{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:52:13Z","timestamp":1791492733784,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bmc.2025.118194","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:34:44Z","timestamp":1744288484000},"page":"118194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Development of GluN2A NMDA receptor positive allosteric modulators: Recent advances and perspectives"],"prefix":"10.1016","volume":"124","author":[{"given":"Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-0146","authenticated-orcid":false,"given":"Mingxin","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118194_b0005","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1124\/pr.109.002451","article-title":"Glutamate receptor ion channels: structure, regulation, and function","volume":"62","author":"Traynelis","year":"2010","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmc.2025.118194_b0010","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.3390\/nu10111564","article-title":"Glutamine: metabolism and immune function, supplementation and clinical translation","volume":"10","author":"Cruzat","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.bmc.2025.118194_b0015","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2017.04.009","article-title":"Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins","volume":"94","author":"Greger","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118194_b0020","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.molmed.2020.03.001","article-title":"NMDARs in cell survival and death: implications in stroke pathogenesis and treatment","volume":"26","author":"Ge","year":"2020","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.bmc.2025.118194_b0025","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1021\/acs.jmedchem.5b02010","article-title":"Discovery of GluN2A-selective NMDA receptor positive allosteric modulators (PAMs): tuning deactivation kinetics via structure-based design","volume":"59","author":"Volgraf","year":"2016","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0030","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/emboj\/cdg303","article-title":"Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core","volume":"22","author":"Furukawa","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.bmc.2025.118194_b0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature13548","article-title":"NMDA receptor structures reveal subunit arrangement and pore architecture","volume":"511","author":"Lee","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118194_b0040","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1251915","article-title":"Crystal structure of a heterotetrameric NMDA receptor ion channel","volume":"344","author":"Karakas","year":"2014","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.bmc.2025.118194_b0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","article-title":"Developmental and regional expression in the rat brain and functional properties of four NMDA receptors","volume":"12","author":"Monyer","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118194_b0050","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1152\/jn.1998.79.2.555","article-title":"Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors","volume":"79","author":"Vicini","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.bmc.2025.118194_b0055","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrn3504","article-title":"NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease","volume":"14","author":"Paoletti","year":"2013","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.bmc.2025.118194_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cophys.2017.12.004","article-title":"Triheteromeric NMDA receptors: from structure to synaptic physiology","volume":"2","author":"Stroebel","year":"2018","journal-title":"Curr Opin Physiol"},{"key":"10.1016\/j.bmc.2025.118194_b0065","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1113\/JP280875","article-title":"Positive allosteric modulation of NMDA receptors: mechanisms, physiological impact and therapeutic potential","volume":"600","author":"Geoffroy","year":"2022","journal-title":"J Physiol"},{"key":"10.1016\/j.bmc.2025.118194_b0070","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13041-018-0357-8","article-title":"Targeting NMDA receptors in stroke: new hope in neuroprotection","volume":"11","author":"Wu","year":"2018","journal-title":"Mol Brain"},{"key":"10.1016\/j.bmc.2025.118194_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108664","article-title":"Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines","volume":"34","author":"Stein","year":"2021","journal-title":"Cell Rep"},{"issue":"Pt 2","key":"10.1016\/j.bmc.2025.118194_b0080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1469-7793.2000.t01-1-00365.x","article-title":"Enhancement of NMDA receptor-mediated currents by light in rat neurones in vitro","volume":"524 Pt 2","author":"Leszkiewicz","year":"2000","journal-title":"J Physiol"},{"key":"10.1016\/j.bmc.2025.118194_b0085","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1021\/jm401695d","article-title":"Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators","volume":"57","author":"Zimmerman","year":"2014","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0090","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/s41586-021-03769-9","article-title":"Structural basis of ketamine action on human NMDA receptors","volume":"596","author":"Zhang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118194_b0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115685","article-title":"Mechanisms of NMDA receptor inhibition by sepimostat-comparison with nafamostat and diarylamidine compounds","volume":"24","author":"Zhigulin","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2025.118194_b0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuron.2014.03.030","article-title":"Extrasynaptic NMDA receptor involvement in central nervous system disorders","volume":"82","author":"Parsons","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118194_b0105","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1242\/jcs.056473","article-title":"Kidins220\/ARMS downregulation by excitotoxic activation of NMDARs reveals its involvement in neuronal survival and death pathways","volume":"122","author":"L\u00f3pez-Men\u00e9ndez","year":"2009","journal-title":"J Cell Sci"},{"key":"10.1016\/j.bmc.2025.118194_b0110","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","article-title":"Excitotoxicity and stroke: identifying novel targets for neuroprotection","volume":"115","author":"Lai","year":"2014","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.bmc.2025.118194_b0115","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0601","article-title":"Organization, control and function of extrasynaptic NMDA receptors","volume":"369","author":"Papouin","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.bmc.2025.118194_b0120","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1523\/JNEUROSCI.6371-11.2012","article-title":"Synaptic NMDA receptors mediate hypoxic excitotoxic death","volume":"32","author":"Wroge","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmc.2025.118194_b0125","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41467-020-15224-w","article-title":"Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory","volume":"11","author":"Chan","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2025.118194_b0130","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01382-6","article-title":"Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications","volume":"50","author":"Danysz","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.bmc.2025.118194_b0135","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.6093256","article-title":"Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain","volume":"226","author":"Simon","year":"1984","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.bmc.2025.118194_b0140","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201899894","article-title":"An inter-dimer allosteric switch controls NMDA receptor activity","volume":"38","author":"Esmenjaud","year":"2019","journal-title":"EMBO J"},{"key":"10.1016\/j.bmc.2025.118194_b0145","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.sbi.2018.12.009","article-title":"Dissecting diverse functions of NMDA receptors by structural biology","volume":"54","author":"Wang","year":"2019","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.bmc.2025.118194_b0150","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cell.2020.05.052","article-title":"Structural basis of functional transitions in mammalian NMDA receptors","volume":"182","author":"Chou","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2025.118194_b0155","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.neuron.2021.05.031","article-title":"Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors","volume":"109","author":"Wang","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118194_b0160","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1113\/JP279028","article-title":"Architecture and function of NMDA receptors: an evolutionary perspective","volume":"599","author":"Stroebel","year":"2021","journal-title":"J Physiol"},{"key":"10.1016\/j.bmc.2025.118194_b0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/nature17679","article-title":"Activation of NMDA receptors and the mechanism of inhibition by ifenprodil","volume":"534","author":"Tajima","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118194_b0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neuron.2007.11.021","article-title":"Structural rearrangements of NR1\/NR2A NMDA receptors during allosteric inhibition","volume":"57","author":"Gielen","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118194_b0175","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1523\/JNEUROSCI.0116-07.2007","article-title":"NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo","volume":"27","author":"Liu","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.bmc.2025.118194_b0180","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1042\/BST0371147","article-title":"Coupling of the NMDA receptor to neuroprotective and neurodestructive events","volume":"37","author":"Hardingham","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.bmc.2025.118194_b0185","doi-asserted-by":"crossref","first-page":"10581","DOI":"10.1073\/pnas.1202810109","article-title":"Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death","volume":"109","author":"Jo","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bmc.2025.118194_b0190","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1038\/sj.jcbfm.9600303","article-title":"Activation of the Akt\/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats","volume":"26","author":"Endo","year":"2006","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.bmc.2025.118194_b0195","doi-asserted-by":"crossref","first-page":"E33","DOI":"10.1038\/10026","article-title":"How BAD phosphorylation is good for survival","volume":"1","author":"Downward","year":"1999","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.bmc.2025.118194_b0200","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nn835","article-title":"Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways","volume":"5","author":"Hardingham","year":"2002","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.bmc.2025.118194_b0205","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-25058-9","article-title":"GluN2A and GluN2B NMDA receptors use distinct allosteric routes","volume":"12","author":"Tian","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.bmc.2025.118194_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2023.117236","article-title":"Design and synthesis of novel GluN2A NMDAR positive allosteric modulators via scaffold hopping strategy as anti-stroke therapeutic agents","volume":"83","author":"Chen","year":"2023","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0215","unstructured":"Wang YT, Peter AC. N-Methyl-D-aspartate receptor allosteric mod ulators and methods for their use. 2021. US patent 11,166,924, 2021 11-19."},{"key":"10.1016\/j.bmc.2025.118194_b0220","doi-asserted-by":"crossref","DOI":"10.1038\/s41557-023-01239-5","article-title":"Isomerization of bioactive acylhydrazones triggered by light or thiols","volume":"15","author":"Zhang","year":"2023","journal-title":"Nat Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0225","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1039\/D3MD00455D","article-title":"Discovery of novel positive allosteric modulators targeting GluN1\/2A NMDARs as anti-stroke therapeutic agents","volume":"15","author":"Zhu","year":"2024","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0230","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuron.2016.01.016","article-title":"Positive allosteric modulators of GluN2A-containing NMDARs with distinct modes of action and impacts on circuit function","volume":"89","author":"Hackos","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.bmc.2025.118194_b0235","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/acsmedchemlett.6b00388","article-title":"GluN2A-selective pyridopyrimidinone series of NMDAR positive allosteric modulators with an improved in vivo profile","volume":"8","author":"Villemure","year":"2017","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118194_b0240","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.celrep.2019.12.030","article-title":"GluN2A NMDA receptor enhancement improves brain oscillations, synchrony, and cognitive functions in Dravet syndrome and Alzheimer's disease models","volume":"30","author":"Hanson","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.bmc.2025.118194_b0245","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1021\/acs.jmedchem.0c02018","article-title":"Discovery of novel and potent N-methyl-d-aspartate receptor positive allosteric modulators with antidepressant-like activity in rodent models","volume":"64","author":"Li","year":"2021","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116576","article-title":"Discovery of pyrazolo[1,5-a]pyrazin-4-ones as potent and brain penetrant GluN2A-selective positive allosteric modulators reducing AMPA receptor binding activity","volume":"56","author":"Sakurai","year":"2022","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2022.117150","article-title":"Design and synthesis of 6-methylpyridin-2-one derivatives as novel and potent GluN2A positive allosteric modulators for the treatment of cognitive impairment","volume":"79","author":"Yukawa","year":"2023","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0260","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neuropharm.2017.04.041","article-title":"A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain","volume":"121","author":"Wang","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2025.118194_b0265","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/bph.16235","article-title":"Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors","volume":"181","author":"Beckley","year":"2024","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2025.118194_b0270","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1021\/acs.jmedchem.2c00313","article-title":"SAGE-718: A first-in-class N-methyl-d-aspartate receptor positive allosteric modulator for the potential treatment of cognitive impairment","volume":"65","author":"Hill","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118194_b0275","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuropharm.2017.07.007","article-title":"Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives","volume":"125","author":"Sapkota","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bmc.2025.118194_b0280","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1111\/bph.15841","article-title":"Pregnane-based steroids are novel positive NMDA receptor modulators that may compensate for the effect of loss-of-function disease-associated GRIN mutations","volume":"179","author":"Kysilov","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2025.118194_b0285","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s11064-013-0987-2","article-title":"NMDA receptor activation: two targets for two co-agonists","volume":"38","author":"Henneberger","year":"2013","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bmc.2025.118194_b0290","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/mds.25306","article-title":"Glycine site agonists of the N-methyl-D-aspartate receptor and Parkinson's disease: a hypothesis","volume":"28","author":"Heresco-Levy","year":"2013","journal-title":"Mov Disord"},{"key":"10.1016\/j.bmc.2025.118194_b0295","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/01616412.1995.11740324","article-title":"Neuroprotective actions of 1-aminocyclopropanecarboxylic acid (ACPC): a partial agonist at strychnine-insensitive glycine sites","volume":"17","author":"Fossom","year":"1995","journal-title":"Neurol Res"},{"key":"10.1016\/j.bmc.2025.118194_b0300","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1517\/13543784.2014.852536","article-title":"GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists","volume":"23","author":"Moskal","year":"2014","journal-title":"Expert Opin Invest Drugs"},{"key":"10.1016\/j.bmc.2025.118194_b0305","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/bph.12599","article-title":"Positive allosteric modulators of the \u03bc-opioid receptor: a novel approach for future pain medications","volume":"172","author":"Burford","year":"2015","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.bmc.2025.118194_b0310","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.neuint.2012.01.004","article-title":"Pharmacological modulation of NMDA receptor activity and the advent of negative and positive allosteric modulators","volume":"61","author":"Monaghan","year":"2012","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bmc.2025.118194_b0315","article-title":"An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups","volume":"24","author":"Perszyk","year":"2018","journal-title":"Elife"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962500135X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096808962500135X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:57:45Z","timestamp":1762347465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096808962500135X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":63,"alternative-id":["S096808962500135X"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118194","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of GluN2A NMDA receptor positive allosteric modulators: Recent advances and perspectives","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118194","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118194"}}