{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:59:48Z","timestamp":1780639188275,"version":"3.54.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24790109"],"award-info":[{"award-number":["JP24790109"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bioorganic &amp; Medicinal Chemistry"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.bmc.2025.118442","type":"journal-article","created":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T14:47:25Z","timestamp":1760280445000},"page":"118442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Down-regulation of Fc\u03b5RI expression on mast cells leads anti-allergic effect"],"prefix":"10.1016","volume":"132","author":[{"given":"Chiaki","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Ujiie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutoshi","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bmc.2025.118442_bb0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0300-483X(00)00400-5","article-title":"Gell and Coombs's classification: is it still valid?","volume":"158","author":"Descotes","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.bmc.2025.118442_bb0015","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/337187a0","article-title":"Complete structure and expression in transfected cells of high affinity IgE receptor","volume":"337","author":"Blank","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118442_bb0020","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0092-8674(93)90540-7","article-title":"Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor \u03b1 chain gene","volume":"75","author":"Dombrowicz","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bmc.2025.118442_bb0025","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4049\/jimmunol.2300188","article-title":"Butyrate, valerate, and niacin ameliorate anaphylaxis by suppressing IgE-dependent mast cell activation: roles of GRP109A, PGE2, and epigenetic regulation","volume":"212","author":"Nagata","year":"2024","journal-title":"J Immunol"},{"key":"10.1016\/j.bmc.2025.118442_bb0030","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.bmcl.2010.01.160","article-title":"New inhibitors for expression of IgE receptor on human mast cell","volume":"20","author":"Tamura","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118442_bb0035","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1016\/j.bmcl.2010.05.038","article-title":"Inhibitors for expression of IgE receptor on human mast cell from Puerariae Flos","volume":"20","author":"Tamura","year":"2010","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118442_bb0040","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1016\/j.bmcl.2018.09.007","article-title":"Inhibitor for Fc\u03b5RI expression on mast cell from Verbasucum thapsus L","volume":"28","author":"Tamura","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.bmc.2025.118442_bb0045","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1515\/znb-1981-0819","article-title":"Conformations of chlorophylls a and a\u2019 and their magnesium-free derivatives as revealed by circular dichroism and proton magnetic resonance","volume":"36b","author":"Hynninen","year":"1981","journal-title":"Z Naturforsch"},{"key":"10.1016\/j.bmc.2025.118442_bb0050","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1751-1097.2007.00092.x","article-title":"Mono-(l)-aspartylchlorin-e6","volume":"83","author":"Hargus","year":"2007","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.bmc.2025.118442_bb0055","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/216151a0","article-title":"Absolute configuration and the structure of chlorophyll","volume":"216","author":"Fleming","year":"1967","journal-title":"Nature"},{"key":"10.1016\/j.bmc.2025.118442_bb0060","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.3390\/ijms20163861","article-title":"Chlorin, phthalocyanine, and porphyrin types derivatives in phototreatment of cutaneous manifestations: a review","volume":"20","author":"Annunzio","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bmc.2025.118442_bb0065","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/26\/5\/055102","article-title":"Chlorin e6\u2013ZnSe\/ZnS quantum dots based system as reagent for photodynamic therapy","volume":"26","author":"Martynenko","year":"2015","journal-title":"Nanotechnology"},{"key":"10.1016\/j.bmc.2025.118442_bb0070","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s13273-019-0030-z","article-title":"Ameliorative effect of chlorin e6-mediated photodynamic therapy on DNCB-induced atopic dermatitis-like skin lesions in mice","volume":"15","author":"Ryu","year":"2019","journal-title":"Mol Cell Toxicol"},{"key":"10.1016\/j.bmc.2025.118442_bb0075","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.3891\/acta.chem.scand.27-1771","article-title":"Chlorophylls. IV. Preparation and purification of some derivatives of chlorophylls a and b","volume":"27","author":"Hynninen","year":"1973","journal-title":"Acta Chem Scand"},{"key":"10.1016\/j.bmc.2025.118442_bb0080","doi-asserted-by":"crossref","first-page":"7774","DOI":"10.1021\/la904574m","article-title":"Peroxide decoloration of CI acid orange 7 catalyzed by manganese chlorophyll derivatives at the surfaces of micelles and lipid bilayers","volume":"26","author":"Ishigure","year":"2010","journal-title":"Langmuir"},{"key":"10.1016\/j.bmc.2025.118442_bb0085","doi-asserted-by":"crossref","unstructured":"Rho, MC.; Chung, M.Y.; Song, H.Y.; Kwon, O. E.; Lee, S. W.; Baek, J. A.; Jeune, K. H.; Kim, K.; Lee, H. S.; Kim, Y. K. Pheophorbide a-methyl ester, acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki. Arch Pharm Res 2003; 26: 716\u2013718. doi: https:\/\/doi.org\/10.1007\/BF02976679.","DOI":"10.1007\/BF02976679"},{"key":"10.1016\/j.bmc.2025.118442_bb0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1002\/chem.200902377","article-title":"A nucleic acid dependent chemical photocatalysis in live human cells","volume":"16","author":"Arian","year":"2010","journal-title":"Chem Eur J"},{"key":"10.1016\/j.bmc.2025.118442_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0022-1759(94)90151-1","article-title":"Cytofluorometric quantification of IgE and IgE receptors on individual mast cells","volume":"177","author":"Chen","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.bmc.2025.118442_bb0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/BF00220383","article-title":"Ultrastructure of mucosal mast cells in normal and compound 48\/80-treated rats","volume":"150","author":"Enerb\u00e4ck","year":"1974","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.bmc.2025.118442_bb0105","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1248\/bpb.22.870","article-title":"Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats","volume":"22","author":"Matsuda","year":"1999","journal-title":"Biol Pharm Bull"}],"container-title":["Bioorganic &amp; Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968089625003839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:02:31Z","timestamp":1780635751000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968089625003839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":20,"alternative-id":["S0968089625003839"],"URL":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118442","relation":{},"ISSN":["0968-0896"],"issn-type":[{"value":"0968-0896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Down-regulation of Fc\u03b5RI expression on mast cells leads anti-allergic effect","name":"articletitle","label":"Article Title"},{"value":"Bioorganic & Medicinal Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bmc.2025.118442","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"118442"}}