{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:28:18Z","timestamp":1792898898432,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI116420"],"award-info":[{"award-number":["AI116420"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bmc.2025.118406","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:07:14Z","timestamp":1758701234000},"page":"118406","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Design, synthesis and SAR studies of N\u2032-(Ethynylsalicylidene)arenecarbohydrazides as next-generation broad-spectrum antifungal agents"],"prefix":"10.1016","volume":"131","author":[{"given":"Ashna","family":"Garg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel S.","family":"Matos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krupanandan","family":"Haranahalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shridevi Shrinivasa","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nivea Pereira","family":"de Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline Mota","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Del Poeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwao","family":"Ojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bmc.2025.118406_bb0005","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jof3040057","article-title":"Global and multi-national prevalence of fungal diseases\u2014estimate precision","volume":"3","author":"Bongomin","year":"2017","journal-title":"J. fungi"},{"key":"10.1016\/j.bmc.2025.118406_bb0010","series-title":"World Health Organization Releases First-Ever List of Health-Threatening Fungi","author":"WHO","year":"2022"},{"issue":"2","key":"10.1016\/j.bmc.2025.118406_bb0015","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41576-023-00649-y","article-title":"Genomic surveillance for antimicrobial resistance\u2014a one health perspective","volume":"25","author":"Djordjevic","year":"2024","journal-title":"Nat. Rev. Genet."},{"issue":"10442","key":"10.1016\/j.bmc.2025.118406_bb0020","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1016\/S0140-6736(24)00862-6","article-title":"Burden of bacterial antimicrobial resistance in low-income and middle-income countries avertible by existing interventions: an evidence review and modelling analysis","volume":"403","author":"Lewnard","year":"2024","journal-title":"Lancet"},{"issue":"10442","key":"10.1016\/j.bmc.2025.118406_bb0025","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1016\/S0140-6736(24)00876-6","article-title":"The scope of the antimicrobial resistance challenge","volume":"403","author":"Okeke","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bmc.2025.118406_bb0030","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1086\/524071","article-title":"Resistance to antifungal agents: mechanisms and clinical impact","volume":"46","author":"Kanafani","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.bmc.2025.118406_bb0035","series-title":"Antibiotic Resistance Threats in the United States; Atlanta, GA","author":"CDC","year":"2019"},{"issue":"5","key":"10.1016\/j.bmc.2025.118406_bb0040","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/pharmaceutics16050665","article-title":"Antibiotic loaded Phytosomes as a way to develop innovative lipid formulations of polyene macrolides","volume":"16","author":"Efimova","year":"2024","journal-title":"Pharmaceutics"},{"issue":"8","key":"10.1016\/j.bmc.2025.118406_bb0045","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1016\/j.apsb.2021.04.010","article-title":"Delivery strategies of amphotericin B for invasive fungal infections","volume":"11","author":"Wang","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"10","key":"10.1016\/j.bmc.2025.118406_bb0050","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1086\/598327","article-title":"Clinical relevance of the pharmacokinetic interactions of azole antifungal drugs with other coadministered agents","volume":"48","author":"Br\u00fcggemann","year":"2009","journal-title":"Clin. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bmc.2025.118406_bb0055","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/14756366.2022.2050224","article-title":"Echinocandins\u2013structure, mechanism of action and use in antifungal therapy","volume":"37","author":"Szyma\u0144ski","year":"2022","journal-title":"J. Enzyme Inhibition Med. Chem."},{"key":"10.1016\/j.bmc.2025.118406_bb0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/DDDT.S339349","article-title":"Ibrexafungerp for the treatment of vulvovaginal candidiasis: design, development and place in therapy","author":"Phillips","year":"2023","journal-title":"Drug Design, Develop Therapy"},{"key":"10.1016\/j.bmc.2025.118406_bb0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.plipres.2015.11.003","article-title":"Plasma membrane lipids and their role in fungal virulence","volume":"61","author":"Rella","year":"2016","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bmc.2025.118406_bb0070","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fimmu.2019.00090","article-title":"The role of glycosphingolipids in immune cell functions","volume":"10","author":"Zhang","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bmc.2025.118406_bb0075","doi-asserted-by":"crossref","first-page":"00615","DOI":"10.1128\/mBio.00647-15","article-title":"Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids","volume":"6","author":"Mor","year":"2015","journal-title":"MBio"},{"issue":"2","key":"10.1016\/j.bmc.2025.118406_bb0080","doi-asserted-by":"crossref","first-page":"00118","DOI":"10.1128\/mBio.00188-18","article-title":"Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids","volume":"9","author":"Mor","year":"2018","journal-title":"Mbio"},{"issue":"6","key":"10.1016\/j.bmc.2025.118406_bb0085","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1172\/JCI27890","article-title":"Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans","volume":"116","author":"Rittershaus","year":"2006","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.bmc.2025.118406_bb0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3390\/jof6030142","article-title":"Antifungal drug development: targeting the fungal sphingolipid pathway","volume":"6","author":"McEvoy","year":"2020","journal-title":"J. Fungi"},{"issue":"9","key":"10.1016\/j.bmc.2025.118406_bb0095","doi-asserted-by":"crossref","first-page":"00920","DOI":"10.1128\/AAC.00946-20","article-title":"Preclinical evaluation of acylhydrazone SB-AF-1002 as a novel broad-spectrum antifungal agent","volume":"64","author":"Lazzarini","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"17","key":"10.1016\/j.bmc.2025.118406_bb0100","doi-asserted-by":"crossref","first-page":"8249","DOI":"10.1021\/acs.jmedchem.9b01004","article-title":"SAR studies on aromatic acylhydrazone-based inhibitors of fungal sphingolipid synthesis as next-generation antifungal agents","volume":"62","author":"Haranahalli","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118406_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117610","article-title":"SAR study of N\u2032-(Salicylidene) heteroarenecarbohydrazides as promising antifungal agents","volume":"100","author":"Sun","year":"2024","journal-title":"Bioorg. Med. Chem."},{"issue":"6","key":"10.1016\/j.bmc.2025.118406_bb0110","doi-asserted-by":"crossref","first-page":"e03923","DOI":"10.1128\/spectrum.03967-23","article-title":"Combination therapy of itraconazole and an acylhydrazone derivative (D13) for the treatment of sporotrichosis in cats","volume":"12","author":"Dib Ferreira Gremi\u00e3o","year":"2024","journal-title":"Microbiol. Spectrum"},{"issue":"3","key":"10.1016\/j.bmc.2025.118406_bb0115","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.apsb.2023.11.021","article-title":"Late-stage modification of bioactive compounds: improving druggability through efficient molecular editing","volume":"14","author":"Huo","year":"2023","journal-title":"Acta Pharm. Sin. B."},{"issue":"12","key":"10.1016\/j.bmc.2025.118406_bb0120","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1021\/acschembio.5b00515","article-title":"Experimental and theoretical evaluation of the ethynyl moiety as a halogen bioisostere","volume":"10","author":"Wilcken","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"15","key":"10.1016\/j.bmc.2025.118406_bb0125","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4155\/fmc-2016-0093","article-title":"AutoQSAR: an automated machine learning tool for best-practice quantitative structure\u2013activity relationship modeling","volume":"8","author":"Dixon","year":"2016","journal-title":"Future Med. Chem."},{"issue":"3","key":"10.1016\/j.bmc.2025.118406_bb0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/21501203.2019.1574927","article-title":"Resistance mechanism and proteins in aspergillus species against antifungal agents","volume":"10","author":"Shishodia","year":"2019","journal-title":"Mycology"},{"issue":"9","key":"10.1016\/j.bmc.2025.118406_bb0135","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J. Med. Chem."},{"issue":"W1","key":"10.1016\/j.bmc.2025.118406_bb0140","doi-asserted-by":"crossref","first-page":"W469","DOI":"10.1093\/nar\/gkae254","article-title":"Deep-PK: deep learning for small molecule pharmacokinetic and toxicity prediction","volume":"52","author":"Myung","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2025.118406_bb0145","series-title":"Physicochemical Properties","author":"Davis","year":"2023"},{"key":"10.1016\/j.bmc.2025.118406_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/chem.202500414","article-title":"The versatility of Diazirines: properties, synthetic and modern applications","volume":"31","author":"Lepage","year":"2025","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.bmc.2025.118406_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28031408","article-title":"Heteroaromatic diazirines are essential building blocks for material and medicinal chemistry","volume":"28","author":"Murai","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2025.118406_bb0160","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/molecules28020514","article-title":"Discovery of a novel Trifluoromethyl Diazirine inhibitor of SARS-CoV-2 Mpro","volume":"28","author":"Citarella","year":"2023","journal-title":"Molecules"},{"issue":"30","key":"10.1016\/j.bmc.2025.118406_bb0165","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1002\/ange.201702748","article-title":"Doubly caged linker for AND-type Fluorogenic construction of protein\/antibody bioconjugates and in situ quantification","volume":"129","author":"Liu","year":"2017","journal-title":"Angew. Chem."},{"issue":"6","key":"10.1016\/j.bmc.2025.118406_bb0170","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1021\/jp5068507","article-title":"2-(2-hydroxyphenyl)-benzothiazole (HBT)-rhodamine dyad: acid-switchable absorption and fluorescence of excited-state intramolecular proton transfer (ESIPT)","volume":"119","author":"Majumdar","year":"2015","journal-title":"J. Phys. Chem. B"},{"issue":"27","key":"10.1016\/j.bmc.2025.118406_bb0175","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1039\/C8OB01207E","article-title":"Total synthesis and structural revision of (\u00b1)-nidemone","volume":"16","author":"Hsu","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.bmc.2025.118406_bb0180","article-title":"PA: clinical and laboratory standards institute","author":"Wayne","year":"2012","journal-title":"Perform Standards Antimicrobial Susceptibility Test."},{"issue":"5","key":"10.1016\/j.bmc.2025.118406_bb0185","doi-asserted-by":"crossref","first-page":"e02322","DOI":"10.1128\/mbio.02328-22","article-title":"Vaccination with live or heat-killed Aspergillus fumigatus \u0394 sglA conidia fully protects immunocompromised mice from invasive aspergillosis","volume":"13","author":"Fernandes","year":"2022","journal-title":"MBio"},{"key":"10.1016\/j.bmc.2025.118406_bb0190","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejmech.2015.07.032","article-title":"Thiazole compounds with activity against Cryptococcus gattii and Cryptococcus neoformans in vitro","volume":"102","author":"de S\u00e1","year":"2015","journal-title":"Eur. J. Med. Chem."},{"issue":"5","key":"10.1016\/j.bmc.2025.118406_bb0195","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1093\/jac\/dkh434","article-title":"Combinations of antifungal agents in therapy\u2013what value are they?","volume":"54","author":"Cuenca-Estrella","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"issue":"4","key":"10.1016\/j.bmc.2025.118406_bb0200","doi-asserted-by":"crossref","first-page":"01421","DOI":"10.1128\/mBio.01458-21","article-title":"Screening of chemical libraries for new antifungal drugs against aspergillus fumigatus reveals sphingolipids are involved in the mechanism of action of miltefosine","volume":"12","author":"Dos Reis","year":"2021","journal-title":"Mbio"},{"issue":"5","key":"10.1016\/j.bmc.2025.118406_bb0205","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/02681218980000401","article-title":"Killing of Aspergillus fumigatus spores by human lung macrophages: a paradoxical effect of heat-labile serum components","volume":"27","author":"Robertson","year":"1989","journal-title":"J. Med. Vet. Mycol."},{"issue":"1","key":"10.1016\/j.bmc.2025.118406_bb0210","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s42269-020-00389-7","article-title":"Quantitative structure-activity relationship (QSAR) modelling study of some novel carboxamide series as new anti-tubercular agents","volume":"44","author":"Abdullahi","year":"2020","journal-title":"Bull. Natl. Res. Cent."}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:33:32Z","timestamp":1780403612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625003475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":42,"alternative-id":["S0968089625003475"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118406","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, synthesis and SAR studies of N\u2032-(Ethynylsalicylidene)arenecarbohydrazides as next-generation broad-spectrum antifungal agents","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118406","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118406"}}