{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:25:42Z","timestamp":1770009942793,"version":"3.49.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bmc.2024.117826","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T01:52:38Z","timestamp":1720144358000},"page":"117826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Synthesis and biological evaluation of O4\u2032-benzyl-hispidol derivatives and analogs as dual monoamine oxidase-B inhibitors and anti-neuroinflammatory agents"],"prefix":"10.1016","volume":"110","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1048-6281","authenticated-orcid":false,"given":"Ahmed H.E.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeonwoo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rium","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Jeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-8949","authenticated-orcid":false,"given":"Aya M.","family":"Almatary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-6409","authenticated-orcid":false,"given":"Selwan M.","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeongae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Kil","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Duk","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2024.117826_b0005","doi-asserted-by":"crossref","first-page":"11889","DOI":"10.1021\/acscatal.8b03525","article-title":"Monoamine oxidase: tunable activity for amine resolution and functionalization","volume":"8","author":"Batista","year":"2018","journal-title":"ACS Catal"},{"key":"10.1016\/j.bmc.2024.117826_b0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1389450117666151209123402","article-title":"A perspective on monoamine oxidase enzyme as drug target: challenges and opportunities","volume":"18","author":"Kumar","year":"2017","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.bmc.2024.117826_b0015","doi-asserted-by":"crossref","first-page":"6486","DOI":"10.1016\/j.bmc.2015.08.012","article-title":"Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors","volume":"23","author":"Choi","year":"2015","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0020","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jad.2021.01.021","article-title":"Revisiting monoamine oxidase inhibitors for the treatment of depressive disorders: a systematic review and network meta-analysis","volume":"282","author":"Suchting","year":"2021","journal-title":"J Affect Disord"},{"key":"10.1016\/j.bmc.2024.117826_b0025","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3389\/fphar.2016.00340","article-title":"Inhibitors of MAO-A and MAO-B in psychiatry and neurology","volume":"7","author":"Finberg","year":"2016","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmc.2024.117826_b0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2174\/1871527316666170124165222","article-title":"Monoamine oxidase B inhibitors in Parkinson\u2019s disease","volume":"16","author":"Dezsi","year":"2017","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.bmc.2024.117826_b0035","doi-asserted-by":"crossref","first-page":"42660","DOI":"10.1039\/C6RA00302H","article-title":"Recent developments on the structure\u2013activity relationship studies of MAO inhibitors and their role in different neurological disorders","volume":"6","author":"Kumar","year":"2016","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2024.117826_b0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3934\/Neuroscience.2023017","article-title":"Depletion of dopamine in Parkinson\u2019s disease and relevant therapeutic options: a review of the literature","volume":"10","author":"Ramesh","year":"2023","journal-title":"AIMS Neurosci"},{"key":"10.1016\/j.bmc.2024.117826_b0045","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3233\/JPD-212976","article-title":"Monoamine oxidase-B inhibitors for the treatment of Parkinson\u2019s disease: past, present, and future","volume":"12","author":"Tan","year":"2022","journal-title":"J Parkinsons Dis"},{"key":"10.1016\/j.bmc.2024.117826_b0050","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12272-019-01133-0","article-title":"Significant roles of neuroinflammation in Parkinson\u2019s disease: therapeutic targets for PD prevention","volume":"42","author":"Lee","year":"2019","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2024.117826_b0055","doi-asserted-by":"crossref","first-page":"4784268","DOI":"10.1155\/2018\/4784268","article-title":"Linking neuroinflammation and neurodegeneration in Parkinson\u2019s disease","volume":"2018","author":"Gelders","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.bmc.2024.117826_b0060","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.3390\/ijms22094676","article-title":"The contribution of microglia to neuroinflammation in Parkinson\u2019s disease","volume":"22","author":"Badanjak","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2024.117826_b0065","doi-asserted-by":"crossref","first-page":"154553","DOI":"10.1016\/j.phymed.2022.154553","article-title":"3\u02b9,4\u02b9-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4\/MD2 interaction","volume":"109","author":"Lee","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bmc.2024.117826_b0070","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd4510","article-title":"The re-emergence of natural products for drug discovery in the genomics era","volume":"14","author":"Harvey","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2024.117826_b0075","doi-asserted-by":"crossref","first-page":"115566","DOI":"10.1016\/j.ejmech.2023.115566","article-title":"Design, synthesis, and evaluation of new anti-inflammatory natural products amide derivatives endowed with anti-blood cancer activity towards development of potential multifunctional agents against hematological cancers","volume":"258","author":"Hassan","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0080","doi-asserted-by":"crossref","first-page":"115421","DOI":"10.1016\/j.ejmech.2023.115421","article-title":"Scaffold hopping of N-benzyl-3,4,5-trimethoxyaniline: 5,6,7-Trimethoxyflavan derivatives as novel potential anticancer agents modulating hippo signaling pathway","volume":"256","author":"Hassan","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0085","doi-asserted-by":"crossref","first-page":"857789","DOI":"10.3389\/fphar.2022.857789","article-title":"Mosloflavone-resveratrol hybrid TMS-HDMF-5z exhibits potent in vitro and in vivo anti-inflammatory effects through NF-\u03baB, AP-1, and JAK\/STAT inactivation","volume":"13","author":"Kim","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmc.2024.117826_b0090","doi-asserted-by":"crossref","first-page":"111965","DOI":"10.1016\/j.ejmech.2019.111965","article-title":"Flavone-based arylamides as potential anticancers: design, synthesis and in vitro cell-based\/cell-free evaluations","volume":"187","author":"Hassan","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0095","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.3390\/ijms19061578","article-title":"Natural products for drug discovery in the 21st century: innovations for novel drug discovery","volume":"19","author":"Thomford","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2024.117826_b0100","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2024.117826_b0105","doi-asserted-by":"crossref","first-page":"115211","DOI":"10.1016\/j.ejmech.2023.115211","article-title":"Bestatin analogs-4-quinolinone hybrids as antileishmanial hits: Design, repurposing rational, synthesis, in vitro and in silico studies","volume":"250","author":"Hassan","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0110","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.3390\/cancers11121927","article-title":"The anti-proliferative activity of the hybrid TMS-TMF-4f compound against human cervical cancer involves apoptosis mediated by STAT3 inactivation","volume":"11","author":"Hong","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.bmc.2024.117826_b0115","doi-asserted-by":"crossref","first-page":"104121","DOI":"10.1016\/j.bioorg.2020.104121","article-title":"Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches","volume":"103","author":"Farag","year":"2020","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0120","doi-asserted-by":"crossref","first-page":"2229071","DOI":"10.1080\/14756366.2023.2229071","article-title":"Rational repurposing, synthesis, in vitro and in silico studies of chromone-peptidyl hybrids as potential agents against Leishmania donovani","volume":"38","author":"Hassan","year":"2023","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0125","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3390\/ph16111594","article-title":"Design, synthesis, and repurposing of rosmarinic acid-\u03b2-amino-\u03b1-ketoamide hybrids as antileishmanial agents","volume":"16","author":"Hassan","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2024.117826_b0130","doi-asserted-by":"crossref","unstructured":"Wang H., Pan X., Zhang Y., Wang X., Xiao X., Ji C. MolHyb: A web server for structure-based drug design by molecular hybridization. J Chem Inf Model. 2022;62:2916\u20132922. https:\/\/doi.org\/10.1021\/acs.jcim.2c00443.","DOI":"10.1021\/acs.jcim.2c00443"},{"key":"10.1016\/j.bmc.2024.117826_b0135","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.2174\/1568026619666190619115735","article-title":"Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases","volume":"19","author":"Ivasiv","year":"2019","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0140","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s12272-017-0977-z","article-title":"Design, synthesis and evaluation of alkylphosphocholine-gefitinib conjugates as multitarget anticancer agents","volume":"41","author":"Alam","year":"2018","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2024.117826_b0145","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1021\/acs.jmedchem.1c00683","article-title":"Rational multitargeted drug design strategy from the perspective of a medicinal chemist","volume":"64","author":"Li","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0150","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.4155\/fmc-2021-0119","article-title":"Multitarget therapeutic approaches for Alzheimer\u2019s and Parkinson\u2019s diseases: An opportunity or an illusion?","volume":"13","author":"Matos","year":"2021","journal-title":"Future Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0155","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.4155\/fmc.15.99","article-title":"New melatonin\u2013cinnamate hybrids as multi-target drugs for neurodegenerative diseases: Nrf2-induction, antioxidant effect and neuroprotection","volume":"7","author":"Buendia","year":"2015","journal-title":"Future Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0160","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/molecules21040466","article-title":"Navigating the chemical space of multitarget-directed ligands: From hybrids to fragments in Alzheimer\u2019s disease","volume":"21","author":"Prati","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2024.117826_b0165","doi-asserted-by":"crossref","first-page":"114358","DOI":"10.1016\/j.ejmech.2022.114358","article-title":"Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer\u2019s disease","volume":"237","author":"Brunetti","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0170","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3390\/ph16111597","article-title":"Repurposing synthetic congeners of a natural product aurone unveils a lead antitumor agent inhibiting folded P-loop conformation of MET receptor tyrosine kinase","volume":"16","author":"Hassan","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2024.117826_b0175","doi-asserted-by":"crossref","first-page":"115256","DOI":"10.1016\/j.ejmech.2023.115256","article-title":"Design, synthesis, and repurposing of O6-aminoalkyl-sulfuretin analogs towards discovery of potential lead compounds as antileishmanial agents","volume":"251","author":"Hassan","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0180","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3390\/ph15091058","article-title":"Design, rational repurposing, synthesis, in vitro evaluation, homology modeling and in silico study of sulfuretin analogs as potential antileishmanial hit compounds","volume":"15","author":"Hassan","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2024.117826_b0185","doi-asserted-by":"crossref","unstructured":"Mazziotti I., Petrarolo G., La Motta C. Aurones: A golden resource for active compounds. Molecules. 2022;27:2. https:\/\/doi.org\/10.3390\/molecules27010002.","DOI":"10.3390\/molecules27010002"},{"key":"10.1016\/j.bmc.2024.117826_b0190","doi-asserted-by":"crossref","first-page":"8461","DOI":"10.3390\/cimb45100533","article-title":"Recent trends in the antidiabetic prominence of natural and synthetic analogues of aurones","volume":"45","author":"Aluru","year":"2023","journal-title":"Curr Issues Mol Biol"},{"key":"10.1016\/j.bmc.2024.117826_b0195","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2174\/1385272827666230407110607","article-title":"A review of the various synthetic approaches to access aurone derivatives and their biological activities","volume":"27","author":"Lathwal","year":"2023","journal-title":"Curr Org Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0200","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.phytochem.2017.06.017","article-title":"Occurrences, biosynthesis and properties of aurones as high-end evolutionary products","volume":"142","author":"Boucherle","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bmc.2024.117826_b0205","first-page":"121","article-title":"Aurones and furoaurones: Biological activities and synthesis","volume":"56","author":"Hassan","year":"2018","journal-title":"Bull Fac Pharm Cairo Univ"},{"key":"10.1016\/j.bmc.2024.117826_b0210","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s13765-015-0065-3","article-title":"Anti-inflammatory effect of Rhus verniciflua stokes extract in the murine macrophage cell line, Raw 264.7","volume":"58","author":"Moon","year":"2015","journal-title":"J Korean Soc Appl Biol Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0215","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ejmech.2017.06.018","article-title":"Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease","volume":"137","author":"Kadayat","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0220","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1080\/14756366.2022.2036737","article-title":"Positional scanning of natural product hispidol\u2019s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases","volume":"37","author":"Hassan","year":"2022","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0225","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bmcl.2018.01.049","article-title":"Selective inhibition of monoamine oxidase A by hispidol","volume":"28","author":"Baek","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2024.117826_b0230","doi-asserted-by":"crossref","first-page":"115895","DOI":"10.1016\/j.bmc.2020.115895","article-title":"Recent advances on synthesis and biological activities of aurones","volume":"29","author":"Sui","year":"2021","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0235","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1021\/ci800219h","article-title":"Identification and selection of \u201cprivileged fragments\u201d suitable for primary screening","volume":"48","author":"Gianti","year":"2008","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2024.117826_b0240","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2174\/1568026623666230718100541","article-title":"Current fragment-to-lead approaches starting from the 7-azaindole: the pharmacological versatility of a privileged molecular fragment","volume":"23","author":"Marcos Santos","year":"2023","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0245","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1021\/acs.jcim.8b00285","article-title":"A database built for the exploration of bioactive fragment space for drug discovery","volume":"58","author":"Yang","year":"2018","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2024.117826_b0250","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1039\/C7OB02193C","article-title":"Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point","volume":"15","author":"Rodrigues","year":"2017","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0255","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1021\/acsinfecdis.6b00036","article-title":"5-Fluoroimidazo[4,5-b]pyridine Is a privileged fragment that conveys bioavailability to potent trypanosomal methionyl-tRNA synthetase inhibitors","volume":"2","author":"Zhang","year":"2016","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.bmc.2024.117826_b0260","doi-asserted-by":"crossref","first-page":"2200084","DOI":"10.1002\/ardp.202200084","article-title":"Revealing the role of the benzyloxy pharmacophore in the design of a new class of monoamine oxidase-B inhibitors","volume":"355","author":"Sudevan","year":"2022","journal-title":"Arch Pharm"},{"key":"10.1016\/j.bmc.2024.117826_b0265","doi-asserted-by":"crossref","first-page":"115142","DOI":"10.1016\/j.ejmech.2023.115142","article-title":"Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson\u2019s disease","volume":"249","author":"Cao","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0270","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1515\/BMC.2011.030","article-title":"Structures and mechanism of the monoamine oxidase family","volume":"2","author":"Gaweska","year":"2011","journal-title":"Biomol Concepts"},{"key":"10.1016\/j.bmc.2024.117826_b0275","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s00702-018-1915-z","article-title":"The structure of monoamine oxidases: past, present, and future","volume":"125","author":"Iacovino","year":"2018","journal-title":"J Neural Transm"},{"key":"10.1016\/j.bmc.2024.117826_b0280","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2018-001137","article-title":"A planetary vision for one health","volume":"3","author":"Rabinowitz","year":"2018","journal-title":"BMJ Glob Health"},{"key":"10.1016\/j.bmc.2024.117826_b0285","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/embor.2013.61","article-title":"One world, one health","volume":"14","author":"van Helden","year":"2013","journal-title":"EMBO Rep"},{"key":"10.1016\/j.bmc.2024.117826_b0290","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1016\/S2542-5196(18)30124-4","article-title":"Environment: the neglected component of the One Health triad","volume":"2","author":"Essack","year":"2018","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.bmc.2024.117826_b0295","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/medicina57030240","article-title":"Assessing environmental factors within the one health approach","volume":"57","author":"Humboldt-Dachroeden","year":"2021","journal-title":"Medicina"},{"key":"10.1016\/j.bmc.2024.117826_b0300","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1016\/S2542-5196(22)00090-0","article-title":"Pollution and health: a progress update","volume":"6","author":"Fuller","year":"2022","journal-title":"Lancet Planet Health"},{"key":"10.1016\/j.bmc.2024.117826_b0305","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.chemosphere.2017.11.163","article-title":"Environmental pollution and health hazards from distillery wastewater and treatment approaches to combat the environmental threats: a review","volume":"194","author":"Chowdhary","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.bmc.2024.117826_b0310","doi-asserted-by":"crossref","first-page":"36206","DOI":"10.1021\/acsomega.2c03405","article-title":"Vicinal diaryl-substituted isoxazole and pyrazole derivatives with in vitro growth inhibitory and in vivo antitumor activity","volume":"7","author":"Turanl\u0131","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.bmc.2024.117826_b0315","doi-asserted-by":"crossref","first-page":"128804","DOI":"10.1016\/j.bmcl.2022.128804","article-title":"Synthesis, in vitro, in silico and in vivo hypoglycemic and lipid-lowering effects of 4-benzyloxy-5-benzylidene-1,3-thiazolidine-2,4-diones mediated by dual PPAR \u03b1\/\u03b3 modulation","volume":"70","author":"Madrigal-Angulo","year":"2022","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2024.117826_b0320","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202300219","article-title":"Fused 1,4-Dihydropyridines and Their Corresponding Pyridines: Synthesis, Molecular Modeling and Cholinesterase Inhibition","volume":"8","author":"Najafi","year":"2023","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2024.117826_b0325","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41467-020-20644-9","article-title":"Collective synthesis of acetylenic pharmaceuticals via enantioselective Nickel\/Lewis acid-catalyzed propargylic alkylation","volume":"12","author":"Chang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2024.117826_b0330","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejmech.2012.08.026","article-title":"Synthesis and antimicrobial evaluation of l-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone","volume":"56","author":"Jin","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0335","doi-asserted-by":"crossref","first-page":"112243","DOI":"10.1016\/j.ejmech.2020.112243","article-title":"Design, synthesis and biological evaluation of tetrahydroquinoline-based reversible LSD1 inhibitors","volume":"194","author":"Wang","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0340","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ejmech.2016.11.016","article-title":"Benzyloxynitrostyrene analogues \u2013 a novel class of selective and highly potent inhibitors of monoamine oxidase B","volume":"125","author":"Van der Walt","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117826_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5607\/en.2011.20.1.1","article-title":"MAO-inhibitors in Parkinson\u2019s disease","volume":"20","author":"Riederer","year":"2011","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.bmc.2024.117826_b0350","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3390\/antiox8080265","article-title":"Astrocytic oxidative\/nitrosative stress contributes to Parkinson\u2019s disease pathogenesis: the dual role of reactive astrocytes","volume":"8","author":"Rizor","year":"2019","journal-title":"Antioxidants"},{"key":"10.1016\/j.bmc.2024.117826_b0355","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.bbadis.2008.12.006","article-title":"Oxidative and nitrosative stress in Parkinson\u2019s disease","volume":"1792","author":"Tsang","year":"2009","journal-title":"Biochim Biophys Acta - Mol Basis Dis"},{"key":"10.1016\/j.bmc.2024.117826_b0360","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41531-022-00370-3","article-title":"Nitrosative stress in Parkinson\u2019s disease","volume":"8","author":"Stykel","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"key":"10.1016\/j.bmc.2024.117826_b0365","doi-asserted-by":"crossref","first-page":"9459","DOI":"10.1038\/s41598-017-09528-z","article-title":"Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype","volume":"7","author":"Kang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2024.117826_b0370","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm1362","article-title":"Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity","volume":"12","author":"Kawano","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.bmc.2024.117826_b0375","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1002\/jnr.21425","article-title":"PGE2 receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE2 neurotoxicity","volume":"85","author":"Carrasco","year":"2007","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.bmc.2024.117826_b0380","doi-asserted-by":"crossref","first-page":"16016","DOI":"10.1523\/JNEUROSCI.2203-13.2013","article-title":"Suppression of inflammation with conditional deletion of the prostaglandin E2 EP2 receptor in macrophages and brain microglia","volume":"33","author":"Jenny","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmc.2024.117826_b0385","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-2094-4-2","article-title":"Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated \u03b1-synuclein","volume":"4","author":"Jin","year":"2007","journal-title":"J Neuroinflam"},{"key":"10.1016\/j.bmc.2024.117826_b0390","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3390\/antiox12051033","article-title":"Synthesis and biological evaluation of O6-aminoalkyl-hispidol analogs as multifunctional monoamine oxidase-B inhibitors towards management of neurodegenerative diseases","volume":"12","author":"Hassan","year":"2023","journal-title":"Antioxidants"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089624002402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089624002402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T04:09:26Z","timestamp":1722053366000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089624002402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":78,"alternative-id":["S0968089624002402"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2024.117826","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of O4\u2032-benzyl-hispidol derivatives and analogs as dual monoamine oxidase-B inhibitors and anti-neuroinflammatory agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2024.117826","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"117826"}}