{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:55:22Z","timestamp":1768514122719,"version":"3.49.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bmc.2025.118094","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T02:03:33Z","timestamp":1738289013000},"page":"118094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Discovery of 3-indolylbenzoquinone derivatives with therapeutic potential for breast cancer"],"prefix":"10.1016","volume":"120","author":[{"given":"Mingli","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wengxue","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoxue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuxiu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5122-2226","authenticated-orcid":false,"given":"Qiu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118094_b0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s13304-017-0424-1","article-title":"Breast cancer in young women: an overview","volume":"69","author":"Anastasiadi","year":"2017","journal-title":"Updates Surg"},{"key":"10.1016\/j.bmc.2025.118094_b0010","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1021\/bi00062a003","article-title":"Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition","volume":"32","author":"D\u00edaz","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bmc.2025.118094_b0015","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1002\/cam4.5370","article-title":"NBDHEX re-sensitizes adriamycin-resistant breast cancer by inhibiting glutathione S-transferase pi","volume":"12","author":"Sha","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.bmc.2025.118094_b0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/d41573-019-00201-w","article-title":"Breast cancer drug approvals by the US FDA from 1949 to 2018","volume":"19","author":"Leo","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.bmc.2025.118094_b0025","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1056\/NEJMoa1813904","article-title":"Alpelisib for PIK3CA-Mutated, Hormone Receptor-Positive Advanced Breast Cancer","volume":"380","author":"Andr\u00e9","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmc.2025.118094_b0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJMoa1505270","volume":"373","author":"Turner","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.bmc.2025.118094_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-022-01559-3","article-title":"PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies","volume":"25","author":"Chen","year":"2023","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.bmc.2025.118094_b0040","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1021\/acs.jmedchem.0c01180","article-title":"Small-Molecule Drug Discovery in Triple Negative Breast Cancer: Current Situation and Future Directions","volume":"64","author":"Liao","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00280-009-1144-0","article-title":"Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells","volume":"66","author":"Guo","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.bmc.2025.118094_b0050","article-title":"Synthesis and antihistaminic activity of novel pyrazoline derivatives","volume":"2","author":"Shaik","year":"2010","journal-title":"Int J ChemTech Res"},{"key":"10.1016\/j.bmc.2025.118094_b0055","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/jhet.349","article-title":"Biological importance of the indole nucleus in recent years: A comprehensive review","volume":"47","author":"Sharma","year":"2010","journal-title":"J Heterocycl Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0060","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.phrs.2007.08.002","article-title":"The potential insulin sensitizing and glucose lowering effects of a novel indole derivative in vitro and in vivo","volume":"56","author":"Li","year":"2007","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.bmc.2025.118094_b0065","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1248\/cpb.58.1529","article-title":"Synthesis and antiviral activity of new indole-based heterocycles","volume":"58","author":"Abdel-Gawad","year":"2010","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/j.bmc.2025.118094_b0070","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1016\/j.bmcl.2006.09.019","article-title":"Synthesis and anti-microbial activity of pyrazolylbisindoles\u2013promising anti-fungal compounds","volume":"16","author":"Sivaprasad","year":"2006","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118094_b0075","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/ja.2011.110","article-title":"Identification of novel deoxyribofuranosyl indole antimicrobial agents","volume":"65","author":"Paudel","year":"2012","journal-title":"J Antibiot (Tokyo)"},{"key":"10.1016\/j.bmc.2025.118094_b0080","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.bmcl.2016.04.080","article-title":"Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities","volume":"26","author":"Tantak","year":"2016","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118094_b0085","doi-asserted-by":"crossref","first-page":"6831","DOI":"10.1016\/j.bmc.2013.07.028","article-title":"Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3'-hydroxy-4'-methoxyphenyl)-3-(3\u2033,4\u2033,5\u2033-trimethoxybenzoyl)-6-methoxyindole (OXi8006)","volume":"21","author":"Macdonough","year":"2013","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0090","doi-asserted-by":"crossref","DOI":"10.3906\/kim-1111-5","article-title":"Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents","author":"Akko\u00e7","year":"2012","journal-title":"Turk J Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0095","doi-asserted-by":"crossref","first-page":"6660","DOI":"10.1038\/s41598-020-63377-x","article-title":"Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents","volume":"10","author":"Kumari","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.bmc.2025.118094_b0100","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1186\/1556-276X-6-482","article-title":"Nanoliposomes for encapsulation and delivery of the potential antitumoral methyl 6-methoxy-3-(4-methoxyphenyl)-1H-indole-2-carboxylate","volume":"6","author":"Abreu","year":"2011","journal-title":"Nanoscale Res Lett"},{"key":"10.1016\/j.bmc.2025.118094_b0105","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.addr.2004.02.014","article-title":"Nanoparticle and targeted systems for cancer therapy","volume":"56","author":"Brannon-Peppas","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.bmc.2025.118094_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113632","article-title":"Recent advances of quinones as a privileged structure in drug discovery","volume":"223","author":"Zhang","year":"2021","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejmech.2014.05.041","article-title":"2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1)","volume":"82","author":"Bian","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2016.06.019","article-title":"da Silva J\u00fanior, Synthesis and antitumor activity of selenium-containing quinone-based triazoles possessing two redox centres, and theirmechanistic insights","volume":"122","author":"da Cruz","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0125","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ejmech.2019.05.063","article-title":"Betulin-1,4-quinone hybrids: Synthesis, anticancer activity and molecular docking study with NQO1 enzyme","volume":"177","author":"Kadela-Tomanek","year":"2019","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0130","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/cbdd.13752","article-title":"Novel \u03b2-carboline-based indole-4,7-quinone derivatives as NAD(P)H: Quinone-oxidoreductase-1 inhibitor with potent antitumor activities by inducing reactive oxygen species, apoptosis, and DNA damage","volume":"96","author":"Guo","year":"2020","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.bmc.2025.118094_b0135","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ejmech.2014.08.009","article-title":"Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation","volume":"85","author":"Devi Bala","year":"2014","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0140","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ejmech.2016.03.042","article-title":"Design, synthesis and biological evaluation of diaziridinyl quinone isoxazole hybrids","volume":"117","author":"Swapnaja","year":"2016","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0145","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejmech.2016.12.054","article-title":"Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives","volume":"127","author":"Yang","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0150","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1021\/acsinfecdis.9b00086","article-title":"Discovery of Simplified Sampangine Derivatives with Potent Antifungal Activities against Cryptococcal Meningitis","volume":"5","author":"Li","year":"2019","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.bmc.2025.118094_b0155","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/ptr.6471","article-title":"The anti-hepatitis B virus therapeutic potential of anthraquinones derived from Aloe vera","volume":"33","author":"Parvez","year":"2019","journal-title":"Phytother Res"},{"key":"10.1016\/j.bmc.2025.118094_b0160","doi-asserted-by":"crossref","first-page":"8576","DOI":"10.1021\/jm5010804","article-title":"Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-\u03b2 aggregation and to exert anticholinesterase and antioxidant effects","volume":"57","author":"Nepovimova","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0165","first-page":"642","article-title":"Antitumor effect and structure-activity relationship of asterriquinone analogs","volume":"73","author":"Shimizu","year":"1982","journal-title":"Gan"},{"key":"10.1016\/j.bmc.2025.118094_b0170","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0006-291X(91)90484-O","article-title":"Inhibition of HIV-reverse transcriptase activity by asterriquinone and its analogues","volume":"174","author":"Ono","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.bmc.2025.118094_b0175","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1248\/bpb.21.945","article-title":"Relationship between the structure and cytotoxic activity of asterriquinone, an antitumor metabolite of Aspergillus terreus, and its alkyl ether derivatives","volume":"21","author":"Kaji","year":"1998","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.bmc.2025.118094_b0180","first-page":"2239","article-title":"Asterriquinone derivatives as candidates for new orally available anti-diabetics","volume":"59","author":"Tanaka","year":"2001","journal-title":"Nihon Rinsho"},{"key":"10.1016\/j.bmc.2025.118094_b0185","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.bmcl.2004.03.047","article-title":"Synthesis and evaluation of novel 1,4-naphthoquinone derivatives as antiviral, antifungal and anticancer agents","volume":"14","author":"Tandon","year":"2004","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118094_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25092058","article-title":"Differential Proliferation Effect of the Newly Synthesized Valine, Tyrosine and Tryptophan-Naphthoquinones in Immortal and Tumorigenic Cervical Cell Lines","volume":"25","author":"C\u00f3rdova-Rivas","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2025.118094_b0195","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ejmech.2012.04.019","article-title":"Synthesis and anti-breast cancer activity of new indolylquinone derivatives","volume":"54","author":"Li","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114375","article-title":"Design, synthesis, and evaluation of a novel series of mono-indolylbenzoquinones derivatives for the potential treatment of breast cancer","volume":"237","author":"Jia","year":"2022","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0205","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1039\/B610213C","article-title":"Fluorine in medicinal chemistry","volume":"37","author":"Purser","year":"2008","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.bmc.2025.118094_b0210","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1871520619666191028111351","article-title":"Heterocyclic Compounds Bearing Triazine Scaffold and Their Biological Significance: A Review","volume":"20","author":"Verma","year":"2020","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/C8QO01180J","article-title":"Novel potential artificial MRSA DNA intercalators: synthesis and biological evaluation of berberine-derived thiazolidinediones","volume":"6","author":"Sun","year":"2019","journal-title":"Org Chem Front"},{"key":"10.1016\/j.bmc.2025.118094_b0220","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nrc.2016.138","article-title":"Cell cycle proteins as promising targets in cancer therapy","volume":"17","author":"Otto","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.bmc.2025.118094_b0225","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0092-8674(95)90482-4","article-title":"DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product","volume":"82","author":"Hartley","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2025.118094_b0230","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1158\/0008-5472.CAN-21-1756","article-title":"DNA-PKcs: A Targetable Protumorigenic Protein Kinase","volume":"82","author":"Dylgjeri","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2025.118094_b0235","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41419-020-02998-6","article-title":"PI3K\/AKT pathway as a key link modulates the multidrug resistance of cancers","volume":"11","author":"Liu","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.bmc.2025.118094_b0240","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.ctrv.2014.03.004","article-title":"Targeting the PI3K\/AKT\/mTOR pathway in estrogen receptor-positive breast cancer","volume":"40","author":"Ciruelos Gil","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.bmc.2025.118094_b0245","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nature07943","article-title":"The cancer genome","volume":"458","author":"Stratton","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118094_b0250","doi-asserted-by":"crossref","DOI":"10.1080\/14756366.2023.2237209","article-title":"Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK)","volume":"38","author":"Huang","year":"2023","journal-title":"J Enzyme Inhib Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0255","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1021\/acs.jmedchem.0c01652","article-title":"Structure-Based Drug Design and Synthesis of PI3K\u03b1-Selective Inhibitor (PF-06843195)","volume":"64","author":"Cheng","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118094_b0260","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/cmdc.202000131","article-title":"Antitumour Anthracyclines: Progress and Perspectives","volume":"15","author":"Martins-Teixeira","year":"2020","journal-title":"ChemMedChem"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625000355?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625000355?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T21:12:26Z","timestamp":1740517946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625000355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":52,"alternative-id":["S0968089625000355"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118094","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of 3-indolylbenzoquinone derivatives with therapeutic potential for breast cancer","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118094"}}