{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:30:52Z","timestamp":1792989052520,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["109-2320-B-400-015"],"award-info":[{"award-number":["109-2320-B-400-015"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["110-2320-B-400-004-MY2"],"award-info":[{"award-number":["110-2320-B-400-004-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005057","name":"National Tsing Hua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["MOHW110-TDU-C-222-000010"],"award-info":[{"award-number":["MOHW110-TDU-C-222-000010"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bmc.2023.117502","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T11:11:42Z","timestamp":1697281902000},"page":"117502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Analysis of structure\u2013activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors"],"prefix":"10.1016","volume":"95","author":[{"given":"Po-Wei","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4437-3530","authenticated-orcid":false,"given":"Wei-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine-Hsine","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Shin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9857-068X","authenticated-orcid":false,"given":"Liuh-Yow","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3011-8440","authenticated-orcid":false,"given":"Chun-Wei","family":"Tung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3287-0193","authenticated-orcid":false,"given":"Shau-Hua","family":"Ueng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2023.117502_b0005","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/nature08476","article-title":"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity","volume":"461","author":"Ishikawa","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117502_b0010","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.1038\/ncomms11932","article-title":"Activation of STING requires palmitoylation at the Golg","volume":"7","author":"Mukai","year":"2016","journal-title":"Nature Communications"},{"key":"10.1016\/j.bmc.2023.117502_b0015","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-019-0998-5","article-title":"Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP\u2013AMP","volume":"567","author":"Shang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117502_b0020","first-page":"ra20","article-title":"STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway","volume":"201","author":"Tanaka","year":"2012","journal-title":"Science Signaling"},{"key":"10.1016\/j.bmc.2023.117502_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.03.056","article-title":"TBK1 and IKK\u03b5 act redundantly to mediate STING-induced NF-\u03baB responses in myeloid cells","volume":"31","author":"Balka","year":"2020","journal-title":"Cell Reports"},{"key":"10.1016\/j.bmc.2023.117502_b0030","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP Synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.bmc.2023.117502_b0035","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signaling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117502_b0040","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1172\/JCI79100","article-title":"Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations","volume":"124","author":"Jeremiah","year":"2014","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.bmc.2023.117502_b0045","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jaci.2020.06.032","article-title":"A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI)","volume":"146","author":"Lin","year":"2020","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.bmc.2023.117502_b0050","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/art.40002","article-title":"Expression of cyclic GMP-AMP synthase in patients with systemic lupus erythematosus","volume":"69","author":"An","year":"2017","journal-title":"Arthritis & Rheumatology"},{"key":"10.1016\/j.bmc.2023.117502_b0055","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri3850","article-title":"Aicardi-Gouti\u00e8res syndrome and the type I interferonopathies","volume":"15","author":"Crow","year":"2015","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.bmc.2023.117502_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101706","article-title":"STING mediates lupus via the activation of conventional dendritic cell maturation and plasmacytoid dendritic cell differentiation","volume":"23","author":"Thim-Uam","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.bmc.2023.117502_b0065","doi-asserted-by":"crossref","first-page":"eaax7942","DOI":"10.1126\/scisignal.aax7942","article-title":"The cytosolic DNA sensor cGAS recognizes neutrophil extracellular traps","volume":"14","author":"Apel","year":"2021","journal-title":"Science Signaling"},{"key":"10.1016\/j.bmc.2023.117502_b0070","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS\u2013STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.bmc.2023.117502_b0075","unstructured":"Fosbenner DT, Graybill TL, Kang J, et al. Modulators of stimulator of interferon genes (sting), WO2019069270, 2019."},{"key":"10.1016\/j.bmc.2023.117502_b0080","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1016\/j.celrep.2018.11.097","article-title":"The cyclopeptide astin c specifically inhibits the innate immune CDN sensor STING","volume":"25","author":"Li","year":"2018","journal-title":"Cell Reports"},{"key":"10.1016\/j.bmc.2023.117502_b0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1021\/acsmedchemlett.8b00466","article-title":"Discovery of a novel cGAMP competitive ligand of the inactive form of STING","volume":"10","author":"Siu","year":"2019","journal-title":"ACS Medicinal Chemistry Letters"},{"key":"10.1016\/j.bmc.2023.117502_b0090","article-title":"STING inhibitors target the cyclic dinucleotide binding pocket","volume":"118","author":"Hong","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bmc.2023.117502_b0095","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117502_b0100","unstructured":"Result that inquired from \u201cThe Cortellis Drug Discovery Intelligence\u201d database in Jan. 2023."},{"key":"10.1016\/j.bmc.2023.117502_b0105","unstructured":"Banerjee M, Basu S, Shrivastava RK. Small molecules as STING antagonists and their preparation, WO2021161230, 2021."},{"key":"10.1016\/j.bmc.2023.117502_b0110","unstructured":"Kiyoi T, Matsumoto H, Takamatsu S. Preparation of benzimidazole derivative for inhibiting activation of STING pathway, WO2021193756, 2021."},{"key":"10.1016\/j.bmc.2023.117502_b0115","first-page":"E7768","article-title":"Nitro- fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling","volume":"115","author":"Hansen","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bmc.2023.117502_b0120","series-title":"An activity-guided map of electrophile-cysteine interactions in Primary human immune cells","author":"Cravatt","year":"2021"},{"key":"10.1016\/j.bmc.2023.117502_b0125","article-title":"Targeting STING oligomerization with small-molecule inhibitors","volume":"120","author":"Humphries","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.bmc.2023.117502_b0130","doi-asserted-by":"crossref","DOI":"10.1021\/jacs.3c03637","article-title":"Development of LB244, an irreversible STING antagonist","author":"Barasa","year":"2023","journal-title":"Journal of the American Chemical Society"},{"key":"10.1016\/j.bmc.2023.117502_b0135","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1055\/s-0032-1316857","article-title":"Total synthesis of 4-azaeudistomin Y1 and analogues by inverse-electron-demand Diels-Alder reactions of 3-aminoindoles with 1,3,5-triazines","volume":"45","author":"Xu","year":"2013","journal-title":"Synthesis"},{"key":"10.1016\/j.bmc.2023.117502_b0140","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/abbs\/gmaa051","article-title":"TBK1, a central kinase in innate immune sensing of nucleic acids and beyond","volume":"52","author":"Zhou","year":"2020","journal-title":"Acta Biochimica et Biophysica Sinica (Shanghai)"},{"key":"10.1016\/j.bmc.2023.117502_b0145","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.febslet.2013.01.052","article-title":"Negative regulation of TBK1-mediated antiviral immunity","volume":"587","author":"Zhao","year":"2013","journal-title":"FEBS Letters"},{"key":"10.1016\/j.bmc.2023.117502_b0150","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13046-022-02352-y","article-title":"The role of TBK1 in cancer pathogenesis and anticancer immunity","volume":"41","author":"Runde","year":"2022","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"10.1016\/j.bmc.2023.117502_b0155","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s41586-019-0998-5","article-title":"Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP","volume":"567","author":"Shang","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117502_b0160","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13321-020-00456-1","article-title":"An open source chemical structure curation pipeline using RDKit","volume":"12","author":"Bento","year":"2020","journal-title":"J. Cheminform."},{"key":"10.1016\/j.bmc.2023.117502_b0165","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1021\/acs.jpcb.7b02320","article-title":"Building a more predictive protein force field: a systematic and reproducible route to AMBER-FB15","volume":"121","author":"Wang","year":"2017","journal-title":"The Journal of Physical Chemistry. B"},{"key":"10.1016\/j.bmc.2023.117502_b0170","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"Journal of Chemical Information and Modeling"},{"key":"10.1016\/j.bmc.2023.117502_b0175","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/jcc.23702","article-title":"CHARMM-GUI membrane builder toward realistic biological membrane simulations","volume":"35","author":"Wu","year":"2014","journal-title":"Journal of Computational Chemistry"},{"key":"10.1016\/j.bmc.2023.117502_b0180","doi-asserted-by":"crossref","first-page":"D370","DOI":"10.1093\/nar\/gkr703","article-title":"OPM database and PPM web server: resources for positioning of proteins in membranes","volume":"40","author":"Lomize","year":"2012","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.bmc.2023.117502_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.888147","article-title":"Post-translational modifications of STING: a potential therapeutic target","volume":"13","author":"Kang","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.bmc.2023.117502_b0190","doi-asserted-by":"crossref","DOI":"10.1063\/5.0019056","article-title":"A fast and high-quality charge model for the next generation general AMBER force field","volume":"153","author":"He","year":"2020","journal-title":"The Journal of Chemical Physics"},{"key":"10.1016\/j.bmc.2023.117502_b0195","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/acs.jctc.1c01217","article-title":"Lipid21: complex lipid membrane simulations with AMBER","volume":"18","author":"Dickson","year":"2022","journal-title":"Journal of Chemical Theory and Computation"},{"key":"10.1016\/j.bmc.2023.117502_b0200","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"The Journal of Chemical Physics"},{"key":"10.1016\/j.bmc.2023.117502_b0205","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"Journal of Chemical Theory and Computation"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623003504?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623003504?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:24:16Z","timestamp":1760837056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089623003504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":41,"alternative-id":["S0968089623003504"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117502","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of structure\u2013activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117502"}}