_b0045","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41564-020-0714-0","article-title":"The continued threat of emerging flaviviruses","volume":"5","author":"Pierson","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.bmc.2023.117488_b0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0035-9203(52)90042-4","article-title":"Zika Virus (I). Isolations and serological specificity","volume":"46","author":"Dick","year":"1952","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.bmc.2023.117488_b0055","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.str.2018.05.006","article-title":"Refinement and Analysis of the Mature Zika Virus Cryo-EM Structure at 3.1 \u00c5 Resolution","volume":"26","author":"Sevvana","year":"2018","journal-title":"Structure"},{"key":"10.1016\/j.bmc.2023.117488_b0060","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jobm.201700398","article-title":"Zika virus: what we need to know?","volume":"58","author":"Javed","year":"2018","journal-title":"J Basic Microbiol"},{"key":"10.1016\/j.bmc.2023.117488_b0065","unstructured":"Ministry of Health (Brazil). Health surveillance department. Health surveillance in Brazil 2003|2022: from the creation of the health surveillance secretary to the present day. Bol Epidemiol. http:\/\/www.saude.gov.br\/boletins-epidemiologicos."},{"key":"10.1016\/j.bmc.2023.117488_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105517","article-title":"Therapeutics for flaviviral infections","volume":"210","author":"Bifani","year":"2023","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2023.117488_b0075","doi-asserted-by":"crossref","unstructured":"Ramos PRP da S, Mottin M, Lima CS, et al. Natural Compounds as Non-Nucleoside Inhibitors of Zika Virus Polymerase through Integration of In Silico and In Vitro Approaches. Pharmaceuticals. 2022;15:1493. 10.3390\/ph15121493.","DOI":"10.3390\/ph15121493"},{"key":"10.1016\/j.bmc.2023.117488_b0080","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.drudis.2006.06.016","article-title":"Hit discovery and hit-to-lead approaches","volume":"11","author":"Keser\u0171","year":"2006","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.bmc.2023.117488_b0085","article-title":"Overview of Hit to Lead: The Medicinal Chemist\u2019s Role from HTS Retest to Lead Optimization Hand Off","volume":"1\u201324","author":"Lipinski","year":"2009","journal-title":"In"},{"key":"10.1016\/j.bmc.2023.117488_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113220","article-title":"Synthetic and medicinal perspective of quinolines as antiviral agents","volume":"215","author":"Kaur","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0095","doi-asserted-by":"crossref","first-page":"8693","DOI":"10.1093\/nar\/gkz650","article-title":"Zika virus NS3 is a canonical RNA helicase stimulated by NS5 RNA polymerase","volume":"47","author":"Xu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.bmc.2023.117488_b0100","first-page":"1439","article-title":"Structure-Based Macrocyclization of Substrate Analogue NS2B-NS3 Protease Inhibitors of Zika","volume":"15","author":"Braun","year":"2020","journal-title":"West Nile and Dengue Viruses Chemmedchem"},{"key":"10.1016\/j.bmc.2023.117488_b0105","article-title":"Flavivirus enzymes and their inhibitors","volume":"265\u2013303","author":"Knyazhanskaya","year":"2021","journal-title":"In"},{"key":"10.1016\/j.bmc.2023.117488_b0110","first-page":"503","article-title":"Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor","volume":"353","author":"Lei","year":"2016","journal-title":"Science (1979)"},{"key":"10.1016\/j.bmc.2023.117488_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106109","article-title":"Structure-based design of a novel inhibitor of the ZIKA virus NS2B\/NS3 protease","volume":"128","author":"Xiong","year":"2022","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2022.105255","article-title":"Identification of a small compound that specifically inhibits Zika virus in vitro and in vivo by targeting the NS2B-NS3 protease","volume":"199","author":"Miao","year":"2022","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2023.117488_b0125","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202200336","article-title":"Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease","volume":"18","author":"Braun","year":"2023","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2023.117488_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116392","article-title":"SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B\/NS3 proteases","volume":"47","author":"Maus","year":"2021","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0135","doi-asserted-by":"crossref","unstructured":"Mottin M, de Paula Sousa BK, de Moraes Roso Mesquita NC, et al. Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika. J Chem Inf Model. 2022;62:6825-6843. 10.1021\/acs.jcim.2c00596.","DOI":"10.1021\/acs.jcim.2c00596"},{"key":"10.1016\/j.bmc.2023.117488_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.106269","article-title":"Allosteric quinoxaline-based inhibitors of the flavivirus NS2B\/NS3 protease","volume":"131","author":"Zephyr","year":"2023","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0145","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1021\/acsmedchemlett.9b00405","article-title":"Discovery of Zika Virus NS2B\/NS3 Inhibitors That Prevent Mice from Life-Threatening Infection and Brain Damage","volume":"11","author":"Coluccia","year":"2020","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2023.117488_b0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.antiviral.2016.12.016","article-title":"Identification of novel small molecule inhibitors against NS2B\/NS3 serine protease from Zika virus","volume":"139","author":"Lee","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2023.117488_b0155","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1021\/acs.jmedchem.9b01697","article-title":"Proline-Based Allosteric Inhibitors of Zika and Dengue Virus NS2B\/NS3 Proteases","volume":"62","author":"Millies","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0160","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/jphp.13331","article-title":"Benzothiazoles as potential antiviral agents","volume":"72","author":"Asiri","year":"2020","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.bmc.2023.117488_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198388","article-title":"Discovery of an imidazonaphthyridine and a riminophenazine as potent anti-Zika virus agents through a replicon-based high-throughput screening","volume":"299","author":"Fernandes","year":"2021","journal-title":"Virus Res"},{"key":"10.1016\/j.bmc.2023.117488_b0170","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.antiviral.2017.09.004","article-title":"Cell-line dependent antiviral activity of sofosbuvir against Zika virus","volume":"146","author":"Mumtaz","year":"2017","journal-title":"Antiviral Res"},{"key":"10.1016\/j.bmc.2023.117488_b0175","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1021\/jm901070c","article-title":"Quantitative Analyses of Aggregation, Autofluorescence, and Reactivity Artifacts in a Screen for Inhibitors of a Thiol Protease","volume":"53","author":"Jadhav","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0180","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1021\/jm061317y","article-title":"A High-Throughput Screen for Aggregation-Based Inhibition in a Large Compound Library","volume":"50","author":"Feng","year":"2007","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0185","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nprot.2006.77","article-title":"A detergent-based assay for the detection of promiscuous inhibitors","volume":"1","author":"Feng","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bmc.2023.117488_b0190","doi-asserted-by":"crossref","unstructured":"Rodney Rodrigues de Assis D, Almeida Oliveira A, Luiz Porto S, et al. 4-Chlorophenylthioacetone-derived thiosemicarbazones as potent antitrypanosomal drug candidates: Investigations on the mode of action. Bioorg Chem 2021;113:105018. 10.1016\/j.bioorg.2021.105018.","DOI":"10.1016\/j.bioorg.2021.105018"},{"key":"10.1016\/j.bmc.2023.117488_b0195","doi-asserted-by":"crossref","first-page":"13054","DOI":"10.1021\/acs.jmedchem.1c01151","article-title":"Structure-Based Optimization of Quinazolines as Cruzain and Tbr CATL Inhibitors","volume":"64","author":"Barbosa da Silva","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0200","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1021\/jm9009229","article-title":"Divergent Modes of Enzyme Inhibition in a Homologous Structure\u2212Activity Series","volume":"52","author":"Ferreira","year":"2009","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0205","doi-asserted-by":"crossref","unstructured":"do Valle Moreira T, Martins LC, Diniz LA, Bernardes TCD, de Oliveira RB, Ferreira RS. Screening the Pathogen Box to Discover and Characterize New Cruzain and TbrCatL Inhibitors. Pathogens. 2023;12(2):251. 10.3390\/pathogens12020251.","DOI":"10.3390\/pathogens12020251"},{"key":"10.1016\/j.bmc.2023.117488_b0210","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1021\/jm010533y","article-title":"A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening","volume":"45","author":"McGovern","year":"2002","journal-title":"J Med Chem"},{"year":"1976","series-title":"Biochemical Calculations: How to Solve Mathematical Problems in General Biochemistry","author":"Segel","key":"10.1016\/j.bmc.2023.117488_b0215"},{"key":"10.1016\/j.bmc.2023.117488_b0220","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1021\/acs.jmedchem.0c00413","article-title":"A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays","volume":"63","author":"K\u00fchl","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0225","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2023.117488_b0230","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1021\/acs.jmedchem.9b00775","article-title":"Drugs for the Treatment of Zika Virus Infection","volume":"63","author":"Bernatchez","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0235","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2165\/00003088-200342010-00003","article-title":"Role of P-Glycoprotein in Pharmacokinetics","volume":"42","author":"Lin","year":"2003","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.bmc.2023.117488_b0240","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1128\/AAC.48.4.1073-1081.2004","article-title":"P Glycoprotein in Human Immunodeficiency Virus Type 1 Infection and Therapy","volume":"48","author":"Sankatsing","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2023.117488_b0245","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","article-title":"Drug-like properties and the causes of poor solubility and poor permeability","volume":"44","author":"Lipinski","year":"2000","journal-title":"J Pharmacol Toxicol Methods"},{"key":"10.1016\/j.bmc.2023.117488_b0250","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/cc9800071","article-title":"A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases","volume":"1","author":"Ghose","year":"1999","journal-title":"J Comb Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0255","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular Properties That Influence the Oral Bioavailability of Drug Candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0260","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm000292e","article-title":"Prediction of Drug Absorption Using Multivariate Statistics","volume":"43","author":"Egan","year":"2000","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0265","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1021\/jm015507e","article-title":"Simple Selection Criteria for Drug-like Chemical Matter","volume":"44","author":"Muegge","year":"2001","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0270","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117488_b0275","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cmdc.200700139","article-title":"Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases","volume":"3","author":"Brenk","year":"2008","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2023.117488_b0280","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2023.117488_b0285","doi-asserted-by":"crossref","first-page":"e0005048","DOI":"10.1371\/journal.pntd.0005048","article-title":"Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil","volume":"10","author":"Donald","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.bmc.2023.117488_b0290","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.ijbiomac.2022.12.102","article-title":"Roles of Bothrops jararacussu toxins I and II: Antiviral findings against Zika virus","volume":"227","author":"Cassani","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.bmc.2023.117488_b0295","doi-asserted-by":"crossref","first-page":"8717","DOI":"10.1038\/s41598-021-88039-4","article-title":"Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus","volume":"11","author":"Santos","year":"2021","journal-title":"Sci Rep"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962300336X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962300336X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:22:47Z","timestamp":1760836967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962300336X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":59,"alternative-id":["S096808962300336X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117488","relation":{},"ISSN":["0968-0896"],"issn-type":[{"type":"print","value":"0968-0896"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery and structural optimization of a new series of N-acyl-2-aminobenzothiazole as inhibitors of Zika virus","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117488","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117488"}}