{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T08:47:47Z","timestamp":1777884467083,"version":"3.51.4"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["106-3011-B-010-001"],"award-info":[{"award-number":["106-3011-B-010-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["107-3011-B-010-001"],"award-info":[{"award-number":["107-3011-B-010-001"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["108-2321-B-010-016"],"award-info":[{"award-number":["108-2321-B-010-016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005057","name":"National Tsing Hua University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024990","name":"National Yang Ming Chiao Tung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bmc.2025.118281","type":"journal-article","created":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T10:11:16Z","timestamp":1749377476000},"page":"118281","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Synthesis and biological evaluation of indoline derivatives as CDGSH iron sulfur domain 2 activators"],"prefix":"10.1016","volume":"128","author":[{"given":"Chun-Hsu","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2828-028X","authenticated-orcid":false,"given":"Lee-Ya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Qing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Hui","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Shin","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Fen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinq-Chyi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118281_b0005","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.cell.2021.04.015","article-title":"Mechanisms and disease consequences of nonalcoholic fatty liver disease","volume":"184","author":"Loomba","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2025.118281_b0010","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2025.118281_b0015","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1053\/j.gastro.2016.01.002","article-title":"How safe is moderate alcohol consumption in overweight and obese individuals?","volume":"150","author":"Sookoian","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bmc.2025.118281_b0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/cld.81","article-title":"Nonalcoholic fatty liver disease: definitions, risk factors, and workup","volume":"1","author":"Puri","year":"2012","journal-title":"Clin Liver Dis"},{"key":"10.1016\/j.bmc.2025.118281_b0025","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s40265-024-02045-0","article-title":"Resmetirom: first approval","volume":"84","author":"Keam","year":"2024","journal-title":"Drug"},{"key":"10.1016\/j.bmc.2025.118281_b0030","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.bmc.2025.118281_b0035","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.3109\/10715762.2014.936431","article-title":"Cisd2 mediates lifespan: is there an interconnection among Ca2+ homeostasis, autophagy, and lifespan?","volume":"48","author":"Wang","year":"2014","journal-title":"Free Radic Res"},{"key":"10.1016\/j.bmc.2025.118281_b0040","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1093\/hmg\/ddu193","article-title":"Cisd2 modulates differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis","volume":"23","author":"Wang","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.bmc.2025.118281_b0045","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/nyas.12838","article-title":"Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells","volume":"1350","author":"Wang","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.bmc.2025.118281_b0050","article-title":"CISD2 maintains cellular homeostasis","volume":"1868","author":"Shen","year":"2021","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.bmc.2025.118281_b0055","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1101\/gad.1779509","article-title":"Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice","volume":"23","author":"Chen","year":"2009","journal-title":"Genes Dev"},{"key":"10.1016\/j.bmc.2025.118281_b0060","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.4161\/auto.5.7.9351","article-title":"Cisd2 mediates mitochondrial integrity and life span in mammals","volume":"5","author":"Chen","year":"2009","journal-title":"Autophagy"},{"key":"10.1016\/j.bmc.2025.118281_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000508","article-title":"Cisd2 is essential to delaying cardiac aging and to maintaining heart functions","volume":"17","author":"Yeh","year":"2019","journal-title":"PLoS Biol"},{"key":"10.1016\/j.bmc.2025.118281_b0070","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13523","article-title":"Cisd2 slows down liver aging and attenuates age-related metabolic dysfunction in male mice","volume":"20","author":"Huang","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.bmc.2025.118281_b0075","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.1093\/hmg\/dds210","article-title":"A persistent level of Cisd2 extends healthy lifespan and delays aging in mice","volume":"21","author":"Wu","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.bmc.2025.118281_b0080","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.tem.2019.02.005","article-title":"Calcium signaling as a therapeutic target for liver steatosis","volume":"30","author":"Ali","year":"2019","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bmc.2025.118281_b0085","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1016\/j.celrep.2017.10.099","article-title":"CISD2 haploinsufficiency disrupts calcium homeostasis, causes nonalcoholic fatty liver disease, and promotes hepatocellular carcinoma","volume":"21","author":"Shen","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.bmc.2025.118281_b0090","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3390\/antiox10040559","article-title":"Cisd2 protects the liver from oxidative stress and ameliorates western diet-induced nonalcoholic fatty liver disease","volume":"10","author":"Huang","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.bmc.2025.118281_b0095","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.18632\/aging.203929","article-title":"Enhancing CISD2 expression to retard liver aging","volume":"14","author":"Huang","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bmc.2025.118281_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115583","article-title":"Discovery of tetrasubstituted thiophenes as Cisd2 activators: a potential novel therapeutic option in nonalcoholic fatty liver disease","volume":"258","author":"Yao","year":"2023","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118281_b0105","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1021\/jm960734f","article-title":"Synthesis and biological evaluation of nonclassical 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines with novel side chain substituents as potential inhibitors of dihydrofolate reductases","volume":"40","author":"Gangjee","year":"1997","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118281_b0110","unstructured":"Wu C, Raju BG, Kogan T, Blok N. N-heteroaryl aryl-substituted thienyl-furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin. US6420567B1; 2002."},{"key":"10.1016\/j.bmc.2025.118281_b0115","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1021\/acscatal.7b02682","article-title":"Site-selective deuteration ofN-heterocycles via iridium-catalyzed hydrogen isotope exchange","volume":"7","author":"Kerr","year":"2017","journal-title":"ACS Catal"},{"key":"10.1016\/j.bmc.2025.118281_b0120","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.3390\/biomedicines9091229","article-title":"Cisd2 preserves the youthful pattern of the liver proteome during natural aging of mice","volume":"9","author":"Huang","year":"2021","journal-title":"Biomedicines"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625002226?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625002226?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:26:23Z","timestamp":1777602383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625002226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":24,"alternative-id":["S0968089625002226"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118281","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and biological evaluation of indoline derivatives as CDGSH iron sulfur domain 2 activators","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118281","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118281"}}