{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:32:35Z","timestamp":1787639555308,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.bmc.2025.118422","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:26:22Z","timestamp":1759008382000},"page":"118422","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Synthesis, in-silico and in-vitro evaluation of quinoline-chromene hybrids as dual topoisomerase inhibitors"],"prefix":"10.1016","volume":"131","author":[{"given":"Anjali","family":"Saxena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noimul Hasan","family":"Siddiquee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hasan","family":"Shahariar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhrajit","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"M.Lynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118422_bb0005","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1001\/jama.303.11.1108","article-title":"Cancer: the basics","volume":"303","author":"Torpy","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.bmc.2025.118422_bb0010","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.bmc.2025.118422_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117681","article-title":"Inhibition of cancer cells by Quinoline-based compounds: a review with mechanistic insights","author":"Saxena","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: an overview","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bmc.2025.118422_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111592","article-title":"Novel 4-quinoline-thiosemicarbazone derivatives: synthesis, antiproliferative activity, in vitro and in silico biomacromolecule interaction studies and topoisomerase inhibition","volume":"182","author":"Ribeiro","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejmech.2018.02.058","article-title":"Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity","volume":"149","author":"Alonso","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2019.126905","article-title":"From coins to cancer therapy: gold, silver and copper complexes targeting human topoisomerases","volume":"30","author":"Ceramella","year":"2020","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.bmc.2025.118422_bb0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.18231\/j.ijpp.2022.003","article-title":"DNA Topoisomerases: As target for anti-cancer drugs","volume":"9","author":"Kulkarni","year":"2022","journal-title":"Indian J Pharm Pharmacol"},{"key":"10.1016\/j.bmc.2025.118422_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ph16101456","article-title":"Prospects of topoisomerase inhibitors as promising anti-Cancer agents","volume":"16","author":"Yakkala","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bmc.2025.118422_bb0050","doi-asserted-by":"crossref","first-page":"7963","DOI":"10.1021\/acs.jmedchem.1c00100","article-title":"Recent Progress on tubulin inhibitors with dual targeting capabilities for Cancer therapy","volume":"64","author":"Shuai","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0055","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/acs.jmedchem.9b00726","article-title":"Dual inhibitors of human DNA topoisomerase II and other Cancer-related targets","volume":"63","author":"Skok","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0060","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1093\/nar\/gkad1157","article-title":"Using energy to go downhill\u2014a genoprotective role for ATPase activity in DNA topoisomerase II","volume":"52","author":"Bandak","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bmc.2025.118422_bb0065","first-page":"53","article-title":"Human DNA topoisomerase I: structure","author":"Champoux","year":"2012","journal-title":"Enzymology and Biology"},{"key":"10.1016\/j.bmc.2025.118422_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-49567-5","article-title":"Topoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription","volume":"15","author":"Teng","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bmc.2025.118422_bb0075","article-title":"Prognostic significance of DNA topoisomerase II alpha (TOP2A) in cholangiocarcinoma","volume":"28","author":"Ong","year":"2023","journal-title":"Front Biosci - Landmark"},{"key":"10.1016\/j.bmc.2025.118422_bb0080","doi-asserted-by":"crossref","first-page":"546","DOI":"10.13005\/ojc\/390303","article-title":"From molecules to medicine: the remarkable pharmacological odyssey of Quinoline and it's derivatives","volume":"39","author":"Panchal","year":"2023","journal-title":"Orient. J. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0085","series-title":"Key Heterocycl. Cores Smart Anticancer Drug\u2013Design Part II","first-page":"174","article-title":"Natural products as anticancer agents: Recent advancement and future directions","author":"Chaudhary","year":"2022"},{"key":"10.1016\/j.bmc.2025.118422_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.1088477","article-title":"Anti-microbial, anti-oxidant, and anti-breast cancer properties unraveled in yeast carotenoids produced via cost-effective fermentation technique utilizing waste hydrolysate","volume":"13","author":"Sinha","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bmc.2025.118422_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25173791","article-title":"Chromene- and quinoline-3-carbaldehydes: useful intermediates in the synthesis of heterocyclic scaffolds","volume":"25","author":"Rocha","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2025.118422_bb0100","doi-asserted-by":"crossref","first-page":"828","DOI":"10.14233\/ajchem.2023.26894","article-title":"Synthesis, characterization and molecular modeling of Pyrazole-Quinoline hybrids as new class of antibacterial, antimicrobial, anticancer agents and DFT study","volume":"35","author":"Patel","year":"2023","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5539\/ijc.v12n1p99","article-title":"A novel and different approach for the synthesis of Quinoline derivatives starting directly from Nitroarenes and their evaluation as anti-Cancer agents","volume":"12","author":"Sultana","year":"2020","journal-title":"Int. J. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0110","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2174\/1568026622666220428093955","article-title":"Recent Updates on the Anticancer Activity of Quinoxaline Hybrids (Jan. 2017-Jan. 2022)","volume":"22","author":"Feng","year":"2022","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.59298\/ROJPHM\/2024\/41812","article-title":"Renewed insight into Cancer mechanism and therapy: advances, challenges, and future directions","volume":"4","author":"Mutebi","year":"2024","journal-title":"Res Output J Public Heal Med"},{"key":"10.1016\/j.bmc.2025.118422_bb0120","series-title":"Key Heterocycl. Cores Smart Anticancer Drug\u2013Design Part I","first-page":"167","article-title":"Structure-Activity-Relationship (SAR) Studies of novel hybrid Quinoline and quinolone derivatives as anticancer agents","author":"Panda","year":"2022"},{"key":"10.1016\/j.bmc.2025.118422_bb0125","doi-asserted-by":"crossref","first-page":"31139","DOI":"10.1039\/D0RA05594H","article-title":"Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review","volume":"10","author":"Mohamed","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.bmc.2025.118422_bb0130","first-page":"288","article-title":"Tailored Quinolines demonstrate flexibility to exert antitumor effects through varied mechanisms-a medicinal perspective, anticancer. Agents","volume":"21","author":"Sharma","year":"2020","journal-title":"Med. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0135","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1042\/BCJ20160583","article-title":"Topoisomerases as anticancer targets","volume":"475","author":"Delgado","year":"2018","journal-title":"Biochem. J."},{"key":"10.1016\/j.bmc.2025.118422_bb0140","first-page":"527","article-title":"Recent developments of Quinoline-heterocyclic conjugates as anticancer agents","volume":"66","author":"Santali","year":"2023","journal-title":"Egypt. J. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108689","article-title":"Fluorenyl-phthalimide hybrids as potent aldose reductase inhibitors with selective anticancer activity: rational design, synthesis, and molecular insights","volume":"163","author":"Gundogdu","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.135596","article-title":"Identification of potential N-substituted 5-benzylidenethiazolidine-2,4-dione derivatives as \u03b1-amylase inhibitors: computational cum synthetic studies","volume":"1287","author":"Gupta","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2025.118422_bb0155","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1071\/CH16232","article-title":"An in silico approach of coumarin-derived inhibitors for human DNA topoisomerase i","volume":"69","author":"Guruge","year":"2016","journal-title":"Aust. J. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0160","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jphotobiol.2017.01.010","article-title":"Allosteric inhibition of topoisomerase I by pinostrobin: molecular docking, spectroscopic and topoisomerase I activity studies","volume":"167","author":"Jadaun","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.bmc.2025.118422_bb0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40203-017-0024-2","article-title":"Molecular docking studies on thirteen fluoroquinolines with human topoisomerase II a and b","volume":"5","author":"Jadhav","year":"2017","journal-title":"Silico Pharmacol"},{"key":"10.1016\/j.bmc.2025.118422_bb0170","first-page":"68","article-title":"Molecular docking studies of some topoisomerase II inhibitors: implications in designing of novel anticancer drugs, Radiol","volume":"6","author":"Arthur","year":"2019","journal-title":"Infect. Dis."},{"key":"10.1016\/j.bmc.2025.118422_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/slct.202501259","article-title":"Evaluation of Annomontine-based anticancer agents: a synergistic computational and cytotoxicity approach","volume":"10","author":"Saxena","year":"2025","journal-title":"ChemistrySelect"},{"key":"10.1016\/j.bmc.2025.118422_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0310802","article-title":"Nature's defense against emerging neurodegenerative threats: dynamic simulation, PCA, DCCM identified potential plant-based antiviral lead targeting Borna disease virus nucleoprotein","volume":"19","author":"Siddiquee","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bmc.2025.118422_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.139924","article-title":"Molecular docking, QSAR, and simulation analyses of EGFR-targeting phytochemicals in non-small cell lung cancer","volume":"1321","author":"Talukder","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.bmc.2025.118422_bb0190","first-page":"1","article-title":"Natural products in precision neurological disease (Cryptococcal meningitis): structure-based phytochemical screening of Glycyrrhiza glabra plant against Cryptococcus neoformans farnesyltransferase (FTase)","author":"Siddiquee","year":"2025","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.bmc.2025.118422_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108788","article-title":"N-substituted phthalimide\u2013carboxylic acid hybrids as dual-targeted aldose reductase inhibitors: synthesis, mechanistic insights, and cancer-relevant profiling","volume":"163","author":"Zognjani","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108861","article-title":"Chalcone-inspired indole, carbazole, and phenothiazine hybrids as potent aldose reductase inhibitors with selective anticancer potential: rational design, synthesis, and multi-level characterization","volume":"164","author":"G\u00fcle\u00e7","year":"2025","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bmc.2025.118422_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2024.125558","article-title":"Bioactivity, cytotoxicity, and molecular modeling studies of novel sulfonamides as dual inhibitors of carbonic anhydrases and acetylcholinesterase","volume":"410","author":"G\u00fcle\u00e7","year":"2024","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.bmc.2025.118422_bb0210","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot087379","article-title":"Crystal violet assay for determining viability of cultured cells","volume":"2016","author":"Feoktistova","year":"2016","journal-title":"Cold Spring Harb. Protoc."}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:34:40Z","timestamp":1780403680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625003633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":42,"alternative-id":["S0968089625003633"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118422","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synthesis, in-silico and in-vitro evaluation of quinoline-chromene hybrids as dual topoisomerase inhibitors","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118422","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118422"}}