{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:22:16Z","timestamp":1792034536028,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bmc.2024.118014","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T16:18:23Z","timestamp":1732292303000},"page":"118014","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-2022","authenticated-orcid":false,"given":"Wei","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhujie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqiang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2024.118014_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.bmc.2024.118014_b0010","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bmc.2024.118014_b0015","doi-asserted-by":"crossref","first-page":"5938","DOI":"10.3390\/ijms23115938","article-title":"An overview of oxidative stress, neuroinflammation, and neurodegenerative diseases","volume":"23","author":"Teleanu","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2024.118014_b0020","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41392-023-01486-5","article-title":"Role of neuroinflammation in neurodegeneration development","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bmc.2024.118014_b0025","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.bmc.2024.118014_b0030","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.bmc.2024.118014_b0035","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bmc.2024.118014_b0040","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.4155\/fmc.13.125","article-title":"Anti-neuroinflammatory agents for the treatment of Alzheimer\u2019s disease","volume":"5","author":"Zhou","year":"2013","journal-title":"Future Med Chem"},{"key":"10.1016\/j.bmc.2024.118014_b0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12974-023-02753-6","article-title":"Exercise suppresses neuroinflammation for alleviating Alzheimer\u2019s disease","volume":"20","author":"Wang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.bmc.2024.118014_b0050","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/ptr.8200","article-title":"Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer\u2019s disease: Targeting neuroinflammation strategies","volume":"38","author":"Azzini","year":"2024","journal-title":"Phytother Res"},{"key":"10.1016\/j.bmc.2024.118014_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2020.112394","article-title":"Chemical variability, pharmacological potential, multivariate and molecular docking analyses of essential oils obtained from four medicinal plants","volume":"150","author":"Jugreet","year":"2020","journal-title":"Ind Crop Prod"},{"key":"10.1016\/j.bmc.2024.118014_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119476","article-title":"Neuroprotection by curcumin: A review on brain delivery strategies","volume":"585","author":"Askarizadeh","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.bmc.2024.118014_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.133728","article-title":"Extraction of curcuminoids and ar-turmerone from turmeric (Curcuma longa L.) using hydrophobic deep eutectic solvents (HDESs) and application as HDES-based microemulsions","volume":"396","author":"Kongpol","year":"2022","journal-title":"Food Chem"},{"key":"10.1016\/j.bmc.2024.118014_b0070","doi-asserted-by":"crossref","first-page":"1700281","DOI":"10.1002\/mnfr.201700281","article-title":"Aromatic-turmerone attenuates LPS-induced neuroinflammation and consequent memory impairment by targeting TLR4-dependent signaling pathway","volume":"62","author":"Chen","year":"2018","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.bmc.2024.118014_b0075","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.intimp.2018.09.015","article-title":"Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB\/c mice","volume":"64","author":"Li","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmc.2024.118014_b0080","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s10787-022-01007-w","article-title":"Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice","volume":"30","author":"Li","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bmc.2024.118014_b0085","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF02974486","article-title":"Structure activity relationship of ar-turmerone analogues","volume":"16","author":"Baik","year":"1993","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2024.118014_b0090","doi-asserted-by":"crossref","first-page":"9502","DOI":"10.1021\/jo0351318","article-title":"Stereospecific Pd(0)-catalyzed arylation of an allylic hydroxy phosphonate derivative: formal synthesis of (S)-(+)-ar-turmerone","volume":"68","author":"Rowe","year":"2003","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2024.118014_b0095","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1021\/jo00956a039","article-title":"Dianions of beta-ketophosphonates. Two-step synthesis of (+)-ar-turmerone","volume":"38","author":"Grieco","year":"1973","journal-title":"J Org Chem"},{"key":"10.1016\/j.bmc.2024.118014_b0100","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1039\/P19920001519","article-title":"Structures of \u03b1- and \u03b2-turmerone","author":"Golding","year":"1992","journal-title":"J Chem Soc Perkin Trans 1"},{"key":"10.1016\/j.bmc.2024.118014_b0105","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neubiorev.2014.06.002","article-title":"Pathologic role of glial nitric oxide in adult and pediatric neuroinflammatory diseases","volume":"45","author":"Ghasemi","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.bmc.2024.118014_b0110","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1089\/ars.2013.5745","article-title":"Redox control of microglial function: molecular mechanisms and functional significance","volume":"21","author":"Rojo","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.bmc.2024.118014_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","article-title":"Neuroinflammation in Alzheimer\u2019s disease: current progress in molecular signaling and therapeutics","volume":"46","author":"Thakur","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.bmc.2024.118014_b0120","first-page":"3194","article-title":"Neuroinflammatory markers: Key indicators in the pathology of neurodegenerative diseases","volume":"27","author":"Rauf","year":"2022","journal-title":"Mol. Basel Switz."},{"key":"10.1016\/j.bmc.2024.118014_b0125","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2015.06.010","article-title":"Diversity and plasticity of microglial cells in psychiatric and neurological disorders","volume":"154","author":"Nakagawa","year":"2015","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.bmc.2024.118014_b0130","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/s41423-023-01053-6","article-title":"Brain macrophage development, diversity and dysregulation in health and disease","volume":"20","author":"Silvin","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.bmc.2024.118014_b0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41577-023-00907-4","article-title":"Microglia regulation of central nervous system myelin health and regeneration","volume":"24","author":"Kent","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.bmc.2024.118014_b0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.abb8587","article-title":"Microglia modulate neurodegeneration in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"370","author":"Bartels","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.bmc.2024.118014_b0145","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.3390\/cells10051090","article-title":"Aromatic-turmerone analogs protect dopaminergic neurons in midbrain slice cultures through their neuroprotective activities","volume":"10","author":"Hori","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bmc.2024.118014_b0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.bmc.2024.118014_b0155","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-024-00722-y","article-title":"The endotoxin hypothesis of Alzheimer\u2019s disease","volume":"19","author":"Brown","year":"2024","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.bmc.2024.118014_b0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-015-0291-y","article-title":"Rodent models of neuroinflammation for Alzheimer\u2019s disease","volume":"12","author":"Nazem","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.bmc.2024.118014_b0165","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nat Protoc"},{"key":"10.1016\/j.bmc.2024.118014_b0170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13321-018-0283-x","article-title":"ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database","volume":"10","author":"Dong","year":"2018","journal-title":"J. Cheminformatics"},{"key":"10.1016\/j.bmc.2024.118014_b0175","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1021\/ci500004h","article-title":"AlzPlatform: An Alzheimer\u2019s disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research","volume":"54","author":"Liu","year":"2014","journal-title":"J Chem Inf Model"},{"key":"10.1016\/j.bmc.2024.118014_b0180","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btad577","article-title":"A machine learning-based quantitative model (LogBB_Pred) to predict the blood\u2013brain barrier permeability (logBB value) of drug compounds","volume":"39","author":"Shaker","year":"2023","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bmc.2024.118014_b0185","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1007\/s12640-021-00426-x","article-title":"Luteolin suppresses microglia neuroinflammatory responses and relieves inflammation-induced cognitive impairments","volume":"39","author":"Zhou","year":"2021","journal-title":"Neurotox Res"},{"key":"10.1016\/j.bmc.2024.118014_b0190","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/cbf.3623","article-title":"TTP488 ameliorates NLRP3-associated inflammation, viability, apoptosis, and ROS production in an Alzheimer\u2019s disease cell model by mediating the JAK1\/STAT3\/NF\u03baB\/IRF3 pathway","volume":"39","author":"Xue","year":"2021","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.bmc.2024.118014_b0195","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev-immunol-101921-035639","article-title":"Complement in the brain: Contributions to neuroprotection, neuronal plasticity, and neuroinflammation","volume":"41","author":"Bohlson","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.bmc.2024.118014_b0200","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s11011-020-00533-2","article-title":"Dihydroartemisinin ameliorates LPS-induced neuroinflammation by inhibiting the PI3K\/AKT pathway","volume":"35","author":"Gao","year":"2020","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.bmc.2024.118014_b0205","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.4103\/1673-5374.373680","article-title":"The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer\u2019s disease: a narrative review","volume":"18","author":"Zhang","year":"2023","journal-title":"Neural Regen Res"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089624004280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089624004280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T09:01:08Z","timestamp":1737795668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089624004280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":41,"alternative-id":["S0968089624004280"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2024.118014","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2024.118014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118014"}}