{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:13:51Z","timestamp":1793726031581,"version":"4.6.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["T32AI148103"],"award-info":[{"award-number":["T32AI148103"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01AI130186"],"award-info":[{"award-number":["R01AI130186"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic & Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmc.2025.118437","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:21:17Z","timestamp":1760001677000},"page":"118437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Halogenated N-(1,3,4-oxadiazol-2-yl) benzamides are effective eradicators of methicillin-resistant Staphylococcus aureus biofilms"],"prefix":"10.1016","volume":"132","author":[{"given":"George A.","family":"Naclerio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher S.","family":"Vennard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I.","family":"Onyedibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dielson da S.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader S.","family":"Abutaleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marxa L.","family":"Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed N.","family":"Seleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman O.","family":"Sintim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118437_bb0005","unstructured":"CDC. COVID-19 & Antibiotic Resistance. Centers for Disease Control and Prevention. 2022. https:\/\/www.cdc.gov\/drugresistance\/covid19.html. Accessed 9 Apr 2024."},{"key":"10.1016\/j.bmc.2025.118437_bb0010","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the global burden of disease study 2019","volume":"400","author":"Ikuta","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.bmc.2025.118437_bb0015","series-title":"WHO Bacterial Priority Pathogens List, 2024: Bacterial Pathogens of Public Health Importance to Guide Research, Development and Strategies to Prevent and Control Antimicrobial Resistance","author":"World Health Organization","year":"2024"},{"key":"10.1016\/j.bmc.2025.118437_bb0020","first-page":"742","article-title":"New antibiotics for Staphylococcus aureus infection: an update from the world Association of Infectious Diseases and Immunological Disorders (WAidid) and the Italian Society of Anti-Infective Therapy (SITA)","volume":"12","author":"Esposito","year":"2023","journal-title":"Antibiot Basel Switz"},{"key":"10.1016\/j.bmc.2025.118437_bb0025","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.2217\/fmb.12.76","article-title":"Biofilm-specific antibiotic resistance","volume":"7","author":"Mah","year":"2012","journal-title":"Future Microbiol"},{"key":"10.1016\/j.bmc.2025.118437_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ijos.2014.65","article-title":"Strategies for combating bacterial biofilm infections","volume":"7","author":"Wu","year":"2015","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.bmc.2025.118437_bb0035","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.4155\/fmc-2020-0046","article-title":"Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets","volume":"12","author":"Naclerio","year":"2020","journal-title":"Future Med Chem"},{"key":"10.1016\/j.bmc.2025.118437_bb0040","series-title":"Fairfull-Smith KE","first-page":"7","author":"Verderosa","year":"2019"},{"key":"10.1016\/j.bmc.2025.118437_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115389","article-title":"Bacterial biofilm inhibitors: an overview","volume":"264","author":"Kalia","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.bmc.2025.118437_bb0050","doi-asserted-by":"crossref","first-page":"10282","DOI":"10.1073\/pnas.1302816110","article-title":"Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity","volume":"110","author":"Ramadoss","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2025.118437_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2019.115097","article-title":"Synthesis and evaluation of 1,3,4-oxadiazole derivatives for development as broad-spectrum antibiotics","volume":"27","author":"Tresse","year":"2019","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.bmc.2025.118437_bb0060","doi-asserted-by":"crossref","first-page":"11934","DOI":"10.1021\/acs.jmedchem.0c01198","article-title":"Ultrapotent inhibitor of Clostridioides difficile growth, which suppresses recurrence in vivo","volume":"63","author":"Naclerio","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.bmc.2025.118437_bb0065","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1039\/C9MD00391F","article-title":"Potent trifluoromethoxy, trifluoromethylsulfonyl, trifluoromethylthio and pentafluorosulfanyl containing (1,3,4-oxadiazol-2-yl)benzamides against drug-resistant gram-positive bacteria","volume":"11","author":"Naclerio","year":"2020","journal-title":"RSC Med Chem"},{"key":"10.1016\/j.bmc.2025.118437_bb0070","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.3390\/ijms22052427","article-title":"N-(1,3,4-Oxadiazol-2-yl)Benzamides as antibacterial agents against Neisseria gonorrhoeae","volume":"22","author":"Naclerio","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2025.118437_bb0075","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.ejmech.2018.06.023","article-title":"N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria","volume":"155","author":"Opoku-Temeng","year":"2018","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118437_bb0080","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3390\/molecules25102277","article-title":"Lipoteichoic acid biosynthesis inhibitors as potent inhibitors of S. aureus and E. faecalis growth and biofilm formation","volume":"25","author":"Naclerio","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bmc.2025.118437_bb0085","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/cmdc.201900053","article-title":"Antibacterial small molecules that potently inhibit Staphylococcus aureus Lipoteichoic acid biosynthesis","volume":"14","author":"Naclerio","year":"2019","journal-title":"ChemMedChem"},{"key":"10.1016\/j.bmc.2025.118437_bb0090","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1016\/j.jmb.2017.10.007","article-title":"A genetic tool to quantify trans-translation activity in vivo","volume":"429","author":"Mac\u00e9","year":"2017","journal-title":"J Mol Biol"},{"key":"10.1016\/j.bmc.2025.118437_bb0095","doi-asserted-by":"crossref","first-page":"16529","DOI":"10.1073\/pnas.1904700116","article-title":"A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus","volume":"116","author":"Kim","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.bmc.2025.118437_bb0100","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1128\/AAC.47.8.2538-2544.2003","article-title":"Correlation of Daptomycin bactericidal activity and membrane depolarization in Staphylococcus aureus","volume":"47","author":"Silverman","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.bmc.2025.118437_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mib.2015.05.008","article-title":"Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution","volume":"27","author":"Bollenbach","year":"2015","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.bmc.2025.118437_bb0110","first-page":"12","article-title":"Synergistic Microbicidal effect of AUR and PEITC against Staphylococcus aureus skin infection","author":"Chen","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.bmc.2025.118437_bb0115","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/ijms20061255","article-title":"Thinking outside the bug: molecular targets and strategies to overcome antibiotic resistance","volume":"20","author":"Monserrat-Martinez","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2025.118437_bb0120","unstructured":"Ed12 | Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 12th Edition. Clinical & Laboratory Standards Institute. https:\/\/clsi.org\/standards\/products\/microbiology\/documents\/m07\/. Accessed 12 Apr 2024."},{"key":"10.1016\/j.bmc.2025.118437_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2021.101543","article-title":"New and simplified method for drug combination studies by checkerboard assay","volume":"8","author":"Bellio","year":"2021","journal-title":"MethodsX"},{"key":"10.1016\/j.bmc.2025.118437_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111830","article-title":"Modifying the lipophilic part of phenylthiazole antibiotics to control their drug-likeness","volume":"185","author":"Hosny","year":"2020","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.bmc.2025.118437_bb0135","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0167-7012(00)00122-6","article-title":"A modified microtiter-plate test for quantification of staphylococcal biofilm formation","volume":"40","author":"Stepanovic","year":"2000","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.bmc.2025.118437_bb0140","doi-asserted-by":"crossref","unstructured":"Onyedibe KI, Dayal N, Sintim HO. SF5- and SCF3-substituted tetrahydroquinoline compounds as potent bactericidal agents against multidrug-resistant persister Gram-positive bacteria. RSC Med Chem. 12:1879\u201393.","DOI":"10.1039\/D1MD00211B"},{"key":"10.1016\/j.bmc.2025.118437_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jgar.2019.04.016","article-title":"An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection","volume":"19","author":"Mohammad","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.bmc.2025.118437_bb0150","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1038\/s41598-020-64352-2","article-title":"Auranofin rapidly eradicates methicillin-resistant Staphylococcus aureus (MRSA) in an infected pressure ulcer mouse model","volume":"10","author":"Mohammad","year":"2020","journal-title":"Sci Rep"}],"container-title":["Bioorganic & Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:59:30Z","timestamp":1780635570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625003785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":30,"alternative-id":["S0968089625003785"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118437","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Halogenated N-(1,3,4-oxadiazol-2-yl) benzamides are effective eradicators of methicillin-resistant Staphylococcus aureus biofilms","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"118437"}}