{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T10:26:14Z","timestamp":1789640774954,"version":"4.0.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bmc.2023.117544","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T03:07:36Z","timestamp":1701832056000},"page":"117544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["A dual mechanism with H2S inhibition and membrane damage of morusin from Morus alba Linn. against MDR-MRSA"],"prefix":"10.1016","volume":"97","author":[{"given":"Yan-Yan","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Shun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Zhen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2023.117544_b0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2023.117544_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.bmc.2023.117544_b0015","article-title":"The staggering death toll of drug-resistant bacteria","author":"Thompson","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117544_b0020","unstructured":"O'Neill J, Tackling drug-resistant infections globally: final report and recommendations; 2016."},{"key":"10.1016\/j.bmc.2023.117544_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121249","article-title":"Infection microenvironment-related antibacterial nanotherapeutic strategies","volume":"280","author":"Wang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.bmc.2023.117544_b0030","doi-asserted-by":"crossref","first-page":"13517","DOI":"10.1073\/pnas.1408601111","article-title":"Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase","volume":"111","author":"Zhang","year":"2014","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2023.117544_b0035","doi-asserted-by":"crossref","first-page":"8095","DOI":"10.2147\/IJN.S179380","article-title":"Exosome-encapsulated antibiotic against intracellular infections of methicillin-resistant Staphylococcus aureus","volume":"13","author":"Yang","year":"2018","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.bmc.2023.117544_b0040","unstructured":"Antibiotic resistance threats in the United States, 2019; 2019."},{"key":"10.1016\/j.bmc.2023.117544_b0045","unstructured":"Organization WH, Target product profiles for antibacterial resistance diagnostics; 2020."},{"key":"10.1016\/j.bmc.2023.117544_b0050","doi-asserted-by":"crossref","first-page":"2100749","DOI":"10.1002\/advs.202100749","article-title":"Plant Natural Flavonoids Against Multidrug Resistant Pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv Sci"},{"key":"10.1016\/j.bmc.2023.117544_b0055","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1002\/mbo3.1249","article-title":"Survival strategies of bacteria in response to excessive reactive oxygen species: a review","volume":"48","author":"Zhang","year":"2021","journal-title":"Microbiology"},{"key":"10.1016\/j.bmc.2023.117544_b0060","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.1209855","article-title":"H2S: A Universal Defense Against Antibiotics in Bacteria","volume":"334","author":"Shatalin","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bmc.2023.117544_b0065","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1016\/j.chembiol.2020.10.012","article-title":"Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival","volume":"27","author":"Croppi","year":"2020","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.bmc.2023.117544_b0070","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.tips.2016.05.001","article-title":"Natural Products as a Source for Novel Antibiotics","volume":"37","author":"Moloney","year":"2016","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.bmc.2023.117544_b0075","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrmicro2319","article-title":"Antibiotic resistance and its cost: is it possible to reverse resistance?","volume":"8","author":"Andersson","year":"2010","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmc.2023.117544_b0080","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3390\/antibiotics9110830","article-title":"African Plant-Based Natural Products with Antivirulence Activities to the Rescue of Antibiotics","volume":"9","author":"Mahavy","year":"2020","journal-title":"Antibiotics-Basel."},{"key":"10.1016\/j.bmc.2023.117544_b0085","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.bmc.2023.117544_b0090","doi-asserted-by":"crossref","first-page":"8665","DOI":"10.1021\/acs.jmedchem.8b01781","article-title":"Antibiotic Adjuvants: Make Antibiotics Great Again!","volume":"62","author":"Douafer","year":"2019","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117544_b0095","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.phymed.2003.09.005","article-title":"Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai","volume":"11","author":"Sohn","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bmc.2023.117544_b0100","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tifs.2015.03.007","article-title":"Prenylated flavonoids, promising nutraceuticals with impressive biological activities","volume":"44","author":"Yang","year":"2015","journal-title":"Trends Food Sci Tech."},{"key":"10.1016\/j.bmc.2023.117544_b0105","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3390\/molecules21050608","article-title":"Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues","volume":"21","author":"Stompor","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2023.117544_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114542","article-title":"Bioguided isolation, identification and bioactivity evaluation of anti-MRSA constituents from Morus alba Linn","volume":"281","author":"Zhu","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmc.2023.117544_b0115","doi-asserted-by":"crossref","first-page":"10222","DOI":"10.1021\/acs.jafc.9b01795","article-title":"Natural Flavones from Morus alba against Methicillin-Resistant Staphylococcus aureus via Targeting the Proton Motive Force and Membrane Permeability","volume":"67","author":"Wu","year":"2019","journal-title":"J Agr Food Chem."},{"key":"10.1016\/j.bmc.2023.117544_b0120","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jsps.2020.08.006","article-title":"Prenylated phenolics as promising candidates for combination antibacterial therapy: Morusin and kuwanon G","volume":"28","author":"Aelenei","year":"2020","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.bmc.2023.117544_b0125","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.1039\/C9FO01233H","article-title":"Destruction of the cell membrane and inhibition of cell phosphatidic acid biosynthesis in Staphylococcus aureus: an explanation for the antibacterial mechanism of morusin","volume":"10","author":"Pang","year":"2019","journal-title":"Food Funct"},{"key":"10.1016\/j.bmc.2023.117544_b0130","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41586-018-0344-3","article-title":"The outer membrane is an essential load-bearing element in Gram-negative bacteria","volume":"559","author":"Rojas","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117544_b0135","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.mi.37.100183.002441","article-title":"Structure, function, and assembly of cell walls of gram-positive bacteria","volume":"37","author":"Shockman","year":"1983","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.bmc.2023.117544_b0140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s13659-014-0033-3","article-title":"Chemical Composition of the Essential Oil of Mastic Gum and their Antibacterial Activity Against Drug-Resistant Helicobacter pylori","volume":"4","author":"Miyamoto","year":"2014","journal-title":"Nat Prod Bioprosp."},{"key":"10.1016\/j.bmc.2023.117544_b0145","doi-asserted-by":"crossref","first-page":"12903","DOI":"10.1021\/acs.jmedchem.1c01073","article-title":"Development of Membrane-Active Honokiol\/Magnolol Amphiphiles as Potent Antibacterial Agents against Methicillin-Resistant Staphylococcus aureus (MRSA)","volume":"64","author":"Guo","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117544_b0150","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1002\/anie.201209979","article-title":"Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials","volume":"52","author":"O'Connell","year":"2013","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.bmc.2023.117544_b0155","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1021\/ar400066v","article-title":"Designing mimics of membrane active proteins","volume":"46","author":"Sgolastra","year":"2013","journal-title":"Accounts Chem Res."},{"key":"10.1016\/j.bmc.2023.117544_b0160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1021\/acs.jmedchem.5b01500","article-title":"Nonpeptidic Amphiphilic Xanthone Derivatives: Structure-Activity Relationship and Membrane-Targeting Properties","volume":"59","author":"Koh","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117544_b0165","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s11259-008-9194-z","article-title":"Synergistic effects of miconazole and polymyxin B on microbial pathogens","volume":"33","author":"Pietschmann","year":"2009","journal-title":"Vet Res Commun"},{"key":"10.1016\/j.bmc.2023.117544_b0170","doi-asserted-by":"crossref","first-page":"16879","DOI":"10.1021\/acs.jmedchem.2c01674","article-title":"Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections","volume":"65","author":"Yang","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2023.117544_b0175","doi-asserted-by":"crossref","first-page":"S279","DOI":"10.1093\/cid\/10.Supplement_2.S279","article-title":"Structure and functions of the cell envelope of gram-negative bacteria","volume":"10","author":"Nikaido","year":"1988","journal-title":"Reviews Infect Dis"},{"key":"10.1016\/j.bmc.2023.117544_b0180","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.mi.38.100184.001321","article-title":"Alterations in outer membrane permeability","volume":"38","author":"Hancock","year":"1984","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.bmc.2023.117544_b0185","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/jb.97.1.448-452.1969","article-title":"Electron microscopic studies on mode of action of polymyxin","volume":"97","author":"Koike","year":"1969","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2023.117544_b0190","doi-asserted-by":"crossref","first-page":"16194","DOI":"10.1038\/nmicrobiol.2016.194","article-title":"Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids","volume":"2","author":"Pader","year":"2017","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.bmc.2023.117544_b0195","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/nchembio.2207","article-title":"Discovery of MRSA active antibiotics using primary sequence from the human microbiome","volume":"12","author":"Chu","year":"2016","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.bmc.2023.117544_b0200","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.cell.2020.05.005","article-title":"A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance","volume":"181","author":"Martin","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2023.117544_b0205","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.bbabio.2011.09.018","article-title":"Chemiosmotic coupling in oxidative and photosynthetic phosphorylation, 1966","volume":"1807","author":"Mitchell","year":"2011","journal-title":"Biochim. Biophys. Acta-Bioenerg."},{"key":"10.1016\/j.bmc.2023.117544_b0210","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/jb.147.3.820-826.1981","article-title":"Interconversion of Components of the Bacterial Proton Motive Force by Electrogenic Potassium-Transport","volume":"147","author":"Bakker","year":"1981","journal-title":"J Bacteriol"},{"key":"10.1016\/j.bmc.2023.117544_b0215","doi-asserted-by":"crossref","first-page":"7235","DOI":"10.1021\/bi9826299","article-title":"Mechanism of Interaction of Different Classes of Cationic Antimicrobial Peptides with Planar Bilayers and with the Cytoplasmic Membrane of Escherichia coli","volume":"38","author":"Wu","year":"1999","journal-title":"Biochemistry-US."},{"key":"10.1016\/j.bmc.2023.117544_b0220","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.chembiol.2013.07.006","article-title":"Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus","volume":"20","author":"Farha","year":"2013","journal-title":"Chem Biol"},{"key":"10.1016\/j.bmc.2023.117544_b0225","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1073\/pnas.1509743112","article-title":"Antibiotic efficacy is linked to bacterial cellular respiration","volume":"112","author":"Lobritz","year":"2015","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.bmc.2023.117544_b0230","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nrmicro1839","article-title":"Membrane lipid homeostasis in bacteria","volume":"6","author":"Zhang","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.bmc.2023.117544_b0235","doi-asserted-by":"crossref","first-page":"E3","DOI":"10.1038\/nature08667","article-title":"Essentiality of FASII pathway for Staphylococcus aureus","volume":"463","author":"Balemans","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2023.117544_b0240","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.mib.2011.07.029","article-title":"Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?","volume":"14","author":"Parsons","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bmc.2023.117544_b0245","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s13659-018-0169-7","article-title":"(\u00b1)-Zanthonitidine A, a Pair of Enantiomeric Furoquinoline Alkaloids from Zanthoxylum nitidum with Antibacterial Activity","volume":"8","author":"Zhao","year":"2018","journal-title":"Nat Prod Bioprosp."},{"key":"10.1016\/j.bmc.2023.117544_b0250","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1021\/acsinfecdis.9b00419","article-title":"Uncovering the Hidden Antibiotic Potential of Cannabis","volume":"6","author":"Farha","year":"2020","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.bmc.2023.117544_b0255","series-title":"Chapter 6 - Use of Essential Oils and Their Components against Multidrug-Resistant Bacteria, Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components","first-page":"65","author":"Faleiro","year":"2013"},{"key":"10.1016\/j.bmc.2023.117544_b0260","doi-asserted-by":"crossref","first-page":"6483","DOI":"10.1038\/s41598-019-42906-3","article-title":"Propidium iodide staining underestimates viability of adherent bacterial cells","volume":"9","author":"Rosenberg","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2023.117544_b0265","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/antibiotics9020092","article-title":"A Rapid Fluorescence-Based Microplate Assay to Investigate the Interaction of Membrane Active Antimicrobial Peptides with Whole Gram-Positive Bacteria","volume":"9","author":"Boix-Lemonche","year":"2020","journal-title":"Antibiotics-Basel."},{"key":"10.1016\/j.bmc.2023.117544_b0270","doi-asserted-by":"crossref","first-page":"e2100749","DOI":"10.1002\/advs.202100749","article-title":"Plant Natural Flavonoids Against Multidrug Resistant Pathogens","volume":"8","author":"Song","year":"2021","journal-title":"Adv Sci"},{"key":"10.1016\/j.bmc.2023.117544_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112758","article-title":"Phytochemical and anti-MRSA constituents of Zanthoxylum nitidum","volume":"148","author":"Zeng","year":"2022","journal-title":"Biomed Pharmacother"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623003929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089623003929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T01:23:45Z","timestamp":1760837025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089623003929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":55,"alternative-id":["S0968089623003929"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117544","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual mechanism with H2S inhibition and membrane damage of morusin from Morus alba Linn. against MDR-MRSA","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2023.117544","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117544"}}