{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:49:02Z","timestamp":1776761342326,"version":"3.51.2"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bmc.2025.118091","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:29:15Z","timestamp":1738276155000},"page":"118091","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Development of carbazole-based molecules for inhibition of mutant hSOD1 protein aggregation in Amyotrophic Lateral Sclerosis"],"prefix":"10.1016","volume":"120","author":[{"given":"Siddharth","family":"Gusain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Bhushan","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kajal","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meenakshi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daman","family":"Saluja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118091_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1750-1172-4-3","article-title":"Amyotrophic lateral sclerosis","volume":"4","author":"Wijesekera","year":"2009","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.bmc.2025.118091_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103732","article-title":"Predictors of survival in patients with amyotrophic lateral sclerosis: a large meta-analysis","volume":"74","author":"Su","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bmc.2025.118091_b0015","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000351153","article-title":"Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature","volume":"41","author":"Chio","year":"2013","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.bmc.2025.118091_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21767\/2573-5349.100022","article-title":"Translational research on amyotrophic lateral sclerosis (ALS): the preclinical SOD1 mouse model","volume":"03","author":"Mina","year":"2018","journal-title":"J Transl Neurosci"},{"key":"10.1016\/j.bmc.2025.118091_b0025","article-title":"Exploring FDA-Approved Drugs and Potential Treatment Options for ALS","author":"PharmaNewsIntelligence","year":"2023","journal-title":"PharmaNewsIntelligence"},{"key":"10.1016\/j.bmc.2025.118091_b0030","unstructured":"Cerillo JL, Parmar M. Tofersen, in: StatPearls (StatPearls Publishing, Treasure Island (FL), (2023)."},{"key":"10.1016\/j.bmc.2025.118091_b0035","volume":"2\u20136","author":"Robberecht","year":"2000","journal-title":"Genetics of Amyotrophic Lateral Sclerosis"},{"key":"10.1016\/j.bmc.2025.118091_b0040","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s00415-005-0742-y","article-title":"SOD1 mutations in amyotrophic lateral sclerosis: Results from a multicenter Italian study","volume":"252","author":"Battistini","year":"2005","journal-title":"J Neurol"},{"key":"10.1016\/j.bmc.2025.118091_b0045","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1073\/pnas.1320786110","article-title":"Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS","volume":"111","author":"Ivanova","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2025.118091_b0050","doi-asserted-by":"crossref","first-page":"15923","DOI":"10.1074\/jbc.M112087200","article-title":"Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis","volume":"277","author":"Hayward","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0055","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1074\/jbc.M210419200","article-title":"Familial amyotrophic lateral sclerosis mutants of copper\/zinc superoxide dismutase are susceptible to disulfide reduction","volume":"278","author":"Tiwari","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0060","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1073\/pnas.0305143101","article-title":"Dimer destabilization in superoxide dismutase may result in disease-causing properties: Structures of motor neuron disease mutants","volume":"101","author":"Hough","year":"2004","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2025.118091_b0065","doi-asserted-by":"crossref","first-page":"20130","DOI":"10.1074\/jbc.M111.218842","article-title":"Proteins that bind to misfolded mutant superoxide dismutase-1 in spinal cords from transgenic amyotrophic lateral sclerosis (ALS) model mice","volume":"286","author":"Zetterstr\u00f6m","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0070","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2010.07.019","article-title":"Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS","volume":"67","author":"Israelson","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118091_b0075","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1002\/ardp.201400365","article-title":"9H-carbazole derivatives containing the N-benzyl-1,2,3-triazole moiety as new acetylcholinesterase inhibitors","volume":"348","author":"Akrami","year":"2015","journal-title":"Arch. Pharm. (Weinheim)"},{"key":"10.1016\/j.bmc.2025.118091_b0080","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bmc.2016.01.010","article-title":"Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents","volume":"24","author":"Fang","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0085","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1021\/acschemneuro.6b00388","article-title":"Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer\u2019s Disease","volume":"8","author":"Wu","year":"2017","journal-title":"ACS Chem Nerosci"},{"key":"10.1016\/j.bmc.2025.118091_b0090","doi-asserted-by":"crossref","first-page":"17016","DOI":"10.1073\/pnas.1213960109","article-title":"Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis","volume":"109","author":"Tesla","year":"2012","journal-title":"Proc Nat Acad Sci"},{"key":"10.1016\/j.bmc.2025.118091_b0095","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12551-016-0218-6","article-title":"Dynamic light scattering: a practical guide and applications in biomedical sciences","volume":"8","author":"Stetefeld","year":"2016","journal-title":"Biophys Rev"},{"key":"10.1016\/j.bmc.2025.118091_b0100","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.bbapap.2015.01.014","article-title":"Curcumin binds to the pre-fibrillar aggregates of Cu\/Zn superoxide dismutase (SOD1) and alters its amyloidogenic pathway resulting in reduced cytotoxicity","volume":"1854","author":"Bhatia","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2025.118091_b0105","first-page":"5096","article-title":"Structure-guided pharmacophore based virtual screening, docking, and molecular dynamics to discover repurposed drugs as novel inhibitors against endoribonuclease Nsp15 of SARS-CoV-2","volume":"41","author":"Jha","year":"2023","journal-title":"J Biomol Struct Dyn"},{"key":"10.1016\/j.bmc.2025.118091_b0110","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1021\/cn500147v","article-title":"Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis","volume":"5","author":"Trippier","year":"2014","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.bmc.2025.118091_b0115","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.bbrc.2016.07.055","article-title":"Pathways to mitochondrial dysfunction in ALS pathogenesis","volume":"483","author":"Carr\u00ec","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2025.118091_b0120","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1093\/hmg\/ddq202","article-title":"ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2","volume":"19","author":"Pedrini","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.bmc.2025.118091_b0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41598-021-03891-8","article-title":"SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity","volume":"12","author":"Berdy\u0144ski","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2025.118091_b0130","doi-asserted-by":"crossref","first-page":"18663","DOI":"10.1073\/pnas.0807058105","article-title":"Initiation and elongation in fibrillation of ALS-linked superoxide dismutase","volume":"105","author":"Chattopadhyay","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bmc.2025.118091_b0135","doi-asserted-by":"crossref","first-page":"22221","DOI":"10.1074\/jbc.M110.113597","article-title":"Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis","volume":"285","author":"Furukawa","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0140","doi-asserted-by":"crossref","first-page":"15094","DOI":"10.1073\/pnas.0406650101","article-title":"The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis","volume":"101","author":"Khare","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bmc.2025.118091_b0145","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/glia.22444","article-title":"Extracellular aggregated Cu\/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype","volume":"61","author":"Roberts","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.bmc.2025.118091_b0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010627","article-title":"Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis","volume":"5","author":"Chia","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2025.118091_b0155","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nature02265","article-title":"Therapeutic approaches to protein-misfolding diseases","volume":"426","author":"Cohen","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118091_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130114","article-title":"Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases","volume":"1866","author":"Kimura","year":"2022","journal-title":"Biochim Biophys Acta - Gen Subj"},{"key":"10.1016\/j.bmc.2025.118091_b0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fmolb.2016.00040","article-title":"Screening of drugs inhibiting in vitro oligomerization of Cu\/Zn-superoxide dismutase with a mutation causing amyotrophic lateral sclerosis","volume":"3","author":"Anzai","year":"2016","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.bmc.2025.118091_b0170","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/s42003-021-02862-z","article-title":"Novel chemical inhibitor against SOD1 misfolding and aggregation protects neuron-loss and ameliorates disease symptoms in ALS mouse model","volume":"4","author":"Woo","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.bmc.2025.118091_b0175","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/17482968.2010.522586","article-title":"Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis","volume":"12","author":"Benmohamed","year":"2011","journal-title":"Amyotroph Lateral Scler"},{"key":"10.1016\/j.bmc.2025.118091_b0180","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1021\/acs.jmedchem.5b00561","article-title":"Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis","volume":"58","author":"Zhang","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2014.12.031","article-title":"Thiazole: a promising heterocycle for the development of potent CNS active agents","volume":"92","author":"Mishra","year":"2015","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0190","article-title":"The neuroprotective potential of carbazole in traumatic brain injury","volume":"1\u201311","author":"Pathania","year":"2024","journal-title":"Brain Inj"},{"key":"10.1016\/j.bmc.2025.118091_b0195","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1021\/jm401919s","article-title":"Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(\u2212)-P7C3-S243], with improved druglike properties","volume":"57","author":"Naidoo","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0200","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.bbadis.2014.02.009","article-title":"Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis","volume":"1842","author":"Tan","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2025.118091_b0205","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1016\/j.febslet.2013.06.046","article-title":"Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis","volume":"587","author":"Furukawa","year":"2013","journal-title":"FEBS Lett"},{"key":"10.1016\/j.bmc.2025.118091_b0210","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nmeth.2641","article-title":"Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination","volume":"10","author":"Dickinson","year":"2013","journal-title":"Nat Methods"},{"key":"10.1016\/j.bmc.2025.118091_b0215","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pep.2017.04.001","article-title":"An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1)","volume":"134","author":"Tachu","year":"2017","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.bmc.2025.118091_b0220","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ejmech.2016.09.057","article-title":"Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer\u2019s disease","volume":"125","author":"Mishra","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0225","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1016\/j.bmc.2016.06.027","article-title":"Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-\u03b2-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer\u2019s disease","volume":"24","author":"Mishra","year":"2016","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118091_b0230","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.3390\/biom11111567","article-title":"Role of CD36 in palmitic acid lipotoxicity in neuro-2a neuroblastoma cells","volume":"11","author":"Urso","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bmc.2025.118091_b0235","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.pharep.2017.03.006","article-title":"Novel synthetic analogs of diallyl disulfide triggers cell cycle arrest and apoptosis via ROS generation in MIA PaCa-2 cells","volume":"69","author":"Saini","year":"2017","journal-title":"Pharmacol. Rep. PR"},{"key":"10.1016\/j.bmc.2025.118091_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.103524","article-title":"Development of novel carbazole derivatives with effective multifunctional action against Alzheimer\u2019s diseases: design, synthesis, in silico, in vitro and in vivo investigation","volume":"95","author":"Mishra","year":"2020","journal-title":"Bioorg Chem."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962500032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962500032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T21:12:21Z","timestamp":1740517941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962500032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":48,"alternative-id":["S096808962500032X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118091","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of carbazole-based molecules for inhibition of mutant hSOD1 protein aggregation in Amyotrophic Lateral Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118091","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118091"}}