{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:32:38Z","timestamp":1787592758711,"version":"build-2736575974"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"National Major Scientific and Technological Special Project for Significant New Drugs Development","award":["2018ZX09735006"],"award-info":[{"award-number":["2018ZX09735006"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bmc.2025.118284","type":"journal-article","created":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T10:55:09Z","timestamp":1749898509000},"page":"118284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Synthesis and anticancer activity of betulin-succinate derivatives in vitro and in the zebrafish xenograft tumor model"],"prefix":"10.1016","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5692-0390","authenticated-orcid":false,"given":"Ting","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangcheng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yindi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118284_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.biotechadv.2019.06.008","article-title":"Betulin and its derivatives as novel compounds with different pharmacological effects","volume":"38","author":"Amiri","year":"2020","journal-title":"Biotechnol Adv"},{"key":"10.1016\/j.bmc.2025.118284_b0010","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2025.118284_b0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/1752-153X-6-137","article-title":"Study of the betulin enriched birch bark extracts effects on human carcinoma cells and earinflammation","volume":"6","author":"Dehelean","year":"2012","journal-title":"Chem Cent J"},{"key":"10.1016\/j.bmc.2025.118284_b0020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.intimp.2015.11.028","article-title":"Betulin attenuates lung and liver injuries in sepsis","volume":"30","author":"Zhao","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.bmc.2025.118284_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.754038","article-title":"Betulin alleviates the inflammatory response in mouse chondrocytes and ameliorates osteoarthritis via AKT\/Nrf2\/HO-1\/NF-\u03baB Axis","volume":"12","author":"Ren","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.bmc.2025.118284_b0030","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/09168451.2015.1072460","article-title":"Ameliorative effect of betulin from Betula platyphylla bark on scopolamine-induced amnesic mice","volume":"80","author":"Cho","year":"2016","journal-title":"Biosci Biotech Bioch"},{"key":"10.1016\/j.bmc.2025.118284_b0035","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s11101-019-09623-1","article-title":"Betulin and betulinic acid: triterpenoids derivatives with a powerful biological potential","volume":"18","author":"Hordyjewska","year":"2019","journal-title":"Phytochem Rev"},{"key":"10.1016\/j.bmc.2025.118284_b0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12906-015-0592-9","article-title":"The triterpenoids of Hibiscus syriacus induce apoptosis and inhibit cell migration in breast cancer cells","volume":"15","author":"Hsu","year":"2015","journal-title":"BMC Compl Altern Med"},{"key":"10.1016\/j.bmc.2025.118284_b0045","first-page":"128","article-title":"Treatment of actinic keratoses with a novel betulin-based oleogel. A prospective, randomized, comparative pilot study","volume":"7","author":"Huyke","year":"2009","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.bmc.2025.118284_b0050","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuro.2016.09.009","article-title":"Protective effect of betulin on cognitive decline in Streptozotocin (STZ)-induced diabetic rats","volume":"57","author":"Ma","year":"2016","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bmc.2025.118284_b0055","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.bioorg.2019.03.060","article-title":"New phosphate derivatives of betulin as anticancer agents: synthesis, crystal structure, and molecular docking study","volume":"87","author":"Chrobak","year":"2019","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.bmc.2025.118284_b0060","doi-asserted-by":"crossref","first-page":"72","DOI":"10.26444\/jpccr\/92743","article-title":"Betulin and betulinic acid in cancer research","volume":"12","author":"Hordyjewska","year":"2018","journal-title":"J. Pre. Clin. Clin. Res."},{"key":"10.1016\/j.bmc.2025.118284_b0065","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/tox.22924","article-title":"Betulin inhibits mTOR and induces autophagy to promote apoptosis in human osteosarcoma cell lines","volume":"35","author":"Lin","year":"2020","journal-title":"Environ Toxicol"},{"key":"10.1016\/j.bmc.2025.118284_b0070","doi-asserted-by":"crossref","first-page":"20892","DOI":"10.1039\/C9RA03326B","article-title":"Novel polymeric derivatives of betulin with anticancer activity","volume":"9","author":"Niewolik","year":"2019","journal-title":"RSC Adv"},{"key":"10.1016\/j.bmc.2025.118284_b0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154933","article-title":"Effective method of purification of betulin from birch bark: the importance of its purity for scientific and medicinal use","volume":"11","author":"\u0160iman","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2025.118284_b0080","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1007\/s12272-018-1064-9","article-title":"Bioactivity evaluations of betulin identified from the bark of Betula platyphylla var. japonica for cancer therapy","volume":"41","author":"So","year":"2018","journal-title":"Arch Pharm Res"},{"key":"10.1016\/j.bmc.2025.118284_b0085","first-page":"2663","article-title":"Anti-inflammatory and anticancer properties of birch bark-derived betulin: recent developments","volume":"10","author":"Tuli","year":"2021","journal-title":"Plants (Basel)."},{"key":"10.1016\/j.bmc.2025.118284_b0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12935-016-0369-3","article-title":"Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)","volume":"17","author":"Dr\u0105g-Zalesi\u0144ska","year":"2017","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.bmc.2025.118284_b0095","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/microorganisms9020320","article-title":"Leishmanicidal activity of betulin derivatives in Leishmania amazonensis; effect on plasma and mitochondrial membrane potential, and macrophage nitric oxide and superoxide production","volume":"9","author":"Alcazar","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.bmc.2025.118284_b0100","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.ejmech.2016.09.065","article-title":"Preparation of novel ring-a fused azole derivatives of betulin and evaluation of their cytotoxicity","volume":"125","author":"Grishko","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118284_b0105","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1021\/acs.jnatprod.8b00830","article-title":"Triphenylphosphonium analogues of betulin and betulinic acid with biological activity: a comprehensive review","volume":"82","author":"Grymel","year":"2019","journal-title":"J Nat Prod"},{"key":"10.1016\/j.bmc.2025.118284_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111839","article-title":"Design, synthesis, and biological evaluation of ligustrazine \u2013 betulin amino-acid\/dipeptide derivatives as antitumor agents","volume":"185","author":"Guo","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118284_b0115","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/chromsci\/bmz117","article-title":"Application of TLC to evaluate the lipophilicity of newly synthesized betulin derivatives","volume":"58","author":"B\u0119benek","year":"2020","journal-title":"J Chromatogr Sci"},{"key":"10.1016\/j.bmc.2025.118284_b0120","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.3390\/biom12101540","article-title":"New betulin derivatives with nitrogen heterocyclic moiety-synthesis and anticancer activity In Vitro","volume":"12","author":"B\u0119benek","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bmc.2025.118284_b0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00044-016-1713-9","article-title":"New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity","volume":"26","author":"B\u0119benek","year":"2017","journal-title":"Med Chem Res"},{"key":"10.1016\/j.bmc.2025.118284_b0130","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1021\/acsbiomaterials.1c00563","article-title":"Synthesis and characterization of methacrylate-functionalized betulin derivatives as antibacterial comonomer for dental restorative resins","volume":"7","author":"Zhang","year":"2021","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.bmc.2025.118284_b0135","doi-asserted-by":"crossref","first-page":"6451","DOI":"10.1016\/j.bmc.2010.06.092","article-title":"Conjugates of betulin derivatives with AZT as potent anti-HIV agents","volume":"18","author":"Xiong","year":"2010","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118284_b0140","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1128\/AAC.01391-06","article-title":"Safety and Pharmacokinetics of Bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation","volume":"51","author":"Martin","year":"2007","journal-title":"Healthy Volunteers. Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bmc.2025.118284_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205368","article-title":"Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known As BMS-955176) plus tenofovir\/emtricitabine once daily in treatment-naive hiv-1-infected adults: week 24 primary analysis from a randomized phase iib trial","volume":"13","author":"Morales-Ramirez","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2025.118284_b0150","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1021\/acsmedchemlett.6b00010","article-title":"Discovery of BMS-955176, a second generation HIV-1 maturation inhibitor with broad spectrum antiviral activity","volume":"7","author":"Regueiro-Ren","year":"2016","journal-title":"ACS Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118284_b0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/bcpt.13504","article-title":"Pre-clinical pharmacological profile of QF-036, a potent HIV-1 maturation inhibitor","volume":"128","author":"Zhao","year":"2021","journal-title":"Basic Clin Paharmacol Toxicol"},{"key":"10.1016\/j.bmc.2025.118284_b0160","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.toxlet.2020.04.015","article-title":"Single- and repeated-dose toxicity studies on the novel HIV maturation inhibitor QF-036 in sprague-dawley rats","volume":"329","author":"Cui","year":"2020","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.bmc.2025.118284_b0165","article-title":"Benefits of zebrafish xenograft models in cancer research","volume":"9","author":"Chen","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.bmc.2025.118284_b0170","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1186\/s12885-015-1970-x","article-title":"BPIQ, a novel synthetic quinoline derivative, inhibits growth and induces mitochondrial apoptosis of lung cancer cells in vitro and in zebrafish xenograft model","volume":"15","author":"Chiu","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bmc.2025.118284_b0175","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3390\/biomedicines10071474","article-title":"Zebrafish patient-derived xenograft model to predict treatment outcomes of colorectal cancer patients","volume":"10","author":"Di Franco","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bmc.2025.118284_b0180","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1186\/s13046-019-1389-3","article-title":"Zebrafish modeling reveals that SPINT1 regulates the aggressiveness of skin cutaneous melanoma and its crosstalk with tumor immune microenvironment","volume":"38","author":"G\u00f3mez-Abenza","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.bmc.2025.118284_b0185","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.fsi.2019.09.075","article-title":"cGAMP inhibits tumor growth in colorectal cancer metastasis through the STING\/STAT3 axis in a zebrafish xenograft model","volume":"95","author":"Jiang","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.bmc.2025.118284_b0190","unstructured":"Christophe M, Laval CCK, Marc C, HALAB. Liliane. Novel C-21-Keto Lupane Derivatives Preparation and Use Thereof: Wo, 2009082818A1 [P], 2009.07.09."},{"key":"10.1016\/j.bmc.2025.118284_b0195","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s12935-020-01460-z","article-title":"Zebrafish xenograft model of human lung cancer for studying the function of LINC00152 in cell proliferation and invasion","volume":"20","author":"Shen","year":"2020","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.bmc.2025.118284_b0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13045-015-0126-4","article-title":"Zebrafish as a model for leukemia and other hematopoietic disorders","volume":"8","author":"Rasighaemi","year":"2015","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.bmc.2025.118284_b0205","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s42003-020-1015-0","article-title":"Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy","volume":"3","author":"Rebelo de Almeida","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.bmc.2025.118284_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115167","article-title":"Green tea-derived theabrownin suppresses human non-small cell lung carcinoma in xenograft model through activation of not only p53 signaling but also MAPK\/JNK signaling pathway","volume":"291","author":"Xiao","year":"2022","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.bmc.2025.118284_b0215","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13046-015-0196-8","article-title":"A fresh look at zebrafish from the perspective of cancer research","volume":"34","author":"Zhao","year":"2015","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.bmc.2025.118284_b0220","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ijbiomac.2020.01.033","article-title":"Lectin from Laetiporus sulphureus effectively inhibits angiogenesis and tumor development in the zebrafish xenograft models of colorectal carcinoma and melanoma","volume":"148","author":"Petrovi\u0107","year":"2020","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.bmc.2025.118284_b0225","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3389\/fmicb.2020.00405","article-title":"Exploiting zebrafish xenografts for testing the In Vivo antitumorigenic activity of microcin E492 against human colorectal cancer cells","volume":"11","author":"Varas","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.bmc.2025.118284_b0230","doi-asserted-by":"crossref","first-page":"83071","DOI":"10.18632\/oncotarget.13068","article-title":"Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model","volume":"7","author":"Roel","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bmc.2025.118284_b0235","first-page":"252","article-title":"The zebrafish xenograft models for investigating cancer and cancer therapeutics","volume":"10","author":"Gamble","year":"2021","journal-title":"Biology (Basel)."},{"key":"10.1016\/j.bmc.2025.118284_b0240","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13058-015-0537-8","article-title":"Genetic depletion and pharmacological targeting of alphav integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models","volume":"17","author":"Li","year":"2015","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.bmc.2025.118284_b0245","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13046-021-02173-5","article-title":"Zebrafish xenograft model for studying mechanism and treatment of non-small cell lung cancer brain metastasis","volume":"40","author":"Fan","year":"2021","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.bmc.2025.118284_b0250","article-title":"MARK2\/4 promotes warburg effect and cell growth in non-small cell lung carcinoma through the AMPKalpha1\/mTOR\/HIF-1alpha signaling pathway","volume":"1869","author":"Natarajan","year":"2022","journal-title":"BBA"},{"key":"10.1016\/j.bmc.2025.118284_b0255","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.cub.2022.04.088","article-title":"MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization","volume":"32","author":"Pasapera","year":"2022","journal-title":"Curr Biol"},{"key":"10.1016\/j.bmc.2025.118284_b0260","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3892\/ijo.2016.3768","article-title":"Baicalin attenuates DDP (Cisplatin) resistance in lung cancer by downregulating MARK2 and p-Akt","volume":"50","author":"Xu","year":"2017","journal-title":"Int J Oncol"},{"key":"10.1016\/j.bmc.2025.118284_b0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbo.2020.100290","article-title":"The inhibition of MARK2 suppresses cisplatin resistance of osteosarcoma stem cells by regulating DNA damage and repair","volume":"23","author":"Xu","year":"2020","journal-title":"J Bone Oncol"},{"key":"10.1016\/j.bmc.2025.118284_b0270","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/s41417-024-00737-z","article-title":"Role of MARK2 in the nervous system and cancer","volume":"31","author":"Lei","year":"2024","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.bmc.2025.118284_b0275","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3892\/ijo.2016.3768","article-title":"Baicalin attenuates DDP (cisplatin) resistance in lung cancer by downregulating MARK2 and p-Akt","volume":"50","author":"Xu","year":"2017","journal-title":"Int J Oncol"},{"key":"10.1016\/j.bmc.2025.118284_b0280","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/jcb.30219","article-title":"MARK2 potentiate aerobic glycolysis\u2010mediated cell growth in breast cancer through regulating mTOR\/HIF\u20101\u03b1 and p53 pathways","volume":"123","author":"Ponnusamy","year":"2022","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.bmc.2025.118284_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.132712","article-title":"An overview on applications of SwissADME web tool in the design and development of anticancer, antitubercular and antimicrobial agents: a medicinal chemist's perspective","volume":"1259","author":"Bakchi","year":"2022","journal-title":"J Mol Struct"},{"key":"10.1016\/j.bmc.2025.118284_b0290","doi-asserted-by":"crossref","first-page":"W513","DOI":"10.1093\/nar\/gkae303","article-title":"ProTox 3.0: a webserver for the prediction of toxicity of chemicals","volume":"52","author":"Banerjee","year":"2024","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.bmc.2025.118284_b0295","doi-asserted-by":"crossref","first-page":"19137","DOI":"10.1021\/jacs.1c08922","article-title":"Preservation of HIV-1 Gag helical bundle symmetry by bevirimat is central to maturation inhibition","volume":"143","author":"Pak","year":"2021","journal-title":"J Am Chem Soc"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625002251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625002251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:35:46Z","timestamp":1775097346000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625002251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":59,"alternative-id":["S0968089625002251"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118284","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis and anticancer activity of betulin-succinate derivatives in vitro and in the zebrafish xenograft tumor model","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118284"}}