{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:08:46Z","timestamp":1791295726525,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bmc.2024.117968","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T03:10:13Z","timestamp":1730257813000},"page":"117968","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["H2S-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K\/AKT pathway"],"prefix":"10.1016","volume":"115","author":[{"given":"Haonan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyinglu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiming","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jincai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2024.117968_b0005","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2024.117968_b0010","first-page":"195","article-title":"Progress in approved drugs from natural product resources","volume":"22","author":"Luo","year":"2024","journal-title":"Chin J Nat Med"},{"key":"10.1016\/j.bmc.2024.117968_b0015","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nchem.2479","article-title":"Counting on natural products for drug design","volume":"8","author":"Rodrigues","year":"2016","journal-title":"Nat Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0020","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2024.117968_b0025","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1039\/b604174d","article-title":"Diterpenoids from Isodon species and their biological activities","volume":"23","author":"Sun","year":"2006","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2024.117968_b0030","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1039\/C7NP00027H","article-title":"Diterpenoids from Isodon species: an update","volume":"34","author":"Liu","year":"2017","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.bmc.2024.117968_b0035","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1039\/j39700001674","article-title":"Terpenoids. Part XV. Structure and absolute configuration of oridonin isolated from Isodon japonicus and Isodon trichocarpus","author":"Fujita","year":"1970","journal-title":"J Chem Soc C"},{"key":"10.1016\/j.bmc.2024.117968_b0040","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1038\/s41467-018-04947-6","article-title":"Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity","volume":"9","author":"He","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2024.117968_b0045","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/molecules21050575","article-title":"Antitumor and antibacterial derivatives of oridonin: a main composition of Dong-Ling-Cao","volume":"21","author":"Li","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2024.117968_b0050","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/s41401-022-00995-3","article-title":"Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy","volume":"44","author":"Li","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.bmc.2024.117968_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110011","article-title":"Protective effects of oridonin against osteoporosis by regulating immunity and activating the Wnt3a\/\u03b2-catenin\/VEGF pathway in ovariectomized mice","volume":"118","author":"Yu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmc.2024.117968_b0060","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.biopha.2018.02.011","article-title":"Oridonin inhibits oral cancer growth and PI3K\/Akt signaling pathway","volume":"100","author":"Yang","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmc.2024.117968_b0065","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1002\/ptr.7009","article-title":"Oridonin interrupts cellular bioenergetics to suppress glioma cell growth by down-regulating PCK2","volume":"35","author":"Lin","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/j.bmc.2024.117968_b0070","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.apsb.2021.05.006","article-title":"Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer","volume":"11","author":"Liu","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmc.2024.117968_b0075","article-title":"Anticancer mechanisms on pyroptosis induced by oridonin: new potential targeted therapeutic strategies","volume":"165","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.bmc.2024.117968_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110669","article-title":"Oridonin enhances cytotoxic activity of natural killer cells against lung cancer","volume":"122","author":"Hwang","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmc.2024.117968_b0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ejmech.2016.06.015","article-title":"Discovery and development of natural product oridonin-inspired anticancer agents","volume":"122","author":"Ding","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0090","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.gendis.2020.06.010","article-title":"Oridonin and its derivatives for cancer treatment and overcoming therapeutic resistance","volume":"8","author":"Liu","year":"2021","journal-title":"Genes Dis"},{"key":"10.1016\/j.bmc.2024.117968_b0095","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1021\/acs.jmedchem.7b01514","article-title":"Regio- and stereospecific synthesis of oridonin D-ring aziridinated analogues for the treatment of triple-negative breast cancer via mediated irreversible covalent warheads","volume":"61","author":"Ding","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0100","doi-asserted-by":"crossref","first-page":"8814","DOI":"10.1021\/jm401248x","article-title":"Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis","volume":"56","author":"Ding","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0105","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ejmech.2017.03.055","article-title":"Design, synthesis, and biological evaluation of NAD(P)H: Quinone oxidoreductase (NQO1)-targeted oridonin prodrugs possessing indolequinone moiety for hypoxia-selective activation","volume":"132","author":"Xu","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0110","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ejmech.2019.06.016","article-title":"Hydrogen sulfide donating ent-kaurane and spirolactone-type 6,7-seco-ent-kaurane derivatives: Design, synthesis and antiproliferative properties","volume":"178","author":"Li","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejmech.2019.03.046","article-title":"Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation","volume":"171","author":"Hu","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejmech.2019.04.005","article-title":"Synthesis, and evaluation of in vitro and in vivo anticancer activity of 14-substituted oridonin analogs: a novel and potent cell cycle arrest and apoptosis inducer through the p53-MDM2 pathway","volume":"173","author":"Shen","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114155","article-title":"Identification of new potent anticancer derivatives through simplifying the core structure and modification on their 14-hydroxyl group from oridonin","volume":"231","author":"Liu","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0130","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1021\/acs.jmedchem.6b01652","article-title":"A novel potent anticancer compound optimized from a natural oridonin scaffold induces apoptosis and cell cycle arrest through the mitochondrial pathway","volume":"60","author":"Xu","year":"2017","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ejmech.2012.03.024","article-title":"The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents","volume":"52","author":"Wang","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0140","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1021\/ol4015865","article-title":"Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position","volume":"15","author":"Ding","year":"2013","journal-title":"Org Lett"},{"key":"10.1016\/j.bmc.2024.117968_b0145","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1021\/jm400367n","article-title":"Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility","volume":"56","author":"Ding","year":"2013","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0150","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1021\/acs.jmedchem.0c00408","article-title":"Identification of a potent oridonin analogue for treatment of triple-negative breast cancer","volume":"63","author":"Yao","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0155","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2024.117968_b0160","first-page":"110","article-title":"A review of hydrogen sulfide (H2S) donors: chemistry and potential therapeutic applications","volume":"149","author":"Chadwick","year":"2017","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.bmc.2024.117968_b0165","first-page":"110","article-title":"Organic isothiocyanates as hydrogen sulfide donors","volume":"32","author":"Alma","year":"2019","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.bmc.2024.117968_b0170","doi-asserted-by":"crossref","first-page":"30151","DOI":"10.1074\/jbc.M802529200","article-title":"Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells","volume":"283","author":"Xiao","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0175","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/carcin\/bgh179","article-title":"Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells","volume":"25","author":"Srivastava","year":"2004","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bmc.2024.117968_b0180","doi-asserted-by":"crossref","first-page":"13610","DOI":"10.1021\/jacs.9b06319","article-title":"Cyclic sulfenyl thiocarbamates release carbonyl sulfide and hydrogen sulfide independently in thiol-promoted pathways","volume":"141","author":"Zhao","year":"2019","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.bmc.2024.117968_b0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1039\/D3MD00447C","article-title":"Discovery of novel \u03b2-elemene hybrids with hydrogen sulfide-releasing moiety possessing cardiovascular protective activity for the treatment of atherosclerosis","volume":"15","author":"Zhu","year":"2024","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0190","article-title":"Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways","volume":"187","author":"Li","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2024.117968_b0195","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41580-021-00404-3","article-title":"Cell cycle control in cancer","volume":"23","author":"Matthews","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bmc.2024.117968_b0200","doi-asserted-by":"crossref","first-page":"e1595","DOI":"10.1002\/wsbm.1595","article-title":"Intracellular and microenvironmental regulation of mitochondrial membrane potential in cancer cells","volume":"15","author":"Begum","year":"2023","journal-title":"WIREs Mech Dis"},{"key":"10.1016\/j.bmc.2024.117968_b0205","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.bmc.2024.117968_b0210","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1152\/physrev.00028.2021","article-title":"Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs","volume":"103","author":"Cirino","year":"2023","journal-title":"Physiol Rev"},{"key":"10.1016\/j.bmc.2024.117968_b0215","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.apsb.2020.10.019","article-title":"New possible silver lining for pancreatic cancer therapy: hydrogen sulfide and its donors","volume":"11","author":"Hu","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.bmc.2024.117968_b0220","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nrclinonc.2009.186","article-title":"Taxanes: optimizing adjuvant chemotherapy for early-stage breast cancer","volume":"7","author":"Bedard","year":"2010","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.bmc.2024.117968_b0225","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40659-017-0140-9","article-title":"Awareness and current knowledge of breast cancer","volume":"50","author":"Akram","year":"2017","journal-title":"Biol Res"},{"key":"10.1016\/j.bmc.2024.117968_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106831","article-title":"Oridonin inhibits 4T1 tumor growth by suppressing Treg differentiation via TGF-\u03b2 receptor","volume":"88","author":"Guo","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmc.2024.117968_b0235","first-page":"2289","article-title":"Oridonin inhibits VEGF-A-associated angiogenesis and epithelial-mesenchymal transition of breast cancer in vitro and in vivo","volume":"16","author":"Li","year":"2018","journal-title":"Oncol Lett"},{"key":"10.1016\/j.bmc.2024.117968_b0240","doi-asserted-by":"crossref","first-page":"23878","DOI":"10.18632\/oncotarget.24378","article-title":"Oridonin inhibits aberrant AKT activation in breast cancer","volume":"9","author":"Sun","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2024.117968_b0245","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bmc.2024.117968_b0250","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bmc.2024.117968_b0255","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/CAD.0000000000000154","article-title":"Oridonin inhibits mTOR signaling and the growth of lung cancer tumors","volume":"25","author":"Wang","year":"2014","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.bmc.2024.117968_b0260","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.3892\/ijo.2016.3488","article-title":"Oridonin inhibits gefitinib-resistant lung cancer cells by suppressing EGFR\/ERK\/MMP-12 and CIP2A\/Akt signaling pathways","volume":"48","author":"Xiao","year":"2016","journal-title":"Int J Oncol"},{"key":"10.1016\/j.bmc.2024.117968_b0265","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.21037\/atm-21-2630","article-title":"Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling","volume":"9","author":"Zhao","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.bmc.2024.117968_b0270","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12935-016-0336-z","article-title":"Oridonin inhibits pancreatic cancer cell migration and epithelial-mesenchymal transition by suppressing Wnt\/\u03b2-catenin signaling pathway","volume":"16","author":"Liu","year":"2016","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.bmc.2024.117968_b0275","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41571-018-0112-1","article-title":"Optimizing the outcomes of pancreatic cancer surgery","volume":"16","author":"Strobel","year":"2018","journal-title":"Nat Rev Clin Oncol"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089624003821?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089624003821?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T09:58:08Z","timestamp":1738144688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089624003821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":55,"alternative-id":["S0968089624003821"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2024.117968","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"H2S-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2024.117968","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"117968"}}