{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:12:00Z","timestamp":1780405920463,"version":"3.54.1"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bmc.2025.118382","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:02:05Z","timestamp":1758772925000},"page":"118382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Antibody drug conjugates of echinomycin-based payloads"],"prefix":"10.1016","volume":"131","author":[{"given":"Thomas","family":"Nittoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Cheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Strong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Sathyanarayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Harradence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pearce","family":"Curran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Carosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Kovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118382_bb0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/hlca.19570400124","volume":"40","author":"Corbaz","year":"1957","journal-title":"Helv Chim Acta"},{"issue":"Ser. A","key":"10.1016\/j.bmc.2025.118382_bb0010","first-page":"330","article-title":"Quinoxaline antibiotics. II. Isolation and properties of quinomycins a, b, and c","volume":"14","author":"Yoshida","year":"1961","journal-title":"J Antibiot, Series A"},{"issue":"12","key":"10.1016\/j.bmc.2025.118382_bb0015","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.7164\/antibiotics.36.1664","article-title":"Conversion of triostins to quinomycins by protoplasts of Streptomyces echinatus","volume":"36","author":"Cornish","year":"1983","journal-title":"J Antibiotics"},{"key":"10.1016\/j.bmc.2025.118382_bb0020","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1093\/nar\/13.7.2305","article-title":"A comparison of the structure of echinomycin and triostin A complexed to a DNA fragment","volume":"13","author":"Ughetto","year":"1985","journal-title":"Nucl Acids Res"},{"key":"10.1016\/j.bmc.2025.118382_bb0025","doi-asserted-by":"crossref","first-page":"12397","DOI":"10.1021\/bi00207a006","article-title":"Sequence specificity of quinoxaline antibiotics. 2. NMR studies of the binding of [N-MeCys3,N-MeCys7]TANDEM and triostin A to DNA containing a CpI step","volume":"33","author":"Addess","year":"1994","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.bmc.2025.118382_bb0030","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/jb\/mvh137","article-title":"Identification and characterization of the hypoxia-responsive element of the human placental 6-phosphofructo-2-kinase\/fructose-2,6-bisphosphatase gene","volume":"136","author":"Fukasawa","year":"2004","journal-title":"J Biochem"},{"key":"10.1016\/j.bmc.2025.118382_bb0035","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1158\/0008-5472.CAN-05-1235","article-title":"Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity","volume":"65","author":"Kong","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2025.118382_bb0040","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/s41429-018-0132-1","article-title":"Two novel quinomycins discovered by UPLC-MS from Streptomyces sp. HCCB11876","volume":"72","author":"Yang","year":"2019","journal-title":"J Antibiotics"},{"key":"10.1016\/j.bmc.2025.118382_bb0045","first-page":"7628","article-title":"Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent","volume":"14","author":"Kojima","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bmc.2025.118382_bb0050","first-page":"122","article-title":"Antitumor activity of quinoxaline antibiotics","volume":"16","author":"Katagiri","year":"1963","journal-title":"J Antibiotics (Tokyo) Ser B"},{"issue":"1","key":"10.1016\/j.bmc.2025.118382_bb0055","first-page":"43","article-title":"Quinoxaline antibiotics. IV. Selective antitumor activity of each quinoxaline antibiotic","volume":"18","author":"Matsuura","year":"1965","journal-title":"J Antibiotics, Series A"},{"issue":"63","key":"10.1016\/j.bmc.2025.118382_bb0060","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1021\/acs.jmedchem.9b02039","volume":"13","author":"Koike","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118382_bb0065","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1158\/0008-5472.CAN-05-3973","volume":"66","author":"Kovtun","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.bmc.2025.118382_bb0070","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1021\/bc025536j","volume":"13","author":"Dubowchik","year":"2002","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.bmc.2025.118382_bb0075","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1021\/jm020149g","volume":"45","author":"King","year":"2002","journal-title":"J Med Chem"},{"issue":"7","key":"10.1016\/j.bmc.2025.118382_bb0080","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1021\/bc400217g","volume":"24","author":"Jeffrey","year":"2013","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.bmc.2025.118382_bb0085","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ejps.2008.12.005","volume":"36","author":"Bansala","year":"2009","journal-title":"Euro J Pharma Sci"},{"key":"10.1016\/j.bmc.2025.118382_bb0090","doi-asserted-by":"crossref","first-page":"9995","DOI":"10.1002\/anie.201004243","volume":"49","author":"Jeger","year":"2010","journal-title":"Angew Chem Int Ed"},{"issue":"1","key":"10.1016\/j.bmc.2025.118382_bb0095","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/acs.bioconjchem.8b00843","volume":"30","author":"Ratnayake","year":"2019","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.bmc.2025.118382_bb0100","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1073\/pnas.89.10.4285","volume":"89","author":"Carter","year":"1992","journal-title":"PNAS"},{"issue":"20","key":"10.1016\/j.bmc.2025.118382_bb0105","doi-asserted-by":"crossref","first-page":"5097","DOI":"10.1158\/1078-0432.CCR-15-2822","volume":"22","author":"Ogitani","year":"2016","journal-title":"Clin Cancer Res"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:33:36Z","timestamp":1780403616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625003232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":21,"alternative-id":["S0968089625003232"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118382","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibody drug conjugates of echinomycin-based payloads","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118382","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118382"}}